90fd3c154a196a1bd033ce505e76d48b senandactb-c_a2024_v417_p136150.pdf 12c93e578a50ee28b3f2b1dbf45dadd1acb80919 senandactb-c_a2024_v417_p136150.pdf c4d29a2c17514e2b7941891dc71dbf537c99bffc8e80ad1c10077ce134903755 senandactb-c_a2024_v417_p136150.pdf Title: Multimodal HOCl-responsive MEH-PPV nanoparticles for anti-inflammatory imaging and therapy Subject: Sensors and Actuators: B. Chemical, 417 (2024) 136150. doi:10.1016/j.snb.2024.136150 Keywords: Fluorescence probe,Hypochlorous acid,Inflammatory disease,MEH-PPV,Quercetin,Theranostic Author: Eva Villar-Alvarez Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Thu Jul 18 09:02:46 2024 CEST ModDate: Thu Jul 18 09:04:00 2024 CEST Custom Metadata: yes Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 15 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 8958715 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- VXCJFZ+Univers Type 1C Builtin yes yes yes 1073 0 EVZLMV+TeX_CM_Roman Type 1C Builtin yes yes yes 1077 0 JAIVAP+CharisSIL CID TrueType Identity-H yes yes yes 1081 0 WHMBRK+STIX-Regular Type 1C Custom yes yes yes 1086 0 LPYQBH+CharisSIL-Bold CID TrueType Identity-H yes yes yes 1091 0 RXDHLD+CharisSIL-Italic CID TrueType Identity-H yes yes yes 1096 0 XRBTPA+TeX_CM_Maths_Symbols Type 1C Builtin yes yes yes 1101 0 ACLKQE+CharisSIL CID TrueType Identity-H yes yes yes 1064 0 QBFLEH+CharisSIL-Italic CID TrueType Identity-H yes yes yes 468 0 UJKWJW+TimesNewRomanPSMT CID TrueType Identity-H yes yes yes 477 0 SCYOVL+STIX-Italic Type 1C Custom yes yes yes 482 0 VVCCGG+TeX_CM_Maths_Italic Type 1C Builtin yes yes yes 488 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-11-16 02:43:54 CET RepresentationInformation: senandactb-c_a2024_v417_p136150.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-10-25 07:07:40 CEST Size: 8958715 Format: PDF Version: 1.7 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ErrorMessage: Invalid indirect destination - referenced object 'sec0175' cannot be found ID: PDF-HUL-149 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'sec0175' cannot be found ID: PDF-HUL-122 Offset: 8901546 MIMEtype: application/pdf Profile: Linearized PDF, Tagged PDF PDFMetadata: Objects: 1187 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Multimodal HOCl-responsive MEH-PPV nanoparticles for anti-inflammatory imaging and therapy Destination: mk:title Children: Item: Title: 1 Introduction Destination: mk:H1_1 Item: Title: 2 Materials and methods Destination: mk:H1_2 Children: Item: Title: 2.1 Materials Destination: mk:H2_1 Item: Title: 2.2 Synthesis of MEH-PPV-based NPs Destination: mk:H2_2 Children: Item: Title: 2.2.1 Synthesis of MEH NPs Destination: mk:H3_3 Item: Title: 2.2.2 Synthesis of MEH@CS NPs Destination: mk:H3_4 Item: Title: 2.2.3 Synthesis of QCT-MEH NPs and QCT-MEH@CS NPs Destination: mk:H3_5 Item: Title: 2.2.4 Preparation of oxidizing agents Destination: mk:H3_6 Item: Title: 2.3 NPs characterization Destination: mk:H2_7 Children: Item: Title: 2.3.1 Dynamic light scattering (DLS) and Z-potential (ZP) measurements Destination: mk:H3_8 Item: Title: 2.3.2 Scanning and transmission electron microscopies Destination: mk:H3_9 Item: Title: 2.3.3 UV-Vis and fluorescence spectroscopies Destination: mk:H3_10 Item: Title: 2.3.4 Kinetics experiment Destination: mk:H3_11 Item: Title: 2.3.5 Quantitative analysis of QCT in QCT-MEH@CS NPs Destination: mk:H3_12 Item: Title: 2.4 Biological characterization Destination: mk:H2_13 Children: Item: Title: 2.4.1 Cell culture Destination: mk:H3_14 Item: Title: 2.4.2 Cytotoxicity assay Destination: mk:H3_15 Item: Title: 2.4.3 Confocal and epi-fluorescence microscopy Destination: mk:H3_16 Item: Title: 2.4.4 Flow cytometry Destination: mk:H3_17 Item: Title: 2.4.5 HOCl in vitro detection and inhibition Destination: mk:H3_18 Item: Title: 2.4.6 Determination of IL-6 and TNF-α levels by ELISA Destination: mk:H3_19 Item: Title: 2.4.7 Statistical Analysis