f3f19ae2ded7e7178f7ffc14eef8114d pmc_10815999.pdf ed24c1bff23c658cbbc5e91783da864e2ea793a3 pmc_10815999.pdf 30bb8bb79e98e8a95ac567c46fdf26d5c85fa772872395a746b01803864444fd pmc_10815999.pdf Title: Multi-Omics Approach to Improved Diagnosis and Treatment of Atopic Dermatitis and Psoriasis Subject: Psoriasis and atopic dermatitis fall within the category of cutaneous immune-mediated inflammatory diseases (IMIDs). The prevalence of IMIDs is increasing in industrialized societies, influenced by both environmental changes and a genetic predisposition. However, the exact immune factors driving these chronic, progressive diseases are not fully understood. By using multi-omics techniques in cutaneous IMIDs, it is expected to advance the understanding of skin biology, uncover the underlying mechanisms of skin conditions, and potentially devise precise and personalized approaches to diagnosis and treatment. We provide a narrative review of the current knowledge in genomics, epigenomics, and proteomics of atopic dermatitis and psoriasis. A literature search was performed for articles published until 30 November 2023. Although there is still much to uncover, recent evidence has already provided valuable insights, such as proteomic profiles that permit differentiating psoriasis from mycosis fungoides and -defensin 2 correlation to PASI and its drop due to secukinumab first injection, among others. Keywords: multi-omics; psoriasis; atopic dermatitis; immune mediated inflammatory diseases; genomics; epigenomics; proteomics Author: Lluís Rusiñol and Lluís Puig Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Mon Jan 15 07:46:50 2024 CET ModDate: Mon Jan 15 07:50:43 2024 CET Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 35 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1598624 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- WLENKM+VnURWPalladioL-Bold Type 1 Custom yes yes yes 10 0 SXQPWE+VnURWPalladioL Type 1 Custom yes yes yes 16 0 ZWFJBW+EURM10 Type 1 Builtin yes yes yes 21 0 NNPEXC+URWPalladioL-Bold Type 1 Custom yes yes yes 26 0 UIRPLJ+URWPalladioL-Roma Type 1 Custom yes yes yes 32 0 GDYOUS+URWPalladioL-Ital Type 1 Custom yes yes yes 37 0 IRWHZX+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 53 0 CKUPDE+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 56 0 TVADYO+PazoMath-Italic Type 1 Builtin yes yes yes 76 0 LNOYLB+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 113 0 KRCSXD+PalatinoLinotype-Italic CID TrueType Identity-H yes yes yes 121 0 EIAIRP+PalatinoLinotype-Italic TrueType WinAnsi yes yes yes 129 0 XFNXXD+PalatinoLinotype-Bold TrueType WinAnsi yes yes yes 133 0 QAZCDR+PalatinoLinotype-Roman TrueType WinAnsi yes yes yes 137 0 LNOYLB+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 150 0 EIAIRP+PalatinoLinotype-Italic TrueType WinAnsi yes yes yes 158 0 XFNXXD+PalatinoLinotype-Bold TrueType WinAnsi yes yes yes 162 0 QAZCDR+PalatinoLinotype-Roman TrueType WinAnsi yes yes yes 166 0 LNOYLB+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 182 0 EIAIRP+PalatinoLinotype-Italic TrueType WinAnsi yes yes yes 190 0 XFNXXD+PalatinoLinotype-Bold TrueType WinAnsi yes yes yes 194 0 QAZCDR+PalatinoLinotype-Roman TrueType WinAnsi yes yes yes 198 0 LNOYLB+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 211 0 EIAIRP+PalatinoLinotype-Italic TrueType WinAnsi yes yes yes 219 0 XFNXXD+PalatinoLinotype-Bold TrueType WinAnsi yes yes yes 223 0 QAZCDR+PalatinoLinotype-Roman TrueType WinAnsi yes yes yes 227 0 VORNGC+CMSY10 Type 1 Builtin yes yes yes 236 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-04-27 02:35:22 CEST RepresentationInformation: pmc_10815999.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-04-24 02:37:56 CEST Size: 1598624 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 1197 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Material and Methods Destination: section.2 Item: Title: Current Knowledge in Pathogenesis of Atopic Dermatitis and Psoriasis Destination: section.3 Item: Title: Omics of Atopic Dermatitis and Psoriasis Destination: section.4 Children: Item: Title: Genomics Destination: subsection.4.1 Children: Item: Title: Atopic Dermatitis Destination: subsubsection.4.1.1 Item: Title: Psoriasis Destination: subsubsection.4.1.2 Item: Title: Mendelian Randomization Destination: subsubsection.4.1.3 Item: Title: Ferroptosis, Pyroptosis, and Cuproptosis Destination: subsubsection.4.1.4 Item: Title: Epigenomics Destination: subsection.4.2 Children: Item: Title: DNA Methylation Destination: subsubsection.4.2.1 Item: Title: Histone Modification Destination: subsubsection.4.2.2 Item: Title: Non-Coding RNA Destination: subsubsection.4.2.3 Item: Title: Proteomics Destination: subsection.4.3 Children: Item: Title: Proteomics in AD Destination: subsubsection.4.3.1 Item: Title: Proteomics in Psoriasis Destination: subsubsection.4.3.2 Item: Title: Conclusions Destination: section.5 Item: Title: Future Directions Destination: section.6 Item: Title: References Destination: section.7 Info: Title: Multi-Omics Approach to Improved Diagnosis and Treatment of Atopic Dermatitis and Psoriasis Author: Lluís Rusiñol and Lluís Puig Subject: Psoriasis and atopic dermatitis fall within the category of cutaneous immune-mediated inflammatory diseases (IMIDs). The prevalence of IMIDs is increasing in industrialized societies, influenced by both environmental changes and a genetic predisposition. However, the exact immune factors driving these chronic, progressive diseases are not fully understood. By using multi-omics techniques in cutaneous IMIDs, it is expected to advance the understanding of skin biology, uncover the underlying mechanisms of skin conditions, and potentially devise precise and personalized approaches to diagnosis and treatment. We provide a narrative review of the current knowledge in genomics, epigenomics, and proteomics of atopic dermatitis and psoriasis. A literature search was performed for articles published until 30 November 2023. Although there is still much to uncover, recent evidence has already provided valuable insights, such as proteomic profiles that permit differentiating psoriasis from mycosis fungoides and -defensin 2 correlation to PASI and its drop due to secukinumab first injection, among others. 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