83936f2792bfc47e11f22f8c28348423  327779.pdf
f17f9ac5be645256b2da6aba4a9480c0370af51d  327779.pdf
8964a3370697da5cfa2c36428f22790d649814049cfcc1ec70a6b54d884e89e7  327779.pdf

Title:           Risks of Organ Preservation in Rectal Cancer: Data From Two International Registries on Rectal Cancer
Subject:         J Clin Oncol 2025.43:1663-1672
Keywords:        
Author:          
Creator:         Arbortext Advanced Print Publisher 9.1.510/W Unicode
Producer:        Acrobat Distiller 7.0 (Windows); modified using iText 4.2.0 by 1T3XT
CreationDate:    15th April 2025
ModDate:         Thu Apr 23 10:07:12 2026 CEST
Custom Metadata: yes
Metadata Stream: yes
Tagged:          no
UserProperties:  no
Suspects:        no
Form:            none
JavaScript:      no
Pages:           14
Encrypted:       no
Page size:       584.957 x 782.986 pts
Page rot:        0
File size:       981373 bytes
Optimized:       no
PDF version:     1.3


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
KPEPDD+AdvTTc5dbea8d                 Type 1C           WinAnsi          yes yes no      68  0
KPEPEF+AdvTTc5dbea8d+fb              Type 1C           Custom           yes yes yes     69  0
KPEPED+AdvTTc5dbea8d+22              Type 1C           Custom           yes yes yes     94  0
KPEPFG+AdvTT11e9ef3a.I               Type 1C           WinAnsi          yes yes no      70  0
KPEPEE+AdvTTc5dbea8d+20              Type 1C           WinAnsi          yes yes no      71  0
KPEPFH+AdvOT463cc31e                 Type 1C           WinAnsi          yes yes no      96  0
KPFAAE+AdvTT00e4de1c                 Type 1C           WinAnsi          yes yes no      76  0
KPENMF+AdvTTeaefc7ed.B               Type 1C           WinAnsi          yes yes no      77  0
KPENNG+AdvTTac83875d                 Type 1C           WinAnsi          yes yes no     327  0
KPENPG+AdvTT4c3fd98b.B               Type 1C           WinAnsi          yes yes no      78  0
KPEOAH+AdvTT7b58c9e2                 Type 1C           WinAnsi          yes yes no      79  0
KPEOLE+AdvTT7b58c9e2+01              Type 1C           MacRoman         yes yes no     160  0
KPEPDC+AdvTTadb9db83                 Type 1C           WinAnsi          yes yes no     161  0
Times-Roman                          Type 1            WinAnsi          no  no  no       5  0
KPFAFF+AdvTTef19a6eb.BI              Type 1C           WinAnsi          yes yes no      72  0
KPFAFG+AdvTTef19a6eb.BI+20           Type 1C           WinAnsi          yes yes no      73  0
KPFADE+AdvTTfe9cfb37.B               Type 1C           WinAnsi          yes yes no      74  0
KPFAEE+AdvTT7b58c9e2+fb              Type 1C           Custom           yes yes yes     75  0
KPFAJG+AdvTT00e4de1c+20              Type 1C           WinAnsi          yes yes no      95  0
KPFBAF+AdvPS_SSYB                    Type 1C           WinAnsi          yes yes no     122  0
KPFBAE+AdvTT7d9f0b66.I               Type 1C           WinAnsi          yes yes no     123  0
KPFBGE+Univers                       Type 1C           WinAnsi          yes yes no     134  0
KPFBHE+Univers-Condensed             Type 1C           WinAnsi          yes yes no     135  0
KPFBJH+AdvTT7b58c9e2+20              Type 1C           WinAnsi          yes yes no     136  0
KPFBHF+Univers-Oblique               Type 1C           WinAnsi          yes yes no     137  0
KPFBHG+Helvetica-Bold                Type 1C           WinAnsi          yes yes no     138  0
KPFCNA+AdvTT4c3fd98b.B+20            Type 1C           WinAnsi          yes yes no     159  0
KPFDBA+AdvTTadb9db83+fb              Type 1C           Custom           yes yes yes    172  0
KPFDCA+AdvTTadb9db83+20              Type 1C           WinAnsi          yes yes no     173  0
