5352ce6b989c829b582a0a86faa393fe pmc_10962451.pdf 6c8047f187437a15e2870f0af0ab05304554d55a pmc_10962451.pdf a441ab1dc1fb93385770a6c35a2b08542f9a9ad3a61c8f0f340e16e23fa19662 pmc_10962451.pdf Title: COPD: systemic proteomic profiles in frequent and infrequent exacerbators Keywords: Author: Cesar Jessé Enríquez-Rodríguez Creator: Arbortext Advanced Print Publisher 10.0.1465/W Unicode Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Sat Mar 16 10:59:08 2024 CET ModDate: Sat Mar 23 05:19:22 2024 CET Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 14 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 1895887 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- JPCDKO+AdvTT3e3c8cd7 Type 1C WinAnsi yes yes no 317 0 JPCENI+SourceSansPro-Regular Type 1C Custom yes yes yes 322 0 JPCEPI+SourceSansPro-It Type 1C WinAnsi yes yes no 331 0 JPCEPJ+SourceSansPro-Bold Type 1C WinAnsi yes yes no 332 0 JPCFIH+AdvTT7e2c4963 Type 1C WinAnsi yes yes no 333 0 JPCFII+AdvTT7e2c4963+20 Type 1C WinAnsi yes yes no 334 0 JPCGDF+AdvTTcabc3928.I Type 1C WinAnsi yes yes no 173 0 JPCGDG+AdvTT28ecec5c.I Type 1C WinAnsi yes yes no 167 0 JPCGDH+AdvTT1778526c Type 1C WinAnsi yes yes no 162 0 JPCGDI+AdvTT1420aa1a.I Type 1C WinAnsi yes yes no 171 0 JPCGDJ+AdvTT1778526c+20 Type 1C WinAnsi yes yes no 169 0 JPCGII+AdvOT8608a8d1+2a Type 1C Custom yes yes yes 180 0 JPCGIJ+AdvOT8608a8d1+22 Type 1C Custom yes yes no 181 0 JPCGJJ+AdvTT05cc2067+03 Type 1C Custom yes yes yes 183 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-04-06 02:37:53 CEST RepresentationInformation: pmc_10962451.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-04-03 02:33:04 CEST Size: 1895887 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 374 FreeObjects: 2 IncrementalUpdates: 2 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: COPD: systemic proteomic profiles in frequent and infrequent exacerbators Destination: head1 Children: Item: Title: Abstract Destination: head2 Item: Title: Introduction Destination: head3 Item: Title: Methods Destination: head4 Children: Item: Title: Study design and ethics Destination: head5 Item: Title: Study population Destination: head6 Item: Title: Blood sample collection Destination: head7 Item: Title: LFQ on LC/MS-MS Destination: head8 Item: Title: Immune-based multiplex analysis Destination: head9 Item: Title: Data analysis Destination: head10 Children: Item: Title: Sample size estimation Destination: head11 Item: Title: Descriptive statistics Destination: head12 Item: Title: Differentially abundant proteins Destination: head13 Item: Title: Functional enrichment and network analysis Destination: head14 Item: Title: Results Destination: head15 Children: Item: Title: Participant characteristics Destination: head16 Item: Title: Identified proteome Destination: head17 Item: Title: Differential proteomic profiles Destination: head18 Item: Title: Functional enrichment Destination: head19 Item: Title: Interactions between DAPs Destination: head20 Item: Title: Discussion Destination: head21 Children: Item: Title: Previous studies Destination: head22 Item: Title: Interpretation of novel findings Destination: head23 Children: Item: Title: The frequent exacerbator phenotype Destination: head24 Item: Title: Proteomic profile during acute exacerbations Destination: head25 Item: Title: Strengths and potential limitations Destination: head26 Item: Title: Conclusions Destination: head27 Item: Title: References Destination: head28 Info: Title: COPD: systemic proteomic profiles in frequent and infrequent exacerbators Author: Cesar Jessé Enríquez-Rodríguez Keywords: Creator: Arbortext Advanced Print Publisher 10.0.1465/W Unicode Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Sat Mar 16 11:29:08 CET 2024 ModDate: Sat Mar 23 05:49:22 CET 2024 ID: 0xc076c05082108d3b7d511d8cec3a03f2, 