b972192a855338bdb4ba4b3d045828f0 1-s2.0-S0024320523009219-main.pdf d3a3cd1586d93bc2d44320ec3b1ea97eb8e74629 1-s2.0-S0024320523009219-main.pdf 5b5e1fc01ba8d50c6687638be53f633580a6c5a76278bc783eebf8965624673c 1-s2.0-S0024320523009219-main.pdf Title: Evidence for the involvement of TRPV2 channels in the modulation of vascular tone in the mouse aorta Subject: Life Sciences, 336 (2024) 122286. doi:10.1016/j.lfs.2023.122286 Keywords: TRPV2 channels,Mouse aorta,Endothelium-dependent and independent vasodilatation,Potassium ion channels,Nitric oxide,KATP channels Author: Alex Perálvarez-Marín Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Wed Dec 20 02:02:02 2023 CET ModDate: Wed Dec 20 06:36:16 2023 CET Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 6601941 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- YCRKOC+CharisSIL CID TrueType Identity-H yes yes yes 905 0 TYDBRO+STIX-Regular Type 1C Custom yes yes yes 910 0 DYDQNN+Univers Type 1C Builtin yes yes yes 915 0 SSFCUB+CharisSIL-Bold CID TrueType Identity-H yes yes yes 919 0 NNLAUQ+TeX_CM_Roman Type 1C Builtin yes yes yes 924 0 WVWPDF+CharisSIL-Italic CID TrueType Identity-H yes yes yes 928 0 AVYIOR+CharisSIL CID TrueType Identity-H yes yes yes 896 0 VVCCGG+TeX_CM_Maths_Italic Type 1C Builtin yes yes yes 395 0 VQXFPH+TeX_CM_Maths_Symbols Type 1C Builtin yes yes yes 399 0 NNQACX+CharisSIL-Italic CID TrueType Identity-H yes yes yes 388 0 UQRZUY+TimesNewRomanPSMT CID TrueType Identity-H yes yes yes 36 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-02-02 02:31:54 CET RepresentationInformation: 1-s2.0-S0024320523009219-main.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-01-26 01:35:25 CET Size: 6601941 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF, Tagged PDF PDFMetadata: Objects: 1006 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Evidence for the involvement of TRPV2 channels in the modulation of vascular tone in the mouse aorta Destination: mk:title Children: Item: Title: 1 Introduction Destination: mk:H1_1 Item: Title: 2 Materials and methods Destination: mk:H1_2 Children: Item: Title: 2.1 Animals Destination: mk:H2_1 Item: Title: 2.2 Preparation of aortic rings Destination: mk:H2_2 Item: Title: 2.3 Evaluation of aortic functionality Destination: mk:H2_3 Item: Title: 2.4 Cell culture Destination: mk:H2_4 Item: Title: 2.5 Immunofluorescence Destination: mk:H2_5 Item: Title: 2.6 Biotinylation and subcellular fractionation Destination: mk:H2_6 Item: Title: 2.7 Western blot Destination: mk:H2_7 Item: Title: 2.8 High-performance liquid chromatography (HPLC) Destination: mk:H2_8 Item: Title: 2.9 Drugs and reagents Destination: mk:H2_9 Item: Title: 2.10 Statistical analysis Destination: mk:H2_10 Item: Title: 3 Results Destination: mk:H1_3 Children: Item: Title: 3.1 TRPV2 channels are expressed in the different layers of the mouse aortic wall Destination: mk:H2_11 Item: Title: 3.2 TRPV2 channels modulate vascular tone in the mouse aorta Destination: mk:H2_12 Item: Title: 3.3 Probenecid-induced endothelium-dependent relaxations are mediated by KIR and KV channels Destination: mk:H2_13 Item: Title: 3.4 Activation of muscular TRPV2 channels by probenecid favors ATP accumulation with blockade of KATP channels Destination: mk:H2_14 Item: Title: 3.5 Nitric oxide induces the translocation of TRPV2 channels to the plasma membrane and increases the tranilast-induced pot ... Destination: mk:H2_15 Item: Title: 4 Discussion