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Title:           Immunisation efficacy of a stabilised SARS-CoV-2 spike glycoprotein in two geriatric animal models
Subject:         npj Vaccines, doi:10.1038/s41541-024-00840-0
Keywords:        
Author:          Carla Usai
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      Title: Immunisation efficacy of a stabilised SARS-CoV-2 spike glycoprotein in two geriatric animal’models
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       Item: 
        Title: Results
        Destination: A1
        Children: 
         Item: 
          Title: S-29 is immunogenic and improves the survival of geriatric K18-hACE2 mice upon SARS-CoV-2 inoculation
          Destination: B1
         Item: 
          Title: Immunisation of K18-hACE2 mice with S-29 reduces the amount of sgRNA in respiratory tissues
          Destination: B2
         Item: 
          Title: S-29 immunisation reduce infectious SARS-CoV-2 shedding in NT and lung from K18-hACE2’mice
          Destination: B3
         Item: 
          Title: Immunisation reduces the severity of lung lesions in surviving K18-hACE2 mice and improves viral clearance at early time’points
          Destination: B4
         Item: 
          Title: S-29 is immunogenic and protects geriatric GSH from progressive weight loss upon SARS-CoV-2 inoculation
          Destination: B5
         Item: 
          Title: Immunisation-to-inoculation intervals impact gRNA amount in nasal turbinates and lungs’of GSH
          Destination: B6
         Item: 
          Title: S-29-immunisation does not alter SARS-CoV-2 ability to cause productive infection upon inoculation of geriatric’GSH
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         Item: 
          Title: Immunisation enhances viral protein clearance in NT and lungs’of GSH
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        Title: Discussion
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       Item: 
        Title: Methods
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          Title: Virus isolates
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         Item: 
          Title: Animals
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         Item: 
          Title: In vivo immunogenicity and vaccine efficacy studies
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         Item: 
          Title: Sample collection
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         Item: 
          Title: RNA-extraction and quantitative RT–PCR
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         Item: 
          Title: Viral titration in Vero E6’cells
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         Item: 
          Title: Pathology and immunohistochemistry
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         Item: 
          Title: Immunological’assays
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          Title: Pseudovirus production and neutralisation’assay
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          Title: Statistical analysis
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          Title: Reporting summary
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        Title: Data availability
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        Title: References
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       Item: 
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