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      Title: Renal antiporter ClC-5 regulates collagen I/IV through the β-catenin pathway and lysosomal degradation
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        Title: Introduction
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       Item: 
        Title: Results
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          Title: ClC-5 controls the production and release of collagen types I and IV in renal cells
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         Item: 
          Title: Col I/IV accumulate intracellularly at the ER and lysosomes of CLCN5 KD cells
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          Title: ClC-5 deletion impairs Col I and Col IV degradation
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          Title: CLCN5 depletion affects lysosomal acidification
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          Title: ClC-5 deletion promotes Col I/IV transcription through the β-catenin pathway
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         Item: 
          Title: ClC-5 regulates mucin-1 (MUC1) levels in renal tubule epithelial cells
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          Title: Mice lacking Clcn5 present a renal fibrotic phenotype with increased Col IV deposition
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        Title: Materials and Methods
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          Title: Cell culture
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          Title: Mycoplasma test
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          Title: Clcn5+/+, Clcn5+/−, and Clcn5−/− mice
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          Title: H/E, Sirius Red/Fast Green, and Col IV staining
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          Title: Measurement of basement membrane thickness
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          Title: Collagen secretion assay and Western blot
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          Title: Collagen degradation assay
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          Title: Cycloheximide chase assay
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          Title: Microscopy and immunofluorescence
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          Title: Real-time quantitative RT–PCR
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         Item: 
          Title: Endolysosomal pH determination
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         Item: 
          Title: Cathepsin B activity measurement
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         Item: 
          Title: β-Catenin nuclear translocation
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          Title: Subcellular fractionation assay
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          Title: Statistical analysis
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        Title: Data Availability
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        Title: Author Contributions
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        Title: Conflict of Interest Statement
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       Item: 
        Title: 1.Djudjaj S, Boor P (2019) Cellular and molecular mechanisms of kidney fibrosis. Mol Aspects Med 65: 16–36. 10.1016/j.mam.2 ...
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