889e90ce99b49e255027516e6a5bee69 pmc_10925694.pdf f68b6a49868ea96d6efbabbee98cc31a4a072e6f pmc_10925694.pdf 8b3a8bd4684757e9dd9912876d295b8697bb2e3ffbd7116e840362a2c2872856 pmc_10925694.pdf Keywords: Sjögren’s syndrome, immunofluorescence staining, fluorescent antibody technique, lip biopsy, minor salivary gland biopsy, histopathology, lymphocyte infiltration, lymphoid organization Custom Metadata: no Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 595.389 x 841.663 pts (A4) Page rot: 0 File size: 612773 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- KOAJGD+AdvTTd168d80a.I Type 1C WinAnsi yes yes no 641 0 KOAFLO+AdvTTd3a5f740 Type 1C WinAnsi yes yes no 614 0 KOAFLP+AdvTTd3a5f740+fb Type 1C Custom yes yes yes 615 0 KOAFMA+AdvTTd3a5f740+20 Type 1C WinAnsi yes yes no 616 0 KOAFNB+AdvTTd3a5f740+01 Type 1C MacRoman yes yes no 617 0 KOAFNC+AdvPSA18C Type 1C WinAnsi yes yes no 618 0 KOAFND+AdvTT9b12cd41 Type 1C WinAnsi yes yes no 619 0 KOAFNE+AdvTT2c8ce45a Type 1C WinAnsi yes yes no 629 0 KOAFNF+AdvTT9b12cd41+fb Type 1C Custom yes yes yes 630 0 KOAFNG+AdvTT9b12cd41+20 Type 1C WinAnsi yes yes no 631 0 KOAJEC+AdvPSA323 Type 1C WinAnsi yes yes no 632 0 KOAJGC+AdvTT9b12cd41+01 Type 1C MacRoman yes yes no 639 0 KOAJKC+AdvTT2c8ce45a+20 Type 1C WinAnsi yes yes no 144 0 KOAJKD+AdvTT2c8ce45a+fb Type 1C Custom yes yes yes 145 0 KOAJKE+AdvOT1ef757c0 Type 1C Custom yes yes yes 131 0 KOAJKF+AdvOT1ef757c0+20 Type 1C WinAnsi yes yes no 136 0 KOAJKG+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 137 0 KOAKPP+AdvOT1ef757c0+22 Type 1C Custom yes yes yes 146 0 KOALEO+AdvOT3f84ef53 Type 1C WinAnsi yes yes no 151 0 KOALJN+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 154 0 KOALJO+AdvTT58d178b9+03 Type 1C Custom yes yes yes 155 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-04-26 02:41:04 CEST RepresentationInformation: pmc_10925694.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-04-24 02:31:44 CEST Size: 612773 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 702 FreeObjects: 3 IncrementalUpdates: 2 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Prognostic significance of lymphocytic foci composition in minor salivary gland biopsies for severe disease flare and severity in Sjögren’s syndrome: a 3-year follow-up cohort study Destination: bmark_-805879984 Children: Item: Title: 1 Introduction Destination: s1 Item: Title: 2 Materials and methods Destination: s2 Children: Item: Title: 2.1 Participants Destination: s2_1 Item: Title: 2.2 Variables Destination: s2_2 Item: Title: 2.3 Outcome Destination: s2_3 Item: Title: 2.4 MSGB and immunofluorescence staining Destination: s2_4 Item: Title: 2.5 Statistical analysis Destination: s2_5 Item: Title: 3 Results Destination: s3 Children: Item: Title: 3.1 Baseline population characteristics Destination: s3_1 Item: Title: 3.2 Association with disease severity at diagnosis and severe disease flare Destination: s3_2 Item: Title: 3.3 Association with clinical and serological manifestations Destination: s3_3 Item: Title: 4 Discussion Destination: s4 Item: Title: Data availability statement Destination: s5 Item: Title: Ethics statement Destination: s6 Item: Title: Author contributions Destination: s7 Item: Title: Funding Destination: bmark_1865464027 Item: Title: Conflict of interest Destination: bmark_1089982005 Item: Title: Publisher’s note Destination: bmark_-1256977648 Item: Title: Supplementary material Destination: bmark_632582120 Item: Title: References Destination: bmark_2090415954 Info: Keywords: Sjögren’s syndrome, immunofluorescence staining, fluorescent antibody technique, lip biopsy, minor salivary gland biopsy, histopathology, lymphocyte infiltration, lymphoid organization ID: 0x5237211f36edf15850bf54393074ff3b, 0x2313a676d43b3f4b983e550d414909f6 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2919 ImageHeight: 577 