58e3431e9dd0e38e7221c5d46b12079c Ex_vivo_C5b-9_Deposition.pdf 0becbd967e7f655f0825f6c0527a55cf85f71654 Ex_vivo_C5b-9_Deposition.pdf 98413e8dbd5c974daccc92002fb95c398f5e66f3a35e78d75c18cf6fd5977289 Ex_vivo_C5b-9_Deposition.pdf Title: Ex vivo C5b-9 Deposition Test to Monitor Complement Activity in Clinical and Subclinical Atypical Hemolytic Uremic Syndrome and in Transplantation-Associated Thrombotic Microangiopathy Subject: Kidney International Reports, 9 (2024) 2227-2239. doi:10.1016/j.ekir.2024.04.022 Author: Maria Martin Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Thu Jun 27 04:19:59 2024 CEST ModDate: Thu Jun 27 04:23:14 2024 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 612 x 792 pts (letter) Page rot: 0 File size: 1584829 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- BDNDFA+AdvOT5b84fe17.BI Type 1C WinAnsi yes yes no 590 0 BDNDGA+AdvOT3bf1a849.B Type 1C WinAnsi yes yes no 592 0 BDNDGB+AdvOT0de51fd2 Type 1C WinAnsi yes yes no 594 0 BDNDGC+AdvOT0de51fd2+20 Type 1C WinAnsi yes yes no 596 0 BDNDGD+AdvOTa84cfff1.I Type 1C WinAnsi yes yes no 603 0 BDNDHE+AdvP4C4E74 Type 1C Custom yes yes yes 608 0 BDNDHF+AdvOT0de51fd2+fb Type 1C Custom yes yes yes 602 0 BDNDIG+AdvPSSym Type 1C WinAnsi yes yes no 614 0 BDNDIH+AdvOT7bedbc7e Type 1C WinAnsi yes yes no 612 0 BDNDLJ+AdvOT372b1957.I Type 1C WinAnsi yes yes no 310 0 BDNDLK+AdvOT7bedbc7e+20 Type 1C WinAnsi yes yes no 308 0 BDNDKH+AdvOT7bedbc7e+fb Type 1C Custom yes yes yes 314 0 BDNDKI+AdvPS3FDD77 Type 1C WinAnsi yes yes no 311 0 BDNDMK+AdvOT372b1957.I+20 Type 1C WinAnsi yes yes no 322 0 BDNDML+AdvP4C4E51 Type 1C WinAnsi yes yes no 325 0 BDNDNM+AdvOT0a81dd96.B Type 1C WinAnsi yes yes no 331 0 BDNDNN+AdvOTb4959fff Type 1C WinAnsi yes yes no 346 0 BDNDNO+AdvOTaf810ba6 Type 1C WinAnsi yes yes no 349 0 BDNDNP+AdvOTaf810ba6+fb Type 1C Custom yes yes yes 328 0 BDNDOA+AdvPS4BD310 Type 1C WinAnsi yes yes no 329 0 BDNDOB+AdvOT2c6df7a6 Type 1C WinAnsi yes yes no 338 0 BDNDOC+AdvPS3F4C13 Type 1C WinAnsi yes yes no 336 0 BDNDOD+AdvOTb4959fff+20 Type 1C WinAnsi yes yes no 342 0 BDNGGE+AdvPS480274 Type 1C WinAnsi yes yes no 360 0 BDNGGF+AdvOT0c7211e1.I Type 1C WinAnsi yes yes no 361 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2026-10-03 04:50:04 CEST RepresentationInformation: Ex_vivo_C5b-9_Deposition.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2026-10-02 19:34:04 CEST Size: 1584829 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 683 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Ex vivo C5b-9 Deposition Test to Monitor Complement Activity in Clinical and Subclinical Atypical Hemolytic Uremic Syndrome ... Destination: titlink1 Children: Item: Title: Methods Destination: flink1 Children: Item: Title: Patients and Clinical Parameters Destination: slink1 Item: Title: C5b-9 Deposits Detection by Immunofluorescence Destination: slink2 Item: Title: Statistical Analysis Destination: slink3 Item: Title: Results Destination: flink2 Children: Item: Title: Study Population Destination: slink4 Item: Title: C5b-9 Deposition Test in Patients With aHUS Destination: slink5 Item: Title: C5b-9 Deposition Test in TMA Secondary to Kidney and Lung Transplant Destination: slink6 Item: Title: C5b-9 Deposition Test in TMA Secondary to HSC Transplant Destination: slink7 Item: Title: C5b-9 Deposition Test in an Asymptomatic