ababf753ead8f173a40df5a6160c1ef4  pmc_10784393.pdf
459267eb56ffeb4e7d7acae80ed4a0209da5fc17  pmc_10784393.pdf
6a58150960a4a5f2cc71c66da84d7d29cba5aa3c7f38bed149faf48ab625d9ec  pmc_10784393.pdf

Title:           Tuning plasmid DNA amounts for cost-effective transfections of mammalian cells: when less is more
Subject:         Applied Microbiology and Biotechnology, https://doi.org/10.1007/s00253-024-13003-x
Keywords:        Polyethylenimine;Transfection;Transient gene expression;HEK 293F cells;Recombinant protein
Author:           Aida Carreño 
Creator:         Adobe InDesign 15.1 (Windows)
Producer:        Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
CreationDate:    Wed Jan 10 07:57:03 2024 CET
ModDate:         Wed Jan 17 11:28:01 2024 CET
Custom Metadata: yes
Metadata Stream: yes
Tagged:          no
UserProperties:  no
Suspects:        no
Form:            none
JavaScript:      no
Pages:           11
Encrypted:       no
Page size:       595.276 x 790.866 pts
Page rot:        0
File size:       2356667 bytes
Optimized:       no
PDF version:     1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
MyriadPro-SemiCn                     Type 1C           WinAnsi          yes no  yes     33  0
MyriadPro-SemiboldSemiCn             Type 1C           Custom           yes no  yes     64  0
MyriadPro-Semibold                   Type 1C           Custom           yes no  yes    426  0
WLHIAA+STIX-Regular                  Type 1C           Custom           yes yes yes     34  0
MyriadPro-Bold                       Type 1C           Custom           yes no  yes     35  0
FUOHSN+Wingdings-Regular             Type 1C           WinAnsi          yes yes yes    427  0
STIX-Italic                          Type 1C           WinAnsi          yes no  yes     37  0
CJMXXV+MyriadPro-SemiCn2             Type 1C           WinAnsi          yes yes yes    469  0
SFZGRI+TimesNewRomanPSMT             CID TrueType      Identity-H       yes yes yes     36  0
MyriadPro-BoldSemiCn                 Type 1C           Custom           yes no  yes     38  0
NVMCZS+ArialMT                       Type 1C           WinAnsi          yes yes no      78  0
ArialMT4                             Type 1C           WinAnsi          yes no  no      97  0
ArialMT2                             Type 1C           WinAnsi          yes no  no      98  0
MWCWLU+Arial-BoldMT                  Type 1C           WinAnsi          yes yes no      99  0
ArialMT3                             Type 1C           WinAnsi          yes no  no     100  0
ArialMT5                             Type 1C           WinAnsi          yes no  no     130  0
ArialMT6                             Type 1C           WinAnsi          yes no  no     131  0
MWCWLU+Arial-BoldMT2                 Type 1C           WinAnsi          yes yes no     132  0
Arial-BoldMT3                        Type 1C           WinAnsi          yes no  no     165  0
ArialMT7                             Type 1C           WinAnsi          yes no  no     166  0
ArialMT8                             Type 1C           WinAnsi          yes no  no     206  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2024-03-21 02:36:16 CET
 RepresentationInformation: pmc_10784393.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2024-03-07 02:34:24 CET
  Size: 2356667
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 503
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: en-US
    Outlines: 
     Item: 
      Title: Tuning plasmid DNA amounts for cost-effective transfections of mammalian cells: when less is more
      Children: 
       Item: 
        Title: Abstract 
       Item: 
        Title: Key points
       Item: 
        Title: Introduction
       Item: 
        Title: Material and methods
        Children: 
         Item: 
          Title: Design, synthesis, and cloning of recombinant genes
         Item: 
          Title: Cell culture and transfection
         Item: 
          Title: Cell viability
         Item: 
          Title: SDS-PAGE and western blot analyses
         Item: 
          Title: Microscopy images
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: Effect of pDNA amounts on expression of human GLA enzyme and its mutants
         Item: 
          Title: Effect of pDNA amount on expression of other recombinant proteins
       Item: 
        Title: Discussion
       Item: 
        Title: Acknowledgements 
       Item: 
        Title: References
   Info: 
    Title: Tuning plasmid DNA amounts for cost-effective transfections of mammalian cells: when less is more
    Author:  Aida Carreño 
    Subject: Applied Microbiology and Biotechnology, https://doi.org/10.1007/s00253-024-13003-x
