355ed2aac4bef461bc0d5e2cf811a8c5  anaandbioche_a2024.pdf
04a0727a59408afb76e4215234a6fb3294a28beb  anaandbioche_a2024.pdf
c788de3f383e10694d1f262c8cc383cfc892a245dcbfaeb9c7f8b2c3e4ccc9ef  anaandbioche_a2024.pdf

Title:           YoA novel biomimetic nanoplasmonic sensor for rapid and accurate evaluation of checkpoint inhibitor immunotherapy
Subject:         Analytical and Bioanalytical Chemistry, https://doi.org/10.1007/s00216-024-05398-3
Keywords:        Localized surface plasmon resonance;Label-free analysis;Sensor biofunctionalization;Artificial cell membrane;Checkpoint inhibitors;Cancer immunotherapy
Author:           Razia Batool 
Creator:         Adobe InDesign 15.1 (Windows)
Producer:        Adobe PDF Library 15.0
CreationDate:    Thu Jun 20 09:20:15 2024 CEST
ModDate:         Thu Jun 20 18:14:26 2024 CEST
Custom Metadata: yes
Metadata Stream: yes
Tagged:          no
UserProperties:  no
Suspects:        no
Form:            none
JavaScript:      no
Pages:           10
Encrypted:       no
Page size:       595.276 x 790.866 pts
Page rot:        0
File size:       1503552 bytes
Optimized:       yes
PDF version:     1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
MyriadPro-SemiCn                     Type 1C           WinAnsi          yes no  yes    337  0
MyriadPro-Semibold                   Type 1C           Custom           yes no  yes    338  0
MyriadPro-SemiboldSemiCn             Type 1C           Custom           yes no  yes    339  0
MyriadPro-Bold                       Type 1C           Custom           yes no  yes    340  0
BCPNHL+STIX-Regular                  Type 1C           Custom           yes yes yes    341  0
STIX-Italic                          Type 1C           Custom           yes no  yes    360  0
JPGRVY+Wingdings-Regular             Type 1C           WinAnsi          yes yes yes    361  0
DUVYKB+MyriadPro-SemiCn2             Type 1C           WinAnsi          yes yes yes    394  0
TLYWUB+TimesLTStd-Roman              Type 1C           Custom           yes yes no     210  0
SHJQGD+TimesLTStd-Bold               Type 1C           WinAnsi          yes yes no     214  0
KXUKEC+STIX-Bold                     Type 1C           WinAnsi          yes yes yes    211  0
MyriadPro-BoldSemiCn                 Type 1C           Custom           yes no  yes    232  0
MyriadPro-SemiCn3                    Type 1C           Custom           yes no  yes    229  0
KDBQTT+Times-Bold                    Type 1C           WinAnsi          yes yes no     252  0
KDBQTT+Helvetica-Bold                Type 1C           WinAnsi          yes yes no     255  0
JERKFV+Times-Roman                   Type 1C           WinAnsi          yes yes no     262  0
Times-Bold2                          Type 1C           WinAnsi          yes no  no     261  0
Times-Roman2                         Type 1C           WinAnsi          yes no  no     256  0
Times-Bold3                          Type 1C           WinAnsi          yes no  no     257  0
Times-Roman3                         Type 1C           WinAnsi          yes no  no     264  0
Times-Bold4                          Type 1C           WinAnsi          yes no  no     267  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2024-12-18 02:49:33 CET
 RepresentationInformation: anaandbioche_a2024.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2024-10-23 03:44:41 CEST
  Size: 1503552
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  Profile: Linearized PDF
  PDFMetadata: 
   Objects: 435
   FreeObjects: 1
   IncrementalUpdates: 1
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: en-US
    Outlines: 
     Item: 
      Title: A novel biomimetic nanoplasmonic sensor for rapid and accurate evaluation of checkpoint inhibitor immunotherapy
      Children: 
       Item: 
        Title: Abstract
       Item: 
        Title: Introduction
       Item: 
        Title: Materials and methods
        Children: 
         Item: 
          Title: Chemical and biological reagents
         Item: 
          Title: Numerical modeling and fabrication of nanoplasmonic sensors
         Item: 
          Title: LSPR biosensor device description
         Item: 
          Title: Formation of PD-L1-functionalized supported lipid bilayer (SLB)
         Item: 
          Title: Analysis of PD1PD-L1 interaction
         Item: 
          Title: Evaluation of anti-PD1 mAb as checkpoint inhibitors
       Item: 
        Title: Results and discussion
        Children: 
         Item: 
          Title: Design, fabrication, and characterization of low-density nanostructured plasmonic sensors
         Item: 
          Title: Formation of a PD-L1-functionalized lipid membrane
         Item: 
          Title: Highly sensitive analysis and monitoring of PD1PD-L1 interactions
         Item: 
          Title: Assessment of monoclonal antibody (mAb) as PD1 checkpoint inhibitor
       Item: 
        Title: Conclusions
       Item: 
        Title: References
   Info: 
    Title: YoA novel biomimetic nanoplasmonic sensor for rapid and accurate evaluation of checkpoint inhibitor immunotherapy
    Author:  Razia Batool 
    Subject: Analytical and Bioanalytical Chemistry, https://doi.org/10.1007/s00216-024-05398-3
    Keywords: Localized surface plasmon resonance;Label-free analysis;Sensor biofunctionalization;Artificial cell membrane;Checkpoint inhibitors;Cancer immunotherapy
    Creator: Adobe InDesign 15.1 (Windows)
    Producer: Adobe PDF Library 15.0
    CreationDate: Thu Jun 20 09:20:15 CEST 2024
    ModDate: Thu Jun 20 18:14:26 CEST 2024
   ID: 0x1e3b5cc41224d749bcad476c50ee0596, 0x9a8e1e67f36d5c4fa1270df52656f1df