Patient With Genetic Risk of aHUS Destination: slink8 Item: Title: Discussion Destination: flink3 Item: Title: Disclosure Destination: flink4 Item: Title: Acknowledgments Destination: flink5 Item: Title: Data Availability Statement Destination: flink6 Item: Title: Author Contributions Destination: flink7 Item: Title: Supplementary Material Destination: flink8 Item: Title: References Destination: blink1 Info: Title: Ex vivo C5b-9 Deposition Test to Monitor Complement Activity in Clinical and Subclinical Atypical Hemolytic Uremic Syndrome and in Transplantation-Associated Thrombotic Microangiopathy Author: Maria Martin Subject: Kidney International Reports, 9 (2024) 2227-2239. doi:10.1016/j.ekir.2024.04.022 Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Thu Jun 27 04:49:59 CEST 2024 ModDate: Thu Jun 27 04:53:14 CEST 2024 ID: 0x3a113625c252d171a60f782a5c60ffb5, 0x2ef8efb225e65744840fe25d8e7ba451 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1022 ImageHeight: 2313 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1346 ImageHeight: 1565 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 957 ImageHeight: 2541 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1812 ImageHeight: 1266 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: BDNDMK+AdvOT372b1957.I+20 FontSubset: true FirstChar: 150 LastChar: 150 FontDescriptor: FontName: BDNDMK+AdvOT372b1957.I+20 Flags: Nonsymbolic FontBBox: -250, -312, 1000, 791 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BDNDML+AdvP4C4E51 FontSubset: true FirstChar: 60 LastChar: 62 FontDescriptor: FontName: BDNDML+AdvP4C4E51 Flags: Nonsymbolic FontBBox: -31, -239, 1041, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BDNDNP+AdvOTaf810ba6+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: BDNDNP+AdvOTaf810ba6+fb Flags: Symbolic FontBBox: 9, 0, 437, 729 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: BDNDOA+AdvPS4BD310 FontSubset: true FirstChar: 109 LastChar: 109 FontDescriptor: FontName: BDNDOA+AdvPS4BD310 Flags: Nonsymbolic FontBBox: 0, -208, 989, 697 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BDNDNM+AdvOT0a81dd96.B FontSubset: true FirstChar: 46 LastChar: 117 FontDescriptor: FontName: BDNDNM+AdvOT0a81dd96.B Flags: Nonsymbolic FontBBox: -72, -250, 885, 968 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BDNDFA+AdvOT5b84fe17.BI FontSubset: true FirstChar: 69 LastChar: 120 FontDescriptor: FontName: BDNDFA+AdvOT5b84fe17.BI Flags: Nonsymbolic FontBBox: -52, -260, 1145, 937 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BDNDGA+AdvOT3bf1a849.B FontSubset: true FirstChar: 44 LastChar: 121 FontDescriptor: FontName: BDNDGA+AdvOT3bf1a849.B Flags: Nonsymbolic FontBBox: -31, -250, 989, 937 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BDNDOC+AdvPS3F4C13 FontSubset: true FirstChar: 109 LastChar: 109 FontDescriptor: FontName: BDNDOC+AdvPS3F4C13 Flags: Nonsymbolic FontBBox: 0, -291, 875, 697 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BDNDGB+AdvOT0de51fd2 FontSubset: true FirstChar: 40 LastChar: 244 FontDescriptor: FontName: BDNDGB+AdvOT0de51fd2 Flags: Nonsymbolic FontBBox: -10, -250, 989, 937 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BDNDOB+AdvOT2c6df7a6 FontSubset: true FirstChar: 40 LastChar: 122 FontDescriptor: FontName: BDNDOB+AdvOT2c6df7a6 Flags: Nonsymbolic FontBBox: -41, -208, 