7618864be1d90218d218da15a55e81f7 VAC_a2024v12p1446.pdf 58c49e8913bbb44408f9b39a5a610b210d5476a5 VAC_a2024v12p1446.pdf 8bf8037cb165132611538bc8e29917f53c54595f2e5b4b427d8222a7bcc58c52 VAC_a2024v12p1446.pdf Title: Boosting Vaccine Research: The 16-Year Journey of TRANSVAC Vaccine Infrastructure Subject: TRANSVAC represents a long-running effort to accelerate the development of novel vaccines by integrating institutions from across Europe under a single collaborative framework. This initiative has empowered the global vaccine community since 2009 including contributing toward the development and optimization of vaccine candidates as well as the provision of new adjuvants, research protocols, and technologies. Scientific services were provided in support of 88 different vaccine development projects, and 400 professionals attended TRANSVAC training events on various vaccine-related topics. Here, we review the accomplishments of the TRANSVAC consortia and analyze the continued needs of academic and industrial vaccine developers in Europe. The findings highlight the benefits of coordination across different sectors, both through research infrastructures such as TRANSVAC and other mechanisms, to address the current and future global health challenges and ensure that European vaccine developers have the support required to successfully compete in the global market. Keywords: research infrastructure; vaccine; research and development Author: William Martin, Catarina Luís, Stefan Jungbluth, Monika Slezak, Frank A. W. Verreck, Holger Spiegel, Carlos A. Guzman, António Roldão, Manuel J. T. Carrondo, Peter Van der Ley, Joaquim Segalés, Hazel M. Dockrell, Mei Mei Ho, Gabriel K. Pedersen, Maria Lawrenz and Ole F. Olesen Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Sun Dec 22 10:46:50 2024 CET ModDate: Sun Dec 22 10:50:43 2024 CET Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 18 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 3000926 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- BNGSYC+VnURWPalladioL-Bold Type 1 Custom yes yes yes 10 0 VXVVEF+URWPalladioL-Bold Type 1 Custom yes yes yes 16 0 OUYPAK+URWPalladioL-Roma Type 1 Custom yes yes yes 22 0 WDCHRF+URWPalladioL-Ital Type 1 Custom yes yes yes 27 0 VJAUGW+VnURWPalladioL Type 1 Custom yes yes yes 32 0 EAGGBO+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 65 0 EAGGCA+PalatinoLinotype TrueType WinAnsi yes yes no 68 0 EAGGCC+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 71 0 EAGGIB+PalatinoLinotype TrueType MacRoman yes yes no 74 0 EAGGBO+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 82 0 EAGGCA+PalatinoLinotype TrueType WinAnsi yes yes no 85 0 EAGGCC+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 88 0 EAGGIB+PalatinoLinotype TrueType MacRoman yes yes no 91 0 EAGGBO+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 111 0 EAGGCA+PalatinoLinotype TrueType WinAnsi yes yes no 114 0 EAGGCC+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 117 0 EAGIDI+Calibri CID TrueType Identity-H yes yes yes 120 0 EAGIEI+Calibri,Bold CID TrueType Identity-H yes yes yes 126 0 EAGGBO+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 138 0 EAGGBP+PalatinoLinotype CID TrueType Identity-H yes yes yes 141 0 EAGGCA+PalatinoLinotype TrueType WinAnsi yes yes no 147 0 EAGGCC+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 150 0 EAGGIB+PalatinoLinotype TrueType MacRoman yes yes no 153 0 AEIEME+CMSY10 Type 1 Builtin yes yes yes 164 0 EAGGBO+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 172 0 EAGGBP+PalatinoLinotype CID TrueType Identity-H yes yes yes 175 0 EAGGCA+PalatinoLinotype TrueType WinAnsi yes yes no 181 0 EAGGCC+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 184 0 EAGGIB+PalatinoLinotype TrueType MacRoman yes yes no 187 0 EAGGBO+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 208 0 EAGGBP+PalatinoLinotype CID TrueType Identity-H yes yes yes 211 0 EAGGCA+PalatinoLinotype TrueType WinAnsi yes yes no 217 0 EAGGCC+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 220 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-02-08 02:53:51 CET RepresentationInformation: VAC_a2024v12p1446.