1f176edcbd5e300e40ec4eb329aeea6a  VEM_a2024v290p110009.pdf
b99bb2c858de60972cf51f9a3f87a2e9cf4a570b  VEM_a2024v290p110009.pdf
093372c9a3e33a77b866ea4898912e1f7d36684e6c50d2cdb5045d4f5cfdab66  VEM_a2024v290p110009.pdf

Title:           Experimental infection of goats with Mycobacterium microti induces subclinical pulmonary tuberculosis and mild responses to tuberculin skin tests
Subject:         Veterinary Microbiology, 290 (2024) 110009. doi:10.1016/j.vetmic.2024.110009
Keywords:        Tuberculosis,Mycobacterium microti,Goat,Experimental infection,Diagnosis
Author:          Cristian Melgarejo
Creator:         Elsevier
Producer:        Acrobat Distiller 8.1.0 (Windows)
CreationDate:    Fri Feb 16 10:06:47 2024 CET
ModDate:         Fri Feb 16 10:08:21 2024 CET
Custom Metadata: yes
Metadata Stream: yes
Tagged:          yes
UserProperties:  no
Suspects:        no
Form:            none
JavaScript:      no
Pages:           6
Encrypted:       no
Page size:       595.276 x 793.701 pts
Page rot:        0
File size:       2574822 bytes
Optimized:       yes
PDF version:     1.7


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
PTLLWB+CharisSIL                     CID TrueType      Identity-H       yes yes yes    452  0
LEPVWT+STIX-Regular                  Type 1C           Custom           yes yes yes    457  0
KKEWGO+TeX_CM_Maths_Symbols          Type 1C           Builtin          yes yes yes    462  0
TXXIRK+CharisSIL-Bold                CID TrueType      Identity-H       yes yes yes    466  0
TIVMKM+CharisSIL-Italic              CID TrueType      Identity-H       yes yes yes    471  0
TOYTTY+STIX-Italic                   Type 1C           Custom           yes yes yes    476  0
NNLAUQ+TeX_CM_Roman                  Type 1C           Builtin          yes yes yes    481  0
GBNAGF+Univers                       Type 1C           Builtin          yes yes yes    485  0
IMCRWL+CharisSIL                     CID TrueType      Identity-H       yes yes yes    443  0
EDCADM+TimesNewRomanPSMT             CID TrueType      Identity-H       yes yes yes    170  0
VIYBTY+CharisSIL-Italic              CID TrueType      Identity-H       yes yes yes    163  0
VVCCGG+TeX_CM_Maths_Italic           Type 1C           Builtin          yes yes yes     26  0
ROILQV+TeX_CM_Bold_Maths_Symbols     Type 1C           Builtin          yes yes yes     53  0
LOQIBR+STIX-Bold                     Type 1C           Custom           yes yes yes     57  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2025-01-28 02:39:30 CET
 RepresentationInformation: VEM_a2024v290p110009.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2025-01-22 07:41:10 CET
  Size: 2574822
  Format: PDF
  Version: 1.7
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  Profile: Linearized PDF, Tagged PDF
  PDFMetadata: 
   Objects: 566
   FreeObjects: 1
   IncrementalUpdates: 1
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: en
    Outlines: 
     Item: 
      Title: Experimental infection of goats with Mycobacterium microti induces subclinical pulmonary tuberculosis and mild responses to ...