822, 968 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BDNDGC+AdvOT0de51fd2+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: BDNDGC+AdvOT0de51fd2+20 Flags: Nonsymbolic FontBBox: -166, -125, 979, 729 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BDNDOD+AdvOTb4959fff+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: BDNDOD+AdvOTb4959fff+20 Flags: Nonsymbolic FontBBox: -156, -104, 1000, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BDNDHF+AdvOT0de51fd2+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: BDNDHF+AdvOT0de51fd2+fb Flags: Symbolic FontBBox: 0, 0, 520, 729 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: BDNDNN+AdvOTb4959fff FontSubset: true FirstChar: 40 LastChar: 122 FontDescriptor: FontName: BDNDNN+AdvOTb4959fff Flags: Nonsymbolic FontBBox: -31, -250, 875, 979 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BDNDGD+AdvOTa84cfff1.I FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: BDNDGD+AdvOTa84cfff1.I Flags: Nonsymbolic FontBBox: -41, -270, 1135, 937 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BDNDNO+AdvOTaf810ba6 FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: BDNDNO+AdvOTaf810ba6 Flags: Nonsymbolic FontBBox: -41, -218, 833, 968 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BDNDHE+AdvP4C4E74 FontSubset: true FirstChar: 2 LastChar: 254 FontDescriptor: FontName: BDNDHE+AdvP4C4E74 Flags: Symbolic FontBBox: -20, -958, 1114, 770 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: BDNDIH+AdvOT7bedbc7e FontSubset: true FirstChar: 37 LastChar: 122 FontDescriptor: FontName: BDNDIH+AdvOT7bedbc7e Flags: Serif, Nonsymbolic FontBBox: -62, -291, 937, 833 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BDNDIG+AdvPSSym FontSubset: true FirstChar: 170 LastChar: 170 FontDescriptor: FontName: BDNDIG+AdvPSSym Flags: Nonsymbolic FontBBox: -177, -291, 1083, 1010 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BDNGGE+AdvPS480274 FontSubset: true FirstChar: 61 LastChar: 61 FontDescriptor: FontName: BDNGGE+AdvPS480274 Flags: Nonsymbolic FontBBox: 0, -208, 1354, 791 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BDNGGF+AdvOT0c7211e1.I FontSubset: true FirstChar: 80 LastChar: 80 FontDescriptor: FontName: BDNGGF+AdvOT0c7211e1.I Flags: Nonsymbolic FontBBox: -41, -260, 1031, 979 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BDNDLK+AdvOT7bedbc7e+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: BDNDLK+AdvOT7bedbc7e+20 Flags: Nonsymbolic FontBBox: -135, -343, 1000, 729 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BDNDLJ+AdvOT372b1957.I FontSubset: true FirstChar: 45 LastChar: 120 FontDescriptor: FontName: BDNDLJ+AdvOT372b1957.I Flags: Nonsymbolic FontBBox: -93, -270, 1031, 812 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BDNDKI+AdvPS3FDD77 FontSubset: true FirstChar: 119 LastChar: 119 FontDescriptor: FontName: BDNDKI+AdvPS3FDD77 Flags: Nonsymbolic FontBBox: 0, -208, 1145, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BDNDKH+AdvOT7bedbc7e+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: BDNDKH+AdvOT7bedbc7e+fb Flags: Symbolic FontBBox: 0, 0, 781, 697 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true XMP: application/pdf doi:10.1016/j.ekir.2024.04.022 Ex vivo C5b-9 Deposition Test to Monitor Complement Activity in Clinical and Subclinical Atypical Hemolytic