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1297
      ImageHeight: 526
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 922
      ImageHeight: 1957
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1562
      ImageHeight: 406
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1481
      ImageHeight: 752
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1678
      ImageHeight: 438
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
   Fonts: 
    Type1: 
     Font: 
      BaseFont: Times-Roman2
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: Times-Roman2
       Flags: Serif, Nonsymbolic
       FontBBox: -168, -218, 1000, 898
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: Times-Bold3
      FirstChar: 32
      LastChar: 110
      FontDescriptor: 
       FontName: Times-Bold3
       Flags: Nonsymbolic
       FontBBox: -168, -218, 1000, 935
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: Times-Bold2
      FirstChar: 32
      LastChar: 98
      FontDescriptor: 
       FontName: Times-Bold2
       Flags: Nonsymbolic
       FontBBox: -168, -218, 1000, 935
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JERKFV+Times-Roman
      FontSubset: true
      FirstChar: 32
      LastChar: 117
      FontDescriptor: 
       FontName: JERKFV+Times-Roman
       Flags: Serif, Nonsymbolic
       FontBBox: -168, -218, 1000, 898
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: STIX-Italic
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: STIX-Italic
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -970, -305, 1429, 1023
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-BoldSemiCn
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-BoldSemiCn
       Flags: Nonsymbolic
       FontBBox: -133, -250, 1161, 894
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: Times-Roman3
      FirstChar: 32
      LastChar: 116
      FontDescriptor: 
       FontName: Times-Roman3
       Flags: Serif, Nonsymbolic
       FontBBox: -168, -218, 1000, 898
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JPGRVY+Wingdings-Regular
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: JPGRVY+Wingdings-Regular
       Flags: Nonsymbolic
       FontBBox: 0, -103, 1359, 439
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: Times-Bold4
      FirstChar: 32
      LastChar: 110
      FontDescriptor: 
       FontName: Times-Bold4
       Flags: Serif, Nonsymbolic
       FontBBox: -168, -218, 1000, 935
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MyriadPro-SemiCn
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-SemiCn
       Flags: Nonsymbolic
       FontBBox: -128, -250, 1059, 876
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Semibold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Semibold
       Flags: Nonsymbolic
       FontBBox: -161, -250, 1198, 972
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: TLYWUB+TimesLTStd-Roman
      FontSubset: true
      FirstChar: 31
      LastChar: 121
      FontDescriptor: 
       FontName: TLYWUB+TimesLTStd-Roman
       Flags: Serif, Nonsymbolic
       FontBBox: -168, -218, 1000, 898
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: MyriadPro-SemiboldSemiCn
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-SemiboldSemiCn
       Flags: Nonsymbolic
       FontBBox: -131, -250, 1115, 886
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: KXUKEC+STIX-Bold
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: KXUKEC+STIX-Bold
       Flags: Serif, Nonsymbolic
       FontBBox: -998, -552, 2000, 1055
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Bold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Bold
       Flags: Nonsymbolic
       FontBBox: -163, -250, 1256, 989
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: BCPNHL+STIX-Regular
      FontSubset: true
      FirstChar: 23
      LastChar: 250
      FontDescriptor: 
       FontName: BCPNHL+STIX-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -970, -486, 2208, 1023
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: SHJQGD+TimesLTStd-Bold
      FontSubset: true
      FirstChar: 32
      LastChar: 99
      FontDescriptor: 
       FontName: SHJQGD+TimesLTStd-Bold
       Flags: Nonsymbolic
       FontBBox: -168, -218, 1012, 935
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: KDBQTT+Times-Bold
      FontSubset: true
      FirstChar: 32
      LastChar: 99
      FontDescriptor: 
       FontName: KDBQTT+Times-Bold
       Flags: Nonsymbolic
       FontBBox: -168, -218, 1000, 935
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: KDBQTT+Helvetica-Bold
      FontSubset: true
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: KDBQTT+Helvetica-Bold
       Flags: Nonsymbolic
       FontBBox: -170, -228, 1003, 962
       FontFile3: true
      Encoding: WinAnsiEncoding
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 5.6-c015 81.159809, 2016/11/11-01:42:16        ">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:xmp="http://ns.adobe.com/xap/1.0/"
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/"
            xmlns:dc="http://purl.org/dc/elements/1.1/"
            xmlns:crossmark="http://crossref.org/crossmark/1.0/"
            xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/"
            xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/"
            xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/"
            xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#"
            xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/"
            xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/"
            xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#"
            xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#"
            xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#"
            xmlns:pdfaField="http://www.aiim.org/pdfa/ns/field#">
         <xmp:CreateDate>2024-06-20T07:20:15</xmp:CreateDate>
         <xmp:CreatorTool>Adobe InDesign 15.1 (Windows)</xmp:CreatorTool>
         <xmp:ModifyDate>2024-06-20T16:14:26Z</xmp:ModifyDate>
         <xmp:MetadataDate>2024-06-20T16:14:26Z</xmp:MetadataDate>
         <pdf:Producer>Adobe PDF Library 15.0</pdf:Producer>
         <pdf:Keywords>Localized surface plasmon resonance;Label-free analysis;Sensor biofunctionalization;Artificial cell membrane;Checkpoint inhibitors;Cancer immunotherapy</pdf:Keywords>
         <pdf:Trapped>False</pdf:Trapped>
         <dc:format>application/pdf</dc:format>
         <dc:identifier>https://doi.org/10.1007/s00216-024-05398-3</dc:identifier>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Springer Berlin Heidelberg</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Analytical and Bioanalytical Chemistry, https://doi.org/10.1007/s00216-024-05398-3</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>Localized surface plasmon resonance</rdf:li>
               <rdf:li>Label-free analysis</rdf:li>
               <rdf:li>Sensor biofunctionalization</rdf:li>
               <rdf:li>Artificial cell membrane</rdf:li>
               <rdf:li>Checkpoint inhibitors</rdf:li>
               <rdf:li>Cancer immunotherapy</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">YoA novel biomimetic nanoplasmonic sensor for rapid and accurate evaluation of checkpoint inhibitor immunotherapy</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li> Razia Batool </rdf:li>
               <rdf:li> Maria Soler </rdf:li>
               <rdf:li> Rukmani Singh </rdf:li>
               <rdf:li> Laura M. Lechuga </rdf:li>
            </rdf:Seq>
         </dc:creator>
         <crossmark:DOI>10.1007/s00216-024-05398-3</crossmark:DOI>
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
         <prism:url>https://doi.org/10.1007/s00216-024-05398-3</prism:url>
         <prism:doi>10.1007/s00216-024-05398-3</prism:doi>
         <prism:issn>1618-2650</prism:issn>
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>Analytical and Bioanalytical Chemistry</prism:publicationName>
         <prism:copyright>The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature</prism:copyright>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:doi>10.1007/s00216-024-05398-3</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
         <xmpMM:DocumentID>uuid:2fd28a7d-5137-4a3c-9087-a7a06148f3eb</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:b9c10a17-77e3-4384-a04a-cf9c6d8409d5</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:2fd28a7d-5137-4a3c-9087-a7a06148f3eb</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2024-06-20T16:13:54Z</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe Document Info PDF eXtension Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:MajorVersionDate</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkMajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:DOI</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrosMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>robots</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://crossref.org/crossmark/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>crossmark</pdfaSchema:prefix>
                  <pdfaSchema:schema>Crossmark Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Usual same as prism:doi</pdfaProperty:description>
                           <pdfaProperty:name>DOI</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The date when a publication was publishe.</pdfaProperty:description>
                           <pdfaProperty:name>MajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://prismstandard.org/namespaces/basic/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>prism</pdfaSchema:prefix>
                  <pdfaSchema:schema>Prism Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary.</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article.&#xA;The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). </pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version.</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Volume number</pdfaProperty:description>
                           <pdfaProperty:name>volume</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Issue number</pdfaProperty:description>
                           <pdfaProperty:name>number</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Starting page</pdfaProperty:description>
                           <pdfaProperty:name>startingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Ending page</pdfaProperty:description>
                           <pdfaProperty:name>endingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. </pdfaProperty:description>
                           <pdfaProperty:name>aggregationType</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.”</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Copyright</pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>DocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:schema>Springer Nature ORCID Schema</pdfaSchema:schema>
                  <pdfaSchema:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>sn</pdfaSchema:prefix>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:name>authorInfo</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag AuthorInformation</pdfaProperty:valueType>