KPFDHA+AdvTTadb9db83+02              Type 1C           WinAnsi          yes yes no     186  0
KPFDGA+AdvTTadb9db83+01              Type 1C           MacRoman         yes yes no     187  0
KPFDLA+Univers-Bold                  Type 1C           WinAnsi          yes yes no     195  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2026-04-24 05:00:17 CEST
 RepresentationInformation: 327779.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2026-04-23 10:28:36 CEST
  Size: 981373
  Format: PDF
  Version: 1.3
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 0
   FreeObjects: 2
   IncrementalUpdates: 0
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseNone
    Outlines: 
     Item: 
      Title: Risks of Organ Preservation in Rectal Cancer: Data From Two International Registries on Rectal Cancer
      Destination: titlink1
      Children: 
       Item: 
        Title: INTRODUCTION
        Destination: flink1
       Item: 
        Title: METHODS
        Destination: flink2
        Children: 
         Item: 
          Title: Hypothesis
          Destination: slink1
         Item: 
          Title: Study Design
          Destination: slink2
         Item: 
          Title: IWWD Database: LRg
          Destination: slink3
         Item: 
          Title: VIKINGO Database: nPCR
          Destination: slink4
         Item: 
          Title: Time
          Destination: slink5
         Item: 
          Title: Statistical Analysis
          Destination: slink6
       Item: 
        Title: RESULTS
        Destination: flink3
        Children: 
         Item: 
          Title: Risk Factors
          Destination: slink7
         Item: 
          Title: DM-Free Survival
          Destination: slink8
         Item: 
          Title: DM
          Destination: slink9
       Item: 
        Title: DISCUSSION
        Destination: flink4
       Item: 
        Title: REFERENCES
        Destination: rlink1
       Item: 
        Title: APPENDIX 1. VIKINGO ConsortiumFrancisco Blanco Antona (Complejo Asistencial de Salamanca), Elena Yagüe Martín (Complejo Hos ...
        Destination: flink5
       Item: 
        Title: APPENDIX 1. VIKINGO Consortium
        Destination: aplink1
       Item: 
        Title: APPENDIX 2. International Watch & Wait Database Consortium
        Destination: aplink2
   Filters: 
    FilterPipeline: FlateDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 228
      ImageHeight: 45
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 159
      ImageHeight: 159
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 228
      ImageHeight: 45
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
   Fonts: 
    Type1: 
     Font: 
      BaseFont: KPFDLA+Univers-Bold
      FontSubset: true
      FirstChar: 68
      LastChar: 87
      FontDescriptor: 
       FontName: KPFDLA+Univers-Bold
       Flags: Nonsymbolic, ForceBold
       FontBBox: -167, -250, 995, 938
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: KPEPDD+AdvTTc5dbea8d
      FontSubset: true
      FirstChar: 35
      LastChar: 227
      FontDescriptor: 
       FontName: KPEPDD+AdvTTc5dbea8d
       Flags: Serif, Nonsymbolic
       FontBBox: -83, -260, 1145, 979
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: KPEPEF+AdvTTc5dbea8d+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: KPEPEF+AdvTTc5dbea8d+fb
       Flags: Symbolic
       FontBBox: 19, 0, 770, 822
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: KPEPFG+AdvTT11e9ef3a.I
      FontSubset: true
      FirstChar: 67
      LastChar: 118
      FontDescriptor: 
       FontName: KPEPFG+AdvTT11e9ef3a.I
       Flags: Nonsymbolic
       FontBBox: -104, -250, 1083, 979
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: KPFBGE+Univers
      FontSubset: true
      FirstChar: 32
