c6c6df04cce6479e03f0815861cb6729 pmc_10791984.pdf 7546d1512fa19aff77b9b8c5bcc6d0ec8f7f9c2e pmc_10791984.pdf 4117a376b22d67f8c9131aaa31c4b9fe1028290ee440b78af040b7e45f52eca1 pmc_10791984.pdf Creator: Arbortext Advanced Print Publisher 9.1.510/W Unicode Producer: Acrobat Distiller 7.0 (Windows) CreationDate: Tue Dec 19 18:04:25 2023 CET ModDate: Tue Dec 19 18:04:25 2023 CET Custom Metadata: no Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 14 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 3303918 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- EOEGID+AdvOTd3a5f740 Type 1C WinAnsi yes yes no 755 0 EOEGIE+AdvOTd3a5f740+20 Type 1C WinAnsi yes yes no 756 0 EOEGIF+AdvOTd3a5f740+fb Type 1C Custom yes yes yes 757 0 EOEGIG+AdvOT9b12cd41 Type 1C WinAnsi yes yes no 758 0 EOEGJG+AdvOT9b12cd41+20 Type 1C WinAnsi yes yes no 759 0 EOEGJH+AdvOT9b12cd41+fb Type 1C Custom yes yes yes 760 0 EOEGJI+AdvOTd168d80a.I Type 1C WinAnsi yes yes no 761 0 EOEGJJ+AdvOTd168d80a.I+22 Type 1C Custom yes yes no 762 0 EOEGKK+AdvOT2c8ce45a Type 1C WinAnsi yes yes no 763 0 EOEIKB+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 775 0 EOEIKC+AdvOT7d6df7ab.I+22 Type 1C Custom yes yes no 776 0 EOEIKD+AdvOT1ef757c0+22 Type 1C Custom yes yes no 777 0 EOEILE+AdvOT1ef757c0+20 Type 1C WinAnsi yes yes no 778 0 EOEILF+AdvOT1ef757c0+03 Type 1C Custom yes yes yes 779 0 EOEIIP+AdvOT1ef757c0 Type 1C WinAnsi yes yes no 780 0 EOEIJA+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 781 0 EOEIOF+AdvOT310e2d14+22 Type 1C Custom yes yes yes 782 0 EOEIPF+AdvOT310e2d14 Type 1C WinAnsi yes yes no 783 0 EOEJCF+AdvOT1ef757c0+21 Type 1C WinAnsi yes yes no 784 0 EOEJDG+AdvOT310e2d14+20 Type 1C Custom yes yes yes 785 0 EOEJDH+AdvOT310e2d14+03 Type 1C Custom yes yes yes 786 0 EOEOJH+AdvOT2c8ce45a+20 Type 1C WinAnsi yes yes no 789 0 EOGNDL+AdvOTb65e897d.B Type 1C WinAnsi yes yes no 796 0 EOHCGN+AdvOTc8b77491.I+22 Type 1C Custom yes yes no 797 0 EOHCGO+AdvOTc8b77491.I Type 1C WinAnsi yes yes no 798 0 EOHDAL+AdvOT1ef757c0+01 Type 1C Custom yes yes no 799 0 EOHDBL+AdvOT9b12cd41+22 Type 1C Custom yes yes no 800 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-06-21 02:48:03 CEST RepresentationInformation: pmc_10791984.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-06-20 02:37:22 CEST Size: 3303918 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 944 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: SIRT7 and p53 interaction in embryonic development and tumorigenesis Destination: titlink1 Children: Item: Title: Introduction Destination: flink1 Item: Title: Material and methods Destination: flink2 Children: Item: Title: Mice Destination: slink1 Item: Title: Cell culture, infections, and transfections Destination: slink2 Item: Title: Colony formation Destination: slink3 Item: Title: Wound-healing assay Destination: slink4 Item: Title: Apoptosis assay Destination: slink5 Item: Title: Histopathology Destination: slink6 Item: Title: Patient survival analysis Destination: slink7 Item: Title: RNA-seq analysis Destination: slink8 Item: Title: RNA isolation and quantitative PCR Destination: slink9 Item: Title: Results Destination: flink3 Children: Item: Title: Loss of p53 exacerbates embryonic lethality of SIRT7 deficient mice Destination: slink10 Item: Title: SIRT7 deficiency increases tumor formation in the absence of p53 Destination: slink11 Item: Title: SIRT7 levels predict patient outcome in some tumors with p53 mutations Destination: slink12 Item: Title: Synergistic effect of SIRT7 and p53 on extracellular matrix gene expression regulation in tumor and embryonic cells Destination: slink13 Item: Title: SIRT7 and p53 co-depletion increases cellular migration in immortalized MEFs Destination: slink14 Item: Title: Discussion Destination: flink4 Item: Title: Data availability statement Destination: flink5 Item: Title: Ethics statement Destination: flink6 Item: Title: Author contributions Destination: flink7 Item: Title: Funding Destination: flink8 Item: Title: Acknowledgments Destination: slink15 Item: Title: Conflict of interest Destination: flink9 Item: Title: Publisher’s note Destination: flink10 Item: Title: Supplementary material Destination: flink11 Item: Title: References Destination: rlink1 Info: Creator: Arbortext Advanced Print Publisher 9.1.510/W Unicode Producer: Acrobat Distiller 7.0 (Windows) CreationDate: Tue Dec 19 18:34:25 CET 2023 ModDate: Tue Dec 19 18:34:25 CET 2023 ID: 0x92d45c9424a5f675361ddec1564ec99e, 0x0571814f31e3a24393c892b3a1ca6eac Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1978 ImageHeight: 1030 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1978 ImageHeight: 1075 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2006 ImageHeight: 1032 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1749 ImageHeight: 1710 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1983 ImageHeight: 815 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2006 ImageHeight: 1002 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1978 ImageHeight: 1089 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Fonts: Type1: Font: BaseFont: EOEIKB+AdvOT7d6df7ab.I FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: EOEIKB+AdvOT7d6df7ab.I Flags: Serif, Nonsymbolic FontBBox: -135, -250, 1000, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EOEIKC+AdvOT7d6df7ab.I+22 FontSubset: true FirstChar: 21 LastChar: 21 FontDescriptor: FontName: EOEIKC+AdvOT7d6df7ab.I+22 Flags: Nonsymbolic FontBBox: -156, -166, 750, 916 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: EOEIKD+AdvOT1ef757c0+22 FontSubset: true FirstChar: 21 LastChar: 21 FontDescriptor: FontName: EOEIKD+AdvOT1ef757c0+22 Flags: Nonsymbolic FontBBox: -135, -166, 697, 916 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: EOEILE+AdvOT1ef757c0+20 FontSubset: true FirstChar: 146 LastChar: 151 FontDescriptor: FontName: EOEILE+AdvOT1ef757c0+20 Flags: Nonsymbolic FontBBox: -135, -187, 1010, 833 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EOEILF+AdvOT1ef757c0+03 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: EOEILF+AdvOT1ef757c0+03 Flags: Symbolic FontBBox: -125, -270, 854, 791 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EOEIIP+AdvOT1ef757c0 FontSubset: true FirstChar: 35 LastChar: 126 FontDescriptor: FontName: EOEIIP+AdvOT1ef757c0 Flags: Serif, Nonsymbolic FontBBox: -20, -250, 947, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EOEIJA+AdvOT1ef757c0+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: EOEIJA+AdvOT1ef757c0+fb Flags: Symbolic FontBBox: 0, -10, 781, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EOEIOF+AdvOT310e2d14+22 FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: EOEIOF+AdvOT310e2d14+22 Flags: Symbolic FontBBox: -135, -385, 1333, 895 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EOEIPF+AdvOT310e2d14 FontSubset: true FirstChar: 60 LastChar: 62 FontDescriptor: FontName: EOEIPF+AdvOT310e2d14 Flags: Nonsymbolic FontBBox: -20, -427, 1541, 1062 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EOEJCF+AdvOT1ef757c0+21 FontSubset: true FirstChar: 153 LastChar: 153 FontDescriptor: FontName: EOEJCF+AdvOT1ef757c0+21 Flags: Nonsymbolic FontBBox: 0, -20, 822, 697 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EOEJDG+AdvOT310e2d14+20 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: EOEJDG+AdvOT310e2d14+20 Flags: Symbolic FontBBox: -1187, -427, 1541, 1062 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EOEJDH+AdvOT310e2d14+03 FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: EOEJDH+AdvOT310e2d14+03 Flags: Symbolic FontBBox: -437, -427, 1541, 1062 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EOEOJH+AdvOT2c8ce45a+20 FontSubset: true FirstChar: 150 LastChar: 150 FontDescriptor: FontName: EOEOJH+AdvOT2c8ce45a+20 Flags: Nonsymbolic FontBBox: -125, -166, 1125, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EOGNDL+AdvOTb65e897d.B FontSubset: true FirstChar: 44 LastChar: 44 FontDescriptor: FontName: EOGNDL+AdvOTb65e897d.B Flags: Nonsymbolic FontBBox: -20, -250, 968, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EOHCGN+AdvOTc8b77491.I+22 FontSubset: true FirstChar: 21 LastChar: 21 FontDescriptor: FontName: EOHCGN+AdvOTc8b77491.I+22 Flags: Nonsymbolic FontBBox: -52, -177, 510, 697 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: EOHCGO+AdvOTc8b77491.I FontSubset: true FirstChar: 47 LastChar: 47 FontDescriptor: FontName: EOHCGO+AdvOTc8b77491.I Flags: Nonsymbolic FontBBox: -145, -208, 1020, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EOHDAL+AdvOT1ef757c0+01 FontSubset: true FirstChar: 20 LastChar: 20 FontDescriptor: FontName: EOHDAL+AdvOT1ef757c0+01 Flags: Nonsymbolic FontBBox: -20, -250, 947, 854 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: EOHDBL+AdvOT9b12cd41+22 FontSubset: true FirstChar: 21 LastChar: 21 FontDescriptor: FontName: EOHDBL+AdvOT9b12cd41+22 Flags: Nonsymbolic FontBBox: 0, -156, 552, 697 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: EOEGID+AdvOTd3a5f740 FontSubset: true FirstChar: 42 LastChar: 225 FontDescriptor: FontName: EOEGID+AdvOTd3a5f740 Flags: Nonsymbolic FontBBox: -52, -208, 916, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EOEGIE+AdvOTd3a5f740+20 FontSubset: true FirstChar: 134 LastChar: 146 FontDescriptor: FontName: EOEGIE+AdvOTd3a5f740+20 Flags: Nonsymbolic FontBBox: -114, -166, 1062, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EOEGIF+AdvOTd3a5f740+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: EOEGIF+AdvOTd3a5f740+fb Flags: Symbolic FontBBox: 0, 0, 906, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EOEGIG+AdvOT9b12cd41 FontSubset: true FirstChar: 37 LastChar: 242 FontDescriptor: FontName: EOEGIG+AdvOT9b12cd41 Flags: Nonsymbolic FontBBox: -52, -208, 906, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EOEGJG+AdvOT9b12cd41+20 FontSubset: true FirstChar: 134 LastChar: 150 FontDescriptor: FontName: EOEGJG+AdvOT9b12cd41+20 Flags: Nonsymbolic FontBBox: -114, -166, 1010, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EOEGJH+AdvOT9b12cd41+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: EOEGJH+AdvOT9b12cd41+fb Flags: Symbolic FontBBox: 0, 0, 854, 697 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EOEGJI+AdvOTd168d80a.I FontSubset: true FirstChar: 43 LastChar: 118 FontDescriptor: FontName: EOEGJI+AdvOTd168d80a.I Flags: Nonsymbolic FontBBox: -145, -208, 968, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EOEGJJ+AdvOTd168d80a.I+22 FontSubset: true FirstChar: 21 LastChar: 21 FontDescriptor: FontName: EOEGJJ+AdvOTd168d80a.I+22 Flags: Nonsymbolic FontBBox: -52, -156, 489, 697 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: EOEGKK+AdvOT2c8ce45a FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: EOEGKK+AdvOT2c8ce45a Flags: Nonsymbolic FontBBox: -52, -208, 947, 895 FontFile3: true Encoding: WinAnsiEncoding Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 219, 688, 494, 709 Annotation: Subtype: Link Rect: 219, 663, 499, 684 Annotation: Subtype: Link Rect: 219, 638, 355, 659 Annotation: Subtype: Link Rect: 49, 694, 121, 708 Annotation: Subtype: Link Rect: 49, 552, 53, 556 Annotation: Subtype: Link Rect: 56, 550, 156, 557 Annotation: Subtype: Link Rect: 49, 534, 53, 538 Annotation: Subtype: Link Rect: 56, 533, 169, 540 Annotation: Subtype: Link Rect: 63, 382, 150, 