    Keywords: Polyethylenimine;Transfection;Transient gene expression;HEK 293F cells;Recombinant protein
    Creator: Adobe InDesign 15.1 (Windows)
    Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
    CreationDate: Wed Jan 10 07:57:03 CET 2024
    ModDate: Wed Jan 17 11:28:01 CET 2024
   ID: 0x28bb4f2684abf9979ea7dd850a450ce5, 0x341a1e62c80784dabdfa102c204a974b
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 890
      ImageHeight: 317
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 970
      ImageHeight: 1112
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1211
      ImageHeight: 301
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 878
      ImageHeight: 361
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1943
      ImageHeight: 477
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1771
      ImageHeight: 959
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 865
      ImageHeight: 571
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
   Fonts: 
    Type0: 
     Font: 
      BaseFont: SFZGRI+TimesNewRomanPSMT
      Encoding: Identity-H
      ToUnicode: true
    Type1: 
     Font: 
      BaseFont: MyriadPro-SemiboldSemiCn
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-SemiboldSemiCn
       Flags: Nonsymbolic
       FontBBox: -131, -250, 1115, 886
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-SemiCn
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-SemiCn
       Flags: Nonsymbolic
       FontBBox: -128, -250, 1059, 876
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: ArialMT4
      FirstChar: 32
      LastChar: 181
      FontDescriptor: 
       FontName: ArialMT4
       Flags: Nonsymbolic
       FontBBox: -665, -325, 2000, 1040
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: WLHIAA+STIX-Regular
      FontSubset: true
      FirstChar: 23
      LastChar: 252
      FontDescriptor: 
       FontName: WLHIAA+STIX-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -970, -486, 2208, 1023
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: ArialMT2
      FirstChar: 32
      LastChar: 181
      FontDescriptor: 
       FontName: ArialMT2
       Flags: Nonsymbolic
       FontBBox: -665, -325, 2000, 1040
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: ArialMT5
      FirstChar: 32
      LastChar: 181
      FontDescriptor: 
       FontName: ArialMT5
       Flags: Nonsymbolic
       FontBBox: -665, -325, 2000, 1040
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MyriadPro-Bold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Bold
       Flags: Nonsymbolic
       FontBBox: -163, -250, 1256, 989
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MWCWLU+Arial-BoldMT
      FontSubset: true
      FirstChar: 32
      LastChar: 87
      FontDescriptor: 
       FontName: MWCWLU+Arial-BoldMT
       Flags: Nonsymbolic
       FontBBox: -628, -376, 2000, 1056
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: ArialMT6
      FirstChar: 32
      LastChar: 181
      FontDescriptor: 
       FontName: ArialMT6
       Flags: Nonsymbolic
       FontBBox: -665, -325, 2000, 1040
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: ArialMT3
      FirstChar: 32
      LastChar: 181
      FontDescriptor: 
       FontName: ArialMT3
       Flags: Nonsymbolic
       FontBBox: -665, -325, 2000, 1040
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MWCWLU+Arial-BoldMT2
      FontSubset: true
      FirstChar: 32
      LastChar: 80
      FontDescriptor: 
       FontName: MWCWLU+Arial-BoldMT2
       Flags: Nonsymbolic
       FontBBox: -628, -376, 2000, 1056
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: STIX-Italic
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: STIX-Italic
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -970, -305, 1429, 1023
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: Arial-BoldMT3
      FirstChar: 32
      LastChar: 181
      FontDescriptor: 
       FontName: Arial-BoldMT3
       Flags: Nonsymbolic
       FontBBox: -628, -376, 2000, 1056
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MyriadPro-BoldSemiCn
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-BoldSemiCn
       Flags: Nonsymbolic
       FontBBox: -133, -250, 1161, 894
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: ArialMT7
      FirstChar: 32
      LastChar: 181
      FontDescriptor: 
       FontName: ArialMT7
       Flags: Nonsymbolic
       FontBBox: -665, -325, 2000, 1040
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MyriadPro-Semibold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Semibold
       Flags: Nonsymbolic
       FontBBox: -161, -250, 1198, 972
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: FUOHSN+Wingdings-Regular