      Destination: mk:title
      Children: 
       Item: 
        Title: 1 Introduction
        Destination: mk:H1_1
       Item: 
        Title: 2 Materials and methods
        Destination: mk:H1_2
        Children: 
         Item: 
          Title: 2.1 Experimental schedule
          Destination: mk:H2_1
          Children: 
           Item: 
            Title: 2.1.1 Experiment 1
            Destination: mk:H3_2
           Item: 
            Title: 2.1.2 Experiment 2
            Destination: mk:H3_3
         Item: 
          Title: 2.2 Ethics statement
          Destination: mk:H2_4
         Item: 
          Title: 2.3 Antigens and reagents
          Destination: mk:H2_5
         Item: 
          Title: 2.4 Whole blood IFN
          Destination: mk:H2_6
          Children: 
           Item: 
            Title: 2.4.1 -γ release assay (IGRA)
            Destination: mk:H3_7
         Item: 
          Title: 2.5 Antibody detection assays
          Destination: mk:H2_8
         Item: 
          Title: 2.6 Skin tests
          Destination: mk:H2_9
         Item: 
          Title: 2.7 Pathological examination
          Destination: mk:H2_10
         Item: 
          Title: 2.8 MTBC DNA detection
          Destination: mk:H2_11
         Item: 
          Title: 2.9 Mycobacterial culture
          Destination: mk:H2_12
       Item: 
        Title: 3 Results
        Destination: mk:H1_3
        Children: 
         Item: 
          Title: 3.1 Immunodiagnostic results
          Destination: mk:H2_13
         Item: 
          Title: 3.2 Clinical and postmortem findings
          Destination: mk:H2_14
       Item: 
        Title: 4 Discussion
        Destination: mk:H1_4
        Children: 
         Item: 
          Title: 4.1 M. microti experimental challenge in goats can elicit a subclinical infection
          Destination: mk:H2_15
         Item: 
          Title: 4.2 M. microti infection can interfere with current tuberculin skin test protocols of M. bovis / M. caprae eradication programs
          Destination: mk:H2_16
       Item: 
        Title: CRediT authorship contribution statement
        Destination: mk:H1_5
       Item: 
        Title: Declaration of Competing Interest
        Destination: mk:HH1_3
       Item: 
        Title: Data Availability
        Destination: datalink4
       Item: 
        Title: Acknowledgements
        Destination: mk:HH1_5
       Item: 
        Title: Appendix A Supporting information
        Destination: mk:H1_6
       Item: 
        Title: References
        Destination: mk:HH2_1
   Info: 
    Title: Experimental infection of goats with Mycobacterium microti induces subclinical pulmonary tuberculosis and mild responses to tuberculin skin tests
    Author: Cristian Melgarejo
    Subject: Veterinary Microbiology, 290 (2024) 110009. doi:10.1016/j.vetmic.2024.110009
    Keywords: Tuberculosis,Mycobacterium microti,Goat,Experimental infection,Diagnosis
    Creator: Elsevier
    Producer: Acrobat Distiller 8.1.0 (Windows)
    CreationDate: Fri Feb 16 10:06:47 CET 2024
    ModDate: Fri Feb 16 10:08:21 CET 2024
   ID: 0x0a88689ac76e53cab14d2e3dccd20349, 0xfae0e492bfeb7f3604aae6da4f438ad2
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 236
      ImageHeight: 298
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 248
      ImageHeight: 271
      BitsPerSample: 8
      BitsPerSampleUnit: integer
   Fonts: 
    Type0: 
     Font: 
      BaseFont: TXXIRK+CharisSIL-Bold
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: PTLLWB+CharisSIL
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: TIVMKM+CharisSIL-Italic
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: EDCADM+TimesNewRomanPSMT
      Encoding: Identity-H
      ToUnicode: true
    Type1: 
     Font: 
      BaseFont: NNLAUQ+TeX_CM_Roman
      FontSubset: true
      FirstChar: 1
      LastChar: 128
      FontDescriptor: 
       FontName: NNLAUQ+TeX_CM_Roman
       Flags: Symbolic
       FontBBox: -50, -180, 1000, 720
       FontFile3: true
      ToUnicode: true
     Font: 
      BaseFont: GBNAGF+Univers
      FontSubset: true
      FirstChar: 32
      LastChar: 251
      FontDescriptor: 
       FontName: GBNAGF+Univers
       Flags: Symbolic
       FontBBox: -50, -180, 1000, 720
       FontFile3: true
      ToUnicode: true
     Font: 
      BaseFont: ROILQV+TeX_CM_Bold_Maths_Symbols
      FontSubset: true
      FirstChar: 1
      LastChar: 255
      FontDescriptor: 
       FontName: ROILQV+TeX_CM_Bold_Maths_Symbols
       Flags: Symbolic, ForceBold
       FontBBox: -50, -180, 1000, 720
       FontFile3: true
      ToUnicode: true
     Font: 
      BaseFont: LEPVWT+STIX-Regular
      FontSubset: true
      FirstChar: 1
      LastChar: 10
      FontDescriptor: 
       FontName: LEPVWT+STIX-Regular
       Flags: Nonsymbolic
