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Title:          A monoclonal antibody targeting a large surface of the receptor binding motif shows pan-neutralizing SARS-CoV-2 activity
Subject:        Nature Communications, doi:10.1038/s41467-024-45171-9
Keywords:       
Author:         Leire Campos-Mata
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      Title: A monoclonal antibody targeting a large surface of the receptor binding motif shows pan-neutralizing SARS-CoV-2 activity
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        Title: Results
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        Children: 
         Item: 
          Title: Generation of human recombinant SARS-CoV-2-specific monoclonal antibodies
          Destination: B1
         Item: 
          Title: 17T2 mAb shows high neutralization activity against SARS-CoV-2 variants including Omicron sublineages
          Destination: B2
         Item: 
          Title: 17T2 mAb shows prophylactic and therapeutic activity against Omicron BA.1.1 in’vivo in K18-hACE2 transgenic’mice
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         Item: 
          Title: 17T2 binds the Omicron BA.1 spike protein with the RBD domains in the up position and recognizes a large surface overlapping with the receptor binding’motif
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        Title: Methods
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          Title: Ethical statement
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          Title: Human participants and sample collection
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          Title: Single B-cell FACS sorting
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          Title: Expression-cloning of antibodies
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          Title: Production’of Fab
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         Item: 
          Title: Production of recombinant SARS-CoV-2 proteins
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          Title: ELISAs
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          Title: Pseudovirus generation and neutralization’assay
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          Title: Virus neutralization’assay
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         Item: 
          Title: SARS-CoV-2 infection and prophylactic/therapeutic antibody treatment in K18-hACE2’mice
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          Title: Viral load quantification by RT-PCR
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         Item: 
          Title: Viral titration of replicative SARS-CoV-2 in the’lungs
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         Item: 
          Title: Histopathology and SARS-CoV-2 immunohistochemistry
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         Item: 
          Title: Determination of binding kinetics by surface plasmon resonance
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         Item: 
          Title: De-glycosylation of monoclonal antibodies
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         Item: 
          Title: Cryo-electron microscopy sample preparation and data acquisition
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          Title: Image processing
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          Title: Model building and refinement
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          Title: Statistical analysis
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          Title: Reporting summary
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        Title: Data availability
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        Title: References
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        Title: Acknowledgements
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       Item: 
        Title: Competing interests
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       Item: 
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   Type: CRC32
  Checksum: d3f28b7b878622005daf6e4d7f47ea1b
   Type: MD5
  Checksum: 8ed17df5300d03d69e519bd7d33a108794b9a0f1
   Type: SHA-1
  Checksum: 851ecb1ec1de1975547ff8c0f51cfef920dda467b11cd6001339f7918fcba1d6
   Type: SHA-256