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: FUOHSN+Wingdings-Regular
       Flags: Nonsymbolic
       FontBBox: 0, -103, 1359, 439
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: NVMCZS+ArialMT
      FontSubset: true
      FirstChar: 32
      LastChar: 181
      FontDescriptor: 
       FontName: NVMCZS+ArialMT
       Flags: Nonsymbolic
       FontBBox: -665, -325, 2000, 1040
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: ArialMT8
      FirstChar: 32
      LastChar: 181
      FontDescriptor: 
       FontName: ArialMT8
       Flags: Nonsymbolic
       FontBBox: -665, -325, 2000, 1040
       FontFile3: true
      Encoding: WinAnsiEncoding
    CIDFontType2: 
     Font: 
      BaseFont: SFZGRI+TimesNewRomanPSMT
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: SFZGRI+TimesNewRomanPSMT
       Flags: Serif, Symbolic
       FontBBox: -568, -307, 2046, 1040
       FontFile2: true
   XMP: <x:xmpmeta x:xmptk="Adobe XMP Core 5.6-c015 81.159809, 2016/11/11-01:42:16        " xmlns:x="adobe:ns:meta/">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about="" xmlns:author="http://springernature.com/ns/xmpExtensions/2.0/authorInfo/" xmlns:crossmark="http://crossref.org/crossmark/1.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:pdf="http://ns.adobe.com/pdf/1.3/" xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/" xmlns:pdfaField="http://www.aiim.org/pdfa/ns/field#" xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#" xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#" xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#" xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/" xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/" xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/" xmlns:sn="http://springernature.com/ns/xmpExtensions/2.0/" xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#" xmlns:xmp="http://ns.adobe.com/xap/1.0/" xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmp:CreateDate>2024-01-10T06:57:03</xmp:CreateDate>
         <xmp:CreatorTool>Adobe InDesign 15.1 (Windows)</xmp:CreatorTool>
         <xmp:ModifyDate>2024-01-17T11:28:01+01:00</xmp:ModifyDate>
         <xmp:MetadataDate>2024-01-17T11:28:01+01:00</xmp:MetadataDate>
         <pdf:Producer>Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)</pdf:Producer>
         <pdf:Keywords>Polyethylenimine;Transfection;Transient gene expression;HEK 293F cells;Recombinant protein</pdf:Keywords>
         <pdf:Trapped>False</pdf:Trapped>
         <dc:format>application/pdf</dc:format>
         <dc:identifier>https://doi.org/10.1007/s00253-024-13003-x</dc:identifier>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Springer Berlin Heidelberg</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Applied Microbiology and Biotechnology, https://doi.org/10.1007/s00253-024-13003-x</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>Polyethylenimine</rdf:li>
               <rdf:li>Transfection</rdf:li>
               <rdf:li>Transient gene expression</rdf:li>
               <rdf:li>HEK 293F cells</rdf:li>
               <rdf:li>Recombinant protein</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Tuning plasmid DNA amounts for cost-effective transfections of mammalian cells: when less is more</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li> Aida Carreño </rdf:li>
               <rdf:li> Rubén Guerrero-Yagüe </rdf:li>
               <rdf:li> Enriqueta Casal </rdf:li>
               <rdf:li> Rosa Mendoza </rdf:li>
               <rdf:li> José Luis Corchero </rdf:li>
            </rdf:Seq>
         </dc:creator>
         <crossmark:DOI>10.1007/s00253-024-13003-x</crossmark:DOI>
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
         <prism:url>https://doi.org/10.1007/s00253-024-13003-x</prism:url>
         <prism:doi>10.1007/s00253-024-13003-x</prism:doi>
         <prism:issn>1432-0614</prism:issn>
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>Applied Microbiology and Biotechnology</prism:publicationName>
         <prism:copyright>Springer-Verlag GmbH Germany, part of Springer Nature</prism:copyright>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:doi>10.1007/s00253-024-13003-x</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
         <xmpMM:DocumentID>uuid:1b6d4ba1-64ad-4dba-a0f6-72227d4ca6c6</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:1c40a539-30ac-4ee9-957f-ebe08b758ca2</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:1b6d4ba1-64ad-4dba-a0f6-72227d4ca6c6</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2024-01-10T15:27:18Z</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
