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Title:           Polylactic acid nanoplastics (PLA-NPLs) induce adverse effects on an in vitro model of the human lung epithelium: The Calu-3 air-liquid interface (ALI) barrier
Subject:         Journal of Hazardous Materials, 475 (2024) 134900. doi:10.1016/j.jhazmat.2024.134900
Keywords:        Nanoplastics,Polylactic acid,Callu-3 barrier,Long-term exposure,Air-liquid interphase
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      Title: Polylactic acid nanoplastics (PLA-NPLs) induce adverse effects on an in vitro model of the human lung epithelium: The Calu- ...
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       Item: 
        Title: 1 Introduction
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        Title: 2 Materials and methods
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         Item: 
          Title: 2.1 Obtention of PLA-NPLs and fluorescently-labelled PLA-NPLs
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          Title: 2.2 Physicochemical characterization of PLA-NPLs
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          Title: 2.3 The in vitro Calu-3 barrier, and the ALI model
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          Title: 2.4 Treatments with PLA-NPLs
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          Title: 2.5 PLA-NPL’s effects on the Calu-3 barrier function
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           Item: 
            Title: 2.5.1 Trans-epithelial electrical resistance (TEER)
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            Title: 2.5.2 The Lucifer yellow assay
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            Title: 2.5.3 Identification of tight junctions (ZO-1) by immunostaining
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            Title: 2.5.4 Histochemical identification of the barrier’s mucus secretion
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          Title: 2.6 Toxicokinetic analysis
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          Title: 2.7 PLA-NPLs effects on the Calu-3 barrier toxicological profile
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            Title: 2.7.1 Genotoxic and oxidative DNA damage
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            Title: 2.7.2 Proteome array and cytokine release analysis
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          Title: 2.8 Statistical analysis
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        Title: 3 Results and discussion
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          Title: 3.1 PLA-NPLs characterization
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          Title: 3.2 PLA-NPLs toxicokinetic. Adhesion, adsorption, and fate
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          Title: 3.3 PLA-NPLs effects on the barrier structure and functionality
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          Title: 3.4 Genotoxic effects of PLA-NPLs by the comet assay
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          Title: 3.5 Secretome array analysis. Immune response of Calu-3 barriers
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        Title: 4 Conclusions
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        Title: Environmental implication
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        Title: CRediT authorship contribution statement
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        Title: Declaration of Competing Interest
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        Title: Data availability
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        Title: Acknowledgments
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        Title: Appendix A Supporting information
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        Title: References
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   Type: CRC32
  Checksum: ace66d704b83550bdd5c27e89865b3e8
   Type: MD5
  Checksum: 68c8e2c7feb637df2cb86c75c0247de196e4f96e
   Type: SHA-1
  Checksum: 1932add51490ba09d39d17a40134571f1d59ab81ed51dfaca747109cfce18d87
   Type: SHA-256