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Destination: mk:title Children: Item: Title: 1 Introduction Destination: mk:H1_1 Item: Title: 2 Materials and methods Destination: mk:H1_2 Children: Item: Title: 2.1 Chemicals Destination: mk:H2_1 Item: Title: 2.2 Bacterial strains Destination: mk:H2_2 Item: Title: 2.3 Si-QACs synthesis and characterization Destination: mk:H2_3 Item: Title: 2.4 Minimal inhibitory concentration (MIC) Destination: mk:H2_4 Item: Title: 2.5 Fly strains and stock maintenance Destination: mk:H2_5 Item: Title: 2.6 Si-QACs exposure Destination: mk:H2_6 Item: Title: 2.7 Survival assay Destination: mk:H2_7 Item: Title: 2.8 Biomarkers Destination: mk:H2_8 Children: Item: Title: 2.8.1 Mutagenicity Destination: mk:H3_9 Item: Title: 2.8.2 Genotoxicity Destination: mk:H3_10 Item: Title: 2.8.3 Cytotoxicity Destination: mk:H3_11 Item: Title: 2.8.4 Oxidative stress Destination: mk:H3_12 Item: Title: 2.8.5 Apoptosis Destination: mk:H3_13 Item: Title: 2.8.6 DNA repair efficiency Destination: mk:H3_14 Item: Title: 2.8.7 Neurotoxicity Destination: mk:H3_15 Children: Item: Title: 2.8.7.1 Pupal positioning Destination: mk:H4_16 Item: Title: 2.8.7.2 Climbing assay Destination: mk:H4_17 Item: Title: 2.8.7.3 Crawling assay Destination: mk:H4_18 Item: Title: 2.8.7.4 Thermal sensitivity assay Destination: mk:H4_19 Item: Title: 2.8.7.5 Cold sensitivity assay Destination: mk:H4_20 Item: Title: 2.9 in silico analysis Destination: mk:H2_21 Children: Item: Title: 2.9.1 Molecular docking Destination: mk:H3_22 Item: Title: 2.9.2 Molecular dynamics simulation Destination: mk:H3_23 Item: Title: 2.9.3 Skin sensitization Destination: mk:H3_24 Item: Title: 2.9.4 Modeling of molecular descriptors and biomarkers Destination: mk:H3_25 Item: Title: 2.10 Statistical analysis Destination: mk:H2_26 Item: Title: 3 Results and discussion Destination: mk:H1_3 Children: Item: Title: 3.1 Si-QACs characterization Destination: mk:H2_27 Item: Title: 3.2 Antimicrobial activities Destination: mk:H2_28 Item: Title: 3.3 Biomarkers 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Journal of Hazardous Materials, 466 (2024) 133470. doi:10.1016/j.jhazmat.2024.133470 DNA damage Drosophila melanogaster Genotoxicity Oxidative stress Alcohol-free synthesis, biological assessment, in vivo toxicological evaluation, and in silico analysis of novel silane quaternary ammonium compounds differing in structure and chain length as promising disinfectants Ghada Tagorti Burçin Yalçın Merve Güneş Ayşen Yağmur Burgazlı Tuğçe Kuruca Neslihan Cihanoğlu Esin Akarsu Nuray Kaya Ricard Marcos Bülent Kaya journal Journal of Hazardous Materials © 2024 The Author(s). Published by Elsevier B.V. 0304-3894 466 15 March 2024 2024-03-15 133470 133470 10.1016/j.jhazmat.2024.133470 https://doi.org/10.1016/j.jhazmat.2024.133470 2010-04-23 true 10.1016/j.jhazmat.2024.133470 elsevier.com sciencedirect.com http://creativecommons.org/licenses/by/4.0/ VoR 10.1016/j.jhazmat.2024.133470 noindex 2010-04-23 true 9th February 2024 sciencedirect.com elsevier.com Elsevier 2024-02-09T05:47:41 2024-02-09T05:16:20 2024-02-09T05:47:41 True 9th February 2024 Acrobat Distiller 8.1.0 (Windows) DNA damage,Drosophila melanogaster,Genotoxicity,Oxidative stress uuid:1b499bed-4ce8-4c0c-b682-0d58baae1cbe uuid:b6ed5266-03cb-4855-90c0-636283357f42 Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 106, 537, 455, 547 Flags: Print Destination: 904 Annotation: Subtype: Link Rect: 455, 537, 463, 547 Flags: Print Destination: 904 Annotation: Subtype: Link Rect: 131, 524, 267, 534 Flags: Print Destination: 904 Annotation: Subtype: Link Rect: 267, 524, 347, 534 Flags: Print 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