1c3780534723f56a4c7d4cd0e82e654f Decoding_the_molecular.pdf bac6b861f44b192dc312f5f2b9783f64db2171ae Decoding_the_molecular.pdf b64e8ee95723949e4ec6f3548cb737720297d3c118fbb59026da55c8641382ea Decoding_the_molecular.pdf Title: Decoding the molecular and structural determinants of the neurokinin A and Aβ1-42 peptide cross-interaction in the amyloid cascade pathway Subject: ISCIENCE, 27 (2024) 111187. doi:10.1016/j.isci.2024.111187 Author: Mohsen Habibnia Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Mon Nov 4 12:01:01 2024 CET ModDate: Mon Nov 4 12:05:36 2024 CET Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 602.986 x 782.986 pts Page rot: 0 File size: 2746643 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- GLFLFG+HelveticaNeueLTStd-Bd Type 1C WinAnsi yes yes no 959 0 GLFLFH+AdvPSA5BC Type 1C WinAnsi yes yes no 960 0 GLFLFI+AdvPSA5CD Type 1C WinAnsi yes yes no 961 0 GLFLFJ+AdvPS3F4C13 Type 1C WinAnsi yes yes no 962 0 GLFNJM+AdvPSA5B8 Type 1C MacRoman yes yes no 963 0 GLFNJN+AdvPSA5B9 Type 1C WinAnsi yes yes no 964 0 GLFNJO+AdvPSSym Type 1C WinAnsi yes yes no 965 0 Helvetica-Bold Type 1 WinAnsi no no no 982 0 GLFNLP+AdvPSA5CF Type 1C WinAnsi yes yes no 983 0 GKNFDI+AdvPSA5BA Type 1C WinAnsi yes yes no 879 0 GLFNLO+Helvetica-Bold Type 1 WinAnsi no yes no 889 0 GLFNLP+AdvPSA5CF Type 1C WinAnsi yes yes no 878 0 GLFLFG+HelveticaNeueLTStd-Bd Type 1C WinAnsi yes yes no 871 0 GLFLFH+AdvPSA5BC Type 1C Custom yes yes no 880 0 GLFLFI+AdvPSA5CD Type 1C Custom yes yes no 881 0 GLFLFJ+AdvPS3F4C13 Type 1C WinAnsi yes yes no 877 0 GKNFAD+AdvPS4BD310 Type 1C WinAnsi yes yes no 886 0 GKNFBE+AdvPSA5BD Type 1C WinAnsi yes yes no 874 0 GKNFBF+AdvPSA5CE Type 1C WinAnsi yes yes no 885 0 GLFNJM+AdvPSA5B8 Type 1C MacRoman yes yes no 883 0 GLFNJN+AdvPSA5B9 Type 1C WinAnsi yes yes no 884 0 GLFNJO+AdvPSSym Type 1C WinAnsi yes yes no 870 0 GKNFOH+AdvP4C4E74 Type 1C Custom yes yes yes 895 0 GKNIOG+AdvPS7DA6 Type 1C WinAnsi yes yes no 899 0 GKNIOH+AdvPS44A44B Type 1C WinAnsi yes yes no 898 0 GKOACL+AdvPS480274 Type 1C WinAnsi yes yes no 902 0 GKOACM+AdvPSMPi6 Type 1C WinAnsi yes yes no 904 0 GKOAOJ+AdvTimes Type 1C WinAnsi yes yes no 905 0 GKOBHJ+AdvP4C4E46 Type 1C Custom yes yes no 908 0 GKOBHK+AdvTT5843c571 Type 1C WinAnsi yes yes no 911 0 GKOBGH+AdvPS3D56D5 Type 1C WinAnsi yes yes no 909 0 GKOBGI+AdvP4C4E51 Type 1C WinAnsi yes yes no 910 0 GKOBHI+AdvHelN-L Type 1C WinAnsi yes yes no 912 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2026-10-22 04:12:50 CEST RepresentationInformation: Decoding_the_molecular.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2026-10-21 19:25:22 CEST Size: 2746643 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 1056 FreeObjects: 19 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: ELS_ISCI111187_annotate_v27i11.pdf Children: Item: Title: Decoding the molecular and structural determinants of the neurokinin A and Aβ1-42 peptide cross-interaction in the amyloid ... Destination: titlink1 Children: Item: Title: Introduction Destination: flink1 Item: Title: Results Destination: flink2 Children: Item: Title: Building the NKA-Aβ dimer Destination: slink1 Item: Title: NKA stabilizes helical structure in Aβ1-42 Destination: slink2 Item: Title: Phe residue is key in the NKA-Aβ1-42 interaction Destination: slink3 Item: Title: Effect of NKA/NKAW interaction on the Aβ1-42 amyloid pathway Destination: slink4 Item: Title: Effect of the NKA-Aβ1-42 interaction on cell toxicity Destination: slink5 Item: Title: Discussion Destination: flink3 Children: Item: Title: Limitations of the study Destination: slink6 Item: Title: Resource availability Destination: flink4 Children: Item: Title: Lead contact Destination: slink7 Item: Title: Materials availability Destination: slink8 Item: Title: Data and code availability Destination: slink9 Item: Title: Acknowledgments Destination: flink5 Item: Title: Author contributions Destination: flink6 Item: Title: Declaration of interests Destination: flink7 Item: Title: Supplemental information Destination: falink8 Item: Title: References Destination: blink1 Item: Title: STAR★Methods Destination: flink9 Children: Item: Title: Key resources table Destination: slink10 Item: Title: Experimental model and study participant details Destination: slink11 Item: Title: Method details Destination: slink12 Children: Item: Title: Peptide-peptide docking Destination: tlink1 Item: Title: Molecular dynamics simulations and analysis Destination: tlink2 Item: Title: Peptides Destination: tlink3 Item: Title: Sample preparation Destination: tlink4 Item: Title: Circular dichroism measurements Destination: tlink5 Item: Title: Thioflavin T aggregation kinetics Destination: tlink6 Item: Title: Transmission electron microscopy negative staining Destination: tlink7 Item: Title: MTT cell viability assay Destination: tlink8 Item: Title: Quantification and statistical analysis Destination: