556943d197a98d396a2a5831c0ca117f cancers-16-01521.pdf 4651dec91c36d2fc8784279718349c42e474af13 cancers-16-01521.pdf 46c1fa44a6f121f6e9aa7f2a1349570a981df814fdda58af650591649ff802ca cancers-16-01521.pdf Title: Hepatitis-C-Related Hepatocellular Carcinoma, Still a Relevant Etiology beyond a Hepatitis C Infection Cure Subject: Background: In the past decades, global changes, including hepatitis B vaccination, hepatitis B and C antiviral therapies, and the increasing prevalence of steatotic liver disease, have influenced the landscape of liver cancer etiologies. Methods: We performed a retrospective study focused on the etiological factors of de novo hepatocellular carcinoma (HCC) diagnoses in an academic center between 2019 and 2022. Results: Among 352 consecutive patients with HCC, alcohol-related liver disease was the predominant etiology (33.3%), followed by hepatitis C (HCV) infection (30.7%). Significant associations were found between HCC etiology and patient demographics, BCLC stage at diagnosis, and cirrhosis prevalence. Conclusions: Whereas accessibility to antiviral therapy is granted, HCV infection remains as one of the main HCC etiologies. MASLD-related HCC, although growing globally, is not as relevant in our area. Strong public policies need to be implemented to prevent alcohol consumption, the main etiology of liver disease and liver cancer. Keywords: hepatocellular carcinoma; hepatitis C; viral hepatitis; HCV Author: Elena Vargas-Accarino, Mónica Higuera, María Buti and Beatriz Mínguez Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Thu Apr 18 05:16:46 2024 CEST ModDate: Thu Apr 18 05:25:59 2024 CEST Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 8 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 559297 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- YWWVQQ+VnURWPalladioL-Bold Type 1 Custom yes yes yes 10 0 OXWFYT+URWPalladioL-Bold Type 1 Custom yes yes yes 16 0 YPHUHF+URWPalladioL-Roma Type 1 Custom yes yes yes 22 0 KZWHVK+URWPalladioL-Ital Type 1 Custom yes yes yes 27 0 IYDCBB+VnURWPalladioL Type 1 Custom yes yes yes 32 0 LCJEVJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 49 0 LJEZBI+CMSY10 Type 1 Builtin yes yes yes 66 0 CKBPVA+EURM10 Type 1 Builtin yes yes yes 71 0 WBVKDJ+URWPalladioL-BoldItal Type 1 Custom yes yes yes 79 0 JLNLEB+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 94 0 JLNLED+PalatinoLinotype TrueType WinAnsi yes yes no 97 0 JLNLEF+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 100 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2026-03-13 04:29:17 CET RepresentationInformation: cancers-16-01521.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2026-03-12 16:20:09 CET Size: 559297 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 213 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Children: Item: Title: Study Population Destination: subsection.2.1 Item: Title: Variables Destination: subsection.2.2 Item: Title: Statistical Analysis Destination: subsection.2.3 Item: Title: Results Destination: section.3 Item: Title: Discussion Destination: section.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: section.6 Info: Title: Hepatitis-C-Related Hepatocellular Carcinoma, Still a Relevant Etiology beyond a Hepatitis C Infection Cure Author: Elena Vargas-Accarino, Mónica Higuera, María Buti and Beatriz Mínguez Subject: Background: In the past decades, global changes, including hepatitis B vaccination, hepatitis B and C antiviral therapies, and the increasing prevalence of steatotic liver disease, have influenced the landscape of liver cancer etiologies. Methods: We performed a retrospective study focused on the etiological factors of de novo hepatocellular carcinoma (HCC) diagnoses in an academic center between 2019 and 2022. Results: Among 352 consecutive patients with HCC, alcohol-related liver disease was the predominant etiology (33.3%), followed by hepatitis C (HCV) infection (30.7%). Significant associations were found between HCC etiology and patient demographics, BCLC stage at diagnosis, and cirrhosis prevalence. Conclusions: Whereas accessibility to antiviral therapy is granted, HCV infection remains as one of the main HCC etiologies. MASLD-related HCC, although growing globally, is not as relevant in our area. Strong public policies need to be implemented to prevent alcohol consumption, the main etiology of liver disease and liver cancer. 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