      LastChar: 151
      FontDescriptor: 
       FontName: KPFBGE+Univers
       Flags: Nonsymbolic
       FontBBox: -168, -250, 992, 947
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: KPENNG+AdvTTac83875d
      FontSubset: true
      FirstChar: 65
      LastChar: 119
      FontDescriptor: 
       FontName: KPENNG+AdvTTac83875d
       Flags: Nonsymbolic
       FontBBox: -31, -229, 770, 927
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: KPEPEE+AdvTTc5dbea8d+20
      FontSubset: true
      FirstChar: 146
      LastChar: 151
      FontDescriptor: 
       FontName: KPEPEE+AdvTTc5dbea8d+20
       Flags: Nonsymbolic
       FontBBox: -114, -260, 1416, 885
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: KPFBHE+Univers-Condensed
      FontSubset: true
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: KPFBHE+Univers-Condensed
       Flags: Nonsymbolic
       FontBBox: -166, -250, 1000, 989
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: KPFAFF+AdvTTef19a6eb.BI
      FontSubset: true
      FirstChar: 40
      LastChar: 121
      FontDescriptor: 
       FontName: KPFAFF+AdvTTef19a6eb.BI
       Flags: Nonsymbolic
       FontBBox: -104, -218, 802, 937
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: KPFBJH+AdvTT7b58c9e2+20
      FontSubset: true
      FirstChar: 146
      LastChar: 151
      FontDescriptor: 
       FontName: KPFBJH+AdvTT7b58c9e2+20
       Flags: Nonsymbolic
       FontBBox: 0, -197, 906, 760
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: KPFAFG+AdvTTef19a6eb.BI+20
      FontSubset: true
      FirstChar: 146
      LastChar: 146
      FontDescriptor: 
       FontName: KPFAFG+AdvTTef19a6eb.BI+20
       Flags: Nonsymbolic
       FontBBox: -72, -197, 885, 760
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: KPFBHF+Univers-Oblique
      FontSubset: true
      FirstChar: 80
      LastChar: 118
      FontDescriptor: 
       FontName: KPFBHF+Univers-Oblique
       Flags: Nonsymbolic, Italic
       FontBBox: -174, -250, 1145, 947
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: KPFADE+AdvTTfe9cfb37.B
      FontSubset: true
      FirstChar: 45
      LastChar: 121
      FontDescriptor: 
       FontName: KPFADE+AdvTTfe9cfb37.B
       Flags: Nonsymbolic
       FontBBox: -83, -260, 1166, 979
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: KPFBHG+Helvetica-Bold
      FontSubset: true
      FirstChar: 65
      LastChar: 67
      FontDescriptor: 
       FontName: KPFBHG+Helvetica-Bold
       Flags: Nonsymbolic, ForceBold
       FontBBox: -170, -228, 1003, 962
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: KPFAEE+AdvTT7b58c9e2+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: KPFAEE+AdvTT7b58c9e2+fb
       Flags: Symbolic
       FontBBox: 9, 0, 854, 770
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: KPFAAE+AdvTT00e4de1c
      FontSubset: true
      FirstChar: 37
      LastChar: 169
      FontDescriptor: 
       FontName: KPFAAE+AdvTT00e4de1c
       Flags: Nonsymbolic
       FontBBox: -52, -239, 885, 916
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: KPENMF+AdvTTeaefc7ed.B
      FontSubset: true
      FirstChar: 38
      LastChar: 124
      FontDescriptor: 
       FontName: KPENMF+AdvTTeaefc7ed.B
       Flags: Nonsymbolic
       FontBBox: -41, -218, 770, 937
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: KPENPG+AdvTT4c3fd98b.B
      FontSubset: true
      FirstChar: 44
      LastChar: 122
      FontDescriptor: 
       FontName: KPENPG+AdvTT4c3fd98b.B
       Flags: Nonsymbolic
       FontBBox: -41, -218, 906, 937
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: KPEOAH+AdvTT7b58c9e2
      FontSubset: true
      FirstChar: 37
      LastChar: 241
      FontDescriptor: 