         <sn:authorInfo>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <author:name> Aida Carreño </author:name>
                  <author:orcid>http://orcid.org/0000-0001-7725-7515</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name> Rubén Guerrero-Yagüe </author:name>
                  <author:orcid>http://orcid.org/0000-0002-6012-2734</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name> Enriqueta Casal </author:name>
                  <author:orcid>http://orcid.org/0000-0002-0334-0380</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name> Rosa Mendoza </author:name>
                  <author:orcid>http://orcid.org/0000-0002-0488-4814</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name> José Luis Corchero </author:name>
                  <author:orcid>http://orcid.org/0000-0002-6109-144X</author:orcid>
               </rdf:li>
            </rdf:Bag>
         </sn:authorInfo>
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe Document Info PDF eXtension Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:MajorVersionDate</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkMajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:DOI</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrosMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>robots</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://crossref.org/crossmark/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>crossmark</pdfaSchema:prefix>
                  <pdfaSchema:schema>Crossmark Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Usual same as prism:doi</pdfaProperty:description>
                           <pdfaProperty:name>DOI</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The date when a publication was publishe.</pdfaProperty:description>
                           <pdfaProperty:name>MajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://prismstandard.org/namespaces/basic/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>prism</pdfaSchema:prefix>
                  <pdfaSchema:schema>Prism Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary.</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article.
The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). </pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version.</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Volume number</pdfaProperty:description>
                           <pdfaProperty:name>volume</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Issue number</pdfaProperty:description>
                           <pdfaProperty:name>number</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Starting page</pdfaProperty:description>
                           <pdfaProperty:name>startingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Ending page</pdfaProperty:description>
                           <pdfaProperty:name>endingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. </pdfaProperty:description>
                           <pdfaProperty:name>aggregationType</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.”</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Copyright</pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>DocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:schema>Springer Nature ORCID Schema</pdfaSchema:schema>
                  <pdfaSchema:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>sn</pdfaSchema:prefix>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:name>authorInfo</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag AuthorInformation</pdfaProperty:valueType>
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Author information: contains the name of each author and his/her ORCiD (ORCiD: Open Researcher and Contributor ID). An ORCiD is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors.</pdfaProperty:description>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:type>AuthorInformation</pdfaType:type>
                           <pdfaType:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/authorInfo/</pdfaType:namespaceURI>
                           <pdfaType:prefix>author</pdfaType:prefix>
                           <pdfaType:description>Specifies the types of author information: name and ORCID of an author.</pdfaType:description>
                           <pdfaType:field>
                              <rdf:Seq>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>name</pdfaField:name>
                                    <pdfaField:valueType>Text</pdfaField:valueType>
                                    <pdfaField:description>Gives the name of an author.</pdfaField:description>
                                 </rdf:li>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>orcid</pdfaField:name>
