f5b63d3320d8aed74044155f85e69434 biology-13-00150.pdf 9f9f6e20703c544dcb6ee83831e391fe86bdec3d biology-13-00150.pdf a87c116504aee50214ff3e3a613137ea7c0b446cdeec2fea8da7779209a0c14d biology-13-00150.pdf Title: Unraveling the Intricacies of the Seminal Microbiome and Its Impact on Human Fertility Subject: Although the microbial communities from seminal fluid were an unexplored field some decades ago, their characteristics and potential roles are gradually coming to light. Therefore, a complex and specific microbiome population with commensal niches and fluctuating species has started to be revealed. In fact, certain clusters of bacteria have been associated with fertility and health, while the outgrowth of several species is potentially correlated with infertility indicators. This constitutes a compelling reason for outlining the external elements that may induce changes in the seminal microbiome composition, like lifestyle factors, gut microbiota, pathologies, prebiotics, and probiotics. In this review, we summarize the main findings about seminal microbiome, its origins and composition, its relationship with fertility, health, and influence factors, while reminding readers of the limitations and advantages introduced from technical variabilities during the experimental procedures. Keywords: microbiome; semen; sperm; fertility; human; bacteria; viruses Author: Celia Corral-Vazquez, Joan Blanco, Zaida Sarrate and Ester Anton Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Tue Feb 27 09:51:07 2024 CET ModDate: Tue Feb 27 09:56:25 2024 CET Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1504482 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- OBVRZU+VnURWPalladioL Type 1 Custom yes yes yes 10 0 ZIBJJD+URWPalladioL-Bold Type 1 Custom yes yes yes 16 0 UPSVZY+URWPalladioL-Roma Type 1 Custom yes yes yes 22 0 QOQJJJ+URWPalladioL-Ital Type 1 Custom yes yes yes 27 0 CKUQXN+CMSY10 Type 1 Builtin yes yes yes 32 0 GLCFZC+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 48 0 KINEIN+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 74 0 KINEIO+PalatinoLinotype CID TrueType Identity-H yes yes yes 77 0 KINEIP+PalatinoLinotype TrueType WinAnsi yes yes no 83 0 KINEJB+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 86 0 KINFEN+PalatinoLinotype TrueType MacRoman yes yes no 89 0 KINHLP+PalatinoLinotype,Bold TrueType MacRoman yes yes no 92 0 KINEIN+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 102 0 KINEIO+PalatinoLinotype CID TrueType Identity-H yes yes yes 105 0 KINEIP+PalatinoLinotype TrueType WinAnsi yes yes no 111 0 KINEJB+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 114 0 KINFEN+PalatinoLinotype TrueType MacRoman yes yes no 117 0 KINEIN+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 134 0 KINEIO+PalatinoLinotype CID TrueType Identity-H yes yes yes 137 0 KINEIP+PalatinoLinotype TrueType WinAnsi yes yes no 143 0 KINEJB+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 146 0 KINFEN+PalatinoLinotype TrueType MacRoman yes yes no 149 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-04-03 02:42:23 CEST RepresentationInformation: biology-13-00150.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-03-21 01:34:43 CET Size: 1504482 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 576 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Origin of the Seminal Microbiome and General Composition Destination: section.2 Item: Title: The Semen Microbiome in Fertility Disorders Destination: section.3 Item: Title: Influence of External Factors over Sperm Microbiome Composition Destination: section.4 Item: Title: Technical Considerations in the Study of the Seminal Microbiome Destination: section.5 Item: Title: Discussion and Future Directions Destination: section.6 Item: Title: References Destination: section.7 Info: Title: Unraveling the Intricacies of the Seminal Microbiome and Its Impact on Human Fertility Author: Celia Corral-Vazquez, Joan Blanco, Zaida Sarrate and Ester Anton Subject: Although the microbial communities from seminal fluid were an