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1372 ImageHeight: 495 BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: KOAJGD+AdvTTd168d80a.I FontSubset: true FirstChar: 46 LastChar: 117 FontDescriptor: FontName: KOAJGD+AdvTTd168d80a.I Flags: Serif, Nonsymbolic FontBBox: -145, -208, 968, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KOAJKE+AdvOT1ef757c0 FontSubset: true FirstChar: 2 LastChar: 248 FontDescriptor: FontName: KOAJKE+AdvOT1ef757c0 Flags: Serif, Symbolic FontBBox: -20, -250, 947, 854 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: KOAFLO+AdvTTd3a5f740 FontSubset: true FirstChar: 37 LastChar: 246 FontDescriptor: FontName: KOAFLO+AdvTTd3a5f740 Flags: Serif, Nonsymbolic FontBBox: -52, -208, 916, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KOAFLP+AdvTTd3a5f740+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: KOAFLP+AdvTTd3a5f740+fb Flags: Symbolic FontBBox: 0, 0, 906, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: KOAFMA+AdvTTd3a5f740+20 FontSubset: true FirstChar: 134 LastChar: 146 FontDescriptor: FontName: KOAFMA+AdvTTd3a5f740+20 Flags: Nonsymbolic FontBBox: -114, -166, 1062, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KOAJKF+AdvOT1ef757c0+20 FontSubset: true FirstChar: 146 LastChar: 151 FontDescriptor: FontName: KOAJKF+AdvOT1ef757c0+20 Flags: Nonsymbolic FontBBox: -135, -187, 1010, 833 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KOAFNB+AdvTTd3a5f740+01 FontSubset: true FirstChar: 245 LastChar: 245 FontDescriptor: FontName: KOAFNB+AdvTTd3a5f740+01 Flags: Nonsymbolic FontBBox: -52, -208, 947, 885 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: KOAJKG+AdvOT1ef757c0+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: KOAJKG+AdvOT1ef757c0+fb Flags: Symbolic FontBBox: 0, -10, 781, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: KOAFNC+AdvPSA18C FontSubset: true FirstChar: 180 LastChar: 180 FontDescriptor: FontName: KOAFNC+AdvPSA18C Flags: Nonsymbolic FontBBox: -156, -208, 1125, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KOAFND+AdvTT9b12cd41 FontSubset: true FirstChar: 37 LastChar: 246 FontDescriptor: FontName: KOAFND+AdvTT9b12cd41 Flags: Serif, Nonsymbolic FontBBox: -52, -208, 906, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KOAJKC+AdvTT2c8ce45a+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: KOAJKC+AdvTT2c8ce45a+20 Flags: Nonsymbolic FontBBox: -125, -166, 1125, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KOAJKD+AdvTT2c8ce45a+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: KOAJKD+AdvTT2c8ce45a+fb Flags: Symbolic FontBBox: 0, 0, 947, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: KOAKPP+AdvOT1ef757c0+22 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: KOAKPP+AdvOT1ef757c0+22 Flags: Symbolic FontBBox: -135, -166, 697, 916 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: KOAFNE+AdvTT2c8ce45a FontSubset: true FirstChar: 42 LastChar: 246 FontDescriptor: FontName: KOAFNE+AdvTT2c8ce45a Flags: Serif, Nonsymbolic FontBBox: -52, -208, 947, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KOAFNF+AdvTT9b12cd41+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: KOAFNF+AdvTT9b12cd41+fb Flags: Symbolic FontBBox: 0, 0, 854, 697 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: KOAFNG+AdvTT9b12cd41+20 FontSubset: true FirstChar: 134 LastChar: 146 FontDescriptor: FontName: KOAFNG+AdvTT9b12cd41+20 Flags: Nonsymbolic FontBBox: -114, -166, 1010, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KOALEO+AdvOT3f84ef53 FontSubset: true FirstChar: 98 LastChar: 98 FontDescriptor: FontName: KOALEO+AdvOT3f84ef53 Flags: Nonsymbolic FontBBox: -177, -291, 1083, 1000 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KOAJEC+AdvPSA323 FontSubset: true FirstChar: 180 LastChar: 180 FontDescriptor: FontName: KOAJEC+AdvPSA323 Flags: Nonsymbolic FontBBox: -156, -239, 1104, 770 