0x218570affaeb3d4aa674fc042bfb4eda Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 149 ImageHeight: 743 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 797 ImageHeight: 666 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1029 ImageHeight: 743 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1173 ImageHeight: 700 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 898 ImageHeight: 884 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 898 ImageHeight: 883 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 301 ImageHeight: 2353 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 898 ImageHeight: 590 BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: JPCENI+SourceSansPro-Regular FontSubset: true FirstChar: 2 LastChar: 150 FontDescriptor: FontName: JPCENI+SourceSansPro-Regular Flags: Symbolic FontBBox: -40, -224, 754, 732 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JPCGDH+AdvTT1778526c FontSubset: true FirstChar: 37 LastChar: 215 FontDescriptor: FontName: JPCGDH+AdvTT1778526c Flags: Serif, Nonsymbolic FontBBox: -20, -208, 937, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JPCGDG+AdvTT28ecec5c.I FontSubset: true FirstChar: 45 LastChar: 121 FontDescriptor: FontName: JPCGDG+AdvTT28ecec5c.I Flags: Serif, Nonsymbolic FontBBox: -125, -250, 833, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JPCGDJ+AdvTT1778526c+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: JPCGDJ+AdvTT1778526c+20 Flags: Nonsymbolic FontBBox: -208, -250, 1062, 822 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JPCEPI+SourceSansPro-It FontSubset: true FirstChar: 101 LastChar: 118 FontDescriptor: FontName: JPCEPI+SourceSansPro-It Flags: Nonsymbolic, Italic FontBBox: -2, -12, 492, 498 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JPCGDI+AdvTT1420aa1a.I FontSubset: true FirstChar: 46 LastChar: 118 FontDescriptor: FontName: JPCGDI+AdvTT1420aa1a.I Flags: Nonsymbolic FontBBox: -104, -208, 906, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JPCEPJ+SourceSansPro-Bold FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: JPCEPJ+SourceSansPro-Bold Flags: Nonsymbolic FontBBox: -8, -209, 802, 726 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JPCFIH+AdvTT7e2c4963 FontSubset: true FirstChar: 35 LastChar: 250 FontDescriptor: FontName: JPCFIH+AdvTT7e2c4963 Flags: Serif, Nonsymbolic FontBBox: -31, -250, 791, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JPCGDF+AdvTTcabc3928.I FontSubset: true FirstChar: 46 LastChar: 122 FontDescriptor: FontName: JPCGDF+AdvTTcabc3928.I Flags: Serif, Nonsymbolic FontBBox: -114, -250, 822, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JPCFII+AdvTT7e2c4963+20 FontSubset: true FirstChar: 147 LastChar: 150 FontDescriptor: FontName: JPCFII+AdvTT7e2c4963+20 Flags: Nonsymbolic FontBBox: -447, -250, 1156, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JPCGII+AdvOT8608a8d1+2a FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: JPCGII+AdvOT8608a8d1+2a Flags: Symbolic FontBBox: 0, -437, 1385, 937 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JPCGIJ+AdvOT8608a8d1+22 FontSubset: true FirstChar: 21 LastChar: 21 FontDescriptor: FontName: JPCGIJ+AdvOT8608a8d1+22 Flags: Nonsymbolic FontBBox: 0, -322, 1218, 968 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: JPCGJJ+AdvTT05cc2067+03 FontSubset: true FirstChar: 1 LastChar: 4 FontDescriptor: FontName: JPCGJJ+AdvTT05cc2067+03 Flags: Symbolic FontBBox: -427, -250, 895, 833 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JPCDKO+AdvTT3e3c8cd7 FontSubset: true FirstChar: 44 LastChar: 243 FontDescriptor: FontName: JPCDKO+AdvTT3e3c8cd7 Flags: Serif, Nonsymbolic FontBBox: -41, -250, 822, 885 FontFile3: true Encoding: WinAnsiEncoding XMP: Arbortext Advanced Print Publisher 10.0.1465/W Unicode 