       FontBBox: -970, -486, 2208, 1023
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: LOQIBR+STIX-Bold
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: LOQIBR+STIX-Bold
       Flags: Nonsymbolic, ForceBold
       FontBBox: -998, -552, 2000, 1055
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: VVCCGG+TeX_CM_Maths_Italic
      FontSubset: true
      FirstChar: 1
      LastChar: 127
      FontDescriptor: 
       FontName: VVCCGG+TeX_CM_Maths_Italic
       Flags: Symbolic
       FontBBox: -50, -180, 1000, 720
       FontFile3: true
      ToUnicode: true
     Font: 
      BaseFont: TOYTTY+STIX-Italic
      FontSubset: true
      FirstChar: 1
      LastChar: 2
      FontDescriptor: 
       FontName: TOYTTY+STIX-Italic
       Flags: Nonsymbolic, Italic
       FontBBox: -970, -305, 1429, 1023
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: KKEWGO+TeX_CM_Maths_Symbols
      FontSubset: true
      FirstChar: 1
      LastChar: 138
      FontDescriptor: 
       FontName: KKEWGO+TeX_CM_Maths_Symbols
       Flags: Symbolic
       FontBBox: -50, -180, 1000, 720
       FontFile3: true
      ToUnicode: true
    CIDFontType2: 
     Font: 
      BaseFont: TXXIRK+CharisSIL-Bold
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: TXXIRK+CharisSIL-Bold
       Flags: Nonsymbolic, ForceBold
       FontBBox: -720, -533, 1759, 1320
       FontFile2: true
     Font: 
      BaseFont: PTLLWB+CharisSIL
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: PTLLWB+CharisSIL
       Flags: Nonsymbolic
       FontBBox: -692, -533, 1623, 1319
       FontFile2: true
     Font: 
      BaseFont: TIVMKM+CharisSIL-Italic
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: TIVMKM+CharisSIL-Italic
       Flags: Nonsymbolic, Italic
       FontBBox: -716, -533, 1627, 1318
       FontFile2: true
     Font: 
      BaseFont: EDCADM+TimesNewRomanPSMT
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: EDCADM+TimesNewRomanPSMT
       Flags: Nonsymbolic
       FontBBox: -568, -307, 2000, 1007
       FontFile2: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="XMP Core 5.1.2">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>10.1016/j.vetmic.2024.110009</dc:identifier>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Elsevier B.V.</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Veterinary Microbiology, 290 (2024) 110009. doi:10.1016/j.vetmic.2024.110009</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>Tuberculosis</rdf:li>
               <rdf:li>Mycobacterium microti</rdf:li>
               <rdf:li>Goat</rdf:li>
               <rdf:li>Experimental infection</rdf:li>
               <rdf:li>Diagnosis</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Experimental infection of goats with Mycobacterium microti induces subclinical pulmonary tuberculosis and mild responses to tuberculin skin tests</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Cristian Melgarejo</rdf:li>
               <rdf:li>Alex Cobos</rdf:li>
               <rdf:li>Mariano Domingo</rdf:li>
               <rdf:li>Guillermo Cantero</rdf:li>
               <rdf:li>Xavier Moll</rdf:li>
               <rdf:li>Iker A. Sevilla</rdf:li>
               <rdf:li>Joseba M. Garrido</rdf:li>
               <rdf:li>Lorraine Michelet</rdf:li>
               <rdf:li>Maria Laura Boschiroli</rdf:li>
               <rdf:li>Enric Vidal</rdf:li>
               <rdf:li>Bernat Pérez de Val</rdf:li>
            </rdf:Seq>
         </dc:creator>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:prism="http://prismstandard.org/namespaces/basic/3.0/">
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>Veterinary Microbiology</prism:publicationName>
         <prism:copyright>© 2024 The Authors. Published by Elsevier B.V.</prism:copyright>
         <prism:issn>0378-1135</prism:issn>
         <prism:volume>290</prism:volume>
         <prism:coverDisplayDate>1 March 2024</prism:coverDisplayDate>
         <prism:coverDate>2024-03-01</prism:coverDate>
         <prism:pageRange>110009</prism:pageRange>
         <prism:startingPage>110009</prism:startingPage>
         <prism:doi>10.1016/j.vetmic.2024.110009</prism:doi>
         <prism:url>https://doi.org/10.1016/j.vetmic.2024.110009</prism:url>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:crossmark="http://crossref.org/crossmark/1.0/">
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:DOI>10.1016/j.vetmic.2024.110009</crossmark:DOI>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>elsevier.com</rdf:li>
               <rdf:li>sciencedirect.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:ali="http://www.niso.org/schemas/ali/1.0/">
         <ali:license_ref>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <ali:uri>http://creativecommons.org/licenses/by-nc-nd/4.0/</ali:uri>