Uremic Syndrome and in Transplantation-Associated Thrombotic Microangiopathy Maria Martin Carmen Llorens-Cebria Juan León-Román Janire Perurena-Prieto Víctor Perez-Beltran Silvia Saumell Irina B. Torres Irene Agraz Joana Sellarès Natàlia Ramos Oriol Bestard Mercedes López Francesc Moreso Gema Ariceta Maria José Soler Manuel Hernandez-Gonzalez Conxita Jacobs-Cachá aHUS biomarkers C5 blockade C5b-9 deposition test complement system transplant-associated TMA Kidney International Reports, 9 (2024) 2227-2239. doi:10.1016/j.ekir.2024.04.022 International Society of Nephrology journal Kidney International Reports © 2024 International Society of Nephrology. Published by Elsevier Inc. 2468-0249 9 7 July 2024 2227-2239 2227 2239 10.1016/j.ekir.2024.04.022 https://doi.org/10.1016/j.ekir.2024.04.022 2010-04-23 true 10.1016/j.ekir.2024.04.022 elsevier.com sciencedirect.com VoR 7.0 10.1016/j.ekir.2024.04.022 noindex 2010-04-23 true sciencedirect.com elsevier.com Elsevier 2024-06-27T07:49:59+05:30 2024-06-27T07:53:14+05:30 2024-06-27T07:53:14+05:30 True 1 https://www.elsevier.com/tdm/tdmrep-policy.json Acrobat Distiller 8.1.0 (Windows) uuid:ffdfc6fe-2171-43b6-b849-36372fd79d19 uuid:17ae4e27-1d46-4861-9aed-f7af02ac8fcf http://creativecommons.org/licenses/by-nc-nd/4.0/ Pages: Page: Label: 2227 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 138, 596, 138, 598 Annotation: Subtype: Link Rect: 138, 599, 143, 610 Destination: 492 Annotation: Subtype: Link Rect: 145, 599, 150, 610 Destination: 492 Annotation: Subtype: Link Rect: 275, 596, 275, 598 Annotation: Subtype: Link Rect: 275, 599, 279, 610 Destination: 492 Annotation: Subtype: Link Rect: 282, 599, 286, 610 Destination: 492 Annotation: Subtype: Link Rect: 387, 596, 387, 598 Annotation: Subtype: Link Rect: 387, 599, 392, 610 Destination: 492 Annotation: Subtype: Link Rect: 514, 596, 514, 598 Annotation: Subtype: Link Rect: 514, 599, 519, 610 Destination: 492 Annotation: Subtype: Link Rect: 173, 582, 173, 584 Annotation: Subtype: Link Rect: 173, 585, 178, 596 Destination: 492 Annotation: Subtype: Link Rect: 258, 582, 258, 584 Annotation: Subtype: Link Rect: 258, 585, 263, 596 Destination: 492 Annotation: Subtype: Link Rect: 343, 582, 343, 584 Annotation: Subtype: Link Rect: 343, 585, 347, 596 Destination: 492 Annotation: Subtype: Link Rect: 413, 582, 413, 584 Annotation: Subtype: Link Rect: 413, 585, 418, 596 Destination: 492 Annotation: Subtype: Link Rect: 420, 585, 424, 596 Destination: 492 Annotation: Subtype: Link Rect: 507, 582, 507, 584 Annotation: Subtype: Link Rect: 507, 585, 512, 596 Destination: 492 Annotation: Subtype: Link Rect: 514, 585, 518, 596 Destination: 492 Annotation: Subtype: Link Rect: 146, 568, 146, 570 Annotation: Subtype: Link Rect: 146, 571, 151, 582 Destination: 492 Annotation: Subtype: Link Rect: 153, 571, 158, 582 Destination: 492 Annotation: Subtype: Link Rect: 231, 568, 231, 570 Annotation: Subtype: Link Rect: 231, 571, 236, 582 Destination: 492 Annotation: Subtype: Link Rect: 238, 571, 242, 582 Destination: 492 Annotation: Subtype: Link Rect: 332, 568, 332, 570 Annotation: Subtype: Link Rect: 332, 571, 336, 582 Destination: 492 Annotation: Subtype: Link Rect: 430, 568, 430, 570 Annotation: Subtype: Link Rect: 430, 571, 435, 582 Destination: 492 Annotation: Subtype: Link Rect: 437, 571, 441, 582 Destination: 492 