slink13 Info: Title: Decoding the molecular and structural determinants of the neurokinin A and Aβ1-42 peptide cross-interaction in the amyloid cascade pathway Author: Mohsen Habibnia Subject: ISCIENCE, 27 (2024) 111187. doi:10.1016/j.isci.2024.111187 Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Mon Nov 04 12:31:01 CET 2024 ModDate: Mon Nov 04 12:35:36 CET 2024 ID: 0xf494b1b392354795a191213dc04e80f9, 0x301c72e9930ef848a947cbc3bf355982 Filters: FilterPipeline: FlateDecode FilterPipeline: JPXDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpx ImageWidth: 35 ImageHeight: 34 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: JPXDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 785 ImageHeight: 785 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpx ImageWidth: 35 ImageHeight: 34 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: JPXDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 670 ImageHeight: 330 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 872 ImageHeight: 565 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 997 ImageHeight: 569 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 997 ImageHeight: 588 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 670 ImageHeight: 248 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1009 ImageHeight: 281 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 872 ImageHeight: 338 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Fonts: Type1: Font: BaseFont: GLFLFH+AdvPSA5BC FontSubset: true FirstChar: 65 LastChar: 116 FontDescriptor: FontName: GLFLFH+AdvPSA5BC Flags: Nonsymbolic FontBBox: -156, -239, 1135, 791 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GLFLFI+AdvPSA5CD FontSubset: true FirstChar: 44 LastChar: 122 FontDescriptor: FontName: GLFLFI+AdvPSA5CD Flags: Nonsymbolic FontBBox: -156, -239, 1000, 781 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GLFLFJ+AdvPS3F4C13 FontSubset: true FirstChar: 98 LastChar: 98 FontDescriptor: FontName: GLFLFJ+AdvPS3F4C13 Flags: Nonsymbolic FontBBox: 0, -291, 875, 697 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GKNIOH+AdvPS44A44B FontSubset: true FirstChar: 36 LastChar: 71 FontDescriptor: FontName: GKNIOH+AdvPS44A44B Flags: Nonsymbolic FontBBox: 0, -197, 1000, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GLFNJM+AdvPSA5B8 FontSubset: true FirstChar: 44 LastChar: 223 FontDescriptor: FontName: GLFNJM+AdvPSA5B8 Flags: Nonsymbolic FontBBox: -156, -281, 1000, 791 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: GKNIOG+AdvPS7DA6 FontSubset: true FirstChar: 116 LastChar: 116 FontDescriptor: FontName: GKNIOG+AdvPS7DA6 Flags: Nonsymbolic FontBBox: -20, -208, 1000, 770 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GLFNJN+AdvPSA5B9 FontSubset: true FirstChar: 50 LastChar: 118 FontDescriptor: FontName: GLFNJN+AdvPSA5B9 Flags: Nonsymbolic FontBBox: -156, -281, 1041, 791 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GLFNJO+AdvPSSym FontSubset: true FirstChar: 170 LastChar: 170 FontDescriptor: FontName: GLFNJO+AdvPSSym Flags: Nonsymbolic FontBBox: -177, -291, 1083, 1010 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GKOACL+AdvPS480274 FontSubset: true FirstChar: 43 LastChar: 66 FontDescriptor: FontName: GKOACL+AdvPS480274 Flags: Nonsymbolic FontBBox: 0, -208, 1354, 791 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GKOACM+AdvPSMPi6 FontSubset: true FirstChar: 100 LastChar: 100 FontDescriptor: FontName: GKOACM+AdvPSMPi6 Flags: Nonsymbolic FontBBox: 0, -177, 989, 739 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GKOAOJ+AdvTimes FontSubset: true FirstChar: 45 LastChar: 45 FontDescriptor: FontName: GKOAOJ+AdvTimes Flags: Nonsymbolic FontBBox: -217, -212, 1005, 766 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GKOBHJ+AdvP4C4E46 FontSubset: true FirstChar: 1 LastChar: 5 FontDescriptor: FontName: GKOBHJ+AdvP4C4E46 Flags: Symbolic FontBBox: 21, -1159, 413, 40 FontFile3: true EncodingDictionary: Differences: true Font: BaseFont: GKOBGH+AdvPS3D56D5 FontSubset: true FirstChar: 116 LastChar: 116 FontDescriptor: FontName: GKOBGH+AdvPS3D56D5 Flags: Nonsymbolic FontBBox: -52, -208, 1000, 770 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GKOBGI+AdvP4C4E51 FontSubset: true FirstChar: 61 LastChar: 61 FontDescriptor: FontName: GKOBGI+AdvP4C4E51 Flags: Nonsymbolic FontBBox: -31, -239, 1041, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GKOBHK+AdvTT5843c571 FontSubset: true FirstChar: 186 LastChar: 186 FontDescriptor: FontName: GKOBHK+AdvTT5843c571 Flags: Nonsymbolic FontBBox: -72, -208, 927, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GKOBHI+AdvHelN-L FontSubset: true FirstChar: 43 LastChar: 61 FontDescriptor: FontName: GKOBHI+AdvHelN-L Flags: Nonsymbolic FontBBox: -156, -208, 1041, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: Helvetica-Bold FirstChar: 108 LastChar: 108 FontDescriptor: FontName: Helvetica-Bold Flags: Nonsymbolic, ForceBold FontBBox: -170, -228, 1003, 962 Encoding: WinAnsiEncoding Font: BaseFont: GLFNLP+AdvPSA5CF FontSubset: true FirstChar: 65 LastChar: 83 FontDescriptor: FontName: GLFNLP+AdvPSA5CF Flags: Nonsymbolic FontBBox: -156, -239, 1000, 781 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GLFNJO+AdvPSSym FontSubset: true FirstChar: 170 LastChar: 170 FontDescriptor: FontName: GLFNJO+AdvPSSym Flags: Nonsymbolic FontBBox: -177, -291, 1083, 1010 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GLFLFG+HelveticaNeueLTStd-Bd FontSubset: true FirstChar: 83 LastChar: 110 FontDescriptor: FontName: GLFLFG+HelveticaNeueLTStd-Bd Flags: Nonsymbolic, ForceBold FontBBox: -166, -218, 1078, 975 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GKNFBE+AdvPSA5BD FontSubset: true FirstChar: 105 LastChar: 118 FontDescriptor: FontName: GKNFBE+AdvPSA5BD Flags: Nonsymbolic FontBBox: -156, -239, 1166, 791 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GLFLFJ+AdvPS3F4C13 FontSubset: true FirstChar: 98 LastChar: 112 FontDescriptor: FontName: GLFLFJ+AdvPS3F4C13 Flags: Nonsymbolic FontBBox: 0, -291, 875, 697 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GLFNLP+AdvPSA5CF FontSubset: true FirstChar: 65 LastChar: 83 FontDescriptor: FontName: GLFNLP+AdvPSA5CF Flags: Nonsymbolic FontBBox: -156, -239, 1000, 781 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GKNFDI+AdvPSA5BA FontSubset: true FirstChar: 46 LastChar: 121 FontDescriptor: FontName: GKNFDI+AdvPSA5BA Flags: Nonsymbolic FontBBox: -156, -270, 1031, 791 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GLFLFH+AdvPSA5BC FontSubset: true FirstChar: 30 LastChar: 146 FontDescriptor: FontName: GLFLFH+AdvPSA5BC Flags: Nonsymbolic FontBBox: -156, -239, 1135, 791 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: GLFLFI+AdvPSA5CD FontSubset: true FirstChar: 25 LastChar: 189 FontDescriptor: FontName: GLFLFI+AdvPSA5CD Flags: Nonsymbolic FontBBox: -156, -239, 1000, 781 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: GLFNJM+AdvPSA5B8 FontSubset: true FirstChar: 40 LastChar: 251 FontDescriptor: FontName: GLFNJM+AdvPSA5B8 Flags: Nonsymbolic FontBBox: -156, -281, 1000, 791 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: GLFNJN+AdvPSA5B9 FontSubset: true FirstChar: 50 LastChar: 120 FontDescriptor: FontName: GLFNJN+AdvPSA5B9 Flags: Nonsymbolic FontBBox: -156, -281, 1041, 791 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GKNFBF+AdvPSA5CE FontSubset: true FirstChar: 46 LastChar: 121 FontDescriptor: FontName: GKNFBF+AdvPSA5CE Flags: Nonsymbolic FontBBox: -166, -239, 1031, 781 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GKNFAD+AdvPS4BD310 FontSubset: true FirstChar: 98 LastChar: 109 FontDescriptor: FontName: GKNFAD+AdvPS4BD310 Flags: Nonsymbolic FontBBox: 0, -208, 989, 697 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GLFNLO+Helvetica-Bold FontSubset: true FirstChar: 108 LastChar: 108 FontDescriptor: FontName: Helvetica-Bold Flags: Nonsymbolic, ForceBold FontBBox: -170, -228, 1003, 962 Encoding: WinAnsiEncoding Font: BaseFont: GLFLFG+HelveticaNeueLTStd-Bd FontSubset: true FirstChar: 83 LastChar: 110 FontDescriptor: FontName: GLFLFG+HelveticaNeueLTStd-Bd Flags: Nonsymbolic, ForceBold FontBBox: -166, -218, 1078, 975 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GKNFOH+AdvP4C4E74 FontSubset: true FirstChar: 1 LastChar: 240 FontDescriptor: FontName: GKNFOH+AdvP4C4E74 Flags: Symbolic FontBBox: -20, -958, 1114, 770 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true XMP: application/pdf doi:10.1016/j.isci.2024.111187 Decoding the molecular and structural determinants of the neurokinin A and Aβ1-42 peptide cross-interaction in the amyloid cascade pathway Mohsen Habibnia Eric Catalina-Hernandez Mario Lopez-Martin David Masnou-Sanchez Alex Peralvarez-Marin Biochemistry Molecular neuroscience Pathophysiology Protein folding ISCIENCE, 27 (2024) 111187. doi:10.1016/j.isci.2024.111187 Elsevier Inc. journal ISCIENCE © 2024 Published by Elsevier Inc. 2589-0042 27 11 15 November 2024 2024-11-15 111187 111187 10.1016/j.isci.2024.111187 https://doi.org/10.1016/j.isci.2024.111187 2010-04-23 true 10.1016/j.isci.2024.111187 elsevier.com sciencedirect.com VoR 7.0.1 10.1016/j.isci.2024.111187 noindex 2010-04-23 true sciencedirect.com elsevier.com Elsevier 2024-11-04T16:31:01+05:30 2024-11-04T16:35:36+05:30 2024-11-04T16:35:36+05:30 True 1 https://www.elsevier.com/tdm/tdmrep-policy.json Acrobat Distiller 8.1.0 (Windows) uuid:378282d2-e1ac-4584-9d82-9586f5cc4f72 uuid:937c160c-2964-46de-8b45-88e9368d94f1 http://creativecommons.org/licenses/by-nc-nd/4.0/ Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 455, 410, 518, 416 Annotation: Subtype: Link Rect: 455, 68, 518, 74 Annotation: Subtype: Link Rect: 455, 60, 501, 66 Annotation: Subtype: Link Rect: 57, 16, 73, 32 Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 