389 Annotation: Subtype: Link Rect: 124, 313, 150, 320 Annotation: Subtype: Link Rect: 49, 304, 171, 311 Annotation: Subtype: Link Rect: 49, 33, 192, 40 Annotation: Subtype: Link Rect: 499, 33, 545, 40 Annotation: Subtype: Link Rect: 49, 787, 314, 801 Annotation: Subtype: Link Rect: 446, 800, 459, 805 Annotation: Subtype: Link Rect: 459, 799, 517, 806 Annotation: Subtype: Link Rect: 458, 781, 545, 788 Thumb: true Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 208, 715, 285, 724 Destination: 30 Annotation: Subtype: Link Rect: 173, 691, 238, 700 Destination: 30 Annotation: Subtype: Link Rect: 93, 643, 209, 652 Destination: 31 Annotation: Subtype: Link Rect: 241, 607, 290, 616 Destination: 31 Annotation: Subtype: Link Rect: 49, 595, 114, 604 Destination: 31 Annotation: Subtype: Link Rect: 218, 560, 288, 569 Destination: 30 Annotation: Subtype: Link Rect: 49, 548, 131, 557 Destination: 30 Annotation: Subtype: Link Rect: 265, 500, 290, 509 Destination: 30 Annotation: Subtype: Link Rect: 49, 488, 162, 497 Destination: 30 Annotation: Subtype: Link Rect: 273, 452, 290, 461 Destination: 30 Annotation: Subtype: Link Rect: 49, 440, 122, 449 Destination: 30 Annotation: Subtype: Link Rect: 127, 440, 202, 449 Destination: 30 Annotation: Subtype: Link Rect: 136, 416, 285, 425 Destination: 30 Annotation: Subtype: Link Rect: 171, 392, 252, 401 Destination: 30 Annotation: Subtype: Link Rect: 259, 392, 290, 401 Destination: 30 Annotation: Subtype: Link Rect: 49, 380, 95, 389 Destination: 30 Annotation: Subtype: Link Rect: 102, 380, 184, 389 Destination: 30 Annotation: Subtype: Link Rect: 91, 332, 147, 341 Destination: 30 Annotation: Subtype: Link Rect: 154, 332, 233, 341 Destination: 30 Annotation: Subtype: Link Rect: 52, 237, 151, 246 Destination: 30 Annotation: Subtype: Link Rect: 159, 237, 224, 246 Destination: 30 Annotation: Subtype: Link Rect: 248, 225, 290, 234 Destination: 30 Annotation: Subtype: Link Rect: 49, 213, 66, 222 Destination: 30 Annotation: Subtype: Link Rect: 168, 213, 223, 222 Destination: 30 Annotation: Subtype: Link Rect: 147, 117, 222, 126 Destination: 30 Annotation: Subtype: Link Rect: 76, 105, 149, 114 Destination: 30 Annotation: Subtype: Link Rect: 153, 105, 221, 114 Destination: 30 Annotation: Subtype: Link Rect: 100, 81, 170, 90 Destination: 30 Annotation: Subtype: Link Rect: 366, 739, 460, 748 Destination: 30 Annotation: Subtype: Link Rect: 349, 512, 408, 521 Destination: 30 Annotation: Subtype: Link Rect: 458, 189, 540, 198 Destination: 30 Annotation: Subtype: Link Rect: 505, 165, 545, 174 Destination: 30 Annotation: Subtype: Link Rect: 304, 153, 321, 162 Destination: 30 Annotation: Subtype: Link Rect: 49, 33, 192, 40 Annotation: Subtype: Link Rect: 499, 33, 545, 40 Annotation: Subtype: Link Rect: 457, 799, 545, 806 Thumb: true Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 464, 524, 545, 533 Annotation: Subtype: Link Rect: 304, 512, 316, 521 Annotation: Subtype: Link Rect: 324, 512, 389, 521 Destination: 30 Annotation: Subtype: Link Rect: 393, 512, 446, 521 Destination: 30 Annotation: Subtype: Link Rect: 387, 213, 457, 222 Destination: 30 Annotation: Subtype: Link Rect: 461, 213, 527, 222 Destination: 30 Annotation: Subtype: Link Rect: 466, 189, 527, 198 Destination: 30 Annotation: Subtype: Link Rect: 508, 165, 545, 174 Destination: 30 Annotation: Subtype: Link Rect: 304, 153, 321, 162 Destination: 30 Annotation: Subtype: Link Rect: 371, 117, 422, 126 Destination: 30 Annotation: Subtype: Link Rect: 434, 105, 499, 114 Destination: 30 Annotation: Subtype: Link Rect: 49, 33, 192, 40 Annotation: Subtype: Link Rect: 499, 33, 545, 40 Annotation: Subtype: Link Rect: 457, 799, 545, 806 Thumb: true Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 213, 739, 267, 748 Destination: 30 Annotation: Subtype: Link Rect: 193, 655, 250, 664 Destination: 31 Annotation: Subtype: Link Rect: 118, 595, 168, 604 Destination: 31 Annotation: Subtype: Link Rect: 138, 560, 290, 569 Annotation: Subtype: Link Rect: 49, 548, 71, 557 Annotation: Subtype: Link Rect: 202, 81, 274, 90 Destination: 30 Annotation: Subtype: Link Rect: 378, 751, 452, 760 Destination: 30 Annotation: Subtype: Link Rect: 387, 727, 503, 736 Destination: 31 Annotation: Subtype: Link Rect: 465, 691, 500, 700 Destination: 22 Annotation: Subtype: Link Rect: 438, 679, 522, 688 Destination: 30 Annotation: Subtype: Link Rect: 336, 619, 422, 628 Destination: 30 Annotation: Subtype: Link Rect: 411, 560, 449, 569 Destination: 22 Annotation: Subtype: Link Rect: 307, 500, 357, 509 Destination: 22 Annotation: Subtype: Link Rect: 307, 488, 380, 497 Destination: 30 Annotation: Subtype: Link Rect: 495, 428, 531, 437 Destination: 22 Annotation: Subtype: Link Rect: 307, 392, 344, 401 Destination: 22 Annotation: Subtype: Link Rect: 400, 297, 472, 306 Destination: 30 Annotation: Subtype: Link Rect: 307, 285, 403, 294 Destination: 29 Annotation: Subtype: Link Rect: 464, 177, 545, 186 Destination: 29 Annotation: Subtype: Link Rect: 304, 165, 313, 174 Destination: 29 Annotation: Subtype: Link Rect: 411, 153, 490, 162 Destination: 30 Annotation: Subtype: Link Rect: 407, 93, 474, 102 Destination: 30 Annotation: Subtype: Link Rect: 479, 93, 540, 102 Destination: 30 Annotation: Subtype: Link Rect: 49, 33, 192, 40 Annotation: Subtype: Link Rect: 499, 33, 545, 40 Annotation: Subtype: Link Rect: 457, 799, 545, 806 Thumb: true Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 222, 345, 285, 354 Destination: 30 Annotation: Subtype: Link Rect: 151, 298, 188, 307 Destination: 22 Annotation: Subtype: Link Rect: 52, 238, 159, 247 Destination: 29 Annotation: Subtype: Link Rect: 199, 214, 232, 223 Destination: 23 Annotation: Subtype: Link Rect: 227, 190, 266, 199 Destination: 23 Annotation: Subtype: Link Rect: 136, 130, 185, 139 Destination: 23 Annotation: Subtype: Link Rect: 248, 106, 285, 115 Destination: 23 Annotation: Subtype: Link Rect: 436, 202, 504, 211 Destination: 30 Annotation: Subtype: Link Rect: 509, 202, 545, 211 Destination: 30 Annotation: Subtype: Link Rect: 304, 190, 321, 199 Destination: 30 Annotation: Subtype: Link Rect: 374, 166, 408, 175 Destination: 24 Annotation: Subtype: Link Rect: 507, 142, 540, 151 Destination: 24 Annotation: Subtype: Link Rect: 409, 71, 445, 79 Destination: 24 Annotation: Subtype: Link Rect: 49, 33, 192, 40 Annotation: Subtype: Link Rect: 499, 33, 545, 40 Annotation: Subtype: Link Rect: 457, 799, 545, 806 Thumb: true Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 210, 321, 248, 330 Destination: 24 Annotation: Subtype: Link Rect: 155, 261, 204, 270 Destination: 24 Annotation: Subtype: Link Rect: 52, 213, 181, 222 Destination: 29 Annotation: Subtype: Link Rect: 108, 153, 139, 162 Destination: 25 Annotation: Subtype: Link Rect: 204, 129, 239, 138 Destination: 25 Annotation: Subtype: Link Rect: 213, 94, 248, 103 Destination: 25 Annotation: Subtype: Link Rect: 248, 70, 285, 79 Destination: 25 Annotation: Subtype: Link Rect: 440, 381, 540, 390 Destination: 30 Annotation: Subtype: Link Rect: 500, 345, 540, 354 Destination: 25 Annotation: Subtype: Link Rect: 374, 273, 420, 282 Destination: 25 Annotation: Subtype: Link Rect: 49, 33, 192, 40 Annotation: Subtype: Link Rect: 499, 33, 545, 40 Annotation: Subtype: Link Rect: 457, 799, 545, 806 Thumb: true Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 141, 369, 171, 378 Destination: 26 Annotation: Subtype: Link Rect: 176, 369, 285, 378 Destination: 29 Annotation: Subtype: Link Rect: 269, 345, 290, 354 Destination: 30 Annotation: Subtype: Link Rect: 49, 333, 117, 342 Destination: 30 