Destination: mk:H1_4 Item: Title: 5 Conclusion Destination: mk:H1_5 Item: Title: Ethics statement Destination: mk:H1_6 Item: Title: CRediT authorship contribution statement Destination: mk:H1_7 Item: Title: Funding Destination: mk:H1_8 Item: Title: Declaration of competing interest Destination: mk:HH1_2 Item: Title: Data availability Destination: datalink3 Item: Title: Acknowledgments Destination: mk:HH1_4 Item: Title: Appendix A Supplementary data Destination: mk:H1_9 Item: Title: References Destination: mk:HH2_1 Info: Title: Evidence for the involvement of TRPV2 channels in the modulation of vascular tone in the mouse aorta Author: Alex Perálvarez-Marín Subject: Life Sciences, 336 (2024) 122286. doi:10.1016/j.lfs.2023.122286 Keywords: TRPV2 channels,Mouse aorta,Endothelium-dependent and independent vasodilatation,Potassium ion channels,Nitric oxide,KATP channels Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Wed Dec 20 02:02:02 CET 2023 ModDate: Wed Dec 20 06:36:16 CET 2023 ID: 0xb32f2cf44eae721d9af7bb330eb3d6af, 0xadfceceb08341601a8a4bf68577eed00 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 236 ImageHeight: 298 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 248 ImageHeight: 271 BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type0: Font: BaseFont: WVWPDF+CharisSIL-Italic Encoding: Identity-H ToUnicode: true Font: BaseFont: UQRZUY+TimesNewRomanPSMT Encoding: Identity-H ToUnicode: true Font: BaseFont: SSFCUB+CharisSIL-Bold Encoding: Identity-H ToUnicode: true Font: BaseFont: YCRKOC+CharisSIL Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: DYDQNN+Univers FontSubset: true FirstChar: 32 LastChar: 251 FontDescriptor: FontName: DYDQNN+Univers Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: VVCCGG+TeX_CM_Maths_Italic FontSubset: true FirstChar: 1 LastChar: 127 FontDescriptor: FontName: VVCCGG+TeX_CM_Maths_Italic Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: NNLAUQ+TeX_CM_Roman FontSubset: true FirstChar: 1 LastChar: 128 FontDescriptor: FontName: NNLAUQ+TeX_CM_Roman Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: TYDBRO+STIX-Regular FontSubset: true FirstChar: 1 LastChar: 7 FontDescriptor: FontName: TYDBRO+STIX-Regular Flags: Nonsymbolic FontBBox: -970, -486, 2208, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: VQXFPH+TeX_CM_Maths_Symbols FontSubset: true FirstChar: 1 LastChar: 138 FontDescriptor: FontName: VQXFPH+TeX_CM_Maths_Symbols Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true CIDFontType2: Font: BaseFont: WVWPDF+CharisSIL-Italic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: WVWPDF+CharisSIL-Italic Flags: Nonsymbolic, Italic FontBBox: -716, -533, 1627, 1318 FontFile2: true Font: BaseFont: UQRZUY+TimesNewRomanPSMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: UQRZUY+TimesNewRomanPSMT Flags: Nonsymbolic FontBBox: -568, -307, 2000, 1007 FontFile2: true Font: BaseFont: SSFCUB+CharisSIL-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: SSFCUB+CharisSIL-Bold Flags: Nonsymbolic, ForceBold FontBBox: -720, -533, 1759, 1320 FontFile2: true Font: BaseFont: YCRKOC+CharisSIL CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: YCRKOC+CharisSIL Flags: Nonsymbolic FontBBox: -692, -533, 1623, 1319 FontFile2: true XMP: application/pdf 10.1016/j.lfs.2023.122286 Elsevier Inc. Life Sciences, 336 (2024) 122286. doi:10.1016/j.lfs.2023.122286 TRPV2 channels Mouse aorta Endothelium-dependent and independent vasodilatation