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Author information: contains the name of each author and his/her ORCiD (ORCiD: Open Researcher and Contributor ID). An ORCiD is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors.</pdfaProperty:description>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:type>AuthorInformation</pdfaType:type>
                           <pdfaType:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/authorInfo/</pdfaType:namespaceURI>
                           <pdfaType:prefix>author</pdfaType:prefix>
                           <pdfaType:description>Specifies the types of author information: name and ORCID of an author.</pdfaType:description>
                           <pdfaType:field>
                              <rdf:Seq>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>name</pdfaField:name>
                                    <pdfaField:valueType>Text</pdfaField:valueType>
                                    <pdfaField:description>Gives the name of an author.</pdfaField:description>
                                 </rdf:li>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>orcid</pdfaField:name>
                                    <pdfaField:valueType>URI</pdfaField:valueType>
                                    <pdfaField:description>Gives the ORCID of an author.</pdfaField:description>
                                 </rdf:li>
                              </rdf:Seq>
                           </pdfaType:field>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 513, 726, 546, 694
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 167, 735, 173, 720
       Flags: Print
       AppearanceDictionary: true
       Destination: 123
      Annotation: 
       Subtype: Link
       Rect: 278, 673, 283, 658
       Flags: Print
       AppearanceDictionary: true
       Destination: 123
      Annotation: 
       Subtype: Link
       Rect: 461, 723, 466, 708
       Flags: Print
       AppearanceDictionary: true
       Destination: 123
      Annotation: 
       Subtype: Link
       Rect: 428, 623, 434, 608
       Flags: Print
       AppearanceDictionary: true
       Destination: 123
      Annotation: 
       Subtype: Link
       Rect: 469, 510, 474, 495
       Flags: Print
       AppearanceDictionary: true
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 523, 398, 528, 383
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 533, 398, 538, 383
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 409, 273, 413, 258
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 535, 273, 540, 258
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
     Thumb: true
    Page: 
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 142, 661, 147, 646
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 194, 599, 205, 584
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 190, 586, 200, 571
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 81, 424, 91, 409
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 225, 361, 235, 346
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 253, 124, 258, 109
       Flags: Print
       AppearanceDictionary: true
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 179, 99, 184, 84
       Flags: Print
       AppearanceDictionary: true
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 446, 99, 456, 84
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
     Thumb: true
    Page: 
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 187, 724, 197, 709
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 216, 574, 221, 559
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 227, 574, 232, 559
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 239, 574, 249, 559
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 205, 449, 210, 434
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 215, 449, 220, 434
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 225, 449, 235, 434
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 224, 99, 234, 84
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 239, 99, 249, 84
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
     Thumb: true
    Page: 
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 54, 411, 59, 396
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 64, 411, 69, 396
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 74, 411, 84, 396
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 275, 311, 285, 296
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 216, 149, 226, 134
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 447, 711, 452, 696
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 457, 711, 462, 696
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 467, 711, 477, 696
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 528, 511, 533, 496
       Flags: Print
       AppearanceDictionary: true
       Destination: 63
      Annotation: 
       Subtype: Link
       Rect: 516, 199, 522, 184
       Flags: Print
       AppearanceDictionary: true
       Destination: 63
      Annotation: 
       Subtype: Link
       Rect: 389, 124, 394, 109
       Flags: Print
       AppearanceDictionary: true
       Destination: 63
      Annotation: 
       Subtype: Link
       Rect: 368, 111, 374, 96
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
     Thumb: true
    Page: 
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 112, 86, 122, 71