               </rdf:li>
            </rdf:Bag>
         </ali:license_ref>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:jav="http://www.niso.org/schemas/jav/1.0/">
         <jav:journal_article_version>VoR</jav:journal_article_version>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/">
         <ZIFNOyPiLmdeQndqGywn8ysNNy9aJlt77otuGnPeQn9r8ntiLngn7o9eQmM2MnMmKntiTma/>
         <pdfx:doi>10.1016/j.vetmic.2024.110009</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:CreationDate--Text>16th February 2024</pdfx:CreationDate--Text>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>sciencedirect.com</rdf:li>
               <rdf:li>elsevier.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xmp="http://ns.adobe.com/xap/1.0/">
         <xmp:CreatorTool>Elsevier</xmp:CreatorTool>
         <xmp:ModifyDate>2024-02-16T09:08:21</xmp:ModifyDate>
         <xmp:CreateDate>2024-02-16T09:06:47</xmp:CreateDate>
         <xmp:MetadataDate>2024-02-16T09:08:21</xmp:MetadataDate>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xmpRights="http://ns.adobe.com/xap/1.0/rights/">
         <xmpRights:Marked>True</xmpRights:Marked>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:CreationDate--Text>16th February 2024</pdf:CreationDate--Text>
         <pdf:Producer>Acrobat Distiller 8.1.0 (Windows)</pdf:Producer>
         <pdf:Keywords>Tuberculosis,Mycobacterium microti,Goat,Experimental infection,Diagnosis</pdf:Keywords>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmpMM:DocumentID>uuid:1b499bed-4ce8-4c0c-b682-0d58baae1cbe</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:b6ed5266-03cb-4855-90c0-636283357f42</xmpMM:InstanceID>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 125, 559, 132, 569
       Flags: Print
       Destination: 428
      Annotation: 
       Subtype: Link
       Rect: 132, 554, 197, 565
       Flags: Print
       Destination: 428
      Annotation: 
       Subtype: Link
       Rect: 197, 559, 204, 569
       Flags: Print
       Destination: 428
      Annotation: 
       Subtype: Link
       Rect: 204, 559, 211, 569
       Flags: Print
       Destination: 428
      Annotation: 
       Subtype: Link
       Rect: 212, 554, 309, 565
       Flags: Print
       Destination: 428
      Annotation: 
       Subtype: Link
       Rect: 309, 559, 315, 569
       Flags: Print
       Destination: 428
      Annotation: 
       Subtype: Link
       Rect: 316, 559, 323, 569
       Flags: Print
       Destination: 428
      Annotation: 
       Subtype: Link
       Rect: 323, 554, 422, 565
       Flags: Print
       Destination: 428
      Annotation: 
       Subtype: Link
       Rect: 422, 559, 428, 569
       Flags: Print
       Destination: 428
      Annotation: 
       Subtype: Link
       Rect: 429, 554, 437, 565
       Flags: Print
       Destination: 428
      Annotation: 
       Subtype: Link
       Rect: 94, 546, 101, 556
       Flags: Print
       Destination: 428
      Annotation: 
       Subtype: Link
       Rect: 101, 541, 180, 552
       Flags: Print
       Destination: 428
      Annotation: 
       Subtype: Link
       Rect: 180, 541, 372, 552
       Flags: Print
       Destination: 428
      Annotation: 
       Subtype: Link
       Rect: 372, 541, 410, 552
       Flags: Print
       Destination: 428
      Annotation: 
       Subtype: Link
       Rect: 116, 528, 181, 539
       Flags: Print
       Destination: 428
      Annotation: 
       Subtype: Link
       Rect: 181, 533, 187, 543
       Flags: Print
       Destination: 428
      Annotation: 
       Subtype: Link
       Rect: 188, 533, 194, 543
       Flags: Print
       Destination: 428
      Annotation: 
       Subtype: Link
       Rect: 195, 535, 199, 541
       Flags: Print
       Destination: 428
      Annotation: 
       Subtype: Link
       Rect: 195, 533, 201, 543
       Flags: Print
       Destination: 428
      Annotation: 
       Subtype: Link
       Rect: 202, 528, 308, 539
       Flags: Print
       Destination: 428
      Annotation: 
       Subtype: Link
       Rect: 308, 533, 314, 543
       Flags: Print
       Destination: 428
      Annotation: 
       Subtype: Link
       Rect: 315, 533, 322, 543
       Flags: Print
       Destination: 428
      Annotation: 
       Subtype: Link
       Rect: 322, 535, 326, 541
       Flags: Print
       Destination: 428
      Annotation: 
       Subtype: Link
       Rect: 322, 533, 329, 543
       Flags: Print
       Destination: 428
      Annotation: 
       Subtype: Link
       Rect: 329, 528, 334, 539
       Flags: Print
       Destination: 428
      Annotation: 
       Subtype: Link
       Rect: 496, 199, 557, 207
       Flags: Print
       Destination: 98
      Annotation: 
       Subtype: Link
       Rect: 306, 188, 324, 196
       Flags: Print