138, 579, 142, 589 Destination: 1 Annotation: Subtype: Link Rect: 144, 579, 148, 589 Destination: 1 Annotation: Subtype: Link Rect: 150, 579, 154, 589 Destination: 1 Annotation: Subtype: Link Rect: 266, 579, 270, 589 Destination: 1 Annotation: Subtype: Link Rect: 272, 579, 276, 589 Destination: 1 Annotation: Subtype: Link Rect: 278, 579, 282, 589 Destination: 1 Annotation: Subtype: Link Rect: 374, 579, 378, 589 Destination: 1 Annotation: Subtype: Link Rect: 380, 579, 384, 589 Destination: 1 Annotation: Subtype: Link Rect: 386, 579, 390, 589 Destination: 1 Annotation: Subtype: Link Rect: 499, 579, 503, 589 Destination: 1 Annotation: Subtype: Link Rect: 505, 579, 508, 589 Destination: 1 Annotation: Subtype: Link Rect: 173, 565, 177, 575 Destination: 1 Annotation: Subtype: Link Rect: 179, 565, 183, 575 Destination: 1 Annotation: Subtype: Link Rect: 184, 565, 188, 575 Destination: 1 Annotation: Subtype: Link Rect: 190, 565, 195, 575 Destination: 1 Annotation: Subtype: Link Rect: 206, 370, 209, 378 Destination: 229 Annotation: Subtype: Link Rect: 200, 359, 209, 367 Destination: 229 Annotation: Subtype: Link Rect: 279, 348, 288, 356 Destination: 229 Annotation: Subtype: Link Rect: 76, 316, 89, 324 Destination: 229 Annotation: Subtype: Link Rect: 156, 316, 163, 324 Destination: 229 Annotation: Subtype: Link Rect: 232, 316, 239, 324 Destination: 229 Annotation: Subtype: Link Rect: 386, 316, 392, 324 Destination: 229 Annotation: Subtype: Link Rect: 393, 316, 400, 324 Destination: 229 Annotation: Subtype: Link Rect: 302, 272, 309, 280 Destination: 229 Annotation: Subtype: Link Rect: 310, 272, 316, 280 Destination: 229 Annotation: Subtype: Link Rect: 174, 261, 180, 269 Destination: 229 Annotation: Subtype: Link Rect: 432, 250, 438, 258 Destination: 229 Annotation: Subtype: Link Rect: 332, 228, 338, 236 Destination: 229 Annotation: Subtype: Link Rect: 339, 228, 345, 236 Destination: 229 Annotation: Subtype: Link Rect: 523, 228, 529, 236 Destination: 229 Annotation: Subtype: Link Rect: 386, 202, 412, 210 Destination: 67 Annotation: Subtype: Link Rect: 416, 206, 422, 214 Destination: 229 Annotation: Subtype: Link Rect: 211, 184, 218, 192 Destination: 229 Annotation: Subtype: Link Rect: 219, 184, 225, 192 Destination: 229 Annotation: Subtype: Link Rect: 88, 173, 94, 181 Destination: 229 Annotation: Subtype: Link Rect: 96, 173, 102, 181 Destination: 229 Annotation: Subtype: Link Rect: 103, 173, 110, 181 Destination: 229 Annotation: Subtype: Link Rect: 304, 162, 319, 170 Destination: 229 Annotation: Subtype: Link Rect: 538, 151, 544, 159 Destination: 229 Annotation: Subtype: Link Rect: 227, 140, 233, 148 Destination: 229 Annotation: Subtype: Link Rect: 92, 129, 98, 137 Destination: 229 Annotation: Subtype: Link Rect: 100, 129, 106, 137 Destination: 229 Annotation: Subtype: Link Rect: 112, 57, 181, 64 Annotation: Subtype: Link Rect: 57, 50, 175, 56 Annotation: Subtype: Link Rect: 57, 16, 73, 32 Annotation: Subtype: Link Rect: 360, 11, 520, 18 Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 73, 413, 102, 421 Destination: 67 Annotation: Subtype: Link Rect: 530, 413, 544, 421 Destination: 67 Annotation: Subtype: Link Rect: 57, 402, 75, 410 Destination: 67 Annotation: Subtype: Link Rect: 507, 402, 535, 410 Destination: 67 Annotation: Subtype: Link Rect: 402, 392, 431, 400 Destination: 67 Annotation: Subtype: Link Rect: 76, 381, 109, 389 Destination: 208 Annotation: Subtype: Link Rect: 428, 370, 460, 378 Destination: 67 Annotation: Subtype: Link Rect: 482, 370, 491, 378 Destination: 208 Annotation: Subtype: Link Rect: 255, 359, 283, 367 Destination: 67 Annotation: Subtype: Link Rect: 302, 309, 331, 317 Destination: 96 Annotation: Subtype: Link Rect: 324, 298, 353, 306 Destination: 96 Annotation: Subtype: Link Rect: 491, 298, 519, 306 Destination: 96 Annotation: Subtype: Link Rect: 148, 287, 181, 295 Destination: 208 Annotation: Subtype: Link Rect: 327, 646, 330, 654 Destination: 67 Annotation: Subtype: Link Rect: 382, 646, 385, 654 Destination: 67 Annotation: Subtype: Link Rect: 459, 646, 462, 654 Destination: 67 Annotation: Subtype: Link Rect: 526, 646, 529, 654 Destination: 67 Annotation: Subtype: Link Rect: 212, 557, 218, 563 Destination: 229 Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 322, 307, 355, 315 Destination: 208 Annotation: Subtype: Link Rect: 190, 296, 219, 304 Destination: 127 Annotation: Subtype: Link Rect: 264, 296, 297, 304 Destination: 208 Annotation: Subtype: Link Rect: 216, 274, 248, 282 Destination: 127 Annotation: Subtype: Link Rect: 330, 274, 363, 282 Destination: 208 Annotation: Subtype: Link Rect: 88, 252, 121, 260 Destination: 127 Annotation: Subtype: Link Rect: 156, 244, 162, 252 Destination: 229 Annotation: Subtype: Link Rect: 479, 244, 485, 252 Destination: 229 Annotation: Subtype: Link Rect: 487, 244, 493, 252 Destination: 229 Annotation: Subtype: Link Rect: 87, 233, 93, 241 Destination: 