Annotation: Subtype: Link Rect: 517, 568, 517, 570 Annotation: Subtype: Link Rect: 517, 571, 522, 582 Destination: 492 Annotation: Subtype: Link Rect: 524, 571, 529, 582 Destination: 492 Annotation: Subtype: Link Rect: 531, 571, 536, 582 Destination: 492 Annotation: Subtype: Link Rect: 160, 554, 160, 556 Annotation: Subtype: Link Rect: 160, 557, 164, 568 Destination: 492 Annotation: Subtype: Link Rect: 166, 557, 171, 568 Destination: 492 Annotation: Subtype: Link Rect: 173, 557, 178, 568 Destination: 492 Annotation: Subtype: Link Rect: 331, 554, 331, 556 Annotation: Subtype: Link Rect: 331, 557, 336, 568 Destination: 492 Annotation: Subtype: Link Rect: 338, 557, 342, 568 Destination: 492 Annotation: Subtype: Link Rect: 483, 554, 483, 556 Annotation: Subtype: Link Rect: 483, 557, 487, 568 Destination: 492 Annotation: Subtype: Link Rect: 490, 557, 494, 568 Destination: 492 Annotation: Subtype: Link Rect: 496, 557, 501, 568 Destination: 492 Annotation: Subtype: Link Rect: 216, 234, 375, 242 Annotation: Subtype: Link Rect: 135, 201, 332, 209 Annotation: Subtype: Link Rect: 411, 79, 415, 90 Destination: 168 Annotation: Subtype: Link Rect: 417, 79, 421, 90 Destination: 168 Annotation: Subtype: Link Rect: 503, 66, 507, 77 Destination: 168 Annotation: Subtype: Link Rect: 509, 66, 513, 77 Destination: 168 Annotation: Subtype: Link Rect: 77, 113, 167, 121 Annotation: Subtype: Link Rect: 484, 704, 562, 719 Page: Label: 2228 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 86, 699, 90, 710 Destination: 168 Annotation: Subtype: Link Rect: 92, 699, 96, 710 Destination: 168 Annotation: Subtype: Link Rect: 127, 621, 131, 632 Destination: 168 Annotation: Subtype: Link Rect: 133, 621, 137, 632 Destination: 168 Annotation: Subtype: Link Rect: 248, 531, 252, 542 Destination: 168 Annotation: Subtype: Link Rect: 254, 531, 258, 542 Destination: 168 Annotation: Subtype: Link Rect: 260, 531, 264, 542 Destination: 168 Annotation: Subtype: Link Rect: 81, 479, 85, 490 Destination: 168 Annotation: Subtype: Link Rect: 234, 388, 238, 399 Destination: 168 Annotation: Subtype: Link Rect: 110, 362, 118, 373 Destination: 168 Annotation: Subtype: Link Rect: 82, 322, 90, 333 Destination: 168 Annotation: Subtype: Link Rect: 269, 258, 273, 269 Destination: 168 Annotation: Subtype: Link Rect: 275, 258, 293, 269 Destination: 168 Annotation: Subtype: Link Rect: 255, 167, 273, 178 Destination: 224 Annotation: Subtype: Link Rect: 75, 102, 79, 113 Destination: 168 Annotation: Subtype: Link Rect: 342, 727, 361, 737 Destination: 224 Annotation: Subtype: Link Rect: 389, 545, 396, 556 Destination: 224 Annotation: Subtype: Link Rect: 555, 442, 562, 453 Destination: 224 Annotation: Subtype: Link Rect: 443, 390, 461, 401 Destination: 224 Annotation: Subtype: Link Rect: 416, 239, 454, 250 Destination: 53 Annotation: Subtype: Link Rect: 478, 239, 484, 250 Destination: 53 Annotation: Subtype: Link Rect: 407, 213, 522, 224 Destination: 168 Annotation: Subtype: Link Rect: 320, 96, 439, 107 Destination: 168 Page: Label: 2229 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 175, 548, 182, 559 Destination: 224 Annotation: Subtype: Link Rect: 66, 531, 176, 542 Destination: 168 Annotation: Subtype: Link Rect: 51, 259, 89, 270 Destination: 53 Annotation: Subtype: Link Rect: 115, 259, 120, 270 Destination: 53 Annotation: Subtype: Link