       Destination: 98
      Annotation: 
       Subtype: Link
       Rect: 387, 178, 539, 186
       Flags: Print
       Destination: 98
      Annotation: 
       Subtype: Link
       Rect: 364, 167, 557, 175
       Flags: Print
       Destination: 64
      Annotation: 
       Subtype: Link
       Rect: 103, 114, 166, 121
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 204, 114, 273, 121
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 321, 722, 369, 730
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 274, 667, 396, 675
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 37, 87, 188, 94
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 297, 749, 300, 757
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 226, 748, 368, 760
      Annotation: 
       Subtype: Link
       Rect: 499, 616, 528, 645
      Annotation: 
       Subtype: Link
       Rect: 425, 57, 557, 69
      Annotation: 
       Subtype: Link
       Rect: 37, 48, 72, 59
    Page: 
     Label: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 37, 730, 77, 738
       Flags: Print
       Destination: 64
      Annotation: 
       Subtype: Link
       Rect: 62, 709, 131, 717
       Flags: Print
       Destination: 98
      Annotation: 
       Subtype: Link
       Rect: 213, 668, 288, 676
       Flags: Print
       Destination: 98
      Annotation: 
       Subtype: Link
       Rect: 37, 657, 77, 665
       Flags: Print
       Destination: 98
      Annotation: 
       Subtype: Link
       Rect: 219, 626, 288, 634
       Flags: Print
       Destination: 64
      Annotation: 
       Subtype: Link
       Rect: 37, 615, 105, 623
       Flags: Print
       Destination: 64
      Annotation: 
       Subtype: Link
       Rect: 40, 584, 208, 592
       Flags: Print
       Destination: 98
      Annotation: 
       Subtype: Link
       Rect: 245, 375, 288, 383
       Flags: Print
       Destination: 98
      Annotation: 
       Subtype: Link
       Rect: 37, 364, 55, 372
       Flags: Print
       Destination: 98
      Annotation: 
       Subtype: Link
       Rect: 164, 312, 242, 320
       Flags: Print
       Destination: 98
      Annotation: 
       Subtype: Link
       Rect: 166, 207, 253, 215
       Flags: Print
       Destination: 98
      Annotation: 
       Subtype: Link
       Rect: 383, 511, 482, 519
       Flags: Print
       Destination: 98
      Annotation: 
       Subtype: Link
       Rect: 425, 196, 508, 204
       Flags: Print
       Destination: 98
    Page: 
     Label: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 72, 709, 116, 717
       Flags: Print
       Destination: 98
      Annotation: 
       Subtype: Link
       Rect: 248, 135, 288, 143
       Flags: Print
       Destination: 98
      Annotation: 
       Subtype: Link
       Rect: 37, 125, 55, 133
       Flags: Print
       Destination: 98
      Annotation: 
       Subtype: Link
       Rect: 57, 114, 149, 122
       Flags: Print
       Destination: 98
      Annotation: 
       Subtype: Link
       Rect: 366, 689, 392, 696
       Flags: Print
       Destination: 44
      Annotation: 
       Subtype: Link
       Rect: 463, 458, 491, 466
       Flags: Print
       Destination: 44
      Annotation: 
       Subtype: Link
       Rect: 461, 374, 482, 382
       Flags: Print
       Destination: 44
      Annotation: 
       Subtype: Link
       Rect: 421, 311, 441, 319
       Flags: Print
       Destination: 44
      Annotation: 
       Subtype: Link
       Rect: 353, 228, 380, 236
       Flags: Print
       Destination: 44
      Annotation: 
       Subtype: Link
       Rect: 406, 154, 557, 162
       Flags: Print
       Destination: 98
      Annotation: 
       Subtype: Link
       Rect: 306, 144, 324, 152
       Flags: Print
       Destination: 98
      Annotation: 
       Subtype: Link
       Rect: 421, 123, 494, 131
       Flags: Print
       Destination: 98
      Annotation: 
       Subtype: Link
       Rect: 528, 102, 557, 110
       Flags: Print
       Destination: 98
      Annotation: 
       Subtype: Link
       Rect: 306, 92, 445, 100
       Flags: Print
       Destination: 98
    Page: 
     Label: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 494, 100, 557, 108
       Flags: Print
       Destination: 64
      Annotation: 
       Subtype: Link
       Rect: 306, 90, 393, 98
       Flags: Print
       Destination: 64
    Page: 
     Label: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 190, 730, 288, 738
       Flags: Print
       Destination: 64
      Annotation: 
       Subtype: Link
       Rect: 37, 720, 117, 728
       Flags: Print
       Destination: 64
      Annotation: 
       Subtype: Link
       Rect: 188, 699, 283, 707
       Flags: Print
       Destination: 98
      Annotation: 
       Subtype: Link
       Rect: 99, 615, 179, 623