Destination: mk:H3_20 Item: Title: 3 Results and discussion Destination: mk:H1_3 Children: Item: Title: 3.1 Synthesis and physicochemical characterization Destination: mk:H2_21 Item: Title: 3.2 Chemical and colloidal stability Destination: mk:H2_22 Item: Title: 3.3 Cellular uptake and intrinsic cytotoxicity Destination: mk:H2_23 Item: Title: 3.4 HOCl sensitivity and selectivity in bulk suspensions Destination: mk:H2_24 Item: Title: 3.5 Detection of endogenous HOCl reactivity in living cells Destination: mk:H2_25 Item: Title: 3.6 Encapsulation of the HOCl scavenger quercetin (QCT) Destination: mk:H2_26 Item: Title: 3.7 In vitro HOCl inhibition by QCT-MEH@CS NPs Destination: mk:H2_27 Item: Title: 4 Conclusion Destination: mk:H1_4 Item: Title: CRediT authorship contribution statement Destination: mk:H1_5 Item: Title: Declaration of Competing Interest Destination: mk:HH1_3 Item: Title: Data availability Destination: datalink4 Item: Title: Acknowledgement Destination: mk:HH1_5 Item: Title: Appendix. Supporting Information Destination: mk:H1_6 Item: Title: Appendix A Supporting information Destination: mk:H1_7 Item: Title: References Destination: mk:HH2_1 Info: Title: Multimodal HOCl-responsive MEH-PPV nanoparticles for anti-inflammatory imaging and therapy Author: Eva Villar-Alvarez Subject: Sensors and Actuators: B. Chemical, 417 (2024) 136150. doi:10.1016/j.snb.2024.136150 Keywords: Fluorescence probe,Hypochlorous acid,Inflammatory disease,MEH-PPV,Quercetin,Theranostic Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Thu Jul 18 09:02:46 CEST 2024 ModDate: Thu Jul 18 09:04:00 CEST 2024 ID: 0x344aa4a77c50038d5b6ea9e5da744933, 0x15a9d028e6cd33265443f9d34669123d Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 236 ImageHeight: 298 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 248 ImageHeight: 271 BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type0: Font: BaseFont: LPYQBH+CharisSIL-Bold Encoding: Identity-H ToUnicode: true Font: BaseFont: RXDHLD+CharisSIL-Italic Encoding: Identity-H ToUnicode: true Font: BaseFont: JAIVAP+CharisSIL Encoding: Identity-H ToUnicode: true Font: BaseFont: UJKWJW+TimesNewRomanPSMT Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: VXCJFZ+Univers FontSubset: true FirstChar: 32 LastChar: 251 FontDescriptor: FontName: VXCJFZ+Univers Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: SCYOVL+STIX-Italic FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: SCYOVL+STIX-Italic Flags: Nonsymbolic, Italic FontBBox: -970, -305, 1429, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: EVZLMV+TeX_CM_Roman FontSubset: true FirstChar: 1 LastChar: 128 FontDescriptor: FontName: EVZLMV+TeX_CM_Roman Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: VVCCGG+TeX_CM_Maths_Italic FontSubset: true FirstChar: 1 LastChar: 127 FontDescriptor: FontName: VVCCGG+TeX_CM_Maths_Italic Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: XRBTPA+TeX_CM_Maths_Symbols FontSubset: true FirstChar: 1 LastChar: 138 FontDescriptor: FontName: XRBTPA+TeX_CM_Maths_Symbols Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: WHMBRK+STIX-Regular FontSubset: true FirstChar: 1 LastChar: 12 FontDescriptor: FontName: WHMBRK+STIX-Regular Flags: Nonsymbolic FontBBox: -970, -486, 2208, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true CIDFontType2: Font: BaseFont: LPYQBH+CharisSIL-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: LPYQBH+CharisSIL-Bold Flags: Nonsymbolic, ForceBold FontBBox: -720, -533, 1759, 1320 FontFile2: true Font: BaseFont: RXDHLD+CharisSIL-Italic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: RXDHLD+CharisSIL-Italic Flags: Nonsymbolic, Italic FontBBox: -716, -533, 1627, 1318 FontFile2: true Font: BaseFont: JAIVAP+CharisSIL CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: JAIVAP+CharisSIL Flags: Nonsymbolic FontBBox: -692, -533, 1623, 1319 FontFile2: true Font: BaseFont: UJKWJW+TimesNewRomanPSMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: UJKWJW+TimesNewRomanPSMT Flags: Nonsymbolic FontBBox: -568, -307, 2000, 1007 FontFile2: true XMP: application/pdf 10.1016/j.snb.2024.136150 Elsevier B.V. Sensors and Actuators: B. Chemical, 417 (2024) 136150. doi:10.1016/j.snb.2024.136150 Fluorescence probe Hypochlorous acid Inflammatory disease MEH-PPV Quercetin Theranostic Multimodal HOCl-responsive MEH-PPV nanoparticles for anti-inflammatory imaging and therapy Eva Villar-Alvarez Sara Parron-Onate Olga Wienskowska Aleix Carrascull-Marín Christian Bellacanzone Julia Lorenzo Daniel Ruiz-Molina Claudio Roscini journal Sensors and Actuators: B. Chemical © 2024 The Author(s). Published by Elsevier B.V. 0925-4005 417 15 October 2024 2024-10-15 136150 136150 10.1016/j.snb.2024.136150 https://doi.org/10.1016/j.snb.2024.136150 2010-04-23 true 10.1016/j.snb.2024.136150 elsevier.com sciencedirect.com http://creativecommons.org/licenses/by-nc-nd/4.0/ VoR 10.1016/j.snb.2024.136150 noindex 2010-04-23 true 18th July 2024 sciencedirect.com elsevier.com Elsevier 2024-07-18T07:04 2024-07-18T07:02:46 2024-07-18T07:04 True 18th July 2024 Acrobat Distiller 8.1.0 (Windows) Fluorescence probe,Hypochlorous acid,Inflammatory disease,MEH-PPV,Quercetin,Theranostic uuid:1b499bed-4ce8-4c0c-b682-0d58baae1cbe uuid:b6ed5266-03cb-4855-90c0-636283357f42 1 https://www.elsevier.com/tdm/tdmrep-policy.json Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 124, 571, 452, 582 Flags: Print Destination: 1049 Annotation: Subtype: Link Rect: 146, 558, 223, 569 Flags: Print Destination: 1049 Annotation: Subtype: Link Rect: 223, 563, 229, 574 Flags: Print Destination: 1049 Annotation: Subtype: Link Rect: 230, 563, 236, 574 Flags: Print Destination: 1049 Annotation: Subtype: Link Rect: 237, 558, 341, 569 Flags: Print Destination: 1049 Annotation: Subtype: Link Rect: 341, 563, 347, 574 Flags: Print Destination: 1049 Annotation: Subtype: Link Rect: 348, 566, 352, 571 Flags: Print Destination: 1049 Annotation: Subtype: Link Rect: 348, 558, 435, 569 Flags: Print Destination: 1049 Annotation: Subtype: Link Rect: 435, 563, 441, 574 Flags: Print Destination: 1049 Annotation: Subtype: Link Rect: 442, 566, 446, 571 Flags: Print Destination: 1049 Annotation: Subtype: Link Rect: 442, 558, 447, 569 Flags: Print Destination: 1049 Annotation: Subtype: Link Rect: 71, 247, 91, 255 Flags: Print Destination: 215 Annotation: Subtype: Link Rect: 166, 237, 185, 245 Flags: Print Destination: 215 Annotation: Subtype: Link Rect: 108, 216, 126, 224 Flags: Print Destination: 215 Annotation: Subtype: Link Rect: 159, 163, 186, 171 Flags: Print Destination: 215 Annotation: Subtype: Link Rect: 306, 310, 326, 318 Flags: Print Destination: 215 Annotation: Subtype: Link Rect: 338, 278, 356, 286 Flags: Print Destination: 215 Annotation: Subtype: Link Rect: 533, 268, 557, 276 Flags: Print Destination: 215 Annotation: Subtype: Link Rect: 524, 237, 555, 245 Flags: Print Destination: 215 Annotation: Subtype: Link Rect: 306, 184, 335, 192 Flags: Print Destination: 215 Annotation: Subtype: Link Rect: 424, 163, 439, 171 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 525, 153, 540, 161 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 103, 104, 164, 111 Flags: Print Annotation: Subtype: Link Rect: 224, 104, 302, 111 Flags: Print Annotation: Subtype: Link Rect: 321, 722, 369, 730 Flags: Print Annotation: Subtype: Link Rect: 280, 667, 391, 675 Flags: Print Annotation: Subtype: Link Rect: 37, 87, 177, 94 Flags: Print Annotation: Subtype: Link Rect: 297, 749, 300, 757 Flags: Print Annotation: Subtype: Link Rect: 212, 748, 382, 760 Annotation: Subtype: Link Rect: 499, 616, 528, 645 Annotation: Subtype: Link Rect: 425, 59, 557, 70 Annotation: Subtype: Link Rect: 37, 49, 72, 61 Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 37, 730, 53, 738 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 62, 720, 78, 728 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 