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-02-06 07:55:17 CET Size: 3000926 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 383 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Summary and Analysis of TRANSVAC Activities Destination: section.2 Children: Item: Title: Overview of TRANSVAC Services for Vaccine Candidates Destination: subsection.2.1 Children: Item: Title: Therapeutic Vaccines Destination: subsubsection.2.1.1 Item: Title: Interaction with the Vaccine Industry Destination: subsubsection.2.1.2 Item: Title: Developer Feedback Destination: subsubsection.2.1.3 Item: Title: Development of TRANSVAC Services to Support Vaccine R&D Destination: subsection.2.2 Children: Item: Title: Antigen Characterization and Selection Destination: subsubsection.2.2.1 Item: Title: Adjuvants Destination: subsubsection.2.2.2 Item: Title: Immunization Routes Destination: subsubsection.2.2.3 Item: Title: Vaccine Manufacturing Support Destination: subsubsection.2.2.4 Item: Title: Trainings in Vaccinology Destination: subsection.2.3 Children: Item: Title: TRANSVAC Trainee Demographics Destination: subsubsection.2.3.1 Item: Title: Outlook for TRANSVAC Training Courses Destination: subsubsection.2.3.2 Item: Title: Future Perspectives and Conclusions Destination: section.3 Item: Title: References Destination: section.4 Info: Title: Boosting Vaccine Research: The 16-Year Journey of TRANSVAC Vaccine Infrastructure Author: William Martin, Catarina Luís, Stefan Jungbluth, Monika Slezak, Frank A. W. Verreck, Holger Spiegel, Carlos A. Guzman, António Roldão, Manuel J. T. Carrondo, Peter Van der Ley, Joaquim Segalés, Hazel M. Dockrell, Mei Mei Ho, Gabriel K. Pedersen, Maria Lawrenz and Ole F. Olesen Subject: TRANSVAC represents a long-running effort to accelerate the development of novel vaccines by integrating institutions from across Europe under a single collaborative framework. This initiative has empowered the global vaccine community since 2009 including contributing toward the development and optimization of vaccine candidates as well as the provision of new adjuvants, research protocols, and technologies. Scientific services were provided in support of 88 different vaccine development projects, and 400 professionals attended TRANSVAC training events on various vaccine-related topics. Here, we review the accomplishments of the TRANSVAC consortia and analyze the continued needs of academic and industrial vaccine developers in Europe. The findings highlight the benefits of coordination across different sectors, both through research infrastructures such as TRANSVAC and other mechanisms, to address the current and future global health challenges and ensure that European vaccine developers have the support required to successfully compete in the global market. Keywords: research infrastructure; vaccine; research and development Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Sun Dec 22 10:46:50 CET 2024 ModDate: Sun Dec 22 10:50:43 CET 2024 ID: 0xafc16d0ee167272885f16445362f4d2c, 0xafc16d0ee167272885f16445362f4d2c Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: VJAUGW+VnURWPalladioL FontSubset: true FirstChar: 160 LastChar: 226 FontDescriptor: FontName: VJAUGW+VnURWPalladioL Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: VXVVEF+URWPalladioL-Bold FontSubset: true FirstChar: 3 LastChar: 122 FontDescriptor: FontName: VXVVEF+URWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: AEIEME+CMSY10 FontSubset: true FirstChar: 21 LastChar: 48 FontDescriptor: FontName: AEIEME+CMSY10 Flags: Symbolic FontBBox: -29, -960, 1116, 775 FontFile: true ToUnicode: true Font: BaseFont: OUYPAK+URWPalladioL-Roma FontSubset: true FirstChar: 2 LastChar: 252 FontDescriptor: FontName: OUYPAK+URWPalladioL-Roma Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: BNGSYC+VnURWPalladioL-Bold FontSubset: true FirstChar: 162 LastChar: 226 