       Flags: Print
       Destination: 98
      Annotation: 
       Subtype: Link
       Rect: 143, 594, 288, 602
       Flags: Print
       Destination: 98
      Annotation: 
       Subtype: Link
       Rect: 37, 584, 55, 592
       Flags: Print
       Destination: 98
      Annotation: 
       Subtype: Link
       Rect: 194, 563, 264, 571
       Flags: Print
       Destination: 98
      Annotation: 
       Subtype: Link
       Rect: 40, 479, 114, 487
       Flags: Print
       Destination: 98
      Annotation: 
       Subtype: Link
       Rect: 100, 458, 170, 466
       Flags: Print
       Destination: 98
      Annotation: 
       Subtype: Link
       Rect: 183, 353, 255, 361
       Flags: Print
       Destination: 98
      Annotation: 
       Subtype: Link
       Rect: 122, 332, 194, 340
       Flags: Print
       Destination: 98
      Annotation: 
       Subtype: Link
       Rect: 205, 238, 288, 246
       Flags: Print
       Destination: 98
      Annotation: 
       Subtype: Link
       Rect: 37, 228, 55, 236
       Flags: Print
       Destination: 98
      Annotation: 
       Subtype: Link
       Rect: 146, 207, 214, 215
       Flags: Print
       Destination: 98
      Annotation: 
       Subtype: Link
       Rect: 208, 175, 288, 183
       Flags: Print
       Destination: 64
      Annotation: 
       Subtype: Link
       Rect: 37, 165, 146, 173
       Flags: Print
       Destination: 64
      Annotation: 
       Subtype: Link
       Rect: 368, 257, 492, 265
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 427, 194, 548, 200
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 491, 162, 536, 168
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 154, 407, 160
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 493, 122, 539, 128
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 114, 407, 120
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 503, 82, 548, 88
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 74, 386, 80
       Flags: Print
    Page: 
     Label: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 154, 732, 271, 738
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 49, 724, 80, 730
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 158, 684, 285, 690
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 49, 676, 53, 682
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 214, 636, 286, 643
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 49, 628, 104, 635
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 139, 604, 279, 611
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 49, 596, 283, 603
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 49, 588, 87, 595
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 148, 549, 278, 555
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 139, 525, 235, 531
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 89, 493, 207, 499
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 132, 469, 274, 475
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 49, 445, 191, 451
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 227, 413, 273, 419
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 49, 405, 120, 411
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 423, 716, 542, 722
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 676, 429, 682
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 452, 652, 524, 658
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 644, 364, 651
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 435, 612, 510, 619
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 604, 377, 611
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 510, 580, 555, 587
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 572, 397, 579
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 507, 541, 552, 547
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 533, 400, 539
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 419, 509, 553, 515
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 508, 485, 554, 491
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 477, 414, 483
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 387, 445, 532, 451
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 437, 429, 555, 435
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 421, 342, 427
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 306, 413, 547, 419
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 405, 555, 411
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 397, 399, 403
       Flags: Print
  Checksum: 659a51a1
   Type: CRC32
  Checksum: 1f176edcbd5e300e40ec4eb329aeea6a
   Type: MD5
  Checksum: b99bb2c858de60972cf51f9a3f87a2e9cf4a570b
   Type: SHA-1
  Checksum: 093372c9a3e33a77b866ea4898912e1f7d36684e6c50d2cdb5045d4f5cfdab66
   Type: SHA-256