Potassium ion channels Nitric oxide KATP channels Evidence for the involvement of TRPV2 channels in the modulation of vascular tone in the mouse aorta Alex Perálvarez-Marín Montse Solé Judith Serrano Alice Taddeucci Belén Pérez Clara Penas Gemma Manich Marcel Jiménez Pilar D'Ocon Francesc Jiménez-Altayó journal Life Sciences © 2023 The Authors. Published by Elsevier Inc. 0024-3205 336 1 January 2024 2024-01-01 122286 122286 10.1016/j.lfs.2023.122286 https://doi.org/10.1016/j.lfs.2023.122286 2010-04-23 true 10.1016/j.lfs.2023.122286 elsevier.com sciencedirect.com http://creativecommons.org/licenses/by/4.0/ VoR 10.1016/j.lfs.2023.122286 noindex 2010-04-23 true 20th December 2023 sciencedirect.com elsevier.com Elsevier 2023-12-20T05:36:16 2023-12-20T01:02:02 2023-12-20T05:36:16 True 20th December 2023 Acrobat Distiller 8.1.0 (Windows) TRPV2 channels,Mouse aorta,Endothelium-dependent and independent vasodilatation,Potassium ion channels,Nitric oxide,KATP channels uuid:1b499bed-4ce8-4c0c-b682-0d58baae1cbe uuid:b6ed5266-03cb-4855-90c0-636283357f42 Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 144, 576, 150, 587 Flags: Print Destination: 881 Annotation: Subtype: Link Rect: 151, 576, 227, 587 Flags: Print Destination: 881 Annotation: Subtype: Link Rect: 228, 576, 234, 587 Flags: Print Destination: 881 Annotation: Subtype: Link Rect: 234, 571, 317, 582 Flags: Print Destination: 881 Annotation: Subtype: Link Rect: 317, 576, 323, 587 Flags: Print Destination: 881 Annotation: Subtype: Link Rect: 324, 571, 411, 582 Flags: Print Destination: 881 Annotation: Subtype: Link Rect: 411, 576, 418, 587 Flags: Print Destination: 881 Annotation: Subtype: Link Rect: 418, 571, 425, 582 Flags: Print Destination: 881 Annotation: Subtype: Link Rect: 94, 563, 100, 574 Flags: Print Destination: 881 Annotation: Subtype: Link Rect: 101, 558, 168, 569 Flags: Print Destination: 881 Annotation: Subtype: Link Rect: 168, 563, 175, 574 Flags: Print Destination: 881 Annotation: Subtype: Link Rect: 176, 563, 182, 574 Flags: Print Destination: 881 Annotation: Subtype: Link Rect: 183, 558, 268, 569 Flags: Print Destination: 881 Annotation: Subtype: Link Rect: 268, 563, 275, 574 Flags: Print Destination: 881 Annotation: Subtype: Link Rect: 275, 558, 362, 569 Flags: Print Destination: 881 Annotation: Subtype: Link Rect: 362, 563, 368, 574 Flags: Print Destination: 881 Annotation: Subtype: Link Rect: 369, 558, 439, 569 Flags: Print Destination: 881 Annotation: Subtype: Link Rect: 439, 563, 446, 574 Flags: Print Destination: 881 Annotation: Subtype: Link Rect: 447, 558, 452, 569 Flags: Print Destination: 881 Annotation: Subtype: Link Rect: 155, 550, 162, 561 Flags: Print Destination: 881 Annotation: Subtype: Link Rect: 163, 550, 169, 561 Flags: Print Destination: 881 Annotation: Subtype: Link Rect: 170, 550, 174, 561 Flags: Print Destination: 881 Annotation: Subtype: Link Rect: 175, 553, 179, 558 Flags: Print Destination: 881 Annotation: Subtype: Link Rect: 175, 545, 179, 556 Flags: Print Destination: 881 Annotation: Subtype: Link Rect: 232, 157, 245, 165 Flags: Print Destination: 154 Annotation: Subtype: Link Rect: 547, 178, 552, 186 Flags: Print Destination: 154 Annotation: Subtype: Link Rect: 98, 104, 180, 111 Flags: Print Annotation: Subtype: Link Rect: 321, 722, 369, 730 Flags: Print Annotation: Subtype: Link Rect: 274, 667, 397, 675 Flags: Print Annotation: Subtype: Link Rect: 37, 87, 174, 94 Flags: Print Annotation: Subtype: Link Rect: 297, 749, 300, 757 Flags: Print Annotation: Subtype: Link Rect: 244, 748, 349, 760 Annotation: Subtype: Link Rect: 499, 616, 528, 645 Annotation: Subtype: Link Rect: 405, 59, 552, 70 Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 267, 730, 272, 738 Flags: Print Destination: 154 Annotation: Subtype: Link Rect: 40, 699, 53, 707 Flags: Print Destination: 154 Annotation: Subtype: Link Rect: 171, 689, 189, 696 Flags: Print Destination: 154 Annotation: Subtype: Link Rect: 259, 689, 268, 696 Flags: Print Destination: 154 Annotation: Subtype: Link Rect: 84, 678, 93, 686 Flags: Print Destination: 154 Annotation: Subtype: Link Rect: 206, 668, 211, 676 Flags: Print Destination: 154 Annotation: Subtype: Link Rect: 213, 668, 222, 676 Flags: Print Destination: 154 Annotation: Subtype: Link Rect: 105, 647, 114, 655 Flags: Print Destination: 222 Annotation: Subtype: Link Rect: 116, 647, 125, 655 Flags: Print Destination: 222 Annotation: Subtype: Link Rect: 83, 636, 92, 644 Flags: Print Destination: 222 Annotation: Subtype: Link Rect: 213, 636, 222, 644 Flags: Print Destination: 222 Annotation: Subtype: Link Rect: 238, 584, 247, 592 Flags: Print Destination: 154 Annotation: Subtype: Link Rect: 76, 553, 85, 561 Flags: Print Destination: 222 Annotation: Subtype: Link Rect: 40, 458, 53, 466 Flags: Print Destination: 154 Annotation: Subtype: Link Rect: 56, 458, 65, 466 Flags: Print Destination: 222 Annotation: Subtype: Link Rect: 188, 417, 197, 425 Flags: Print Destination: 222 Annotation: Subtype: Link Rect: 77, 396, 86, 404 Flags: Print Destination: 222 Annotation: Subtype: Link Rect: 172, 385, 181, 393 Flags: Print Destination: 222 Annotation: Subtype: Link Rect: 132, 375, 154, 383 Flags: Print Destination: 222 Annotation: Subtype: Link Rect: 212, 364, 234, 372 Flags: Print Destination: 222 Annotation: Subtype: Link Rect: 40, 343, 45, 351 Flags: Print Destination: 154 Annotation: Subtype: Link Rect: 47, 343, 52, 351 Flags: Print Destination: 154 Annotation: Subtype: Link Rect: 453, 605, 462, 612 Flags: Print Destination: 222 Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 117, 573, 126, 581 Flags: Print Destination: 222 Annotation: Subtype: Link Rect: 40, 154, 49, 162 Flags: Print Destination: 222 Annotation: Subtype: Link Rect: 440, 301, 449, 309 Flags: Print Destination: 222 Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 137, 393, 157, 401 Flags: Print Destination: 44 Annotation: Subtype: Link Rect: 83, 287, 92, 295 Flags: Print Destination: 222 Annotation: Subtype: Link Rect: 235, 277, 257, 284 Flags: Print Destination: 60 Annotation: Subtype: Link Rect: 471, 657, 480, 665 Flags: Print Destination: 222 Annotation: Subtype: Link Rect: 532, 657, 541, 665 Flags: Print Destination: 222 Annotation: Subtype: Link Rect: 512, 573, 533, 581 Flags: Print Destination: 60 Annotation: Subtype: Link Rect: 336, 364, 358, 372 Flags: Print Destination: 60 Annotation: Subtype: Link Rect: 309, 322, 330, 330 Flags: Print Destination: 60 Annotation: Subtype: Link Rect: 378, 322, 398, 330 Flags: Print Destination: 60 Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 263, 133, 285, 141 Flags: Print Destination: 222 Annotation: Subtype: Link Rect: 246, 112, 266, 120 Flags: Print Destination: 74 Annotation: Subtype: Link Rect: 72, 102, 92, 110 Flags: Print Destination: 74 Annotation: Subtype: Link Rect: 149, 81, 170, 89 Flags: Print Destination: 74 Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 