Annotation: Subtype: Link Rect: 196, 321, 231, 330 Destination: 26 Annotation: Subtype: Link Rect: 236, 321, 290, 330 Destination: 29 Annotation: Subtype: Link Rect: 49, 309, 109, 318 Destination: 29 Annotation: Subtype: Link Rect: 101, 273, 138, 282 Destination: 26 Annotation: Subtype: Link Rect: 144, 273, 243, 282 Destination: 29 Annotation: Subtype: Link Rect: 109, 261, 206, 270 Destination: 29 Annotation: Subtype: Link Rect: 206, 201, 285, 210 Destination: 31 Annotation: Subtype: Link Rect: 248, 153, 290, 162 Destination: 30 Annotation: Subtype: Link Rect: 49, 141, 66, 150 Destination: 30 Annotation: Subtype: Link Rect: 181, 94, 285, 103 Destination: 29 Annotation: Subtype: Link Rect: 399, 297, 430, 306 Destination: 26 Annotation: Subtype: Link Rect: 337, 261, 373, 270 Destination: 26 Annotation: Subtype: Link Rect: 391, 141, 426, 150 Destination: 26 Annotation: Subtype: Link Rect: 421, 70, 459, 79 Destination: 26 Annotation: Subtype: Link Rect: 470, 70, 531, 79 Destination: 30 Annotation: Subtype: Link Rect: 538, 70, 545, 79 Destination: 30 Annotation: Subtype: Link Rect: 49, 33, 192, 40 Annotation: Subtype: Link Rect: 499, 33, 545, 40 Annotation: Subtype: Link Rect: 457, 799, 545, 806 Thumb: true Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 49, 170, 89, 179 Destination: 30 Annotation: Subtype: Link Rect: 93, 170, 147, 179 Destination: 30 Annotation: Subtype: Link Rect: 191, 135, 231, 144 Destination: 26 Annotation: Subtype: Link Rect: 190, 123, 225, 132 Destination: 26 Annotation: Subtype: Link Rect: 234, 123, 290, 132 Destination: 29 Annotation: Subtype: Link Rect: 49, 111, 115, 120 Destination: 29 Annotation: Subtype: Link Rect: 49, 33, 192, 40 Annotation: Subtype: Link Rect: 499, 33, 545, 40 Annotation: Subtype: Link Rect: 457, 799, 545, 806 Thumb: true Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 49, 33, 192, 40 Annotation: Subtype: Link Rect: 499, 33, 545, 40 Annotation: Subtype: Link Rect: 457, 799, 545, 806 Thumb: true Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 222, 357, 285, 366 Destination: 30 Annotation: Subtype: Link Rect: 221, 333, 251, 342 Destination: 27 Annotation: Subtype: Link Rect: 126, 309, 251, 318 Destination: 30 Annotation: Subtype: Link Rect: 259, 309, 290, 318 Destination: 30 Annotation: Subtype: Link Rect: 49, 297, 95, 306 Destination: 30 Annotation: Subtype: Link Rect: 129, 273, 167, 282 Destination: 26 Annotation: Subtype: Link Rect: 185, 249, 221, 258 Destination: 27 Annotation: Subtype: Link Rect: 257, 225, 288, 234 Destination: 26 Annotation: Subtype: Link Rect: 49, 213, 161, 222 Destination: 29 Annotation: Subtype: Link Rect: 163, 177, 217, 186 Destination: 27 Annotation: Subtype: Link Rect: 52, 153, 146, 162 Destination: 29 Annotation: Subtype: Link Rect: 52, 70, 146, 79 Destination: 29 Annotation: Subtype: Link Rect: 377, 309, 444, 318 Destination: 31 Annotation: Subtype: Link Rect: 308, 249, 360, 258 Destination: 27 Annotation: Subtype: Link Rect: 330, 213, 433, 222 Destination: 30 Annotation: Subtype: Link Rect: 436, 213, 505, 222 Destination: 30 Annotation: Subtype: Link Rect: 418, 165, 453, 174 Destination: 27 Annotation: Subtype: Link Rect: 468, 153, 543, 162 Destination: 30 Annotation: Subtype: Link Rect: 304, 141, 361, 150 Destination: 30 Annotation: Subtype: Link Rect: 423, 118, 477, 126 Destination: 31 Annotation: Subtype: Link Rect: 49, 33, 192, 40 Annotation: Subtype: Link Rect: 499, 33, 545, 40 Annotation: Subtype: Link Rect: 457, 799, 545, 806 Thumb: true Page: Label: 11 Annotations: Annotation: Subtype: Link Rect: 52, 691, 88, 700 Destination: 22 Annotation: Subtype: Link Rect: 154, 643, 220, 652 Destination: 30 Annotation: Subtype: Link Rect: 189, 631, 285, 640 Destination: 30 Annotation: Subtype: Link Rect: 122, 607, 185, 616 