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Title:           Kinetics and toxicity of nanoplastics in ex vivo exposed human whole blood as a model to understand their impact on human health
Subject:         Science of the Total Environment, 948 (2024) 174725. doi:10.1016/j.scitotenv.2024.174725
Keywords:        Nanoplastics,Uptake,Oxidative stress,Hemolysis,Platelets functionality
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      Title: Kinetics and toxicity of nanoplastics in ex vivo exposed human whole blood as a model to understand their impact on human h ...
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        Title: 1 Introduction
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        Title: 2 Materials and methods
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         Item: 
          Title: 2.1 The selected NPLs
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          Title: 2.2 NPLs characterization
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           Item: 
            Title: 2.2.1 Scanning electron microscopy
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            Title: 2.2.2 Dynamic Light Scattering (DLS)
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          Title: 2.3 Blood sample collection and ex vivo NPLs exposure
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          Title: 2.4 Whole blood fractionation
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            Title: 2.4.1 Plasma isolation for cytokine characterization, platelet activation, and coagulation assays
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            Title: 2.4.2 WBCs isolation for internalization and ROS generation assays
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            Title: 2.4.3 Erythrocyte suspension preparation for hemolysis assays
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          Title: 2.5 SEM visualization of NPLs in whole blood
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          Title: 2.6 Quantification of NPLs uptake in WBCs by flow cytometry
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          Title: 2.7 Visualization of NPLs uptake in WBCs by confocal imaging
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          Title: 2.8 Intracellular reactive oxygen species (iROS)
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          Title: 3.1 NPLs characterization
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          Title: 3.2 NPLs visualization in whole-blood by SEM
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          Title: 3.3 Uptake of NPLs in the different blood cell subtypes
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          Title: 3.4 Oxidative stress induction in WBC exposed to NPLs
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          Title: 3.5 Immune response
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          Title: 3.6 Hemolysis induced by NPLs
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          Title: 3.7 Coagulation and platelet functionality
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        Title: CRediT authorship contribution statement
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        Title: Declaration of competing interest
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        Title: Data availability
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        Title: Acknowledgments
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        Title: Appendix A Supplementary data
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    Keywords: Nanoplastics,Uptake,Oxidative stress,Hemolysis,Platelets functionality
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   Type: CRC32
  Checksum: 05a6c55bb9eba013665bcb6f824bcd39
   Type: MD5
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