119, 438, 139, 446 Flags: Print Destination: 60 Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 154, 668, 174, 676 Flags: Print Destination: 74 Annotation: Subtype: Link Rect: 129, 657, 149, 665 Flags: Print Destination: 74 Annotation: Subtype: Link Rect: 216, 626, 236, 634 Flags: Print Destination: 74 Annotation: Subtype: Link Rect: 180, 437, 200, 445 Flags: Print Destination: 85 Annotation: Subtype: Link Rect: 40, 343, 59, 351 Flags: Print Destination: 85 Annotation: Subtype: Link Rect: 59, 322, 80, 330 Flags: Print Destination: 85 Annotation: Subtype: Link Rect: 353, 668, 362, 676 Flags: Print Destination: 222 Annotation: Subtype: Link Rect: 504, 573, 525, 581 Flags: Print Destination: 104 Annotation: Subtype: Link Rect: 477, 553, 497, 561 Flags: Print Destination: 104 Annotation: Subtype: Link Rect: 431, 469, 453, 477 Flags: Print Destination: 104 Annotation: Subtype: Link Rect: 375, 437, 395, 445 Flags: Print Destination: 117 Annotation: Subtype: Link Rect: 539, 375, 552, 383 Flags: Print Destination: 154 Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 128, 172, 149, 180 Flags: Print Destination: 136 Annotation: Subtype: Link Rect: 223, 140, 248, 148 Flags: Print Destination: 144 Annotation: Subtype: Link Rect: 235, 119, 239, 127 Flags: Print Destination: 154 Annotation: Subtype: Link Rect: 82, 98, 91, 106 Flags: Print Destination: 154 Annotation: Subtype: Link Rect: 517, 161, 526, 169 Flags: Print Destination: 222 Annotation: Subtype: Link Rect: 377, 98, 386, 106 Flags: Print Destination: 222 Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 141, 287, 150, 295 Flags: Print Destination: 222 Annotation: Subtype: Link Rect: 152, 287, 161, 295 Flags: Print Destination: 222 Annotation: Subtype: Link Rect: 191, 266, 213, 274 Flags: Print Destination: 222 Annotation: Subtype: Link Rect: 274, 245, 283, 253 Flags: Print Destination: 222 Annotation: Subtype: Link Rect: 40, 183, 49, 191 Flags: Print Destination: 222 Annotation: Subtype: Link Rect: 103, 120, 124, 128 Flags: Print Destination: 136 Annotation: Subtype: Link Rect: 79, 89, 101, 97 Flags: Print Destination: 222 Annotation: Subtype: Link Rect: 393, 329, 402, 337 Flags: Print Destination: 222 Annotation: Subtype: Link Rect: 480, 151, 500, 159 Flags: Print Destination: 136 Annotation: Subtype: Link Rect: 486, 120, 495, 128 Flags: Print Destination: 222 Annotation: Subtype: Link Rect: 429, 57, 438, 65 Flags: Print Destination: 222 Annotation: Subtype: Link Rect: 440, 57, 449, 65 Flags: Print Destination: 222 Page: Label: 10 Page: Label: 11 Annotations: Annotation: Subtype: Link Rect: 71, 101, 80, 109 Flags: Print Destination: 222 Annotation: Subtype: Link Rect: 505, 70, 514, 78 Flags: Print Destination: 222 Page: Label: 12 Annotations: Annotation: Subtype: Link Rect: 209, 730, 218, 738 Flags: Print Destination: 222 Annotation: Subtype: Link Rect: 68, 709, 77, 717 Flags: Print Destination: 222 Annotation: Subtype: Link Rect: 173, 709, 182, 717 Flags: Print Destination: 222 Annotation: Subtype: Link Rect: 96, 678, 121, 686 Flags: Print Destination: 144 Annotation: Subtype: Link Rect: 257, 563, 266, 571 Flags: Print Destination: 222 Annotation: Subtype: Link Rect: 98, 458, 107, 466 Flags: Print Destination: 222 Annotation: Subtype: Link Rect: 109, 458, 118, 466 Flags: Print Destination: 222 Annotation: Subtype: Link Rect: 516, 403, 557, 411 Flags: Print Annotation: Subtype: Link Rect: 306, 392, 417, 400 Flags: Print