       FontName: KPEOAH+AdvTT7b58c9e2
       Flags: Nonsymbolic
       FontBBox: -41, -239, 916, 937
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: KPEPED+AdvTTc5dbea8d+22
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: KPEPED+AdvTTc5dbea8d+22
       Flags: Symbolic
       FontBBox: 9, -250, 875, 906
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: KPFAJG+AdvTT00e4de1c+20
      FontSubset: true
      FirstChar: 150
      LastChar: 151
      FontDescriptor: 
       FontName: KPFAJG+AdvTT00e4de1c+20
       Flags: Nonsymbolic
       FontBBox: 9, -197, 916, 760
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: KPFCNA+AdvTT4c3fd98b.B+20
      FontSubset: true
      FirstChar: 146
      LastChar: 146
      FontDescriptor: 
       FontName: KPFCNA+AdvTT4c3fd98b.B+20
       Flags: Nonsymbolic
       FontBBox: 0, -229, 927, 760
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: KPEPFH+AdvOT463cc31e
      FontSubset: true
      FirstChar: 49
      LastChar: 54
      FontDescriptor: 
       FontName: KPEPFH+AdvOT463cc31e
       Flags: Nonsymbolic
       FontBBox: -20, -239, 989, 812
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: KPEOLE+AdvTT7b58c9e2+01
      FontSubset: true
      FirstChar: 245
      LastChar: 245
      FontDescriptor: 
       FontName: KPEOLE+AdvTT7b58c9e2+01
       Flags: Nonsymbolic
       FontBBox: -41, -239, 916, 1010
       FontFile3: true
      Encoding: MacRomanEncoding
     Font: 
      BaseFont: KPEPDC+AdvTTadb9db83
      FontSubset: true
      FirstChar: 38
      LastChar: 241
      FontDescriptor: 
       FontName: KPEPDC+AdvTTadb9db83
       Flags: Nonsymbolic
       FontBBox: -31, -239, 750, 927
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: KPFDBA+AdvTTadb9db83+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: KPFDBA+AdvTTadb9db83+fb
       Flags: Symbolic
       FontBBox: 19, 0, 697, 770
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: KPFDCA+AdvTTadb9db83+20
      FontSubset: true
      FirstChar: 145
      LastChar: 151
      FontDescriptor: 
       FontName: KPFDCA+AdvTTadb9db83+20
       Flags: Nonsymbolic
       FontBBox: 9, -197, 760, 760
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: KPFBAF+AdvPS_SSYB
      FontSubset: true
      FirstChar: 60
      LastChar: 60
      FontDescriptor: 
       FontName: KPFBAF+AdvPS_SSYB
       Flags: Nonsymbolic
       FontBBox: -197, -270, 1135, 989
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: KPFDHA+AdvTTadb9db83+02
      FontSubset: true
      FirstChar: 136
      LastChar: 136
      FontDescriptor: 
       FontName: KPFDHA+AdvTTadb9db83+02
       Flags: Nonsymbolic
       FontBBox: -31, -218, 468, 760
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: KPFBAE+AdvTT7d9f0b66.I
      FontSubset: true
      FirstChar: 80
      LastChar: 80
      FontDescriptor: 
       FontName: KPFBAE+AdvTT7d9f0b66.I
       Flags: Nonsymbolic
       FontBBox: -104, -239, 927, 937
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: KPFDGA+AdvTTadb9db83+01
      FontSubset: true
      FirstChar: 245
      LastChar: 245
      FontDescriptor: 
       FontName: KPFDGA+AdvTTadb9db83+01
       Flags: Nonsymbolic
       FontBBox: -41, -218, 750, 1010
       FontFile3: true
      Encoding: MacRomanEncoding
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="" xmlns:dc="http://purl.org/dc/elements/1.1/"><dc:format>application/pdf</dc:format><dc:identifier>doi:10.1200/JCO.24.00405</dc:identifier></rdf:Description>
<rdf:Description rdf:about="" xmlns:prism="http://prismstandard.org/namespaces/basic/2.1/"><prism:doi>10.1200/JCO.24.00405</prism:doi><prism:url>https://doi.org/10.1200/JCO.24.00405</prism:url></rdf:Description>