86, 709, 102, 717 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 108, 699, 124, 707 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 159, 689, 175, 696 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 141, 657, 157, 665 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 89, 605, 105, 613 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 199, 573, 215, 581 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 270, 532, 286, 540 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 274, 385, 288, 393 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 37, 375, 49, 383 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 37, 354, 66, 362 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 37, 343, 74, 351 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 83, 343, 112, 351 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 459, 720, 486, 728 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 416, 699, 445, 707 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 306, 626, 335, 634 Flags: Print Destination: 246 Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 127, 689, 143, 696 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 261, 689, 288, 696 Flags: Print Destination: null Annotation: Subtype: Link Rect: 37, 678, 51, 686 Flags: Print Destination: null Annotation: Subtype: Link Rect: 205, 521, 251, 529 Flags: Print Destination: null Annotation: Subtype: Link Rect: 129, 427, 172, 435 Flags: Print Destination: null Annotation: Subtype: Link Rect: 37, 260, 53, 268 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 270, 249, 286, 257 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 175, 228, 191, 236 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 505, 500, 520, 508 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 511, 113, 538, 121 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 406, 92, 439, 100 Flags: Print Destination: null Annotation: Subtype: Link Rect: 306, 50, 322, 58 Flags: Print Destination: 246 Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 140, 500, 156, 508 Flags: Print Destination: 362 Annotation: Subtype: Link Rect: 485, 50, 525, 58 Flags: Print Destination: 246 Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 137, 730, 165, 738 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 207, 720, 223, 728 Flags: Print Destination: 362 Annotation: Subtype: Link Rect: 521, 730, 541, 738 Flags: Print Destination: 52 Annotation: Subtype: Link Rect: 375, 720, 394, 728 Flags: Print Destination: 52 Annotation: Subtype: Link Rect: 477, 709, 497, 717 Flags: Print Destination: 52 Annotation: Subtype: Link Rect: 349, 699, 370, 707 Flags: Print Destination: 52 Annotation: Subtype: Link Rect: 526, 636, 546, 644 Flags: Print Destination: 52 Annotation: Subtype: Link Rect: 508, 605, 535, 613 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 528, 594, 548, 602 Flags: Print Destination: 52 Annotation: Subtype: Link Rect: 526, 542, 542, 550 Flags: Print Destination: 362 Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 86, 699, 110, 707 Flags: Print Destination: null Annotation: Subtype: Link Rect: 88, 647, 104, 655 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 248, 594, 286, 602 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 177, 531, 209, 539 Flags: Print Destination: null Annotation: Subtype: Link Rect: 138, 510, 171, 518 Flags: Print Destination: null Annotation: Subtype: Link Rect: 88, 489, 122, 497 Flags: Print Destination: null Annotation: Subtype: Link Rect: 149, 405, 181, 413 Flags: Print Destination: null Annotation: Subtype: Link Rect: 201, 395, 217, 403 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 245, 332, 261, 340 Flags: Print Destination: 362 Annotation: Subtype: Link Rect: 83, 269, 115, 277 Flags: Print Destination: null Annotation: Subtype: Link Rect: 40, 249, 73, 256 Flags: Print Destination: null Annotation: Subtype: Link Rect: 145, 238, 160, 246 Flags: Print Destination: 362 Annotation: Subtype: Link Rect: 233, 175, 249, 183 Flags: Print Destination: 362 Annotation: Subtype: Link Rect: 176, 165, 192, 173 Flags: Print Destination: 362 Annotation: Subtype: Link Rect: 124, 154, 140, 162 Flags: Print Destination: 362 Annotation: Subtype: Link Rect: 207, 81, 239, 89 Flags: Print Destination: null Annotation: Subtype: Link Rect: 251, 81, 288, 89 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 37, 71, 49, 79 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 177, 50, 206, 58 Flags: Print Destination: null Annotation: Subtype: Link Rect: 426, 709, 441, 717 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 379, 668, 409, 676 Flags: Print Destination: null Annotation: Subtype: Link Rect: 306, 647, 339, 655 Flags: Print Destination: null Annotation: Subtype: Link Rect: 499, 636, 532, 644 Flags: Print Destination: null Annotation: Subtype: Link Rect: 385, 626, 418, 634 Flags: Print Destination: null Annotation: Subtype: Link Rect: 512, 594, 545, 602 Flags: Print Destination: null Annotation: Subtype: Link Rect: 492, 510, 530, 518 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 441, 468, 468, 476 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 416, 426, 439, 434 Flags: Print Destination: 113 Annotation: Subtype: Link Rect: 448, 395, 469, 403 Flags: Print Destination: 113 Annotation: Subtype: Link Rect: 422, 301, 447, 309 Flags: Print Destination: null Annotation: Subtype: Link Rect: 491, 280, 507, 288 Flags: Print Destination: 362 Annotation: Subtype: Link Rect: 342, 259, 362, 267 Flags: Print Destination: 113 Annotation: Subtype: Link Rect: 499, 228, 520, 236 Flags: Print Destination: 113 Annotation: Subtype: Link Rect: 526, 186, 555, 194 Flags: Print Destination: 362 Annotation: Subtype: Link Rect: 393, 165, 413, 173 Flags: Print Destination: 113 Annotation: Subtype: Link Rect: 539, 154, 555, 162 Flags: Print Destination: 362 Annotation: Subtype: Link Rect: 413, 92, 433, 100 Flags: Print Destination: 122 Annotation: Subtype: Link Rect: 525, 71, 547, 79 Flags: Print Destination: 122 Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 91, 107, 112, 115 Flags: Print Destination: 122 Annotation: Subtype: Link Rect: 86, 75, 115, 83 Flags: Print Destination: 362 Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 66, 293, 98, 301 Flags: Print Destination: null Annotation: Subtype: Link Rect: 447, 293, 480, 301 Flags: Print Destination: null Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 152, 709, 172, 717 Flags: Print Destination: 122 Annotation: Subtype: Link Rect: 215, 668, 234, 676 Flags: Print Destination: 122 Annotation: Subtype: Link Rect: 61, 647, 72, 655 Flags: Print Destination: 215 Annotation: Subtype: Link Rect: 213, 594, 232, 602 Flags: Print Destination: 134 Annotation: Subtype: Link Rect: 40, 573, 73, 581 Flags: Print Destination: null Annotation: Subtype: Link Rect: 85, 553, 105, 561 Flags: Print Destination: 134 Annotation: Subtype: Link Rect: 248, 511, 268, 519 Flags: Print Destination: 134 Annotation: Subtype: Link Rect: 395, 720, 410, 728 Flags: Print Destination: 362 Annotation: Subtype: Link Rect: 449, 563, 476, 571 Flags: Print Destination: 362 Annotation: Subtype: Link Rect: 496, 511, 516, 519 Flags: Print Destination: 134 Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 150, 699, 172, 707 Flags: Print Destination: 134 Annotation: Subtype: Link Rect: 113, 668, 162, 676 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 134, 647, 150, 655 Flags: Print Destination: 362 Annotation: Subtype: Link Rect: 236, 615, 247, 623 Flags: Print Destination: 215 Annotation: Subtype: Link Rect: 123, 594, 150, 602 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 230, 553, 250, 561 Flags: Print Destination: 134 Annotation: Subtype: Link Rect: 254, 521, 273, 529 Flags: Print Destination: 215 Annotation: Subtype: Link Rect: 78, 511, 