07e2f32f0a0194b7ab7760cad723638d pmc_10855227.pdf b63fc2a53877583bff3b587dcc82b9e4705fd15c pmc_10855227.pdf 47ce0043165d3a17142f7ed4b80216d4e38a2ae2beebb2b58ea161846d365c9f pmc_10855227.pdf Title: Effectiveness and Cost-Effectiveness of Self-Management Interventions for Adults Living with Heart Failure to Improve Patient-Important Outcomes: An Evidence Map of Randomized Controlled Trials Subject: Self-management interventions (SMIs) may enhance heart failure (HF) outcomes and address challenges associated with disease management. This study aims to review randomized evidence and identify knowledge gaps in SMIs for adult HF patients. Within the COMPAR-EU project, from 2010 to 2018, we conducted searches in the databases MEDLINE, CINAHL, Embase, Cochrane, and PsycINFO. We performed a descriptive analysis using predefined categories and developed an evidence map of randomized controlled trials (RCTs). We found 282 RCTs examining SMIs for HF patients, comparing two to four interventions, primarily targeting individual patients (97%) globally (34 countries, only 31% from an European country). These interventions involved support techniques such as information sharing (95%) and self-monitoring (62%), often through a mix of in-person and remote sessions (43%). Commonly assessed outcomes included quality of life, hospital admissions, mortality, exercise capacity, and self-efficacy. Few studies have focused on lower socio-economic or minority groups. Nurses (68%) and physicians (30%) were the primary providers, and most studies were at low risk of bias in generating a random sequence for participant allocation; however, the reporting was noticeably unclear of methods used to conceal the allocation process. Our analysis has revealed prevalent support techniques and delivery methods while highlighting methodological challenges. These findings provide valuable insights for researchers, clinicians, and policymakers striving to optimize SMIs for individuals living with HF.60pt Keywords: heart failure; self-management interventions; randomized controlled trials; systematic review Author: Marilina Santero, Yang Song, Jessica Beltran, Melixa Medina-Aedo, Carlos Canelo-Aybar, Claudia Valli, Claudio Rocha, Montserrat León-García, Karla Salas-Gama, Chrysoula Kaloteraki, Ena Niño de Guzmán, Marta Ballester, Ana Isabel González-González, Rune Poortvliet, Marieke van der Gaag, Cristina Spoiala, Pema Gurung, Fabienne Willemen, Iza Cools, Julia Bleeker, Angelina Kancheva, Julia Ertl, Tajda Laure, Ivana Kancheva, Kevin Pacheco-Barrios, Jessica Hanae Zafra-Tanaka, Sofia Tsokani, Areti Angeliki Veroniki, Georgios Seitidis, Christos Christogiannis, Katerina Maria Kontouli, Oliver Groene, Rosa Sunol, Carola Orrego, Monique Heijmans and Pablo Alonso-Coello Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Wed Jan 24 09:53:10 2024 CET ModDate: Wed Jan 24 10:02:50 2024 CET Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 14 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1696870 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- PRJKGQ+VnURWPalladioL-Bold Type 1 Custom yes yes yes 10 0 PSUYZB+VnURWPalladioL Type 1 Custom yes yes yes 16 0 ATFJAA+URWPalladioL-Bold Type 1 Custom yes yes yes 21 0 YSWWLH+URWPalladioL-Roma Type 1 Custom yes yes yes 27 0 VBSIUU+URWPalladioL-Ital Type 1 Custom yes yes yes 32 0 XAOEUN+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 48 0 BCDEEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 79 0 BCDFEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 83 0 BCDGEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 87 0 BCDIEE+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 91 0 URYLRZ+URWPalladioL-BoldItal Type 1 Custom yes yes yes 102 0 BCDEEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 115 0 BCDFEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 119 0 BCDGEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 123 0 BCDEEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 139 0 BCDFEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 143 0 BCDGEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 147 0 BCDIEE+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 151 0 WABLSD+SFRM1000 Type 1 Custom yes yes yes 163 0 BCDEEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 173 0 BCDFEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 177 0 BCDGEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 181 0 BCDIEE+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 185 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-04-27 02:35:19 CEST RepresentationInformation: pmc_10855227.