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KOALJN+AdvOT7d6df7ab.I FontSubset: true FirstChar: 40 LastChar: 120 FontDescriptor: FontName: KOALJN+AdvOT7d6df7ab.I Flags: Serif, Nonsymbolic FontBBox: -135, -250, 1000, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KOALJO+AdvTT58d178b9+03 FontSubset: true FirstChar: 0 LastChar: 0 FontDescriptor: FontName: KOALJO+AdvTT58d178b9+03 Flags: Symbolic FontBBox: -645, -354, 916, 895 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: KOAJGC+AdvTT9b12cd41+01 FontSubset: true FirstChar: 245 LastChar: 245 FontDescriptor: FontName: KOAJGC+AdvTT9b12cd41+01 Flags: Nonsymbolic FontBBox: -52, -208, 958, 875 FontFile3: true Encoding: MacRomanEncoding XMP: Hye-Sang Park Laura Martínez-Martínez Berta Magallares López Ivan Castellví Patricia Moya Helena Codes-Mendez Nerea Hernandez Sosa Cesar Diaz-Torne Ana Laiz Luis Sainz Jose Luis Tandaipan Anaís Mariscal Teresa Franco-Leyva Jordi Casademont Candido Juarez Hector Corominas Park H-S, Martínez-Martínez L, Magallares López B, Castellví I, Moya P, Codes-Mendez H, Hernandez Sosa N, Diaz-Torne C, Laiz A, Sainz L, Tandaipan JL, Mariscal A, Franco-Leyva T, Casademont J, Juarez C and Corominas H (2024) Prognostic significance of lymphocytic foci composition in minor salivary gland biopsies for severe disease flare and severity in Sjögren’s syndrome: a 3-year follow-up cohort study. Front. Immunol. 15:1332924 Copyright © 2024 Park, Martínez-Martínez, Magallares López, Castellví, Moya, Codes-Mendez, Hernandez Sosa, Diaz-Torne, Laiz, Sainz, Tandaipan, Mariscal, Franco-Leyva, Casademont, Juarez and Corominas. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Sjögren’s syndrome immunofluorescence staining fluorescent antibody technique lip biopsy minor salivary gland biopsy histopathology lymphocyte infiltration lymphoid organization Prognostic significance of lymphocytic foci composition in minor salivary gland biopsies for severe disease flare and severity in Sjögren’s syndrome: a 3-year follow-up cohort study Sjögren’s syndrome, immunofluorescence staining, fluorescent antibody technique, lip biopsy, minor salivary gland biopsy, histopathology, lymphocyte infiltration, lymphoid organization True https://www.frontiersin.org/legal/copyright-statement Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 221, 685, 472, 706 Annotation: Subtype: Link Rect: 221, 660, 533, 681 Annotation: Subtype: Link Rect: 221, 635, 534, 656 Annotation: Subtype: Link Rect: 221, 610, 532, 631 Annotation: Subtype: Link Rect: 221, 585, 527, 606 Annotation: Subtype: Link Rect: 221, 560, 447, 581 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Annotation: Subtype: Link Rect: 49, 690, 125, 705 Annotation: Subtype: Link Rect: 60, 510, 139, 517 Annotation: Subtype: Link Rect: 49, 320, 159, 327 Annotation: Subtype: Link Rect: 69, 243, 188, 250 Annotation: Subtype: Link Rect: 49, 234, 74, 241 Annotation: Subtype: Link Rect: 450, 802, 506, 809 Annotation: Subtype: Link Rect: 466, 793, 523, 800 Annotation: Subtype: Link Rect: 446, 783, 540, 790 Annotation: Subtype: Link Rect: 49, 789, 233, 806 Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 80, 356, 84, 365 Destination: 86 Annotation: Subtype: Link Rect: 52, 331, 57, 340 Destination: 86 Annotation: Subtype: Link Rect: 61, 331, 66, 340 Destination: 86 Annotation: Subtype: Link Rect: 217, 318, 222, 327 Destination: 86 Annotation: Subtype: Link Rect: 227, 318, 231, 327 Destination: 86 Annotation: Subtype: Link Rect: 143, 268, 147, 277 Destination: 86 Annotation: Subtype: Link Rect: 153, 268, 157, 277 Destination: 86 Annotation: Subtype: Link Rect: 177, 231, 186, 240 Destination: 86 Annotation: Subtype: Link Rect: 129, 168, 138, 177 Destination: 86 Annotation: Subtype: Link Rect: 143, 168, 152, 177 Destination: 86 Annotation: Subtype: Link Rect: 206, 143, 216, 152 Destination: 86 Annotation: Subtype: Link Rect: 134, 