Annotation: Subtype: Link Rect: 322, 353, 538, 359 Flags: Print Annotation: Subtype: Link Rect: 322, 345, 543, 351 Flags: Print Annotation: Subtype: Link Rect: 322, 337, 416, 343 Flags: Print Annotation: Subtype: Link Rect: 322, 329, 536, 336 Flags: Print Annotation: Subtype: Link Rect: 322, 321, 416, 328 Flags: Print Annotation: Subtype: Link Rect: 322, 313, 555, 320 Flags: Print Annotation: Subtype: Link Rect: 322, 305, 413, 312 Flags: Print Annotation: Subtype: Link Rect: 322, 297, 543, 304 Flags: Print Annotation: Subtype: Link Rect: 322, 289, 515, 296 Flags: Print Annotation: Subtype: Link Rect: 322, 281, 551, 288 Flags: Print Annotation: Subtype: Link Rect: 322, 273, 548, 280 Flags: Print Annotation: Subtype: Link Rect: 322, 265, 376, 272 Flags: Print Annotation: Subtype: Link Rect: 322, 257, 555, 264 Flags: Print Annotation: Subtype: Link Rect: 322, 249, 386, 256 Flags: Print Annotation: Subtype: Link Rect: 322, 241, 555, 248 Flags: Print Annotation: Subtype: Link Rect: 322, 233, 533, 240 Flags: Print Annotation: Subtype: Link Rect: 322, 226, 484, 232 Flags: Print Annotation: Subtype: Link Rect: 322, 218, 546, 224 Flags: Print Annotation: Subtype: Link Rect: 322, 210, 508, 216 Flags: Print Annotation: Subtype: Link Rect: 322, 202, 555, 208 Flags: Print Annotation: Subtype: Link Rect: 322, 194, 555, 200 Flags: Print Annotation: Subtype: Link Rect: 322, 186, 555, 192 Flags: Print Annotation: Subtype: Link Rect: 322, 178, 361, 184 Flags: Print Annotation: Subtype: Link Rect: 323, 170, 555, 176 Flags: Print Annotation: Subtype: Link Rect: 323, 162, 549, 168 Flags: Print Annotation: Subtype: Link Rect: 323, 154, 484, 160 Flags: Print Annotation: Subtype: Link Rect: 323, 146, 552, 152 Flags: Print Annotation: Subtype: Link Rect: 323, 138, 551, 144 Flags: Print Annotation: Subtype: Link Rect: 323, 130, 448, 136 Flags: Print Annotation: Subtype: Link Rect: 323, 122, 541, 128 Flags: Print Annotation: Subtype: Link Rect: 323, 114, 555, 120 Flags: Print Annotation: Subtype: Link Rect: 323, 106, 555, 112 Flags: Print Annotation: Subtype: Link Rect: 323, 98, 396, 104 Flags: Print Annotation: Subtype: Link Rect: 323, 90, 540, 96 Flags: Print Annotation: Subtype: Link Rect: 323, 82, 540, 88 Flags: Print Annotation: Subtype: Link Rect: 323, 74, 512, 80 Flags: Print Annotation: Subtype: Link Rect: 323, 66, 536, 73 Flags: Print Annotation: Subtype: Link Rect: 323, 58, 524, 65 Flags: Print Annotation: Subtype: Link Rect: 323, 50, 357, 57 Flags: Print Page: Label: 13 Annotations: Annotation: Subtype: Link Rect: 54, 732, 283, 738 Flags: Print Annotation: Subtype: Link Rect: 54, 724, 280, 730 Flags: Print Annotation: Subtype: Link Rect: 54, 716, 286, 722 Flags: Print Annotation: Subtype: Link Rect: 54, 708, 286, 714 Flags: Print Annotation: Subtype: Link Rect: 54, 700, 258, 706 Flags: Print Annotation: Subtype: Link Rect: 54, 692, 286, 698 Flags: Print Annotation: Subtype: Link Rect: 54, 684, 252, 690 Flags: Print Annotation: Subtype: Link Rect: 54, 676, 266, 682 Flags: Print Annotation: Subtype: Link Rect: 54, 668, 281, 674 Flags: Print Annotation: Subtype: Link Rect: 54, 660, 261, 666 Flags: Print Annotation: Subtype: Link Rect: 54, 652, 185, 658 Flags: Print Annotation: Subtype: Link Rect: 54, 644, 286, 651 Flags: Print Annotation: Subtype: Link Rect: 54, 636, 275, 643 Flags: Print Annotation: Subtype: Link Rect: 54, 628, 282, 635 Flags: Print Annotation: Subtype: Link Rect: 54, 620, 107, 627 Flags: Print