1d8e8c9aeedd30ce50a52c3c88898073 Time_to_Loss_of_Disease_Control.pdf f9075d83a1c4426eb02188e4447e3b7c8bf6b1ca Time_to_Loss_of_Disease_Control.pdf 4c5c5387c790f4f38a0a1431e6ff55688034e5f575926bbea566b7977e1b84a6 Time_to_Loss_of_Disease_Control.pdf Title: Time to Loss of Disease Control following Guselkumab Withdrawal in Relation to Initial Speed of Response: A post hoc Analysis of the VOYAGE 2 Trial Creator: Arbortext Advanced Print Publisher 9.1.510/W Unicode Producer: Acrobat Distiller 7.0 (Windows); modified using iTextSharp.LGPLv2.Core 3.7.4.0 CreationDate: Sat Mar 15 12:53:47 2025 CET ModDate: Wed Oct 14 18:44:30 2026 CEST Custom Metadata: no Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 1561985 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- AMPIEN+AdvOT3ac66ec5.B Type 1C WinAnsi yes yes no 318 0 AMPIFN+AdvOT3b30f6db.B Type 1C WinAnsi yes yes no 48 0 AMPIFO+AdvOT3b30f6db.B+fb Type 1C Custom yes yes yes 154 0 AMPIFP+AdvOT46dcae81 Type 1C WinAnsi yes yes no 49 0 AMPIGA+AdvOT46dcae81+20 Type 1C WinAnsi yes yes no 90 0 AMPIHB+AdvOT46dcae81+fb Type 1C Custom yes yes yes 50 0 AMPIHC+AdvminionSymbols Type 1C WinAnsi yes yes no 319 0 AMPIHD+AdvOTd0125be5.BI Type 1C WinAnsi yes yes no 51 0 AMPIID+AdvOT310e2d14+22 Type 1C Custom yes yes yes 52 0 AMPIIE+AdvOT1ef757c0 Type 1C WinAnsi yes yes no 53 0 AMPIME+MinionPro-Regular Type 1C WinAnsi yes yes no 320 0 OJAPXM+ArialMT CID TrueType Identity-H yes yes yes 1 0 AMPJFC+AdvOT1ef757c0+20 Type 1C WinAnsi yes yes no 45 0 AMPJGC+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 46 0 AMPJGD+AdvOT1ef757c0+03 Type 1C Custom yes yes yes 47 0 AMPJHE+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 70 0 AMPKCB+AdvOT310e2d14 Type 1C WinAnsi yes yes no 83 0 AMPKEB+AdvOT65f8a23b.I Type 1C WinAnsi yes yes no 88 0 AMPKIA+SegoeUI-Bold Type 1C WinAnsi yes yes no 89 0 AMPMAI+Arial-BoldMT Type 1C WinAnsi yes yes no 105 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2026-10-15 04:27:13 CEST RepresentationInformation: Time_to_Loss_of_Disease_Control.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2026-10-14 18:45:21 CEST Size: 1561985 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 364 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Time to Loss of Disease Control following Guselkumab Withdrawal in Relation to Initial Speed of Response: A post hoc Analys ... Destination: titlink1 Children: Item: Title: Introduction Destination: flink1 Item: Title: Methods Destination: flink2 Children: Item: Title: Trial Design Destination: slink1 Item: Title: Patients Destination: slink2 Item: Title: Assessments Destination: slink3 Item: Title: Statistical Analysis Destination: slink4 Item: Title: Results Destination: flink3 Children: Item: Title: Response at Week 28 and Baseline Characteristics Destination: slink5 Item: Title: Time to Loss of Disease Control in Relation to Speed of Response to Guselkumab Destination: slink6 Item: Title: Relationships between Time to Loss of Disease Control and Baseline Characteristics Destination: slink7 Item: Title: Discussion Destination: flink4 Item: Title: Key Message Destination: flink5 Item: Title: Acknowledgments Destination: flink6 Item: Title: Statement of Ethics Destination: flink7 Item: Title: Conflict of Interest Statement Destination: flink8 Item: Title: Funding Sources Destination: flink9 Item: Title: Author Contributions Destination: flink10 Item: Title: Data Availability Statement Destination: flink11 Item: Title: References Destination: rlink1 Info: Title: Time to Loss of Disease Control following Guselkumab Withdrawal in Relation to Initial Speed of Response: A post hoc Analysis of the VOYAGE 2 Trial Creator: Arbortext Advanced Print Publisher 