98, 519 Flags: Print Destination: 134 Annotation: Subtype: Link Rect: 114, 389, 167, 397 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 95, 368, 122, 376 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 100, 348, 123, 355 Flags: Print Destination: 215 Annotation: Subtype: Link Rect: 375, 689, 405, 696 Flags: Print Destination: null Annotation: Subtype: Link Rect: 439, 605, 468, 613 Flags: Print Destination: null Annotation: Subtype: Link Rect: 306, 553, 322, 561 Flags: Print Destination: 362 Annotation: Subtype: Link Rect: 309, 479, 329, 487 Flags: Print Destination: 152 Annotation: Subtype: Link Rect: 400, 406, 438, 414 Flags: Print Destination: 246 Page: Label: 11 Annotations: Annotation: Subtype: Link Rect: 227, 699, 250, 707 Flags: Print Destination: 152 Annotation: Subtype: Link Rect: 37, 657, 53, 665 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 249, 430, 283, 438 Flags: Print Destination: null Annotation: Subtype: Link Rect: 91, 398, 120, 406 Flags: Print Destination: 362 Annotation: Subtype: Link Rect: 172, 325, 207, 333 Flags: Print Destination: null Annotation: Subtype: Link Rect: 37, 304, 53, 312 Flags: Print Destination: 362 Annotation: Subtype: Link Rect: 129, 283, 149, 291 Flags: Print Destination: 52 Annotation: Subtype: Link Rect: 40, 200, 74, 208 Flags: Print Destination: null Annotation: Subtype: Link Rect: 77, 200, 104, 208 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 131, 158, 158, 166 Flags: Print Destination: 176 Annotation: Subtype: Link Rect: 412, 699, 428, 707 Flags: Print Destination: 362 Annotation: Subtype: Link Rect: 514, 678, 552, 686 Flags: Print Destination: null Annotation: Subtype: Link Rect: 309, 573, 342, 581 Flags: Print Destination: null Annotation: Subtype: Link Rect: 357, 521, 384, 529 Flags: Print Destination: 362 Annotation: Subtype: Link Rect: 369, 479, 402, 487 Flags: Print Destination: null Annotation: Subtype: Link Rect: 420, 405, 447, 413 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 409, 353, 431, 361 Flags: Print Destination: 208 Annotation: Subtype: Link Rect: 509, 311, 525, 319 Flags: Print Destination: 362 Annotation: Subtype: Link Rect: 531, 290, 557, 298 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 306, 280, 318, 288 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 507, 207, 528, 215 Flags: Print Destination: 208 Annotation: Subtype: Link Rect: 389, 133, 410, 141 Flags: Print Destination: 208 Annotation: Subtype: Link Rect: 356, 113, 383, 121 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 525, 102, 547, 110 Flags: Print Destination: 208 Annotation: Subtype: Link Rect: 412, 71, 433, 79 Flags: Print Destination: 208 Annotation: Subtype: Link Rect: 362, 60, 389, 68 Flags: Print Destination: 246 Page: Label: 12 Page: Label: 13 Annotations: Annotation: Subtype: Link Rect: 173, 699, 200, 707 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 201, 678, 221, 686 Flags: Print Destination: 208 Annotation: Subtype: Link Rect: 229, 584, 256, 592 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 318, 353, 389, 361 Flags: Print Destination: null Annotation: Subtype: Link Rect: 368, 289, 480, 297 Flags: Print Annotation: Subtype: Link Rect: 491, 233, 536, 240 Flags: Print Annotation: Subtype: Link Rect: 322, 226, 393, 232 Flags: Print Annotation: Subtype: Link Rect: 365, 202, 507, 208 Flags: Print Annotation: Subtype: Link Rect: 448, 178, 555, 184 Flags: Print Annotation: Subtype: Link Rect: 322, 170, 342, 176 Flags: Print Annotation: Subtype: Link Rect: 427, 154, 509, 160 Flags: Print Annotation: Subtype: Link Rect: 322, 146, 374, 152 Flags: Print Annotation: Subtype: Link Rect: 358, 122, 469, 128 Flags: Print Annotation: Subtype: Link Rect: 418, 98, 532, 104 Flags: Print Annotation: Subtype: Link Rect: 533, 82, 555, 88 Flags: Print Annotation: Subtype: Link Rect: 322, 74, 424, 80 Flags: Print Annotation: Subtype: Link Rect: 414, 50, 530, 57 Flags: Print