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Med. 11:1431791. doi: 10.3389/fmed.2024.1431791 Keywords: septic shock; precision medicine; personalized treatment; treatable trait; hemoadsorption; cytokine storm; sepsis phenotypes Author: Luis Chiscano-Camón Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Mon Aug 12 10:01:23 2024 CEST ModDate: Mon Aug 12 10:36:37 2024 CEST Custom Metadata: no Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 595.26 x 842.116 pts (A4) Page rot: 0 File size: 660582 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- YEAZQW+MuseoSans-700 Type 1C Custom yes yes yes 36 0 GQADIC+MuseoSans-300 Type 1C Custom yes yes yes 39 0 WIKMWX+MuseoSans-300Italic Type 1C WinAnsi yes yes no 52 0 JKABNJ+MinionPro-Regular Type 1C Custom yes yes no 55 0 PLCELI+MuseoSans-500 Type 1C Custom yes yes yes 62 0 CVJJBP+RMTMI Type 1C Custom yes yes yes 96 0 JCOJZT+MTGU Type 1C Custom yes yes no 83 0 CXBLJP+MTSY Type 1C Custom yes yes yes 88 0 BBDPIA+MinionPro-It Type 1C Custom yes yes no 91 0 PVVMLZ+MinionPro-Bold Type 1C Custom yes yes no 107 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2026-10-23 04:15:11 CEST RepresentationInformation: fmed-11-1431791.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2026-10-22 15:19:56 CEST Size: 660582 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 422 FreeObjects: 21 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Current perspectives in the management of sepsis and septic shock Destination: ariclecounter.1 Children: Item: Title: 1 Introduction Destination: section*.2 Item: Title: 2 Hyperinflammatory phenotype Destination: section*.3 Children: Item: Title: 2.1 Hyperinflammatory with high endotoxemic phenotype Destination: section*.4 Item: Title: 2.2 Hyperinflammation with high cytokine phenotype Destination: section*.5 Item: Title: 2.3 Sequential hemoadsorption Destination: section*.6 Item: Title: 3 Hypoinflammatory phenotype Destination: section*.7 Children: Item: Title: 3.1 Hypogammaglobulinemia Destination: section*.8 Item: Title: 4 Precision immunotherapy in sepsis. Counterbalancing hyperinflammatory and hypoinflammatory phenotypes Destination: section*.9 Item: Title: 5 Catecholamine–resistant-hypotension Destination: section*.10 Children: Item: Title: 5.1 Focus on vasopressin and angiotensin-II Destination: section*.11 Item: Title: 5.2 Corticosteroids Destination: section*.12 Item: Title: 5.3 Metabolic resuscitation and Vitamin C (ascorbic acid) Destination: section*.13 Item: Title: 6 Low-flow phenotype Destination: section*.14 Item: Title: 7 Endothelial dysfunction Destination: section*.15 Children: Item: Title: 7.1 Adrenomedullin Destination: section*.16 Item: Title: 7.2 Soluble triggering receptor expressed on myeloid cells 1 Destination: section*.17 Item: Title: 7.3 Thrombocytopenia-associated multiple organ failure Destination: section*.18 Item: Title: 8 Conclusions Destination: section*.19 Item: Title: Author contributions Destination: section*.20 Item: Title: Funding Destination: section*.21 Item: Title: Conflict of interest Destination: section*.22 Item: Title: Publisher's note Destination: section*.23 Item: Title: References Destination: section*.24 Info: Title: Current perspectives in the management of sepsis and septic shock Subject: Chiscano-Camón L, Ruiz-Sanmartin A, Bajaña I, Bastidas J, Lopez-Martinez R, Franco-Jarava C, Gonzalez JJ, Larrosa N, Riera J, Nuvials-Casals X, Ruiz-Rodrı́guez JC and Ferrer R (2024) Current perspectives in the management of sepsis and septic shock. 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This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Chiscano-Camón L, Ruiz-Sanmartin A, Bajaña I, Bastidas J, Lopez-Martinez R, Franco-Jarava C, Gonzalez JJ, Larrosa N, Riera J, Nuvials-Casals X, Ruiz-Rodrı́guez JC and Ferrer R (2024) Current perspectives in the management of sepsis and septic shock. Front. Med. 11:1431791. doi: 10.3389/fmed.2024.1431791 Luis Chiscano-Camón Adolf Ruiz-Sanmartin Ivan Bajaña Juliana Bastidas Rocio Lopez-Martinez Clara Franco-Jarava Juan Jose-.3exto 0pt́ Gonzalez Nieves Larrosa Jordi Riera Xavier Nuvials-Casals Juan Carlos Ruiz-Rodrı́guez Ricard Ferrer Current perspectives in the management of sepsis and septic shock septic shock precision medicine personalized treatment treatable trait hemoadsorption cytokine storm sepsis phenotypes uuid:6913cfc8-0143-4f40-97a7-5321a0b7b82f uuid:3cb87c0f-662e-4dce-83ff-a1594f561d90 Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 48, 789, 218, 806 Annotation: Subtype: Link Rect: 456, 800, 481, 808 Annotation: Subtype: Link Rect: 473, 791, 483, 799 Annotation: Subtype: Link Rect: 483, 791, 506, 799 Annotation: Subtype: Link Rect: 506, 791, 524, 799 Annotation: Subtype: Link Rect: 453, 782, 546, 790 Annotation: Subtype: Link Rect: 48, 725, 124, 742 Annotation: Subtype: Link Rect: 57, 585, 175, 593 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