9.1.510/W Unicode Producer: Acrobat Distiller 7.0 (Windows); modified using iTextSharp.LGPLv2.Core 3.7.4.0 CreationDate: Sat Mar 15 13:23:47 CET 2025 ModDate: Wed Oct 14 18:44:30 CEST 2026 ID: 0xc9e87794f3b4a3b1254478034b576c75, 0x0e101635ef17fb9ff3d6b6a81d506b48 Filters: FilterPipeline: FlateDecode Fonts: Type0: Font: BaseFont: OJAPXM+ArialMT Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: AMPIME+MinionPro-Regular FontSubset: true FirstChar: 32 LastChar: 64 FontDescriptor: FontName: AMPIME+MinionPro-Regular Flags: Nonsymbolic FontBBox: -290, -360, 1684, 989 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AMPJHE+AdvOT7d6df7ab.I FontSubset: true FirstChar: 50 LastChar: 121 FontDescriptor: FontName: AMPJHE+AdvOT7d6df7ab.I Flags: Serif, Nonsymbolic FontBBox: -135, -250, 1000, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AMPMAI+Arial-BoldMT FontSubset: true FirstChar: 97 LastChar: 100 FontDescriptor: FontName: AMPMAI+Arial-BoldMT Flags: Nonsymbolic FontBBox: -628, -376, 2000, 1056 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AMPJFC+AdvOT1ef757c0+20 FontSubset: true FirstChar: 145 LastChar: 150 FontDescriptor: FontName: AMPJFC+AdvOT1ef757c0+20 Flags: Nonsymbolic FontBBox: -135, -218, 1010, 833 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AMPJGC+AdvOT1ef757c0+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: AMPJGC+AdvOT1ef757c0+fb Flags: Symbolic FontBBox: 0, -10, 781, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: AMPJGD+AdvOT1ef757c0+03 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: AMPJGD+AdvOT1ef757c0+03 Flags: Symbolic FontBBox: -125, -270, 854, 791 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: AMPIFN+AdvOT3b30f6db.B FontSubset: true FirstChar: 46 LastChar: 121 FontDescriptor: FontName: AMPIFN+AdvOT3b30f6db.B Flags: Nonsymbolic FontBBox: -31, -250, 875, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AMPIFP+AdvOT46dcae81 FontSubset: true FirstChar: 37 LastChar: 242 FontDescriptor: FontName: AMPIFP+AdvOT46dcae81 Flags: Nonsymbolic FontBBox: -41, -250, 833, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AMPIHB+AdvOT46dcae81+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: AMPIHB+AdvOT46dcae81+fb Flags: Symbolic FontBBox: 0, 0, 739, 718 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: AMPIHD+AdvOTd0125be5.BI FontSubset: true FirstChar: 58 LastChar: 117 FontDescriptor: FontName: AMPIHD+AdvOTd0125be5.BI Flags: Nonsymbolic FontBBox: -93, -250, 927, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AMPKCB+AdvOT310e2d14 FontSubset: true FirstChar: 60 LastChar: 62 FontDescriptor: FontName: AMPKCB+AdvOT310e2d14 Flags: Nonsymbolic FontBBox: -20, -427, 1541, 1062 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AMPIID+AdvOT310e2d14+22 FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: AMPIID+AdvOT310e2d14+22 Flags: Symbolic FontBBox: -135, -385, 1333, 895 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: AMPIIE+AdvOT1ef757c0 FontSubset: true FirstChar: 37 LastChar: 239 FontDescriptor: FontName: AMPIIE+AdvOT1ef757c0 Flags: Serif, Nonsymbolic FontBBox: -20, -250, 947, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AMPKEB+AdvOT65f8a23b.I FontSubset: true FirstChar: 78 LastChar: 110 FontDescriptor: FontName: AMPKEB+AdvOT65f8a23b.I Flags: Nonsymbolic FontBBox: -104, -250, 885, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AMPKIA+SegoeUI-Bold FontSubset: true FirstChar: 97 LastChar: 98 FontDescriptor: FontName: AMPKIA+SegoeUI-Bold Flags: Nonsymbolic FontBBox: -573, -431, 1999, 1298 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AMPIFO+AdvOT3b30f6db.B+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: AMPIFO+AdvOT3b30f6db.B+fb Flags: Symbolic FontBBox: 