unexplored field some decades ago, their characteristics and potential roles are gradually coming to light. Therefore, a complex and specific microbiome population with commensal niches and fluctuating species has started to be revealed. In fact, certain clusters of bacteria have been associated with fertility and health, while the outgrowth of several species is potentially correlated with infertility indicators. This constitutes a compelling reason for outlining the external elements that may induce changes in the seminal microbiome composition, like lifestyle factors, gut microbiota, pathologies, prebiotics, and probiotics. In this review, we summarize the main findings about seminal microbiome, its origins and composition, its relationship with fertility, health, and influence factors, while reminding readers of the limitations and advantages introduced from technical variabilities during the experimental procedures. 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177 Annotation: Subtype: Link Rect: 423, 166, 459, 177 Annotation: Subtype: Link Rect: 221, 143, 259, 154 Annotation: Subtype: Link Rect: 424, 120, 461, 131 Annotation: Subtype: Link Rect: 511, 97, 549, 108 Page: Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 59, 719, 96, 729 Annotation: Subtype: Link Rect: 102, 719, 138, 729 Annotation: Subtype: Link Rect: 59, 684, 96, 694 Annotation: Subtype: Link Rect: 466, 660, 504, 671 Annotation: Subtype: Link Rect: 59, 592, 96, 602 Annotation: Subtype: Link Rect: 440, 568, 477, 579 Annotation: Subtype: Link Rect: 322, 545, 360, 556 Annotation: Subtype: Link Rect: 366, 545, 402, 556 Annotation: Subtype: Link Rect: 247, 522, 285, 533 Annotation: Subtype: Link Rect: 291, 522, 327, 533 Annotation: Subtype: Link Rect: 95, 489, 133, 499 Annotation: Subtype: Link Rect: 301, 465, 339, 476 Annotation: Subtype: Link Rect: 345, 465, 381, 476 Annotation: Subtype: Link Rect: 380, 419, 417, 430 Annotation: Subtype: Link Rect: 228, 384, 266, 395 Annotation: Subtype: Link Rect: 459, 362, 497, 372 Annotation: Subtype: Link Rect: 59, 328, 95, 338 Annotation: Subtype: Link Rect: 464, 304, 502, 315 Annotation: Subtype: Link Rect: 77, 270, 114, 280 Annotation: Subtype: Link Rect: 120, 270, 156, 280 Annotation: Subtype: Link Rect: 342, 246, 379, 257 Annotation: Subtype: Link Rect: 385, 246, 421, 257 Annotation: Subtype: Link Rect: 390, 189, 428, 200 Annotation: Subtype: Link Rect: 260, 166, 298, 177 Annotation: Subtype: Link Rect: 295, 131, 332, 142 Annotation: Subtype: Link Rect: 339, 131, 375, 142 Annotation: Subtype: Link Rect: 445, 108, 483, 119 Annotation: Subtype: Link Rect: 245, 74, 283, 85 Page: Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 167, 707, 205, 718 Annotation: Subtype: Link Rect: 420, 683, 458, 694 Annotation: Subtype: Link Rect: 316, 660, 353, 671 Annotation: Subtype: Link Rect: 337, 637, 374, 648 Annotation: Subtype: Link Rect: 380, 637, 416, 648 Annotation: Subtype: Link Rect: 167, 615, 204, 625 Annotation: Subtype: Link Rect: 210, 615, 246, 625 Annotation: Subtype: Link Rect: 406, 591, 443, 602 Annotation: Subtype: Link Rect: 449, 591, 485, 602 Annotation: Subtype: Link Rect: 439, 568, 477, 579 Annotation: Subtype: Link Rect: 59, 535, 96, 545 Annotation: Subtype: Link Rect: 59, 500, 96, 510 Annotation: Subtype: Link Rect: 181, 477, 218, 487 Annotation: Subtype: Link Rect: 185, 454, 223, 464 Annotation: Subtype: Link Rect: 229, 454, 265, 464 Annotation: Subtype: Link Rect: 160, 431, 197, 441 Annotation: Subtype: Link Rect: 203, 431, 239, 441 Annotation: Subtype: Link Rect: 331, 407, 369, 418 Annotation: Subtype: Link Rect: 59, 374, 96, 384 Annotation: Subtype: Link Rect: 102, 374, 138, 384 Annotation: Subtype: Link Rect: 260, 361, 353, 372 Annotation: Subtype: Link Rect: 256, 339, 293, 349 Annotation: Subtype: Link Rect: 255, 305, 292, 315 Checksum: 7cbb3488 Type: CRC32 Checksum: f5b63d3320d8aed74044155f85e69434 Type: MD5 Checksum: 9f9f6e20703c544dcb6ee83831e391fe86bdec3d Type: SHA-1 Checksum: a87c116504aee50214ff3e3a613137ea7c0b446cdeec2fea8da7779209a0c14d Type: SHA-256