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Keywords:        mHNPC, de-escalation, maximal androgen blockade, AR pathway inhibitor, quality of life
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      Title: EORTC 2238 “De-Escalate”: a pragmatic trial to revisit intermittent androgen deprivation therapy in the era of new androgen receptor pathway inhibitors
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        Title: 1 Introduction
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        Title: 2 The new treatment landscape, its benefits, and consequences
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        Title: 3 The need to revisit Intermittent androgen deprivation therapy
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        Title: 4 Why a pragmatic clinical trial to revisit iADT?
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        Title: 5 The challenges of conducting pragmatic clinical trials
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        Title: 6 Assessing the “pragmatism” of a trial
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        Title: 7 Conclusion
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