229 Annotation: Subtype: Link Rect: 230, 183, 262, 191 Destination: 158 Annotation: Subtype: Link Rect: 285, 183, 294, 191 Destination: 208 Annotation: Subtype: Link Rect: 359, 172, 387, 180 Destination: 158 Annotation: Subtype: Link Rect: 445, 161, 478, 169 Destination: 208 Annotation: Subtype: Link Rect: 122, 140, 158, 148 Destination: 208 Annotation: Subtype: Link Rect: 176, 140, 185, 148 Destination: 208 Annotation: Subtype: Link Rect: 129, 129, 157, 137 Destination: 183 Annotation: Subtype: Link Rect: 103, 118, 132, 126 Destination: 183 Annotation: Subtype: Link Rect: 178, 118, 206, 126 Destination: 183 Annotation: Subtype: Link Rect: 420, 49, 454, 57 Destination: 208 Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 358, 298, 391, 306 Destination: 183 Annotation: Subtype: Link Rect: 59, 277, 89, 285 Destination: 183 Annotation: Subtype: Link Rect: 304, 255, 333, 263 Destination: 183 Annotation: Subtype: Link Rect: 374, 255, 403, 263 Destination: 183 Annotation: Subtype: Link Rect: 214, 211, 247, 219 Destination: 208 Annotation: Subtype: Link Rect: 87, 189, 121, 197 Destination: 208 Annotation: Subtype: Link Rect: 507, 189, 540, 197 Destination: 208 Annotation: Subtype: Link Rect: 317, 130, 346, 138 Destination: 208 Annotation: Subtype: Link Rect: 233, 53, 239, 61 Destination: 229 Annotation: Subtype: Link Rect: 240, 53, 247, 61 Destination: 229 Annotation: Subtype: Link Rect: 248, 53, 254, 61 Destination: 229 Annotation: Subtype: Link Rect: 256, 53, 262, 61 Destination: 647 Annotation: Subtype: Link Rect: 318, 53, 324, 61 Destination: 229 Annotation: Subtype: Link Rect: 365, 53, 371, 61 Destination: 229 Annotation: Subtype: Link Rect: 373, 53, 379, 61 Destination: 229 Annotation: Subtype: Link Rect: 380, 53, 387, 61 Destination: 229 Annotation: Subtype: Link Rect: 388, 53, 394, 61 Destination: 647 Annotation: Subtype: Link Rect: 396, 53, 402, 61 Destination: 647 Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 153, 239, 159, 247 Destination: 229 Annotation: Subtype: Link Rect: 474, 239, 481, 247 Destination: 229 Annotation: Subtype: Link Rect: 538, 217, 544, 225 Destination: 229 Annotation: Subtype: Link Rect: 107, 195, 123, 203 Destination: 229 Annotation: Subtype: Link Rect: 124, 195, 130, 203 Destination: 229 Annotation: Subtype: Link Rect: 132, 195, 138, 203 Destination: 229 Annotation: Subtype: Link Rect: 140, 195, 146, 203 Destination: 647 Annotation: Subtype: Link Rect: 147, 195, 154, 203 Destination: 647 Annotation: Subtype: Link Rect: 448, 195, 454, 203 Destination: 647 Annotation: Subtype: Link Rect: 80, 173, 87, 181 Destination: 229 Annotation: Subtype: Link Rect: 473, 118, 479, 126 Destination: 229 Annotation: Subtype: Link Rect: 480, 118, 487, 126 Destination: 229 Annotation: Subtype: Link Rect: 361, 75, 368, 83 Destination: 229 Annotation: Subtype: Link Rect: 255, 49, 288, 57 Destination: 208 Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 98, 458, 104, 466 Destination: 229 Annotation: Subtype: Link Rect: 106, 458, 121, 466 Destination: 229 Annotation: Subtype: Link Rect: 123, 458, 129, 466 Destination: 229 Annotation: Subtype: Link Rect: 131, 458, 137, 466 Destination: 229 Annotation: Subtype: Link Rect: 138, 458, 145, 466 Destination: 229 Annotation: Subtype: Link Rect: 146, 458, 152, 466 Destination: 229 Annotation: Subtype: Link Rect: 154, 458, 160, 466 Destination: 229 Annotation: Subtype: Link Rect: 162, 458, 168, 466 Destination: 229 Annotation: Subtype: Link Rect: 170, 458, 176, 466 Destination: 647 Annotation: Subtype: Link Rect: 530, 245, 544, 252 Annotation: Subtype: Link Rect: 57, 237, 117, 244 Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 255, 390, 293, 397 Destination: 183 Annotation: Subtype: Link Rect: 394, 374, 432, 381 Destination: 183 Annotation: Subtype: Link Rect: 77, 175, 154, 182 Destination: 807 Annotation: Subtype: Link Rect: 77, 167, 270, 174 Destination: 807 Annotation: Subtype: Link Rect: 77, 159, 136, 166 Destination: 807 Annotation: Subtype: Link Rect: 77, 87, 231, 94 Destination: 860 Annotation: Subtype: Link Rect: 212, 49, 339, 56 Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 70, 597, 197, 604 Annotation: Subtype: Link Rect: 70, 589, 144, 596 Annotation: Subtype: Link Rect: 70, 581, 187, 588 Annotation: Subtype: Link Rect: 70, 573, 208, 580 Annotation: Subtype: Link Rect: 70, 565, 189, 572 Annotation: Subtype: Link Rect: 70, 557, 196, 564 Annotation: Subtype: Link Rect: 70, 549, 200, 556 Annotation: Subtype: Link Rect: 70, 541, 202, 548 Annotation: Subtype: Link Rect: 70, 533, 201, 540 Annotation: Subtype: Link Rect: 70, 525, 208, 532 Annotation: Subtype: Link Rect: 70, 517, 145, 524 Annotation: Subtype: Link Rect: 70, 509, 208, 516 Annotation: Subtype: Link Rect: 70, 501, 205, 508 Annotation: Subtype: Link Rect: 70, 493, 208, 500 Annotation: Subtype: Link Rect: 70, 485, 188, 492 Annotation: Subtype: Link Rect: 70, 477, 191, 