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Title:           A Protein Misfolding Shaking Amplification-based method for the spontaneous generation of hundreds of bona fide prions
Subject:         Nature Communications, doi:10.1038/s41467-024-46360-2
Keywords:        
Author:          Hasier Eraña
Creator:         Springer
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     Item: 
      Title: A Protein Misfolding Shaking Amplification-based method for the spontaneous generation of hundreds of bona fide’prions
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       Item: 
        Title: Results
        Destination: A1
        Children: 
         Item: 
          Title: Collection of mammalian prion protein sequences
          Destination: B1
         Item: 
          Title: Generation of plasmids, recombinant protein expression, purification, and substrate preparation for in’vitro misfolding
          Destination: B2
         Item: 
          Title: Spontaneous misfolding of rec-PrP by PMSA, assessment of misfolding proneness, and generation of hundreds of recombinant’prions
          Destination: B3
         Item: 
          Title: Generation of a variable number of biochemically distinguishable conformers
          Destination: B4
         Item: 
          Title: Infectivity of spontaneously misfolded rec-PrPres confirms their bona fide prion’nature
          Destination: B5
         Item: 
          Title: “Gotta catch ‘em all” – The “PrPdex” as a comprehensive mammalian PrP variant encyclopedia
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        Title: Discussion
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       Item: 
        Title: Methods
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          Title: Ethical statement
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         Item: 
          Title: Mouse’work
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         Item: 
          Title: Recombinant prion protein expression and purification
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         Item: 
          Title: Substrate preparation for Protein Misfolding Shaking Amplification
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         Item: 
          Title: Protein Misfolding Shaking Amplification
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         Item: 
          Title: rec-PrPres detection
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         Item: 
          Title: Scoring of spontaneous misfolding proneness
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         Item: 
          Title: Determination of infectivity of the rec-PrPres
          Destination: B14
         Item: 
          Title: PrPSc detection in PMCA products and brains of inoculated animals
          Destination: B15
         Item: 
          Title: Computational methods, AlphaFold prediction of globular PrP structures, and calculation of relative thermodynamic stability
          Destination: B16
         Item: 
          Title: Determination of melting temperatures for distinct rec-PrP by circular dichroism
          Destination: B17
         Item: 
          Title: Statistics and reproducibility
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         Item: 
          Title: Biosafety considerations
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         Item: 
          Title: Reporting summary
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       Item: 
        Title: Data availability
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       Item: 
        Title: References
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        Title: Acknowledgements
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       Item: 
        Title: Author contributions
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       Item: 
        Title: Competing interests
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       Item: 
        Title: Additional information
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   Type: CRC32
  Checksum: ef985e34aa4669d93083f801ed0228f8
   Type: MD5
  Checksum: 8f2d2d7a1ca90b4a4ec5eb730666e5571d1c2f95
   Type: SHA-1
  Checksum: 25e2ab32f5a75b45de2fe98923b47886b4354d84768b08656c5cc00209bccbc5
   Type: SHA-256