                                    <pdfaField:valueType>URI</pdfaField:valueType>
                                    <pdfaField:description>Gives the ORCID of an author.</pdfaField:description>
                                 </rdf:li>
                              </rdf:Seq>
                           </pdfaType:field>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 114, 634, 127, 622
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 237, 634, 249, 622
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 328, 634, 341, 622
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 416, 634, 428, 622
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 525, 634, 537, 622
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 513, 726, 546, 694
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 238, 571, 259, 556
       Flags: Print
       AppearanceDictionary: true
       Destination: 267
      Annotation: 
       Subtype: Link
       Rect: 76, 559, 97, 544
       Flags: Print
       AppearanceDictionary: true
       Destination: 267
      Annotation: 
       Subtype: Link
       Rect: 51, 421, 71, 406
       Flags: Print
       AppearanceDictionary: true
       Destination: 267
      Annotation: 
       Subtype: Link
       Rect: 164, 421, 185, 406
       Flags: Print
       AppearanceDictionary: true
       Destination: 267
      Annotation: 
       Subtype: Link
       Rect: 51, 284, 71, 269
       Flags: Print
       AppearanceDictionary: true
       Destination: 267
      Annotation: 
       Subtype: Link
       Rect: 216, 284, 237, 269
       Flags: Print
       AppearanceDictionary: true
       Destination: 239
      Annotation: 
       Subtype: Link
       Rect: 74, 271, 95, 256
       Flags: Print
       AppearanceDictionary: true
       Destination: 267
      Annotation: 
       Subtype: Link
       Rect: 388, 548, 409, 533
       Flags: Print
       AppearanceDictionary: true
       Destination: 267
      Annotation: 
       Subtype: Link
       Rect: 477, 548, 498, 533
       Flags: Print
       AppearanceDictionary: true
       Destination: 239
      Annotation: 
       Subtype: Link
       Rect: 334, 535, 354, 520
       Flags: Print
       AppearanceDictionary: true
       Destination: 267
      Annotation: 
       Subtype: Link
       Rect: 329, 435, 350, 420
       Flags: Print
       AppearanceDictionary: true
       Destination: 267
      Annotation: 
       Subtype: Link
       Rect: 420, 435, 440, 420
       Flags: Print
       AppearanceDictionary: true
       Destination: 267
      Annotation: 
       Subtype: Link
       Rect: 333, 223, 355, 208
       Flags: Print
       AppearanceDictionary: true
       Destination: 239
     Thumb: true
    Page: 
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 51, 624, 71, 609
       Flags: Print
       AppearanceDictionary: true
       Destination: 239
      Annotation: 
       Subtype: Link
       Rect: 190, 549, 289, 534
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 51, 536, 71, 521
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 103, 374, 108, 359
       Flags: Print
       AppearanceDictionary: true
       Destination: 47
      Annotation: 
       Subtype: Link
       Rect: 453, 485, 474, 470
       Flags: Print
       AppearanceDictionary: true
       Destination: 239
     Thumb: true
    Page: 
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 420, 724, 440, 709
       Flags: Print
       AppearanceDictionary: true
       Destination: 267
      Annotation: 
       Subtype: Link
       Rect: 510, 724, 530, 709
       Flags: Print
       AppearanceDictionary: true
       Destination: 267
      Annotation: 
       Subtype: Link
       Rect: 359, 649, 364, 634
       Flags: Print
       AppearanceDictionary: true
       Destination: 66
      Annotation: 
       Subtype: Link
       Rect: 427, 411, 432, 396
       Flags: Print
       AppearanceDictionary: true
       Destination: 86
     Thumb: true
    Page: 
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 248, 99, 253, 84
       Flags: Print
       AppearanceDictionary: true
       Destination: 86
      Annotation: 
       Subtype: Link
       Rect: 535, 199, 540, 184
       Flags: Print
       AppearanceDictionary: true
       Destination: 86
      Annotation: 
       Subtype: Link
       Rect: 457, 99, 462, 84
       Flags: Print
       AppearanceDictionary: true
       Destination: 122
     Thumb: true
    Page: 
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 327, 599, 332, 584
       Flags: Print
       AppearanceDictionary: true
       Destination: 122
     Thumb: true
    Page: 