484 Annotation: Subtype: Link Rect: 70, 469, 200, 476 Annotation: Subtype: Link Rect: 70, 461, 189, 468 Annotation: Subtype: Link Rect: 70, 453, 201, 460 Annotation: Subtype: Link Rect: 70, 445, 200, 452 Annotation: Subtype: Link Rect: 70, 437, 208, 444 Annotation: Subtype: Link Rect: 70, 429, 202, 436 Annotation: Subtype: Link Rect: 70, 421, 208, 428 Annotation: Subtype: Link Rect: 70, 413, 158, 420 Annotation: Subtype: Link Rect: 70, 405, 192, 412 Annotation: Subtype: Link Rect: 70, 397, 133, 404 Annotation: Subtype: Link Rect: 70, 389, 205, 396 Annotation: Subtype: Link Rect: 70, 381, 172, 388 Annotation: Subtype: Link Rect: 70, 373, 208, 380 Annotation: Subtype: Link Rect: 70, 365, 186, 372 Annotation: Subtype: Link Rect: 70, 357, 191, 364 Annotation: Subtype: Link Rect: 70, 349, 203, 356 Annotation: Subtype: Link Rect: 70, 341, 207, 348 Annotation: Subtype: Link Rect: 70, 333, 131, 340 Annotation: Subtype: Link Rect: 70, 325, 207, 332 Annotation: Subtype: Link Rect: 70, 317, 208, 324 Annotation: Subtype: Link Rect: 70, 309, 193, 316 Annotation: Subtype: Link Rect: 70, 300, 110, 307 Annotation: Subtype: Link Rect: 110, 301, 177, 308 Annotation: Subtype: Link Rect: 70, 293, 198, 300 Annotation: Subtype: Link Rect: 70, 285, 191, 292 Annotation: Subtype: Link Rect: 70, 277, 208, 284 Annotation: Subtype: Link Rect: 70, 269, 104, 276 Annotation: Subtype: Link Rect: 69, 261, 201, 268 Annotation: Subtype: Link Rect: 69, 253, 208, 260 Annotation: Subtype: Link Rect: 69, 245, 176, 252 Annotation: Subtype: Link Rect: 69, 237, 198, 244 Annotation: Subtype: Link Rect: 69, 229, 208, 236 Annotation: Subtype: Link Rect: 69, 221, 159, 228 Annotation: Subtype: Link Rect: 69, 213, 193, 220 Annotation: Subtype: Link Rect: 69, 205, 203, 212 Annotation: Subtype: Link Rect: 69, 197, 206, 204 Annotation: Subtype: Link Rect: 69, 189, 188, 196 Annotation: Subtype: Link Rect: 69, 181, 155, 188 Annotation: Subtype: Link Rect: 69, 173, 205, 180 Annotation: Subtype: Link Rect: 69, 165, 195, 172 Annotation: Subtype: Link Rect: 69, 157, 201, 164 Annotation: Subtype: Link Rect: 69, 149, 191, 156 Annotation: Subtype: Link Rect: 69, 141, 192, 148 Annotation: Subtype: Link Rect: 69, 133, 208, 140 Annotation: Subtype: Link Rect: 69, 125, 191, 132 Annotation: Subtype: Link Rect: 69, 117, 208, 124 Annotation: Subtype: Link Rect: 69, 109, 203, 116 Annotation: Subtype: Link Rect: 69, 101, 204, 108 Annotation: Subtype: Link Rect: 69, 93, 193, 100 Annotation: Subtype: Link Rect: 69, 85, 192, 92 Annotation: Subtype: Link Rect: 69, 77, 208, 84 Annotation: Subtype: Link Rect: 69, 69, 189, 76 Annotation: Subtype: Link Rect: 69, 61, 208, 68 Annotation: Subtype: Link Rect: 69, 53, 206, 60 Annotation: Subtype: Link Rect: 238, 597, 376, 604 Annotation: Subtype: Link Rect: 238, 589, 337, 596 Annotation: Subtype: Link Rect: 238, 581, 360, 588 Annotation: Subtype: Link Rect: 238, 573, 368, 580 Annotation: Subtype: Link Rect: 238, 565, 359, 572 Annotation: Subtype: Link Rect: 238, 557, 370, 564 Annotation: Subtype: Link Rect: 238, 549, 291, 556 Annotation: Subtype: Link Rect: 238, 541, 365, 548 Annotation: Subtype: Link Rect: 238, 533, 343, 540 Annotation: Subtype: Link Rect: 238, 525, 370, 532 Annotation: Subtype: Link Rect: 238, 517, 301, 524 Annotation: Subtype: Link Rect: 238, 509, 376, 516 Annotation: Subtype: Link Rect: 238, 501, 371, 508 Annotation: Subtype: Link Rect: 238, 493, 367, 500 Annotation: Subtype: Link Rect: 238, 485, 362, 492 Annotation: Subtype: Link Rect: 238, 477, 332, 484 Annotation: Subtype: Link Rect: 238, 469, 368, 476 Annotation: Subtype: Link Rect: 238, 461, 356, 468 Annotation: Subtype: Link Rect: 238, 453, 368, 460 Annotation: Subtype: Link Rect: 238, 445, 293, 452 Annotation: Subtype: Link Rect: 238, 437, 348, 444 Annotation: Subtype: Link Rect: 238, 429, 376, 436 Annotation: Subtype: Link Rect: 238, 421, 356, 428 Annotation: Subtype: Link Rect: 238, 413, 327, 420 Annotation: Subtype: Link Rect: 238, 405, 349, 412 Annotation: Subtype: Link Rect: 238, 397, 367, 404 Annotation: Subtype: Link Rect: 238, 389, 354, 396 Annotation: Subtype: Link Rect: 238, 381, 376, 388 Annotation: Subtype: Link Rect: 238, 373, 367, 380 Annotation: Subtype: Link Rect: 238, 365, 340, 372 Annotation: Subtype: Link Rect: 238, 357, 370, 364 Annotation: Subtype: Link Rect: 238, 349, 375, 356 Annotation: Subtype: Link Rect: 238, 341, 265, 348 Annotation: Subtype: Link Rect: 238, 309, 348, 316 Annotation: Subtype: Link Rect: 238, 301, 265, 308 Annotation: Subtype: Link Rect: 238, 293, 360, 300 Annotation: Subtype: Link Rect: 238, 285, 374, 292 Annotation: Subtype: Link Rect: 238, 277, 356, 284 Annotation: Subtype: Link Rect: 238, 269, 358, 276 Annotation: Subtype: Link Rect: 238, 261, 364, 268 Annotation: Subtype: Link Rect: 238, 253, 291, 260 Annotation: Subtype: Link Rect: 238, 245, 361, 252 Annotation: Subtype: Link Rect: 238, 237, 375, 244 Annotation: Subtype: Link Rect: 238, 229, 350, 236 Annotation: Subtype: Link Rect: 238, 221, 376, 228 Annotation: Subtype: Link Rect: 238, 213, 375, 220 Annotation: Subtype: Link Rect: 238, 205, 265, 212 Annotation: Subtype: Link Rect: 238, 197, 362, 204 Annotation: Subtype: Link Rect: 238, 189, 372, 196 Annotation: Subtype: Link Rect: 238, 181, 364, 188 Annotation: Subtype: Link Rect: 238, 173, 374, 180 Annotation: Subtype: Link Rect: 238, 165, 366, 172 Annotation: Subtype: Link Rect: 238, 157, 358, 164 Annotation: Subtype: Link Rect: 238, 149, 376, 156 Annotation: Subtype: Link Rect: 238, 141, 376, 148 Annotation: Subtype: Link Rect: 238, 133, 364, 140 Annotation: Subtype: Link Rect: 238, 125, 347, 132 Annotation: Subtype: Link Rect: 238, 117, 364, 124 Annotation: Subtype: Link Rect: 238, 109, 365, 116 Annotation: Subtype: Link Rect: 238, 101, 261, 108 Annotation: Subtype: Link Rect: 238, 93, 376, 100 Annotation: Subtype: Link Rect: 238, 85, 367, 92 Annotation: Subtype: Link Rect: 238, 77, 369, 84 Annotation: Subtype: Link Rect: 238, 69, 319, 76 Annotation: Subtype: Link Rect: 238, 61, 369, 68 Annotation: Subtype: Link Rect: 238, 53, 355, 60 Annotation: Subtype: Link Rect: 406, 597, 530, 604 Annotation: Subtype: Link Rect: 406, 589, 537, 596 Annotation: Subtype: Link Rect: 406, 581, 448, 588 Annotation: Subtype: Link Rect: 406, 573, 544, 580 Annotation: Subtype: Link Rect: 406, 565, 525, 572 Annotation: Subtype: Link Rect: 406, 557, 521, 564 Annotation: Subtype: Link Rect: 406, 549, 544, 556 Annotation: Subtype: Link Rect: 406, 541, 531, 548 Annotation: Subtype: Link Rect: 406, 533, 538, 540 Annotation: Subtype: Link Rect: 406, 525, 448, 532 Annotation: Subtype: Link Rect: 406, 517, 539, 524 Annotation: Subtype: Link Rect: 406, 509, 544, 516 Annotation: Subtype: Link Rect: 406, 501, 521, 508 Annotation: Subtype: Link Rect: 406, 493, 506, 500 Annotation: Subtype: Link Rect: 406, 485, 531, 492 Annotation: Subtype: Link Rect: 406, 477, 521, 484 Annotation: Subtype: Link Rect: 406, 469, 488, 476 Annotation: Subtype: Link Rect: 406, 461, 530, 468 Annotation: Subtype: Link Rect: 406, 453, 541, 460 Annotation: Subtype: Link Rect: 406, 445, 514, 452 Annotation: Subtype: Link Rect: 406, 437, 541, 444 Annotation: Subtype: Link Rect: 406, 429, 530, 436 Annotation: Subtype: Link Rect: 406, 421, 529, 428 Annotation: Subtype: Link Rect: 406, 413, 535, 420 Annotation: Subtype: Link Rect: 406, 405, 544, 412 Annotation: Subtype: Link Rect: 406, 397, 542, 404 Annotation: Subtype: Link Rect: 406, 389, 444, 396 Annotation: Subtype: Link Rect: 406, 381, 544, 388 Annotation: Subtype: Link Rect: 406, 373, 498, 380 Annotation: Subtype: Link Rect: 406, 365, 536, 372 Annotation: Subtype: Link Rect: 406, 357, 534, 364 Annotation: Subtype: Link Rect: 406, 349, 485, 356 Annotation: Subtype: Link Rect: 406, 341, 542, 348 Annotation: Subtype: Link Rect: 406, 333, 544, 340 Annotation: Subtype: Link Rect: 406, 325, 544, 332 Annotation: Subtype: Link Rect: 406, 317, 522, 324 Annotation: Subtype: Link Rect: 406, 309, 504, 316 Annotation: Subtype: Link Rect: 406, 301, 544, 308 Annotation: Subtype: Link Rect: 406, 293, 542, 300 Annotation: Subtype: Link Rect: 406, 285, 542, 292 Annotation: Subtype: Link Rect: 406, 277, 544, 284 Annotation: Subtype: Link Rect: 406, 269, 456, 276 Annotation: Subtype: Link Rect: 406, 261, 535, 268 Annotation: Subtype: Link Rect: 406, 253, 544, 260 Annotation: Subtype: Link Rect: 406, 245, 543, 252 Annotation: Subtype: Link Rect: 406, 237, 538, 244 Annotation: Subtype: Link Rect: 406, 229, 530, 236 Annotation: Subtype: Link Rect: 406, 221, 433, 228 Annotation: Subtype: Link Rect: 406, 165, 537, 172 Annotation: Subtype: Link Rect: 406, 157, 536, 164 Annotation: Subtype: Link Rect: 406, 149, 544, 156 Annotation: Subtype: Link Rect: 406, 141, 525, 148 Annotation: Subtype: Link Rect: 406, 132, 453, 139 Annotation: Subtype: Link Rect: 453, 132, 479, 139 Annotation: Subtype: Link Rect: 479, 132, 519, 139 Annotation: Subtype: Link Rect: 519, 133, 544, 140 Annotation: Subtype: Link Rect: 406, 126, 509, 133 Annotation: Subtype: Link Rect: 406, 117, 544, 124 Annotation: Subtype: Link Rect: 406, 109, 533, 116 Annotation: Subtype: Link Rect: 406, 101, 543, 108 Annotation: Subtype: Link Rect: 406, 93, 485, 100 Annotation: Subtype: Link Rect: 406, 85, 517, 92 Annotation: Subtype: Link Rect: 519, 85, 544, 92 Annotation: Subtype: Link Rect: 406, 77, 436, 84 Annotation: Subtype: Link Rect: 438, 77, 544, 84 Annotation: Subtype: Link Rect: 406, 69, 444, 76 Annotation: Subtype: Link Rect: 406, 61, 537, 68 Annotation: Subtype: Link Rect: 406, 53, 514, 60 Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 69, 672, 208, 679 Annotation: Subtype: Link Rect: 69, 664, 194, 671 Annotation: Subtype: Link Rect: 69, 656, 159, 663 Annotation: Subtype: Link Rect: 69, 646, 200, 653 Annotation: Subtype: Link Rect: 69, 638, 203, 645 Annotation: Subtype: Link