FontDescriptor: FontName: BNGSYC+VnURWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: WDCHRF+URWPalladioL-Ital FontSubset: true FirstChar: 2 LastChar: 121 FontDescriptor: FontName: WDCHRF+URWPalladioL-Ital Flags: Symbolic FontBBox: -170, -305, 1010, 941 FontFile: true EncodingDictionary: Differences: true ToUnicode: true Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 108, 279, 152, 288 Annotation: Subtype: Link Rect: 34, 267, 143, 276 Annotation: Subtype: Link Rect: 34, 164, 96, 186 Annotation: Subtype: Link Rect: 126, 90, 154, 99 Annotation: Subtype: Link Rect: 34, 78, 149, 87 Annotation: Subtype: Link Rect: 34, 756, 136, 792 Annotation: Subtype: Link Rect: 515, 756, 560, 792 Annotation: Subtype: Link Rect: 118, 662, 129, 676 Annotation: Subtype: Link Rect: 290, 662, 301, 676 Annotation: Subtype: Link Rect: 380, 662, 391, 676 Annotation: Subtype: Link Rect: 492, 662, 503, 676 Annotation: Subtype: Link Rect: 205, 650, 216, 663 Annotation: Subtype: Link Rect: 299, 650, 310, 663 Annotation: Subtype: Link Rect: 116, 637, 127, 651 Annotation: Subtype: Link Rect: 480, 637, 491, 651 Annotation: Subtype: Link Rect: 121, 627, 132, 638 Annotation: Subtype: Link Rect: 199, 136, 205, 148 ActionDest: 59 Annotation: Subtype: Link Rect: 236, 110, 243, 123 ActionDest: 59 Annotation: Subtype: Link Rect: 116, 17, 270, 28 Annotation: Subtype: Link Rect: 406, 17, 560, 28 Annotation: Subtype: Link Rect: 34, 377, 87, 396 Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 527, 718, 534, 727 ActionDest: 234 Annotation: Subtype: Link Rect: 488, 678, 495, 690 ActionDest: 96 Page: Sequence: 3 Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 295, 401, 302, 413 ActionDest: 96 Annotation: Subtype: Link Rect: 380, 276, 503, 288 Annotation: Subtype: Link Rect: 232, 201, 239, 212 ActionDest: 96 Annotation: Subtype: Link Rect: 287, 178, 294, 187 ActionDest: 234 Annotation: Subtype: Link Rect: 301, 102, 308, 111 ActionDest: 234 Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 291, 668, 298, 677 ActionDest: 234 Annotation: Subtype: Link Rect: 384, 627, 503, 639 Annotation: Subtype: Link Rect: 323, 414, 330, 426 ActionDest: 105 Annotation: Subtype: Link Rect: 347, 389, 354, 401 ActionDest: 105 Annotation: Subtype: Link Rect: 252, 316, 259, 325 ActionDest: 234 Annotation: Subtype: Link Rect: 517, 188, 524, 200 ActionDest: 105 Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 367, 166, 373, 174 ActionDest: 234 Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 355, 728, 362, 740 ActionDest: 105 Annotation: Subtype: Link Rect: 237, 693, 244, 702 ActionDest: 234 Annotation: Subtype: Link Rect: 399, 505, 406, 514 ActionDest: 234 Annotation: Subtype: Link Rect: 497, 426, 504, 438 ActionDest: 132 Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 233, 489, 240, 501 ActionDest: 161 Annotation: Subtype: Link Rect: 517, 402, 524, 414 ActionDest: 161 Annotation: Subtype: Link Rect: 235, 251, 242, 263 ActionDest: 161 Annotation: Subtype: Link Rect: 282, 226, 289, 238 ActionDest: 161 Annotation: Subtype: Link Rect: 333, 178, 340, 187 ActionDest: 234 Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 473, 285, 480, 297 ActionDest: 132 Annotation: Subtype: Link Rect: 251, 234, 258, 246 ActionDest: 132 Annotation: Subtype: Link Rect: 438, 234, 560, 246 Annotation: Subtype: Link Rect: 165, 222, 298, 234 Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 274, 499, 504, 511 Annotation: Subtype: Link Rect: 441, 351, 448, 360 ActionDest: 234 Annotation: Subtype: Link Rect: 512, 200, 519, 209 ActionDest: 234 Annotation: Subtype: Link Rect: 352, 175, 364, 184 ActionDest: 234 Annotation: Subtype: Link Rect: 364, 175, 376, 184 ActionDest: 234 Annotation: Subtype: Link Rect: 455, 150, 467, 159 ActionDest: 234 Annotation: Subtype: Link Rect: 203, 87, 215, 96 ActionDest: 234 Annotation: Subtype: Link Rect: 218, 87, 230, 96 ActionDest: 234 Page: Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 483, 703, 495, 712 ActionDest: 237 Annotation: Subtype: Link Rect: 225, 615, 237, 624 ActionDest: 