Page: Label: 14 Annotations: Annotation: Subtype: Link Rect: 89, 708, 216, 714 Flags: Print Annotation: Subtype: Link Rect: 104, 684, 228, 690 Flags: Print Annotation: Subtype: Link Rect: 89, 660, 216, 666 Flags: Print Annotation: Subtype: Link Rect: 82, 636, 216, 643 Flags: Print Annotation: Subtype: Link Rect: 54, 604, 190, 611 Flags: Print Annotation: Subtype: Link Rect: 221, 572, 267, 579 Flags: Print Annotation: Subtype: Link Rect: 54, 565, 152, 571 Flags: Print Annotation: Subtype: Link Rect: 124, 541, 235, 547 Flags: Print Annotation: Subtype: Link Rect: 230, 517, 275, 523 Flags: Print Annotation: Subtype: Link Rect: 54, 509, 116, 515 Flags: Print Annotation: Subtype: Link Rect: 169, 485, 278, 491 Flags: Print Annotation: Subtype: Link Rect: 164, 461, 274, 467 Flags: Print Annotation: Subtype: Link Rect: 172, 437, 282, 443 Flags: Print Annotation: Subtype: Link Rect: 54, 405, 172, 411 Flags: Print Annotation: Subtype: Link Rect: 89, 381, 199, 388 Flags: Print Annotation: Subtype: Link Rect: 171, 357, 243, 364 Flags: Print Annotation: Subtype: Link Rect: 54, 349, 103, 356 Flags: Print Annotation: Subtype: Link Rect: 235, 325, 280, 332 Flags: Print Annotation: Subtype: Link Rect: 54, 317, 126, 324 Flags: Print Annotation: Subtype: Link Rect: 89, 286, 200, 292 Flags: Print Annotation: Subtype: Link Rect: 104, 254, 216, 260 Flags: Print Annotation: Subtype: Link Rect: 104, 230, 230, 236 Flags: Print Annotation: Subtype: Link Rect: 133, 206, 267, 212 Flags: Print Annotation: Subtype: Link Rect: 186, 182, 258, 188 Flags: Print Annotation: Subtype: Link Rect: 54, 174, 91, 180 Flags: Print Annotation: Subtype: Link Rect: 54, 134, 184, 140 Flags: Print Annotation: Subtype: Link Rect: 89, 102, 210, 109 Flags: Print Annotation: Subtype: Link Rect: 54, 78, 172, 85 Flags: Print Annotation: Subtype: Link Rect: 358, 724, 476, 730 Flags: Print Annotation: Subtype: Link Rect: 499, 700, 545, 706 Flags: Print Annotation: Subtype: Link Rect: 323, 692, 396, 698 Flags: Print Annotation: Subtype: Link Rect: 389, 668, 497, 674 Flags: Print Annotation: Subtype: Link Rect: 378, 644, 487, 651 Flags: Print Annotation: Subtype: Link Rect: 464, 620, 536, 627 Flags: Print Annotation: Subtype: Link Rect: 323, 612, 360, 619 Flags: Print Annotation: Subtype: Link Rect: 430, 588, 505, 595 Flags: Print Annotation: Subtype: Link Rect: 323, 580, 377, 587 Flags: Print Annotation: Subtype: Link Rect: 408, 557, 518, 563 Flags: Print Annotation: Subtype: Link Rect: 393, 525, 495, 531 Flags: Print Annotation: Subtype: Link Rect: 351, 501, 495, 507 Flags: Print Annotation: Subtype: Link Rect: 444, 477, 526, 483 Flags: Print Annotation: Subtype: Link Rect: 323, 469, 359, 475 Flags: Print Annotation: Subtype: Link Rect: 373, 437, 503, 443 Flags: Print Annotation: Subtype: Link Rect: 323, 405, 437, 411 Flags: Print Annotation: Subtype: Link Rect: 323, 373, 435, 380 Flags: Print Annotation: Subtype: Link Rect: 344, 349, 456, 356 Flags: Print Annotation: Subtype: Link Rect: 460, 325, 532, 332 Flags: Print Annotation: Subtype: Link Rect: 323, 317, 359, 324 Flags: Print Annotation: Subtype: Link Rect: 468, 294, 540, 300 Flags: Print Annotation: Subtype: Link Rect: 323, 286, 379, 292 Flags: Print Annotation: Subtype: Link Rect: 462, 262, 538, 268 Flags: Print Annotation: Subtype: Link Rect: 323, 254, 374, 260 Flags: Print Annotation: Subtype: Link Rect: 522, 230, 555, 236 Flags: Print Annotation: Subtype: Link Rect: 323, 222, 416, 228 Flags: Print Annotation: Subtype: Link Rect: 468, 198, 543, 204 Flags: Print Annotation: Subtype: Link Rect: 323, 190, 373, 196 Flags: Print Annotation: Subtype: Link Rect: 375, 174, 487, 180 Flags: Print Annotation: Subtype: Link Rect: 438, 150, 513, 156 Flags: Print Annotation: Subtype: Link Rect: 323, 142, 381, 148 Flags: Print Annotation: Subtype: Link Rect: 396, 118, 515, 125 Flags: Print Annotation: Subtype: Link Rect: 351, 86, 452, 93 Flags: Print Annotation: Subtype: Link Rect: 453, 62, 525, 69 Flags: Print Annotation: Subtype: Link Rect: 323, 54, 360, 61 Flags: Print Page: Label: 15 Annotations: Annotation: Subtype: Link Rect: 89, 708, 198, 714 Flags: Print Annotation: Subtype: Link Rect: 54, 684, 160, 690 Flags: Print Annotation: Subtype: Link Rect: 219, 660, 264, 666 Flags: Print Annotation: Subtype: Link Rect: 54, 652, 134, 658 Flags: Print Annotation: Subtype: Link Rect: 208, 636, 280, 643 Flags: Print Annotation: Subtype: Link Rect: 54, 628, 84, 635 Flags: Print Annotation: Subtype: Link Rect: 104, 596, 265, 603 Flags: Print Annotation: Subtype: Link Rect: 89, 565, 198, 571 Flags: Print Annotation: Subtype: Link Rect: 157, 549, 262, 555 Flags: Print Annotation: Subtype: Link Rect: 96, 517, 225, 523 Flags: Print Annotation: Subtype: Link Rect: 249, 493, 282, 499 Flags: Print Annotation: Subtype: Link Rect: 54, 485, 143, 491 Flags: Print Annotation: Subtype: Link Rect: 54, 461, 164, 467 Flags: Print Annotation: Subtype: Link Rect: 82, 437, 210, 443 Flags: Print Annotation: Subtype: Link Rect: 211, 421, 283, 427 Flags: Print Annotation: Subtype: Link Rect: 54, 413, 109, 419 Flags: Print Annotation: Subtype: Link Rect: 221, 397, 266, 403 Flags: Print Annotation: Subtype: Link Rect: 54, 389, 118, 396 Flags: Print Annotation: Subtype: Link Rect: 54, 357, 202, 364 Flags: Print Annotation: Subtype: Link Rect: 189, 333, 261, 340 Flags: Print Annotation: Subtype: Link Rect: 54, 325, 91, 332 Flags: Print Annotation: Subtype: Link Rect: 148, 301, 277, 308 Flags: Print Annotation: Subtype: Link Rect: 75, 278, 217, 284 Flags: Print Annotation: Subtype: Link Rect: 253, 262, 286, 268 Flags: Print Annotation: Subtype: Link Rect: 54, 254, 151, 260 Flags: Print Annotation: Subtype: Link Rect: 241, 230, 286, 236 Flags: Print Annotation: Subtype: Link Rect: 54, 222, 144, 228 Flags: Print Annotation: Subtype: Link Rect: 147, 190, 251, 196 Flags: Print Annotation: Subtype: Link Rect: 54, 166, 176, 172 Flags: Print Annotation: Subtype: Link Rect: 239, 150, 284, 156 Flags: Print Annotation: Subtype: Link Rect: 54, 142, 112, 148 Flags: Print Annotation: Subtype: Link Rect: 141, 118, 281, 125 Flags: Print Annotation: Subtype: Link Rect: 250, 102, 283, 109 Flags: Print Annotation: Subtype: Link Rect: 54, 94, 124, 101 Flags: Print Annotation: Subtype: Link Rect: 323, 716, 445, 722 Flags: Print Annotation: Subtype: Link Rect: 323, 684, 429, 690 Flags: Print Annotation: Subtype: Link Rect: 355, 652, 489, 658 Flags: Print Annotation: Subtype: Link Rect: 435, 628, 507, 635 Flags: Print Annotation: Subtype: Link Rect: 323, 620, 378, 627 Flags: Print Annotation: Subtype: Link Rect: 432, 596, 504, 603 Flags: Print Annotation: Subtype: Link Rect: 323, 588, 394, 595 Flags: Print Annotation: Subtype: Link Rect: 380, 565, 498, 571 Flags: Print Annotation: Subtype: Link Rect: 533, 541, 555, 547 Flags: Print Annotation: Subtype: Link Rect: 323, 533, 435, 539 Flags: Print Annotation: Subtype: Link Rect: 340, 509, 471, 515 Flags: Print Annotation: Subtype: Link Rect: 358, 477, 477, 483 Flags: Print Annotation: Subtype: Link Rect: 448, 453, 555, 459 Flags: Print Annotation: Subtype: Link Rect: 323, 445, 348, 451 Flags: Print Annotation: Subtype: Link Rect: 358, 405, 468, 411 Flags: Print Annotation: Subtype: Link Rect: 380, 381, 498, 388 Flags: Print Annotation: Subtype: Link Rect: 504, 357, 550, 364 Flags: Print Annotation: Subtype: Link Rect: 323, 349, 396, 356 Flags: Print Annotation: Subtype: Link Rect: 323, 317, 444, 324 Flags: Print Annotation: Subtype: Link Rect: 522, 294, 555, 300 Flags: Print Annotation: Subtype: Link Rect: 323, 286, 398, 292 Flags: Print Annotation: Subtype: Link Rect: 323, 246, 435, 252 Flags: Print Checksum: 04f23ac4 Type: CRC32 Checksum: 90fd3c154a196a1bd033ce505e76d48b Type: MD5 Checksum: 12c93e578a50ee28b3f2b1dbf45dadd1acb80919 Type: SHA-1 Checksum: c4d29a2c17514e2b7941891dc71dbf537c99bffc8e80ad1c10077ce134903755 Type: SHA-256