Rect: 69, 630, 202, 637 Annotation: Subtype: Link Rect: 69, 622, 197, 629 Annotation: Subtype: Link Rect: 69, 614, 96, 621 Annotation: Subtype: Link Rect: 69, 603, 196, 610 Annotation: Subtype: Link Rect: 69, 595, 208, 602 Annotation: Subtype: Link Rect: 69, 587, 157, 594 Annotation: Subtype: Link Rect: 69, 577, 208, 584 Annotation: Subtype: Link Rect: 69, 569, 201, 576 Annotation: Subtype: Link Rect: 69, 561, 208, 568 Annotation: Subtype: Link Rect: 69, 553, 197, 560 Annotation: Subtype: Link Rect: 69, 545, 180, 552 Annotation: Subtype: Link Rect: 69, 537, 208, 544 Annotation: Subtype: Link Rect: 69, 529, 190, 536 Annotation: Subtype: Link Rect: 69, 521, 156, 528 Annotation: Subtype: Link Rect: 69, 511, 208, 518 Annotation: Subtype: Link Rect: 69, 503, 176, 510 Annotation: Subtype: Link Rect: 69, 495, 205, 502 Annotation: Subtype: Link Rect: 69, 487, 175, 494 Annotation: Subtype: Link Rect: 69, 479, 110, 486 Annotation: Subtype: Link Rect: 238, 672, 376, 679 Annotation: Subtype: Link Rect: 238, 664, 376, 671 Annotation: Subtype: Link Rect: 238, 656, 355, 663 Annotation: Subtype: Link Rect: 238, 648, 371, 655 Annotation: Subtype: Link Rect: 238, 640, 284, 647 Annotation: Subtype: Link Rect: 238, 629, 375, 636 Annotation: Subtype: Link Rect: 238, 621, 371, 628 Annotation: Subtype: Link Rect: 238, 613, 366, 620 Annotation: Subtype: Link Rect: 238, 605, 374, 612 Annotation: Subtype: Link Rect: 238, 597, 347, 604 Annotation: Subtype: Link Rect: 238, 589, 272, 596 Annotation: Subtype: Link Rect: 238, 578, 374, 585 Annotation: Subtype: Link Rect: 238, 570, 358, 577 Annotation: Subtype: Link Rect: 238, 562, 364, 569 Annotation: Subtype: Link Rect: 238, 554, 365, 561 Annotation: Subtype: Link Rect: 238, 546, 371, 553 Annotation: Subtype: Link Rect: 238, 538, 363, 545 Annotation: Subtype: Link Rect: 238, 530, 289, 537 Annotation: Subtype: Link Rect: 238, 519, 376, 526 Annotation: Subtype: Link Rect: 238, 511, 376, 518 Annotation: Subtype: Link Rect: 238, 503, 376, 510 Annotation: Subtype: Link Rect: 238, 495, 347, 502 Annotation: Subtype: Link Rect: 238, 487, 352, 494 Annotation: Subtype: Link Rect: 238, 479, 298, 486 Annotation: Subtype: Link Rect: 406, 672, 544, 679 Annotation: Subtype: Link Rect: 406, 664, 544, 671 Annotation: Subtype: Link Rect: 406, 656, 541, 663 Annotation: Subtype: Link Rect: 406, 648, 543, 655 Annotation: Subtype: Link Rect: 406, 640, 517, 647 Annotation: Subtype: Link Rect: 406, 632, 526, 639 Annotation: Subtype: Link Rect: 406, 624, 440, 631 Annotation: Subtype: Link Rect: 406, 616, 543, 623 Annotation: Subtype: Link Rect: 406, 608, 544, 615 Annotation: Subtype: Link Rect: 406, 600, 544, 607 Annotation: Subtype: Link Rect: 406, 592, 544, 599 Annotation: Subtype: Link Rect: 406, 584, 474, 591 Annotation: Subtype: Link Rect: 406, 575, 523, 582 Annotation: Subtype: Link Rect: 525, 575, 544, 582 Annotation: Subtype: Link Rect: 406, 567, 522, 574 Annotation: Subtype: Link Rect: 406, 559, 514, 566 Annotation: Subtype: Link Rect: 406, 551, 534, 558 Annotation: Subtype: Link Rect: 406, 543, 440, 550 Annotation: Subtype: Link Rect: 442, 543, 537, 550 Annotation: Subtype: Link Rect: 406, 535, 455, 542 Annotation: Subtype: Link Rect: 406, 527, 540, 534 Annotation: Subtype: Link Rect: 406, 519, 529, 526 Annotation: Subtype: Link Rect: 406, 511, 544, 518 Annotation: Subtype: Link Rect: 406, 503, 531, 510 Annotation: Subtype: Link Rect: 406, 495, 544, 502 Annotation: Subtype: Link Rect: 406, 487, 544, 494 Annotation: Subtype: Link Rect: 406, 479, 451, 486 Page: Label: 11 Annotations: Annotation: Subtype: Link Rect: 293, 237, 299, 245 Destination: 647 Annotation: Subtype: Link Rect: 538, 215, 544, 223 Destination: 647 Annotation: Subtype: Link Rect: 85, 182, 91, 190 Destination: 647 Annotation: Subtype: Link Rect: 481, 129, 487, 137 Destination: 647 Annotation: Subtype: Link Rect: 389, 420, 465, 427 Annotation: Subtype: Link Rect: 241, 408, 321, 415 Annotation: Subtype: Link Rect: 241, 395, 349, 402 Annotation: Subtype: Link Rect: 305, 385, 311, 392 Destination: 647 Annotation: Subtype: Link Rect: 389, 369, 519, 376 Annotation: Subtype: Link Rect: 389, 358, 443, 365 Page: Label: 12 Annotations: Annotation: Subtype: Link Rect: 371, 675, 378, 683 Destination: 647 Annotation: Subtype: Link Rect: 278, 664, 284, 672 Destination: 647 Annotation: Subtype: Link Rect: 520, 664, 526, 672 Destination: 647 Annotation: Subtype: Link Rect: 195, 566, 202, 574 Destination: 647 Annotation: Subtype: Link Rect: 433, 552, 466, 560 Destination: 208 Annotation: Subtype: Link Rect: 345, 312, 383, 320 Destination: 832 Annotation: Subtype: Link Rect: 324, 167, 330, 175 Destination: 647 Page: Label: 13 Checksum: 57307c5d Type: CRC32 Checksum: 1c3780534723f56a4c7d4cd0e82e654f Type: MD5 Checksum: bac6b861f44b192dc312f5f2b9783f64db2171ae Type: SHA-1 Checksum: b64e8ee95723949e4ec6f3548cb737720297d3c118fbb59026da55c8641382ea Type: SHA-256