234 Annotation: Subtype: Link Rect: 237, 615, 249, 624 ActionDest: 234 Annotation: Subtype: Link Rect: 250, 615, 262, 624 ActionDest: 237 Annotation: Subtype: Link Rect: 265, 615, 277, 624 ActionDest: 237 Annotation: Subtype: Link Rect: 327, 562, 427, 574 Annotation: Subtype: Link Rect: 351, 539, 363, 549 ActionDest: 237 Annotation: Subtype: Link Rect: 294, 401, 301, 410 ActionDest: 234 Annotation: Subtype: Link Rect: 302, 401, 314, 410 ActionDest: 237 Annotation: Subtype: Link Rect: 421, 210, 428, 222 ActionDest: 199 Page: Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 346, 200, 516, 212 Annotation: Subtype: Link Rect: 313, 163, 320, 175 ActionDest: 199 Page: Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 474, 627, 481, 639 ActionDest: 202 Page: Sequence: 14 Annotations: Annotation: Subtype: Link Rect: 223, 602, 503, 614 Annotation: Subtype: Link Rect: 412, 505, 424, 514 ActionDest: 237 Annotation: Subtype: Link Rect: 319, 467, 331, 476 ActionDest: 237 Annotation: Subtype: Link Rect: 488, 442, 500, 451 ActionDest: 237 Annotation: Subtype: Link Rect: 388, 417, 400, 426 ActionDest: 237 Annotation: Subtype: Link Rect: 534, 414, 560, 426 Annotation: Subtype: Link Rect: 165, 402, 254, 414 Annotation: Subtype: Link Rect: 168, 389, 337, 401 Annotation: Subtype: Link Rect: 257, 188, 378, 200 Annotation: Subtype: Link Rect: 443, 178, 455, 187 ActionDest: 237 Page: Sequence: 15 Annotations: Annotation: Subtype: Link Rect: 335, 527, 342, 539 ActionDest: 59 Annotation: Subtype: Link Rect: 489, 279, 501, 288 ActionDest: 237 Annotation: Subtype: Link Rect: 246, 241, 253, 250 ActionDest: 234 Annotation: Subtype: Link Rect: 435, 191, 442, 200 ActionDest: 234 Page: Sequence: 16 Annotations: Annotation: Subtype: Link Rect: 221, 630, 233, 639 ActionDest: 237 Annotation: Subtype: Link Rect: 295, 229, 307, 238 ActionDest: 237 Page: Sequence: 17 Annotations: Annotation: Subtype: Link Rect: 247, 452, 284, 463 Annotation: Subtype: Link Rect: 290, 452, 326, 463 Annotation: Subtype: Link Rect: 442, 429, 479, 440 Annotation: Subtype: Link Rect: 486, 429, 522, 440 Annotation: Subtype: Link Rect: 478, 395, 515, 406 Annotation: Subtype: Link Rect: 521, 395, 557, 406 Annotation: Subtype: Link Rect: 147, 372, 326, 383 Annotation: Subtype: Link Rect: 292, 360, 560, 371 Annotation: Subtype: Link Rect: 56, 349, 220, 360 Annotation: Subtype: Link Rect: 328, 337, 560, 348 Annotation: Subtype: Link Rect: 56, 326, 199, 337 Annotation: Subtype: Link Rect: 225, 303, 262, 314 Annotation: Subtype: Link Rect: 100, 281, 137, 291 Annotation: Subtype: Link Rect: 143, 281, 180, 291 Annotation: Subtype: Link Rect: 250, 257, 287, 268 Annotation: Subtype: Link Rect: 293, 257, 329, 268 Annotation: Subtype: Link Rect: 385, 234, 422, 245 Annotation: Subtype: Link Rect: 429, 234, 465, 245 Annotation: Subtype: Link Rect: 467, 211, 505, 222 Annotation: Subtype: Link Rect: 511, 211, 547, 222 Annotation: Subtype: Link Rect: 340, 188, 378, 199 Annotation: Subtype: Link Rect: 306, 153, 344, 166 Annotation: Subtype: Link Rect: 350, 153, 386, 166 Annotation: Subtype: Link Rect: 467, 119, 504, 131 Annotation: Subtype: Link Rect: 206, 84, 244, 95 Page: Sequence: 18 Annotations: Annotation: Subtype: Link Rect: 90, 730, 128, 741 Annotation: Subtype: Link Rect: 134, 730, 170, 741 Annotation: Subtype: Link Rect: 427, 696, 465, 706 Annotation: Subtype: Link Rect: 395, 660, 433, 671 Annotation: Subtype: Link Rect: 373, 626, 410, 637 Annotation: Subtype: Link Rect: 417, 626, 453, 637 Annotation: Subtype: Link Rect: 56, 603, 267, 614 Annotation: Subtype: Link Rect: 95, 569, 132, 579 Annotation: Subtype: Link Rect: 221, 522, 414, 533 Annotation: Subtype: Link Rect: 280, 511, 560, 522 Annotation: Subtype: Link Rect: 56, 499, 86, 510 Annotation: Subtype: Link Rect: 188, 465, 226, 476 Checksum: 937ded02 Type: CRC32 Checksum: 7618864be1d90218d218da15a55e81f7 Type: MD5 Checksum: 58c49e8913bbb44408f9b39a5a610b210d5476a5 Type: SHA-1 Checksum: 8bf8037cb165132611538bc8e29917f53c54595f2e5b4b427d8222a7bcc58c52 Type: SHA-256