Annotation: Subtype: Link Rect: 54, 612, 283, 619 Flags: Print Annotation: Subtype: Link Rect: 54, 604, 286, 611 Flags: Print Annotation: Subtype: Link Rect: 54, 596, 276, 603 Flags: Print Annotation: Subtype: Link Rect: 54, 588, 286, 595 Flags: Print Annotation: Subtype: Link Rect: 54, 580, 274, 587 Flags: Print Annotation: Subtype: Link Rect: 54, 572, 252, 579 Flags: Print Annotation: Subtype: Link Rect: 54, 565, 266, 571 Flags: Print Annotation: Subtype: Link Rect: 54, 557, 286, 563 Flags: Print Annotation: Subtype: Link Rect: 54, 549, 286, 555 Flags: Print Annotation: Subtype: Link Rect: 54, 541, 116, 547 Flags: Print Annotation: Subtype: Link Rect: 54, 533, 281, 539 Flags: Print Annotation: Subtype: Link Rect: 54, 525, 240, 531 Flags: Print Annotation: Subtype: Link Rect: 54, 517, 273, 523 Flags: Print Annotation: Subtype: Link Rect: 54, 509, 248, 515 Flags: Print Annotation: Subtype: Link Rect: 54, 501, 266, 507 Flags: Print Annotation: Subtype: Link Rect: 54, 493, 253, 499 Flags: Print Annotation: Subtype: Link Rect: 54, 485, 265, 491 Flags: Print Annotation: Subtype: Link Rect: 54, 477, 286, 483 Flags: Print Annotation: Subtype: Link Rect: 54, 469, 282, 475 Flags: Print Annotation: Subtype: Link Rect: 54, 461, 100, 467 Flags: Print Annotation: Subtype: Link Rect: 54, 453, 267, 459 Flags: Print Annotation: Subtype: Link Rect: 54, 445, 189, 451 Flags: Print Annotation: Subtype: Link Rect: 54, 437, 286, 443 Flags: Print Annotation: Subtype: Link Rect: 54, 429, 265, 435 Flags: Print Annotation: Subtype: Link Rect: 54, 421, 157, 427 Flags: Print Annotation: Subtype: Link Rect: 54, 413, 286, 419 Flags: Print Annotation: Subtype: Link Rect: 54, 405, 277, 411 Flags: Print Annotation: Subtype: Link Rect: 54, 397, 286, 403 Flags: Print Annotation: Subtype: Link Rect: 54, 389, 100, 396 Flags: Print Annotation: Subtype: Link Rect: 54, 381, 286, 388 Flags: Print Annotation: Subtype: Link Rect: 54, 373, 285, 380 Flags: Print Annotation: Subtype: Link Rect: 54, 365, 109, 372 Flags: Print Annotation: Subtype: Link Rect: 54, 357, 282, 364 Flags: Print Annotation: Subtype: Link Rect: 54, 349, 276, 356 Flags: Print Annotation: Subtype: Link Rect: 54, 341, 217, 348 Flags: Print Annotation: Subtype: Link Rect: 54, 333, 281, 340 Flags: Print Annotation: Subtype: Link Rect: 54, 325, 284, 332 Flags: Print Annotation: Subtype: Link Rect: 54, 317, 279, 324 Flags: Print Annotation: Subtype: Link Rect: 54, 309, 284, 316 Flags: Print Annotation: Subtype: Link Rect: 54, 301, 286, 308 Flags: Print Annotation: Subtype: Link Rect: 54, 294, 286, 300 Flags: Print Annotation: Subtype: Link Rect: 54, 286, 284, 292 Flags: Print Annotation: Subtype: Link Rect: 54, 278, 255, 284 Flags: Print Annotation: Subtype: Link Rect: 54, 270, 286, 276 Flags: Print Annotation: Subtype: Link Rect: 54, 262, 100, 268 Flags: Print Annotation: Subtype: Link Rect: 323, 732, 555, 738 Flags: Print Annotation: Subtype: Link Rect: 323, 724, 547, 730 Flags: Print Annotation: Subtype: Link Rect: 323, 716, 522, 722 Flags: Print Annotation: Subtype: Link Rect: 323, 708, 547, 714 Flags: Print Annotation: Subtype: Link Rect: 323, 700, 555, 706 Flags: Print Annotation: Subtype: Link Rect: 323, 692, 475, 698 Flags: Print Annotation: Subtype: Link Rect: 323, 684, 549, 690 Flags: Print Annotation: Subtype: Link Rect: 323, 676, 547, 682 Flags: Print Annotation: Subtype: Link Rect: 323, 668, 540, 674 Flags: Print Annotation: Subtype: Link Rect: 323, 660, 