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 233, 736, 254, 721
       Flags: Print
       AppearanceDictionary: true
       Destination: 239
      Annotation: 
       Subtype: Link
       Rect: 72, 724, 92, 709
       Flags: Print
       AppearanceDictionary: true
       Destination: 267
      Annotation: 
       Subtype: Link
       Rect: 171, 724, 191, 709
       Flags: Print
       AppearanceDictionary: true
       Destination: 267
      Annotation: 
       Subtype: Link
       Rect: 263, 724, 283, 709
       Flags: Print
       AppearanceDictionary: true
       Destination: 267
      Annotation: 
       Subtype: Link
       Rect: 73, 674, 93, 659
       Flags: Print
       AppearanceDictionary: true
       Destination: 267
      Annotation: 
       Subtype: Link
       Rect: 264, 649, 269, 634
       Flags: Print
       AppearanceDictionary: true
       Destination: 146
      Annotation: 
       Subtype: Link
       Rect: 280, 474, 285, 459
       Flags: Print
       AppearanceDictionary: true
       Destination: 146
      Annotation: 
       Subtype: Link
       Rect: 460, 399, 465, 384
       Flags: Print
       AppearanceDictionary: true
       Destination: 176
     Thumb: true
    Page: 
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 193, 336, 213, 321
       Flags: Print
       AppearanceDictionary: true
       Destination: 267
      Annotation: 
       Subtype: Link
       Rect: 51, 324, 71, 309
       Flags: Print
       AppearanceDictionary: true
       Destination: 267
      Annotation: 
       Subtype: Link
       Rect: 80, 211, 100, 196
       Flags: Print
       AppearanceDictionary: true
       Destination: 267
      Annotation: 
       Subtype: Link
       Rect: 262, 186, 283, 171
       Flags: Print
       AppearanceDictionary: true
       Destination: 267
      Annotation: 
       Subtype: Link
       Rect: 181, 111, 202, 96
       Flags: Print
       AppearanceDictionary: true
       Destination: 267
      Annotation: 
       Subtype: Link
       Rect: 518, 524, 538, 509
       Flags: Print
       AppearanceDictionary: true
       Destination: 239
      Annotation: 
       Subtype: Link
       Rect: 521, 499, 541, 484
       Flags: Print
       AppearanceDictionary: true
       Destination: 239
      Annotation: 
       Subtype: Link
       Rect: 363, 486, 383, 471
       Flags: Print
       AppearanceDictionary: true
       Destination: 239
      Annotation: 
       Subtype: Link
       Rect: 450, 386, 471, 371
       Flags: Print
       AppearanceDictionary: true
       Destination: 267
      Annotation: 
       Subtype: Link
       Rect: 327, 299, 347, 284
       Flags: Print
       AppearanceDictionary: true
       Destination: 267
      Annotation: 
       Subtype: Link
       Rect: 410, 249, 430, 234
       Flags: Print
       AppearanceDictionary: true
       Destination: 267
      Annotation: 
       Subtype: Link
       Rect: 486, 249, 506, 234
       Flags: Print
       AppearanceDictionary: true
       Destination: 239
      Annotation: 
       Subtype: Link
       Rect: 328, 236, 348, 221
       Flags: Print
       AppearanceDictionary: true
       Destination: 239
      Annotation: 
       Subtype: Link
       Rect: 409, 236, 430, 221
       Flags: Print
       AppearanceDictionary: true
       Destination: 267
      Annotation: 
       Subtype: Link
       Rect: 487, 236, 507, 221
       Flags: Print
       AppearanceDictionary: true
       Destination: 267
      Annotation: 
       Subtype: Link
       Rect: 518, 174, 538, 159
       Flags: Print
       AppearanceDictionary: true
       Destination: 267
     Thumb: true
    Page: 
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 131, 724, 152, 709
       Flags: Print
       AppearanceDictionary: true
       Destination: 267
      Annotation: 
       Subtype: Link
       Rect: 51, 686, 71, 671
       Flags: Print
       AppearanceDictionary: true
       Destination: 267
      Annotation: 
       Subtype: Link
       Rect: 263, 674, 283, 659
       Flags: Print
       AppearanceDictionary: true
       Destination: 267
      Annotation: 
       Subtype: Link
       Rect: 83, 511, 103, 496
       Flags: Print
       AppearanceDictionary: true
       Destination: 267
      Annotation: 
       Subtype: Link
       Rect: 220, 336, 240, 321
       Flags: Print
       AppearanceDictionary: true
       Destination: 267
      Annotation: 
       Subtype: Link
       Rect: 217, 236, 237, 221
       Flags: Print
       AppearanceDictionary: true
       Destination: 267
      Annotation: 
       Subtype: Link
       Rect: 472, 511, 492, 496
       Flags: Print
       AppearanceDictionary: true
       Destination: 239
      Annotation: 