81, 143, 90 Destination: 86 Annotation: Subtype: Link Rect: 449, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 504, 719, 512, 728 Destination: 86 Annotation: Subtype: Link Rect: 517, 719, 525, 728 Destination: 86 Annotation: Subtype: Link Rect: 396, 319, 426, 328 Destination: 30 Annotation: Subtype: Link Rect: 449, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 419, 554, 447, 563 Destination: 40 Annotation: Subtype: Link Rect: 383, 504, 485, 513 Destination: 86 Annotation: Subtype: Link Rect: 477, 154, 505, 163 Destination: 48 Annotation: Subtype: Link Rect: 449, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 197, 288, 230, 297 Destination: 30 Annotation: Subtype: Link Rect: 154, 88, 181, 97 Destination: 57 Annotation: Subtype: Link Rect: 449, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 457, 87, 466, 96 Destination: 86 Annotation: Subtype: Link Rect: 473, 74, 482, 83 Destination: 86 Annotation: Subtype: Link Rect: 487, 74, 496, 83 Destination: 86 Annotation: Subtype: Link Rect: 449, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 266, 373, 275, 382 Destination: 86 Annotation: Subtype: Link Rect: 202, 198, 211, 207 Destination: 86 Annotation: Subtype: Link Rect: 468, 248, 476, 257 Destination: 86 Annotation: Subtype: Link Rect: 413, 235, 421, 244 Destination: 86 Annotation: Subtype: Link Rect: 475, 235, 483, 244 Destination: 114 Annotation: Subtype: Link Rect: 307, 223, 316, 232 Destination: 86 Annotation: Subtype: Link Rect: 400, 135, 408, 144 Destination: 114 Annotation: Subtype: Link Rect: 449, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 214, 731, 222, 740 Destination: 86 Annotation: Subtype: Link Rect: 219, 594, 228, 603 Destination: 86 Annotation: Subtype: Link Rect: 234, 594, 242, 603 Destination: 114 Annotation: Subtype: Link Rect: 162, 556, 171, 565 Destination: 86 Annotation: Subtype: Link Rect: 175, 556, 183, 565 Destination: 114 Annotation: Subtype: Link Rect: 264, 519, 272, 528 Destination: 114 Annotation: Subtype: Link Rect: 277, 519, 285, 528 Destination: 114 Annotation: Subtype: Link Rect: 160, 481, 168, 490 Destination: 114 Annotation: Subtype: Link Rect: 449, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 304, 444, 545, 453 Annotation: Subtype: Link Rect: 304, 431, 401, 440 Annotation: Subtype: Link Rect: 62, 341, 139, 348 Annotation: Subtype: Link Rect: 220, 314, 267, 321 Annotation: Subtype: Link Rect: 173, 287, 254, 294 Annotation: Subtype: Link Rect: 97, 252, 177, 259 Annotation: Subtype: Link Rect: 220, 182, 278, 189 Annotation: Subtype: Link Rect: 89, 139, 188, 146 Annotation: Subtype: Link Rect: 163, 104, 213, 111 Annotation: Subtype: Link Rect: 184, 77, 258, 84 Annotation: Subtype: Link Rect: 351, 341, 438, 348 Annotation: Subtype: Link Rect: 304, 260, 389, 267 Annotation: Subtype: Link Rect: 351, 225, 402, 232 Annotation: Subtype: Link Rect: 522, 190, 545, 197 Annotation: Subtype: Link Rect: 304, 182, 380, 189 Annotation: Subtype: Link Rect: 378, 147, 477, 154 Annotation: Subtype: Link Rect: 356, 112, 433, 119 Annotation: Subtype: Link Rect: 357, 77, 435, 84 Annotation: Subtype: Link Rect: 449, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 119, 726, 169, 733 Annotation: Subtype: Link Rect: 265, 700, 290, 707 Annotation: Subtype: Link Rect: 49, 692, 116, 699 Annotation: Subtype: Link Rect: 521, 758, 545, 765 Annotation: Subtype: Link Rect: 304, 750, 372, 757 Annotation: Subtype: Link Rect: 324, 722, 397, 729 Annotation: Subtype: Link Rect: 304, 694, 393, 701 Annotation: Subtype: Link Rect: 335, 666, 401, 673 Annotation: Subtype: Link Rect: 449, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Checksum: 4c5a5e01 Type: CRC32 Checksum: 889e90ce99b49e255027516e6a5bee69 Type: MD5 Checksum: f68b6a49868ea96d6efbabbee98cc31a4a072e6f Type: SHA-1 Checksum: 8b3a8bd4684757e9dd9912876d295b8697bb2e3ffbd7116e840362a2c2872856 Type: SHA-256