<rdf:Description rdf:about="" xmlns:crossmark="http://crossref.org/crossmark/1.0/"><crossmark:MajorVersionDate>2024-10-28</crossmark:MajorVersionDate><crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive><crossmark:CrossMarkDomains><rdf:Seq><rdf:li>ascopubs.org</rdf:li></rdf:Seq></crossmark:CrossMarkDomains><crossmark:DOI>10.1200/JCO.24.00405</crossmark:DOI></rdf:Description>
<rdf:Description rdf:about="" xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/"><pdfx:CrossMarkDomains><rdf:Seq><rdf:li>ascopubs.org</rdf:li></rdf:Seq></pdfx:CrossMarkDomains><pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive><pdfx:doi>10.1200/JCO.24.00405</pdfx:doi><pdfx:CrossmarkMajorVersionDate>2024-10-28</pdfx:CrossmarkMajorVersionDate></rdf:Description>
</rdf:RDF></x:xmpmeta>
   Pages: 
    Page: 
     Label: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 127, 673, 138, 682
      Annotation: 
       Subtype: Link
       Rect: 252, 673, 264, 682
      Annotation: 
       Subtype: Link
       Rect: 376, 673, 387, 682
      Annotation: 
       Subtype: Link
       Rect: 140, 663, 151, 672
      Annotation: 
       Subtype: Link
       Rect: 315, 663, 326, 672
      Annotation: 
       Subtype: Link
       Rect: 404, 663, 415, 672
      Annotation: 
       Subtype: Link
       Rect: 506, 663, 517, 672
      Annotation: 
       Subtype: Link
       Rect: 219, 652, 230, 661
      Annotation: 
       Subtype: Link
       Rect: 391, 652, 402, 661
      Annotation: 
       Subtype: Link
       Rect: 474, 642, 485, 651
      Annotation: 
       Subtype: Link
       Rect: 49, 614, 155, 622
      Annotation: 
       Subtype: Link
       Rect: 277, 152, 279, 159
       Destination: 157
      Annotation: 
       Subtype: Link
       Rect: 283, 152, 286, 159
       Destination: 157
      Annotation: 
       Subtype: Link
       Rect: 259, 115, 262, 122
       Destination: 157
      Annotation: 
       Subtype: Link
       Rect: 266, 115, 270, 122
       Destination: 170
      Annotation: 
       Subtype: Link
       Rect: 271, 78, 274, 86
       Destination: 157
      Annotation: 
       Subtype: Link
       Rect: 277, 78, 280, 86
       Destination: 157
      Annotation: 
       Subtype: Link
       Rect: 282, 78, 286, 86
       Destination: 170
      Annotation: 
       Subtype: Link
       Rect: 343, 151, 346, 158
       Destination: 170
      Annotation: 
       Subtype: Link
       Rect: 350, 151, 353, 158
       Destination: 170
      Annotation: 
       Subtype: Link
       Rect: 542, 139, 548, 146
       Destination: 170
      Annotation: 
       Subtype: Link
       Rect: 454, 115, 459, 122
       Destination: 170
      Annotation: 
       Subtype: Link
       Rect: 494, 559, 513, 568
      Annotation: 
       Subtype: Link
       Rect: 351, 21, 438, 29
      Annotation: 
       Subtype: Link
       Rect: 482, 769, 582, 747
    Page: 
     Label: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 175, 459, 178, 467
       Destination: 157
      Annotation: 
       Subtype: Link
       Rect: 189, 133, 195, 141
       Destination: 170
      Annotation: 
       Subtype: Link
       Rect: 266, 98, 270, 105
       Destination: 157
      Annotation: 
       Subtype: Link
       Rect: 391, 435, 397, 443
       Destination: 170
      Annotation: 
       Subtype: Link
       Rect: 399, 435, 405, 443
       Destination: 170
      Annotation: 
       Subtype: Link
       Rect: 460, 339, 466, 346
       Destination: 170
    Page: 
     Label: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 80, 724, 86, 732
       Destination: 170
      Annotation: 
       Subtype: Link
       Rect: 253, 641, 256, 648
       Destination: 170
      Annotation: 
       Subtype: Link
       Rect: 258, 641, 262, 648
       Destination: 170
      Annotation: 