       Subtype: Link
       Rect: 376, 474, 396, 459
       Flags: Print
       AppearanceDictionary: true
       Destination: 239
      Annotation: 
       Subtype: Link
       Rect: 424, 111, 443, 96
       Flags: Print
       AppearanceDictionary: true
       Destination: 267
      Annotation: 
       Subtype: Link
       Rect: 496, 111, 516, 96
       Flags: Print
       AppearanceDictionary: true
       Destination: 267
      Annotation: 
       Subtype: Link
       Rect: 416, 86, 436, 71
       Flags: Print
       AppearanceDictionary: true
       Destination: 267
      Annotation: 
       Subtype: Link
       Rect: 482, 86, 502, 71
       Flags: Print
       AppearanceDictionary: true
       Destination: 267
     Thumb: true
    Page: 
     Sequence: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 53, 512, 284, 499
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 51, 482, 253, 469
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 392, 554, 542, 541
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 386, 413, 506, 400
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 382, 293, 544, 280
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 372, 253, 482, 240
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 519, 183, 544, 170
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 173, 441, 160
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 228, 736, 289, 723
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 726, 155, 713
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 105, 686, 220, 673
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 125, 666, 269, 653
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 159, 626, 289, 613
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 616, 91, 603
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 586, 190, 573
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 89, 536, 206, 523
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 206, 506, 289, 493
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 496, 96, 483
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 252, 436, 289, 423
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 426, 190, 413
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 208, 396, 289, 383
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 386, 145, 373
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 184, 346, 289, 333
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 336, 112, 323
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 173, 306, 289, 293
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 208, 276, 289, 263
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 266, 147, 253
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 228, 226, 289, 213
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 216, 176, 203
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 160, 146, 289, 133
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 136, 96, 123
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 377, 726, 513, 713
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 492, 686, 544, 673
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 676, 386, 663
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 507, 636, 544, 623
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 626, 445, 613
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 434, 606, 543, 593
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 566, 477, 553
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 463, 506, 544, 493
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 496, 370, 483
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 519, 466, 544, 453
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 456, 447, 443
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 450, 416, 544, 403
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 406, 395, 393
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 364, 366, 473, 353
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 455, 336, 544, 323
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 326, 390, 313
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 494, 296, 544, 283
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 286, 436, 273
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 462, 196, 544, 183
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 186, 379, 173
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
  Checksum: 1ce94366
   Type: CRC32
  Checksum: ababf753ead8f173a40df5a6160c1ef4
   Type: MD5
  Checksum: 459267eb56ffeb4e7d7acae80ed4a0209da5fc17
   Type: SHA-1
  Checksum: 6a58150960a4a5f2cc71c66da84d7d29cba5aa3c7f38bed149faf48ab625d9ec
   Type: SHA-256