0, 0, 833, 718 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: AMPIGA+AdvOT46dcae81+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: AMPIGA+AdvOT46dcae81+20 Flags: Nonsymbolic FontBBox: -156, -197, 1125, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AMPIEN+AdvOT3ac66ec5.B FontSubset: true FirstChar: 68 LastChar: 121 FontDescriptor: FontName: AMPIEN+AdvOT3ac66ec5.B Flags: Nonsymbolic FontBBox: -72, -239, 1000, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AMPIHC+AdvminionSymbols FontSubset: true FirstChar: 183 LastChar: 183 FontDescriptor: FontName: AMPIHC+AdvminionSymbols Flags: Nonsymbolic FontBBox: -135, -947, 1333, 895 FontFile3: true Encoding: WinAnsiEncoding CIDFontType2: Font: BaseFont: OJAPXM+ArialMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: OJAPXM+ArialMT Flags: Nonsymbolic FontBBox: -664, -324, 2000, 1039 FontFile2: true XMP: Acrobat Distiller 7.0 (Windows); modified using iTextSharp.LGPLv2.Core 3.7.4.0 2025-03-15T17:23:47+05:30 2026-10-14T16:44:30+00:00 Arbortext Advanced Print Publisher 9.1.510/W Unicode application/pdf Time to Loss of Disease Control following Guselkumab Withdrawal in Relation to Initial Speed of Response: A post hoc Analysis of the VOYAGE 2 Trial uuid:5ed1449b-2f07-47cc-adf9-661a1da67d29 uuid:fab32962-c542-4b33-8f46-1602c572e194 Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 43, 723, 130, 737 Annotation: Subtype: Link Rect: 234, 698, 305, 706 Annotation: Subtype: Link Rect: 306, 97, 366, 106 Annotation: Subtype: Link Rect: 43, 60, 97, 67 Annotation: Subtype: Link Rect: 43, 51, 104, 58 Annotation: Subtype: Link Rect: 263, 29, 291, 34 Annotation: Subtype: Link Rect: 130, 22, 226, 28 Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 282, 134, 287, 145 Destination: 156 Annotation: Subtype: Link Rect: 181, 97, 187, 107 Destination: 156 Annotation: Subtype: Link Rect: 445, 707, 450, 718 Destination: 156 Annotation: Subtype: Link Rect: 474, 682, 479, 693 Destination: 156 Annotation: Subtype: Link Rect: 526, 607, 531, 618 Destination: 156 Annotation: Subtype: Link Rect: 540, 607, 545, 618 Destination: 156 Annotation: Subtype: Link Rect: 503, 507, 508, 518 Destination: 156 Annotation: Subtype: Link Rect: 509, 445, 515, 456 Destination: 156 Annotation: Subtype: Link Rect: 344, 383, 349, 394 Destination: 156 Annotation: Subtype: Link Rect: 360, 283, 365, 294 Destination: 156 Annotation: Subtype: Link Rect: 372, 283, 383, 294 Destination: 156 Annotation: Subtype: Link Rect: 363, 246, 374, 257 Destination: 156 Annotation: Subtype: Link Rect: 381, 246, 391, 257 Destination: 156 Annotation: Subtype: Link Rect: 513, 196, 524, 207 Destination: 156 Annotation: Subtype: Link Rect: 148, 49, 211, 57 Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 83, 258, 88, 269 Destination: 156 Annotation: Subtype: Link Rect: 270, 159, 275, 170 Destination: 156 Annotation: Subtype: Link Rect: 280, 159, 285, 170 Destination: 156 Annotation: Subtype: Link Rect: 420, 358, 426, 369 Destination: 156 Annotation: Subtype: Link Rect: 358, 333, 382, 344 Destination: 57 Annotation: Subtype: Link Rect: 485, 308, 551, 319 Annotation: Subtype: Link Rect: 303, 296, 388, 307 Annotation: Subtype: Link Rect: 485, 159, 490, 170 Destination: 156 Annotation: Subtype: Link Rect: 527, 146, 532, 157 Destination: 156 Annotation: Subtype: Link Rect: 540, 146, 545, 157 Destination: 156 Annotation: Subtype: Link Rect: 322, 49, 386, 57 Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 92, 707, 116, 718 Destination: 57 Annotation: Subtype: Link Rect: 390, 470, 423, 481 Destination: 85 Annotation: Subtype: Link Rect: 303, 233, 329, 244 Destination: 85 Annotation: Subtype: Link Rect: 352, 184, 376, 195 Destination: 85 Annotation: Subtype: Link Rect: 148, 49, 211, 57 Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 322, 49, 386, 57 Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 126, 121, 152, 132 Destination: 101 Annotation: Subtype: Link Rect: 148, 49, 211, 57 Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 171, 420, 194, 431 Destination: 101 Annotation: Subtype: Link Rect: 172, 370, 196, 381 Destination: 101 Annotation: Subtype: Link Rect: 94, 209, 121, 220 Destination: 113 Annotation: Subtype: Link Rect: 94, 146, 121, 157 Destination: 129 Annotation: Subtype: Link Rect: 234, 97, 259, 108 Destination: 129 Annotation: Subtype: Link Rect: 343, 283, 354, 294 Destination: 156 Annotation: Subtype: Link Rect: 535, 233, 545, 244 Destination: 156 Annotation: Subtype: Link Rect: 307, 196, 312, 207 Destination: 156 Annotation: Subtype: Link Rect: 322, 49, 386, 57 Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 403, 123, 413, 134 Destination: 156 Annotation: Subtype: Link Rect: 148, 49, 211, 57 Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 47, 707, 57, 718 Destination: 156 Annotation: Subtype: Link Rect: 216, 707, 226, 718 Destination: 156 Annotation: Subtype: Link Rect: 135, 570, 140, 581 Destination: 156 Annotation: Subtype: Link Rect: 146, 570, 151, 581 Destination: 156 Annotation: Subtype: Link Rect: 157, 570, 167, 581 Destination: 156 Annotation: Subtype: Link Rect: 173, 570, 184, 581 Destination: 156 Annotation: Subtype: Link Rect: 275, 408, 285, 419 Destination: 156 Annotation: Subtype: Link Rect: 137, 346, 148, 357 Destination: 156 Annotation: Subtype: Link Rect: 233, 109, 244, 120 Destination: 156 Annotation: Subtype: Link Rect: 322, 49, 386, 57 Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 402, 667, 551, 677 Annotation: Subtype: Link Rect: 303, 657, 352, 666 Annotation: Subtype: Link Rect: 374, 636, 449, 645 Annotation: Subtype: Link Rect: 168, 561, 205, 569 Annotation: Subtype: Link Rect: 57, 552, 142, 560 Annotation: Subtype: Link Rect: 152, 485, 205, 494 Annotation: Subtype: Link Rect: 57, 476, 120, 484 Annotation: Subtype: Link Rect: 139, 400, 205, 409 Annotation: Subtype: Link Rect: 57, 391, 107, 399 Annotation: Subtype: Link Rect: 147, 372, 205, 380 Annotation: Subtype: Link Rect: 57, 362, 205, 371 Annotation: Subtype: Link Rect: 57, 353, 82, 361 Annotation: Subtype: Link Rect: 123, 258, 205, 267 Annotation: Subtype: Link Rect: 57, 249, 111, 257 Annotation: Subtype: Link Rect: 230, 571, 366, 579 Annotation: Subtype: Link Rect: 309, 457, 378, 465 Annotation: Subtype: Link Rect: 230, 448, 378, 456 Annotation: Subtype: Link Rect: 230, 438, 304, 446 Annotation: Subtype: Link Rect: 281, 372, 378, 380 Annotation: Subtype: Link Rect: 230, 362, 272, 371 Annotation: Subtype: Link Rect: 259, 306, 370, 314 Annotation: Subtype: Link Rect: 264, 220, 378, 229 Annotation: Subtype: Link Rect: 230, 211, 273, 219 Annotation: Subtype: Link Rect: 492, 552, 551, 560 Annotation: Subtype: Link Rect: 404, 542, 454, 550 Annotation: Subtype: Link Rect: 485, 467, 551, 475 Annotation: Subtype: Link Rect: 404, 457, 454, 465 Annotation: Subtype: Link Rect: 528, 400, 551, 409 Annotation: Subtype: Link Rect: 404, 391, 535, 399 Annotation: Subtype: Link Rect: 404, 315, 538, 323 Annotation: Subtype: Link Rect: 492, 268, 551, 276 Annotation: Subtype: Link Rect: 404, 258, 454, 267 Annotation: Subtype: Link Rect: 487, 173, 551, 181 Annotation: Subtype: Link Rect: 404, 164, 454, 172 Annotation: Subtype: Link Rect: 148, 49, 211, 57 Checksum: 240adb8a Type: CRC32 Checksum: 1d8e8c9aeedd30ce50a52c3c88898073 Type: MD5 Checksum: f9075d83a1c4426eb02188e4447e3b7c8bf6b1ca Type: SHA-1 Checksum: 4c5c5387c790f4f38a0a1431e6ff55688034e5f575926bbea566b7977e1b84a6 Type: SHA-256