Rect: 155, 194, 264, 205 Destination: 168 Annotation: Subtype: Link Rect: 125, 181, 159, 192 Destination: 53 Annotation: Subtype: Link Rect: 210, 117, 244, 127 Destination: 53 Annotation: Subtype: Link Rect: 486, 683, 520, 694 Destination: 53 Annotation: Subtype: Link Rect: 505, 514, 539, 525 Destination: 53 Annotation: Subtype: Link Rect: 320, 463, 354, 474 Destination: 53 Annotation: Subtype: Link Rect: 412, 411, 447, 422 Destination: 53 Annotation: Subtype: Link Rect: 503, 346, 535, 357 Destination: 53 Annotation: Subtype: Link Rect: 349, 307, 381, 318 Destination: 53 Annotation: Subtype: Link Rect: 320, 204, 355, 215 Destination: 53 Annotation: Subtype: Link Rect: 320, 165, 354, 176 Destination: 53 Annotation: Subtype: Link Rect: 330, 152, 439, 163 Destination: 168 Annotation: Subtype: Link Rect: 460, 104, 562, 115 Destination: 168 Annotation: Subtype: Link Rect: 339, 91, 383, 102 Destination: 168 Annotation: Subtype: Link Rect: 464, 78, 498, 89 Destination: 53 Annotation: Subtype: Link Rect: 520, 78, 558, 89 Destination: 66 Annotation: Subtype: Link Rect: 337, 65, 445, 76 Destination: 168 Page: Label: 2230 Sequence: 4 Page: Label: 2231 Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 51, 280, 169, 290 Destination: 168 Annotation: Subtype: Link Rect: 317, 305, 350, 316 Destination: 53 Annotation: Subtype: Link Rect: 408, 280, 444, 290 Destination: 66 Annotation: Subtype: Link Rect: 190, 708, 193, 715 Destination: 168 Annotation: Subtype: Link Rect: 267, 220, 270, 227 Destination: 168 Page: Label: 2232 Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 471, 735, 503, 746 Destination: 53 Annotation: Subtype: Link Rect: 362, 696, 399, 707 Destination: 66 Annotation: Subtype: Link Rect: 410, 670, 447, 681 Destination: 66 Annotation: Subtype: Link Rect: 421, 618, 454, 629 Destination: 53 Annotation: Subtype: Link Rect: 517, 416, 525, 427 Destination: 224 Annotation: Subtype: Link Rect: 320, 385, 358, 396 Destination: 66 Annotation: Subtype: Link Rect: 320, 359, 354, 370 Destination: 53 Annotation: Subtype: Link Rect: 486, 333, 523, 344 Destination: 66 Page: Label: 2233 Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 198, 735, 231, 746 Destination: 53 Annotation: Subtype: Link Rect: 109, 722, 142, 733 Destination: 53 Annotation: Subtype: Link Rect: 192, 683, 229, 694 Destination: 80 Annotation: Subtype: Link Rect: 51, 657, 161, 668 Destination: 168 Annotation: Subtype: Link Rect: 184, 657, 226, 668 Destination: 168 Annotation: Subtype: Link Rect: 104, 579, 138, 590 Destination: 53 Annotation: Subtype: Link Rect: 237, 553, 274, 564 Destination: 80 Annotation: Subtype: Link Rect: 317, 735, 429, 746 Destination: 168 Annotation: Subtype: Link Rect: 522, 644, 556, 655 Destination: 53 Annotation: Subtype: Link Rect: 483, 605, 517, 616 Destination: 53 Annotation: Subtype: Link Rect: 480, 566, 530, 577 Destination: 80 Annotation: Subtype: Link Rect: 317, 553, 425, 564 Destination: 168 Page: Label: 2234 Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 489, 670, 534, 681 Destination: 80 Annotation: Subtype: Link Rect: 317, 657, 428, 668 Destination: 168 Annotation: Subtype: Link Rect: 317, 521, 351, 532 Destination: 53 Annotation: Subtype: Link Rect: 460, 470, 497, 480 Destination: 98 Annotation: Subtype: Link Rect: 513, 457, 546, 468 Destination: 53 Annotation: Subtype: Link