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Masegosa Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Tue Mar 19 16:23:21 2024 CET ModDate: Tue Mar 19 16:24:10 2024 CET Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 8 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 2957663 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- IBHPFC+AdvTTe692faf0 Type 1C WinAnsi yes yes no 412 0 IBHPFD+AdvTT47f7fe79.I Type 1C WinAnsi yes yes no 414 0 IBHPFE+AdvP4C4E59 Type 1C Custom yes yes yes 419 0 IBHPFF+AdvTTe692faf0+fb Type 1C Custom yes yes yes 426 0 IBHPFG+AdvOTb0c9bf5d+03 Type 1C Custom yes yes yes 434 0 IBHPFH+AdvTTc9617e0c.B Type 1C WinAnsi yes yes no 429 0 IBHPGH+AdvP4C4E74 Type 1C Custom yes yes yes 437 0 IBHPGI+AdvOTb0c9bf5d+20 Type 1C WinAnsi yes yes no 444 0 IBHPGJ+AdvPSA35D Type 1C WinAnsi yes yes no 447 0 IBHPHK+AdvOTb0c9bf5d Type 1C WinAnsi yes yes no 449 0 IBHPIL+AdvTT47f7fe79.I+fb Type 1C Custom yes yes yes 219 0 IBHPJL+AdvP4C4E51 Type 1C WinAnsi yes yes no 222 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2026-10-24 04:39:49 CEST RepresentationInformation: 337666.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2026-10-23 09:43:00 CEST Size: 2957663 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 489 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: ICA-27243 improves neuromuscular function and preserves motoneurons in the transgenic SOD1G93A mice Destination: titlink1 Children: Item: Title: Introduction Destination: flink1 Item: Title: Methods Destination: flink2 Children: Item: Title: Spinal cord organotypic cultures Destination: slink1 Item: Title: MN viability assessment Destination: slink2 Item: Title: Animals and treatment Destination: slink3 Item: Title: Electrophysiological tests Destination: slink4 Item: Title: Locomotion tests Destination: slink5 Item: Title: Histological and immunofluorescence analyses Destination: slink6 Item: Title: Statistical analysis Destination: slink7 Item: Title: Results Destination: flink3 Children: Item: Title: ICA-27243 prevents MN degeneration in SCOCs under excitotoxic conditions Destination: slink8 Item: Title: ICA-27243 treatment preserves neuromuscular function and slows disease progression in SOD1G93A mice Destination: slink9 Item: Title: ICA-27243 promotes MN survival in the lumbar spinal cord and reduces glial activation in the SOD1G93A mice Destination: slink10 Item: Title: Discussion Destination: flink4 Item: Title: Author Contribution Destination: flink5 Item: Title: Funding Destination: flink6 Item: Title: Data Availability Destination: flink7 Item: Title: Declaration of competing interest Destination: creditlink2 Item: Title: Acknowledgments Destination: aclink3 Item: Title: References Destination: blink1 Info: Title: ICA-27243 improves neuromuscular function and preserves motoneurons in the transgenic SOD1G93A mice Author: Vera M. 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Masegosa Xavier Navarro Mireia Herrando-Grabulosa ICA-27243 Amyotrophic lateral sclerosis SOD1G93A transgenic mice Motoneuron degeneration Hyperexcitability Neurotherapeutics, 21 (2024) e00319. doi:10.1016/j.neurot.2024.e00319 The Authors journal Neurotherapeutics © 2024 The Authors. 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