347, 666 Flags: Print Annotation: Subtype: Link Rect: 323, 652, 555, 658 Flags: Print Annotation: Subtype: Link Rect: 323, 644, 553, 651 Flags: Print Annotation: Subtype: Link Rect: 323, 636, 530, 643 Flags: Print Annotation: Subtype: Link Rect: 323, 628, 364, 635 Flags: Print Annotation: Subtype: Link Rect: 323, 620, 555, 627 Flags: Print Annotation: Subtype: Link Rect: 323, 612, 555, 619 Flags: Print Annotation: Subtype: Link Rect: 323, 604, 549, 611 Flags: Print Annotation: Subtype: Link Rect: 323, 596, 400, 603 Flags: Print Annotation: Subtype: Link Rect: 323, 588, 555, 595 Flags: Print Annotation: Subtype: Link Rect: 323, 580, 540, 587 Flags: Print Annotation: Subtype: Link Rect: 323, 572, 423, 579 Flags: Print Annotation: Subtype: Link Rect: 323, 565, 554, 571 Flags: Print Annotation: Subtype: Link Rect: 323, 557, 555, 563 Flags: Print Annotation: Subtype: Link Rect: 323, 549, 555, 555 Flags: Print Annotation: Subtype: Link Rect: 323, 541, 477, 547 Flags: Print Annotation: Subtype: Link Rect: 323, 533, 555, 539 Flags: Print Annotation: Subtype: Link Rect: 323, 525, 555, 531 Flags: Print Annotation: Subtype: Link Rect: 323, 517, 510, 523 Flags: Print Annotation: Subtype: Link Rect: 323, 509, 540, 515 Flags: Print Annotation: Subtype: Link Rect: 323, 501, 533, 507 Flags: Print Annotation: Subtype: Link Rect: 323, 493, 553, 499 Flags: Print Annotation: Subtype: Link Rect: 323, 485, 333, 491 Flags: Print Annotation: Subtype: Link Rect: 323, 477, 555, 483 Flags: Print Annotation: Subtype: Link Rect: 323, 469, 508, 475 Flags: Print Annotation: Subtype: Link Rect: 323, 461, 555, 467 Flags: Print Annotation: Subtype: Link Rect: 323, 453, 511, 459 Flags: Print Annotation: Subtype: Link Rect: 323, 445, 555, 451 Flags: Print Annotation: Subtype: Link Rect: 323, 437, 549, 443 Flags: Print Annotation: Subtype: Link Rect: 323, 429, 555, 435 Flags: Print Annotation: Subtype: Link Rect: 323, 421, 447, 427 Flags: Print Annotation: Subtype: Link Rect: 323, 413, 547, 419 Flags: Print Annotation: Subtype: Link Rect: 323, 405, 524, 411 Flags: Print Annotation: Subtype: Link Rect: 323, 397, 541, 403 Flags: Print Annotation: Subtype: Link Rect: 323, 389, 553, 396 Flags: Print Annotation: Subtype: Link Rect: 323, 381, 463, 388 Flags: Print Annotation: Subtype: Link Rect: 323, 373, 555, 380 Flags: Print Annotation: Subtype: Link Rect: 323, 365, 541, 372 Flags: Print Annotation: Subtype: Link Rect: 323, 357, 476, 364 Flags: Print Annotation: Subtype: Link Rect: 323, 349, 550, 356 Flags: Print Annotation: Subtype: Link Rect: 323, 341, 553, 348 Flags: Print Annotation: Subtype: Link Rect: 323, 333, 361, 340 Flags: Print Annotation: Subtype: Link Rect: 323, 325, 553, 332 Flags: Print Annotation: Subtype: Link Rect: 323, 317, 546, 324 Flags: Print Annotation: Subtype: Link Rect: 323, 309, 549, 316 Flags: Print Annotation: Subtype: Link Rect: 323, 301, 555, 308 Flags: Print Annotation: Subtype: Link Rect: 323, 294, 383, 300 Flags: Print Annotation: Subtype: Link Rect: 323, 286, 554, 292 Flags: Print Annotation: Subtype: Link Rect: 323, 278, 555, 284 Flags: Print Annotation: Subtype: Link Rect: 323, 270, 555, 276 Flags: Print Annotation: Subtype: Link Rect: 323, 262, 337, 268 Flags: Print Checksum: a38783fe Type: CRC32 Checksum: b972192a855338bdb4ba4b3d045828f0 Type: MD5 Checksum: d3a3cd1586d93bc2d44320ec3b1ea97eb8e74629 Type: SHA-1 Checksum: 5b5e1fc01ba8d50c6687638be53f633580a6c5a76278bc783eebf8965624673c Type: SHA-256