Rect: 355, 379, 388, 390 Destination: 53 Annotation: Subtype: Link Rect: 416, 353, 451, 364 Destination: 53 Annotation: Subtype: Link Rect: 480, 301, 530, 312 Destination: 98 Annotation: Subtype: Link Rect: 317, 288, 429, 299 Destination: 168 Page: Label: 2235 Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 167, 670, 204, 681 Destination: 98 Annotation: Subtype: Link Rect: 226, 670, 293, 681 Destination: 168 Annotation: Subtype: Link Rect: 48, 657, 87, 668 Destination: 168 Annotation: Subtype: Link Rect: 79, 476, 118, 487 Destination: 113 Annotation: Subtype: Link Rect: 467, 644, 503, 655 Destination: 113 Annotation: Subtype: Link Rect: 514, 618, 552, 629 Destination: 113 Annotation: Subtype: Link Rect: 515, 592, 554, 603 Destination: 113 Page: Label: 2236 Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 173, 714, 191, 724 Destination: 224 Annotation: Subtype: Link Rect: 51, 670, 161, 681 Destination: 168 Annotation: Subtype: Link Rect: 205, 649, 213, 660 Destination: 224 Annotation: Subtype: Link Rect: 134, 623, 152, 634 Destination: 224 Annotation: Subtype: Link Rect: 223, 584, 231, 595 Destination: 224 Annotation: Subtype: Link Rect: 233, 584, 240, 595 Destination: 224 Annotation: Subtype: Link Rect: 243, 584, 250, 595 Destination: 224 Annotation: Subtype: Link Rect: 111, 411, 145, 422 Destination: 53 Annotation: Subtype: Link Rect: 218, 359, 254, 370 Destination: 66 Annotation: Subtype: Link Rect: 211, 242, 245, 253 Destination: 53 Annotation: Subtype: Link Rect: 116, 183, 124, 194 Destination: 224 Annotation: Subtype: Link Rect: 215, 126, 252, 137 Destination: 66 Annotation: Subtype: Link Rect: 101, 74, 134, 85 Destination: 53 Annotation: Subtype: Link Rect: 404, 722, 441, 733 Destination: 66 Annotation: Subtype: Link Rect: 469, 722, 503, 733 Destination: 53 Annotation: Subtype: Link Rect: 454, 696, 491, 707 Destination: 80 Annotation: Subtype: Link Rect: 475, 610, 493, 621 Destination: 224 Annotation: Subtype: Link Rect: 348, 527, 386, 538 Destination: 53 Annotation: Subtype: Link Rect: 441, 514, 478, 525 Destination: 80 Annotation: Subtype: Link Rect: 441, 463, 477, 474 Destination: 80 Annotation: Subtype: Link Rect: 478, 437, 511, 448 Destination: 53 Annotation: Subtype: Link Rect: 452, 424, 492, 435 Destination: 80 Annotation: Subtype: Link Rect: 399, 320, 435, 331 Destination: 98 Annotation: Subtype: Link Rect: 437, 126, 472, 137 Destination: 53 Annotation: Subtype: Link Rect: 464, 66, 472, 77 Destination: 224 Page: Label: 2237 Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 229, 739, 247, 750 Destination: 224 Annotation: Subtype: Link Rect: 51, 540, 93, 551 Destination: 113 Annotation: Subtype: Link Rect: 51, 527, 89, 538 Destination: 113 Annotation: Subtype: Link Rect: 228, 429, 236, 440 Destination: 224 Annotation: Subtype: Link Rect: 286, 377, 293, 388 Destination: 224 Annotation: Subtype: Link Rect: 185, 364, 193, 375 Destination: 224 Annotation: Subtype: Link Rect: 226, 139, 293, 150 Destination: 168 Annotation: Subtype: Link Rect: 48, 126, 87, 137 Destination: 168 Annotation: Subtype: Link Rect: 502, 623, 520, 634 Destination: 224 Page: Label: 2238 Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 48, 398, 150, 407 Annotation: Subtype: Link Rect: 508, 649, 562, 657 Annotation: Subtype: Link Rect: 335, 638, 451, 646 Annotation: Subtype: Link