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-04-24 02:37:36 CEST Size: 1696870 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 358 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Children: Item: Title: Search Destination: subsection.2.1 Item: Title: Eligibility Assessment Destination: subsection.2.2 Item: Title: Data Extraction Destination: subsection.2.3 Item: Title: Data Analysis Destination: subsection.2.4 Item: Title: Results Destination: section.3 Children: Item: Title: Search Results Destination: subsection.3.1 Item: Title: Characteristics of Included RCTs Destination: subsection.3.2 Item: Title: Characteristics of the Participants Destination: subsection.3.3 Item: Title: Self-Management Support Techniques Destination: subsection.3.4 Children: Item: Title: Support Delivery Methods Destination: subsubsection.3.4.1 Item: Title: Location Destination: subsubsection.3.4.2 Item: Title: Type of Provider Destination: subsubsection.3.4.3 Item: Title: Duration and Intensity Destination: subsubsection.3.4.4 Item: Title: Expected Self-Management Behaviors Destination: subsection.3.5 Item: Title: Outcomes Destination: subsection.3.6 Item: Title: Risk of Bias Destination: subsection.3.7 Item: Title: Discussion Destination: section.4 Children: Item: Title: Main Findings Destination: subsection.4.1 Item: Title: Research in Context Destination: subsection.4.2 Item: Title: Strengths and Limitations Destination: subsection.4.3 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: appendix.A. Info: Title: Effectiveness and Cost-Effectiveness of Self-Management Interventions for Adults Living with Heart Failure to Improve Patient-Important Outcomes: An Evidence Map of Randomized Controlled Trials Author: Marilina Santero, Yang Song, Jessica Beltran, Melixa Medina-Aedo, Carlos Canelo-Aybar, Claudia Valli, Claudio Rocha, Montserrat León-García, Karla Salas-Gama, Chrysoula Kaloteraki, Ena Niño de Guzmán, Marta Ballester, Ana Isabel González-González, Rune Poortvliet, Marieke van der Gaag, Cristina Spoiala, Pema Gurung, Fabienne Willemen, Iza Cools, Julia Bleeker, Angelina Kancheva, Julia Ertl, Tajda Laure, Ivana Kancheva, Kevin Pacheco-Barrios, Jessica Hanae Zafra-Tanaka, Sofia Tsokani, Areti Angeliki Veroniki, Georgios Seitidis, Christos Christogiannis, Katerina Maria Kontouli, Oliver Groene, Rosa Sunol, Carola Orrego, Monique Heijmans and Pablo Alonso-Coello Subject: Self-management interventions (SMIs) may enhance heart failure (HF) outcomes and address challenges associated with disease management. This study aims to review randomized evidence and identify knowledge gaps in SMIs for adult HF patients. Within the COMPAR-EU project, from 2010 to 2018, we conducted searches in the databases MEDLINE, CINAHL, Embase, Cochrane, and PsycINFO. We performed a descriptive analysis using predefined categories and developed an evidence map of randomized controlled trials (RCTs). We found 282 RCTs examining SMIs for HF patients, comparing two to four interventions, primarily targeting individual patients (97%) globally (34 countries, only 31% from an European country). These interventions involved support techniques such as information sharing (95%) and self-monitoring (62%), often through a mix of in-person and remote sessions (43%). Commonly assessed outcomes included quality of life, hospital admissions, mortality, exercise capacity, and self-efficacy. Few studies have focused on lower socio-economic or minority groups. Nurses (68%) and physicians (30%) were the primary providers, and most studies were at low risk of bias in generating a random sequence for participant allocation; however, the reporting was noticeably unclear of methods used to conceal the allocation process. Our analysis has revealed prevalent support techniques and delivery methods while highlighting methodological challenges. 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