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Title:           Immunization with V987H-stabilized Spike glycoprotein protects K18-hACE2 mice and golden Syrian hamsters upon SARS-CoV-2 infection
Subject:         Nature Communications, doi:10.1038/s41467-024-46714-w
Keywords:        
Author:          Carlos Ávila-Nieto
Creator:         Springer
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      Title: Immunization with V987H-stabilized Spike glycoprotein protects K18-hACE2 mice and golden Syrian hamsters upon SARS-CoV-2 infection
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       Item: 
        Title: Results
        Destination: A1
        Children: 
         Item: 
          Title: Identification of S glycoprotein mutations that constrain the motility of RBD
          Destination: B1
         Item: 
          Title: S-V987H trimer vaccination protects K18-hACE2 mice from SARS-CoV-2 D614G infection-associated disease
          Destination: B2
         Item: 
          Title: S-V987H trimer vaccination protects golden Syrian hamsters from SARS-CoV-2 infection-associated disease
          Destination: B3
         Item: 
          Title: S-V987H trimer vaccination protects K18-hACE2 mice from the SARS-CoV-2 Beta-variant challenge
          Destination: B4
         Item: 
          Title: S-V987H trimer immunization protects K18-hACE2 mice from the SARS-CoV-2 Omicron BQ1.1-variant challenge
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       Item: 
        Title: Discussion
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       Item: 
        Title: Methods
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         Item: 
          Title: Recombinant trimeric Spike glycoprotein design and modeling
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         Item: 
          Title: Recombinant protein production, quantification, purification, and ACE2 binding
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         Item: 
          Title: Cell culture, viral isolation, and titration
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         Item: 
          Title: In vivo immunization and challenge experiments
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         Item: 
          Title: Quantification of anti-Spike antibodies by’ELISA
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         Item: 
          Title: Neutralizing activity of serum samples
          Destination: B11
         Item: 
          Title: Assessment of Spike-specific T cell response by interferon-γ ELISPOT
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         Item: 
          Title: Viral load quantification in oropharyngeal swab and tissue samples
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         Item: 
          Title: Pathology and immunohistochemistry
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          Title: Statistical analysis
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          Title: Reporting summary
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        Title: Data availability
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        Title: References
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