Rect: 508, 602, 562, 610 Annotation: Subtype: Link Rect: 335, 591, 416, 599 Annotation: Subtype: Link Rect: 498, 566, 562, 574 Annotation: Subtype: Link Rect: 335, 555, 395, 563 Annotation: Subtype: Link Rect: 454, 530, 562, 538 Annotation: Subtype: Link Rect: 335, 519, 393, 527 Annotation: Subtype: Link Rect: 523, 483, 562, 491 Annotation: Subtype: Link Rect: 335, 472, 482, 480 Annotation: Subtype: Link Rect: 458, 436, 562, 444 Annotation: Subtype: Link Rect: 335, 425, 405, 433 Annotation: Subtype: Link Rect: 335, 389, 483, 397 Annotation: Subtype: Link Rect: 498, 353, 562, 361 Annotation: Subtype: Link Rect: 335, 342, 428, 350 Annotation: Subtype: Link Rect: 432, 296, 562, 304 Annotation: Subtype: Link Rect: 335, 285, 360, 293 Annotation: Subtype: Link Rect: 353, 238, 490, 246 Annotation: Subtype: Link Rect: 336, 180, 484, 188 Annotation: Subtype: Link Rect: 498, 144, 562, 152 Annotation: Subtype: Link Rect: 336, 133, 435, 141 Annotation: Subtype: Link Rect: 336, 119, 562, 127 Annotation: Subtype: Link Rect: 336, 108, 562, 116 Annotation: Subtype: Link Rect: 336, 97, 562, 105 Annotation: Subtype: Link Rect: 336, 86, 447, 94 Page: Label: 2239 Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 182, 736, 293, 744 Annotation: Subtype: Link Rect: 67, 725, 111, 733 Annotation: Subtype: Link Rect: 67, 667, 224, 675 Annotation: Subtype: Link Rect: 67, 610, 215, 618 Annotation: Subtype: Link Rect: 109, 563, 264, 571 Annotation: Subtype: Link Rect: 89, 516, 215, 524 Annotation: Subtype: Link Rect: 84, 470, 231, 478 Annotation: Subtype: Link Rect: 84, 412, 233, 420 Annotation: Subtype: Link Rect: 239, 376, 293, 384 Annotation: Subtype: Link Rect: 67, 365, 179, 373 Annotation: Subtype: Link Rect: 229, 329, 293, 337 Annotation: Subtype: Link Rect: 67, 318, 157, 326 Annotation: Subtype: Link Rect: 156, 283, 282, 291 Annotation: Subtype: Link Rect: 146, 225, 293, 233 Annotation: Subtype: Link Rect: 67, 214, 112, 222 Annotation: Subtype: Link Rect: 179, 166, 293, 174 Annotation: Subtype: Link Rect: 67, 155, 120, 163 Annotation: Subtype: Link Rect: 132, 109, 282, 117 Annotation: Subtype: Link Rect: 498, 736, 562, 744 Annotation: Subtype: Link Rect: 336, 725, 390, 733 Annotation: Subtype: Link Rect: 406, 678, 525, 686 Annotation: Subtype: Link Rect: 436, 632, 562, 640 Annotation: Subtype: Link Rect: 336, 621, 360, 629 Annotation: Subtype: Link Rect: 478, 585, 562, 593 Annotation: Subtype: Link Rect: 336, 574, 417, 582 Annotation: Subtype: Link Rect: 336, 516, 483, 524 Annotation: Subtype: Link Rect: 410, 480, 548, 488 Annotation: Subtype: Link Rect: 336, 445, 508, 453 Annotation: Subtype: Link Rect: 537, 409, 562, 417 Annotation: Subtype: Link Rect: 336, 398, 469, 406 Annotation: Subtype: Link Rect: 336, 340, 484, 348 Annotation: Subtype: Link Rect: 393, 294, 542, 302 Annotation: Subtype: Link Rect: 478, 247, 562, 255 Annotation: Subtype: Link Rect: 336, 236, 380, 244 Annotation: Subtype: Link Rect: 371, 189, 533, 197 Annotation: Subtype: Link Rect: 478, 154, 562, 162 Annotation: Subtype: Link Rect: 336, 143, 417, 151 Annotation: Subtype: Link Rect: 353, 85, 502, 93 Checksum: 8c97e12c Type: CRC32 Checksum: 58e3431e9dd0e38e7221c5d46b12079c Type: MD5 Checksum: 0becbd967e7f655f0825f6c0527a55cf85f71654 Type: SHA-1 Checksum: 98413e8dbd5c974daccc92002fb95c398f5e66f3a35e78d75c18cf6fd5977289 Type: SHA-256