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 127, 86, 137, 71
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 392, 285, 397, 270
       Flags: Print
       AppearanceDictionary: true
       Destination: 80
      Annotation: 
       Subtype: Link
       Rect: 309, 123, 315, 108
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
     Thumb: true
    Page: 
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 276, 399, 281, 384
       Flags: Print
       AppearanceDictionary: true
       Destination: 80
      Annotation: 
       Subtype: Link
       Rect: 513, 373, 518, 358
       Flags: Print
       AppearanceDictionary: true
       Destination: 80
      Annotation: 
       Subtype: Link
       Rect: 528, 323, 533, 308
       Flags: Print
       AppearanceDictionary: true
       Destination: 80
     Thumb: true
    Page: 
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 257, 611, 267, 596
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 87, 599, 97, 584
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 221, 536, 226, 521
       Flags: Print
       AppearanceDictionary: true
       Destination: 80
      Annotation: 
       Subtype: Link
       Rect: 89, 336, 94, 321
       Flags: Print
       AppearanceDictionary: true
       Destination: 101
      Annotation: 
       Subtype: Link
       Rect: 363, 686, 368, 671
       Flags: Print
       AppearanceDictionary: true
       Destination: 101
      Annotation: 
       Subtype: Link
       Rect: 327, 674, 332, 659
       Flags: Print
       AppearanceDictionary: true
       Destination: 101
      Annotation: 
       Subtype: Link
       Rect: 416, 499, 421, 484
       Flags: Print
       AppearanceDictionary: true
       Destination: 123
      Annotation: 
       Subtype: Link
       Rect: 452, 461, 462, 446
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 401, 449, 411, 434
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 366, 399, 376, 384
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 386, 399, 396, 384
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
     Thumb: true
    Page: 
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 391, 680, 542, 667
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 392, 267, 542, 254
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 447, 177, 544, 164
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 167, 344, 154
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 507, 137, 544, 124
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 127, 440, 114
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 507, 97, 544, 84
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 87, 439, 74
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 257, 667, 265, 654
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 257, 654, 265, 641
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 257, 642, 265, 629
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 257, 629, 265, 616
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 257, 617, 265, 604
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 257, 604, 265, 591
       Flags: Print
       AppearanceDictionary: true
       Destination: 147
     Thumb: true
    Page: 
     Sequence: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 210, 716, 289, 703
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 706, 106, 693
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 124, 666, 266, 653
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 180, 616, 289, 603
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 606, 111, 593
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 167, 536, 283, 523
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 252, 496, 289, 483
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 486, 178, 473
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 128, 446, 278, 433
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 238, 406, 289, 393
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 396, 164, 383
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 366, 221, 353
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 227, 346, 289, 333
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 336, 146, 323
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 132, 296, 278, 283
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 80, 266, 196, 253
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 446, 726, 544, 713
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 716, 339, 703
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 396, 686, 519, 673
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 392, 646, 509, 633
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 391, 616, 542, 603
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 383, 576, 541, 563
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 366, 536, 515, 523
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 460, 476, 544, 463
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 466, 407, 453
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 424, 426, 544, 413
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 416, 340, 403
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 463, 386, 544, 373
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 376, 376, 363
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
  Checksum: 4b7449e4
   Type: CRC32
  Checksum: 355ed2aac4bef461bc0d5e2cf811a8c5
   Type: MD5
  Checksum: 04a0727a59408afb76e4215234a6fb3294a28beb
   Type: SHA-1
  Checksum: c788de3f383e10694d1f262c8cc383cfc892a245dcbfaeb9c7f8b2c3e4ccc9ef
   Type: SHA-256