Destination: 30 Annotation: Subtype: Link Rect: 52, 536, 80, 545 Destination: 27 Annotation: Subtype: Link Rect: 52, 512, 90, 521 Destination: 26 Annotation: Subtype: Link Rect: 99, 512, 137, 521 Destination: 27 Annotation: Subtype: Link Rect: 146, 512, 241, 521 Destination: 29 Annotation: Subtype: Link Rect: 96, 428, 136, 437 Destination: 27 Annotation: Subtype: Link Rect: 140, 428, 145, 437 Destination: 27 Annotation: Subtype: Link Rect: 52, 404, 119, 413 Destination: 31 Annotation: Subtype: Link Rect: 123, 404, 174, 413 Destination: 31 Annotation: Subtype: Link Rect: 178, 404, 227, 413 Destination: 31 Annotation: Subtype: Link Rect: 146, 320, 207, 329 Destination: 30 Annotation: Subtype: Link Rect: 204, 297, 263, 306 Destination: 31 Annotation: Subtype: Link Rect: 267, 297, 290, 306 Destination: 30 Annotation: Subtype: Link Rect: 49, 285, 86, 294 Destination: 30 Annotation: Subtype: Link Rect: 90, 237, 125, 246 Destination: 23 Annotation: Subtype: Link Rect: 78, 213, 112, 222 Destination: 23 Annotation: Subtype: Link Rect: 52, 189, 125, 198 Destination: 30 Annotation: Subtype: Link Rect: 132, 189, 209, 198 Destination: 30 Annotation: Subtype: Link Rect: 215, 189, 285, 198 Destination: 30 Annotation: Subtype: Link Rect: 271, 153, 290, 162 Destination: 30 Annotation: Subtype: Link Rect: 49, 141, 93, 150 Destination: 30 Annotation: Subtype: Link Rect: 179, 117, 216, 126 Destination: 23 Annotation: Subtype: Link Rect: 52, 93, 137, 102 Destination: 30 Annotation: Subtype: Link Rect: 125, 81, 223, 90 Destination: 29 Annotation: Subtype: Link Rect: 340, 739, 416, 748 Destination: 30 Annotation: Subtype: Link Rect: 443, 643, 473, 652 Destination: 23 Annotation: Subtype: Link Rect: 366, 619, 425, 628 Destination: 30 Annotation: Subtype: Link Rect: 399, 524, 427, 533 Destination: 23 Annotation: Subtype: Link Rect: 337, 464, 401, 473 Destination: 30 Annotation: Subtype: Link Rect: 518, 428, 545, 437 Destination: 30 Annotation: Subtype: Link Rect: 304, 416, 344, 425 Destination: 30 Annotation: Subtype: Link Rect: 349, 416, 416, 425 Destination: 30 Annotation: Subtype: Link Rect: 421, 416, 487, 425 Destination: 30 Annotation: Subtype: Link Rect: 360, 380, 460, 389 Destination: 30 Annotation: Subtype: Link Rect: 491, 368, 545, 377 Destination: 30 Annotation: Subtype: Link Rect: 304, 356, 321, 365 Destination: 30 Annotation: Subtype: Link Rect: 307, 309, 368, 317 Destination: 30 Annotation: Subtype: Link Rect: 381, 189, 415, 198 Destination: 27 Annotation: Subtype: Link Rect: 445, 69, 532, 78 Destination: 29 Annotation: Subtype: Link Rect: 49, 33, 192, 40 Annotation: Subtype: Link Rect: 499, 33, 545, 40 Annotation: Subtype: Link Rect: 457, 799, 545, 806 Thumb: true Page: Label: 12 Annotations: Annotation: Subtype: Link Rect: 317, 548, 545, 557 Annotation: Subtype: Link Rect: 304, 536, 403, 545 Annotation: Subtype: Link Rect: 49, 33, 192, 40 Annotation: Subtype: Link Rect: 499, 33, 545, 40 Annotation: Subtype: Link Rect: 457, 799, 545, 806 Thumb: true Page: Label: 13 Annotations: Annotation: Subtype: Link Rect: 266, 724, 290, 731 Annotation: Subtype: Link Rect: 49, 716, 106, 723 Annotation: Subtype: Link Rect: 143, 689, 202, 696 Annotation: Subtype: Link Rect: 244, 669, 290, 676 Annotation: Subtype: Link Rect: 80, 649, 171, 656 Annotation: Subtype: Link Rect: 223, 629, 290, 636 Annotation: Subtype: Link Rect: 49, 621, 68, 628 Annotation: Subtype: Link Rect: 126, 601, 204, 608 Annotation: Subtype: Link Rect: 184, 581, 245, 588 Annotation: Subtype: Link Rect: 263, 561, 290, 568 Annotation: Subtype: Link Rect: 49, 553, 93, 560 Annotation: Subtype: Link Rect: 214, 525, 290, 532 Annotation: Subtype: Link Rect: 49, 517, 62, 524 Annotation: Subtype: Link Rect: 252, 489, 290, 496 Annotation: Subtype: Link Rect: 49, 481, 83, 488 