       Subtype: Link
       Rect: 126, 581, 132, 588
       Destination: 170
      Annotation: 
       Subtype: Link
       Rect: 133, 581, 139, 588
       Destination: 170
      Annotation: 
       Subtype: Link
       Rect: 58, 233, 64, 241
       Destination: 170
      Annotation: 
       Subtype: Link
       Rect: 196, 90, 201, 97
       Destination: 170
      Annotation: 
       Subtype: Link
       Rect: 472, 209, 475, 217
       Destination: 170
      Annotation: 
       Subtype: Link
       Rect: 351, 21, 438, 29
    Page: 
     Label: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 258, 335, 283, 344
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 87, 214, 116, 223
       Destination: 120
      Annotation: 
       Subtype: Link
       Rect: 179, 142, 209, 150
       Destination: 120
      Annotation: 
       Subtype: Link
       Rect: 489, 708, 522, 717
       Destination: 131
      Annotation: 
       Subtype: Link
       Rect: 430, 504, 455, 513
       Destination: 131
      Annotation: 
       Subtype: Link
       Rect: 406, 480, 439, 489
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 302, 360, 328, 368
       Destination: 131
      Annotation: 
       Subtype: Link
       Rect: 298, 336, 330, 344
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 368, 191, 389, 200
       Destination: 142
      Annotation: 
       Subtype: Link
       Rect: 337, 130, 357, 139
       Destination: 142
    Page: 
     Label: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 233, 292, 280, 300
       Destination: 151
      Annotation: 
       Subtype: Link
       Rect: 182, 102, 188, 109
       Destination: 170
      Annotation: 
       Subtype: Link
       Rect: 430, 259, 435, 267
       Destination: 170
      Annotation: 
       Subtype: Link
       Rect: 327, 198, 333, 206
       Destination: 170
      Annotation: 
       Subtype: Link
       Rect: 315, 175, 321, 182
       Destination: 170
      Annotation: 
       Subtype: Link
       Rect: 351, 21, 438, 29
    Page: 
     Label: 6
    Page: 
     Label: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 378, 428, 385, 435
       Destination: 170
      Annotation: 
       Subtype: Link
       Rect: 351, 21, 438, 29
    Page: 
     Label: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 298, 199, 324, 208
       Destination: 204
    Page: 
     Label: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 170, 688, 176, 696
       Destination: 170
      Annotation: 
       Subtype: Link
       Rect: 248, 250, 276, 258
      Annotation: 
       Subtype: Link
       Rect: 36, 239, 104, 247
      Annotation: 
       Subtype: Link
       Rect: 298, 447, 431, 455
      Annotation: 
       Subtype: Link
       Rect: 298, 162, 338, 170
       Destination: 184
      Annotation: 
       Subtype: Link
       Rect: 357, 162, 397, 170
       Destination: 184
      Annotation: 
       Subtype: Link
       Rect: 351, 21, 438, 29
    Page: 
     Label: 10
    Page: 
     Label: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 469, 672, 536, 680
      Annotation: 
       Subtype: Link
       Rect: 36, 661, 180, 669
      Annotation: 
       Subtype: Link
       Rect: 529, 639, 548, 647
      Annotation: 
       Subtype: Link
       Rect: 36, 629, 72, 637
      Annotation: 
       Subtype: Link
       Rect: 379, 21, 466, 29
    Page: 
     Label: 12
    Page: 
     Label: 13
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 379, 21, 466, 29
    Page: 
     Label: 14
  Checksum: 8311b9dd
   Type: CRC32
  Checksum: 83936f2792bfc47e11f22f8c28348423
   Type: MD5
  Checksum: f17f9ac5be645256b2da6aba4a9480c0370af51d
   Type: SHA-1
  Checksum: 8964a3370697da5cfa2c36428f22790d649814049cfcc1ec70a6b54d884e89e7
   Type: SHA-256