Annotation: Subtype: Link Rect: 206, 461, 270, 468 Annotation: Subtype: Link Rect: 199, 434, 246, 441 Annotation: Subtype: Link Rect: 209, 414, 286, 421 Annotation: Subtype: Link Rect: 160, 386, 233, 393 Annotation: Subtype: Link Rect: 122, 358, 177, 365 Annotation: Subtype: Link Rect: 87, 330, 164, 337 Annotation: Subtype: Link Rect: 60, 294, 131, 301 Annotation: Subtype: Link Rect: 220, 274, 289, 281 Annotation: Subtype: Link Rect: 247, 252, 290, 259 Annotation: Subtype: Link Rect: 49, 244, 100, 251 Annotation: Subtype: Link Rect: 160, 224, 240, 231 Annotation: Subtype: Link Rect: 266, 196, 290, 203 Annotation: Subtype: Link Rect: 49, 188, 92, 195 Annotation: Subtype: Link Rect: 141, 161, 218, 168 Annotation: Subtype: Link Rect: 60, 133, 150, 140 Annotation: Subtype: Link Rect: 179, 105, 253, 112 Annotation: Subtype: Link Rect: 60, 77, 146, 84 Annotation: Subtype: Link Rect: 387, 716, 451, 723 Annotation: Subtype: Link Rect: 369, 689, 442, 696 Annotation: Subtype: Link Rect: 516, 669, 545, 676 Annotation: Subtype: Link Rect: 304, 661, 343, 668 Annotation: Subtype: Link Rect: 521, 641, 545, 648 Annotation: Subtype: Link Rect: 304, 633, 358, 640 Annotation: Subtype: Link Rect: 373, 605, 451, 612 Annotation: Subtype: Link Rect: 392, 577, 446, 584 Annotation: Subtype: Link Rect: 389, 549, 441, 556 Annotation: Subtype: Link Rect: 448, 529, 526, 536 Annotation: Subtype: Link Rect: 437, 501, 508, 508 Annotation: Subtype: Link Rect: 537, 481, 545, 488 Annotation: Subtype: Link Rect: 304, 473, 389, 480 Annotation: Subtype: Link Rect: 406, 446, 472, 452 Annotation: Subtype: Link Rect: 460, 426, 537, 433 Annotation: Subtype: Link Rect: 396, 390, 463, 397 Annotation: Subtype: Link Rect: 503, 362, 545, 369 Annotation: Subtype: Link Rect: 304, 354, 327, 361 Annotation: Subtype: Link Rect: 382, 318, 452, 325 Annotation: Subtype: Link Rect: 315, 290, 395, 297 Annotation: Subtype: Link Rect: 363, 262, 441, 269 Annotation: Subtype: Link Rect: 521, 234, 545, 241 Annotation: Subtype: Link Rect: 304, 226, 380, 233 Annotation: Subtype: Link Rect: 406, 198, 487, 205 Annotation: Subtype: Link Rect: 478, 178, 545, 186 Annotation: Subtype: Link Rect: 304, 171, 328, 178 Annotation: Subtype: Link Rect: 537, 143, 545, 150 Annotation: Subtype: Link Rect: 304, 135, 351, 142 Annotation: Subtype: Link Rect: 518, 107, 545, 114 Annotation: Subtype: Link Rect: 304, 99, 350, 106 Annotation: Subtype: Link Rect: 508, 79, 545, 86 Annotation: Subtype: Link Rect: 304, 71, 321, 78 Annotation: Subtype: Link Rect: 49, 33, 192, 40 Annotation: Subtype: Link Rect: 499, 33, 545, 40 Annotation: Subtype: Link Rect: 457, 799, 545, 806 Thumb: true Page: Label: 14 Annotations: Annotation: Subtype: Link Rect: 143, 737, 213, 744 Annotation: Subtype: Link Rect: 200, 718, 281, 724 Annotation: Subtype: Link Rect: 98, 690, 178, 697 Annotation: Subtype: Link Rect: 60, 662, 123, 669 Annotation: Subtype: Link Rect: 282, 634, 290, 641 Annotation: Subtype: Link Rect: 49, 626, 119, 633 Annotation: Subtype: Link Rect: 521, 745, 545, 752 Annotation: Subtype: Link Rect: 304, 737, 341, 744 Annotation: Subtype: Link Rect: 537, 718, 545, 724 Annotation: Subtype: Link Rect: 304, 710, 341, 716 Annotation: Subtype: Link Rect: 406, 682, 483, 689 Annotation: Subtype: Link Rect: 353, 662, 431, 669 Annotation: Subtype: Link Rect: 519, 634, 545, 641 Annotation: Subtype: Link Rect: 304, 626, 373, 633 Annotation: Subtype: Link Rect: 49, 33, 192, 40 Annotation: Subtype: Link Rect: 499, 33, 545, 40 Annotation: Subtype: Link Rect: 457, 799, 545, 806 Thumb: true Checksum: ecd457e1 Type: CRC32 Checksum: c6c6df04cce6479e03f0815861cb6729 Type: MD5 Checksum: 7546d1512fa19aff77b9b8c5bcc6d0ec8f7f9c2e Type: SHA-1 Checksum: 4117a376b22d67f8c9131aaa31c4b9fe1028290ee440b78af040b7e45f52eca1 Type: SHA-256