2024-03-23T09:49:22+05:30 2024-03-16T15:29:08+05:30 2024-03-23T09:49:22+05:30 application/pdf 10.1183/23120541.00004-2024 COPD: systemic proteomic profiles in frequent and infrequent exacerbators Cesar Jessé Enríquez-Rodríguez Carme Casadevall Rosa Faner Ady Castro-Costa Sergi Pascual-Guàrdia Luis Seijó José Luis López-Campos Germán Peces-Barba Eduard Monsó Esther Barreiro Borja G. Cosío Alvar Agustí Joaquim Gea Acrobat Distiller 8.1.0 (Windows) uuid:f09123cd-c8a9-4cef-b99c-fdccfc13afef uuid:90ce1461-361f-4253-b215-4d504d8ef7a9 http://dx.doi.org/10.1183/23120541.00004-2024 10.1183/23120541.00004-2024 10.1183/23120541.00004-2024 false 2014-12-12 psychoceramics.labs.crossref.org false 2014-12-12 10.1183/23120541.00004-2024 psychoceramics.labs.crossref.org Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 196, 623, 204, 632 Annotation: Subtype: Link Rect: 298, 623, 306, 632 Annotation: Subtype: Link Rect: 201, 610, 209, 619 Annotation: Subtype: Link Rect: 336, 610, 344, 619 Annotation: Subtype: Link Rect: 116, 597, 125, 606 Annotation: Subtype: Link Rect: 201, 597, 210, 606 Annotation: Subtype: Link Rect: 362, 597, 371, 606 Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 196, 622, 204, 631 Annotation: Subtype: Link Rect: 320, 622, 328, 631 Annotation: Subtype: Link Rect: 212, 609, 220, 618 Annotation: Subtype: Link Rect: 358, 609, 366, 618 Annotation: Subtype: Link Rect: 202, 596, 210, 605 Annotation: Subtype: Link Rect: 298, 596, 306, 605 Annotation: Subtype: Link Rect: 481, 596, 489, 605 Annotation: Subtype: Link Rect: 478, 443, 550, 452 Annotation: Subtype: Link Rect: 42, 384, 78, 419 Annotation: Subtype: Link Rect: 336, 385, 360, 394 Annotation: Subtype: Link Rect: 336, 385, 417, 394 Annotation: Subtype: Link Rect: 498, 355, 552, 364 Annotation: Subtype: Link Rect: 164, 345, 249, 354 Annotation: Subtype: Link Rect: 358, 75, 363, 84 Destination: 146 Annotation: Subtype: Link Rect: 367, 75, 372, 84 Destination: 146 Annotation: Subtype: Link Rect: 500, 64, 505, 73 Destination: 146 Annotation: Subtype: Link Rect: 372, 53, 376, 62 Destination: 146 Annotation: Subtype: Link Rect: 383, 53, 388, 62 Destination: 146 Annotation: Subtype: Link Rect: 48, 234, 119, 241 Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 349, 713, 354, 722 Destination: 146 Annotation: Subtype: Link Rect: 358, 713, 363, 722 Destination: 146 Annotation: Subtype: Link Rect: 306, 577, 310, 586 Destination: 146 Annotation: Subtype: Link Rect: 258, 555, 262, 564 Destination: 146 Annotation: Subtype: Link Rect: 343, 544, 347, 553 Destination: 146 Annotation: Subtype: Link Rect: 213, 441, 218, 450 Destination: 146 Annotation: Subtype: Link Rect: 224, 441, 228, 450 Destination: 146 Annotation: Subtype: Link Rect: 431, 419, 435, 428 Destination: 146 Annotation: Subtype: Link Rect: 441, 419, 445, 428 Destination: 146 Annotation: Subtype: Link Rect: 164, 245, 277, 254 Annotation: Subtype: Link Rect: 420, 53, 502, 62 Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 328, 680, 337, 689 Destination: 152 Annotation: Subtype: Link Rect: 341, 680, 350, 689 Destination: 152 Annotation: Subtype: Link Rect: 260, 328, 401, 337 Annotation: Subtype: Link Rect: 167, 317, 188, 326 Annotation: Subtype: Link Rect: 167, 317, 282, 326 Annotation: Subtype: Link Rect: 288, 229, 358, 238 Annotation: Subtype: Link Rect: 260, 218, 369, 227 Annotation: Subtype: Link Rect: 164, 174, 192, 183 Destination: 72 Annotation: Subtype: Link Rect: 414, 119, 502, 128 Annotation: Subtype: Link Rect: 283, 97, 368, 106 Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 413, 378, 501, 387 Annotation: Subtype: Link Rect: 272, 356, 357, 365 Annotation: Subtype: Link Rect: 167, 334, 255, 343 Annotation: Subtype: Link Rect: 412, 312, 498, 321 Annotation: Subtype: Link Rect: 531, 312, 552, 321 Destination: 87 Annotation: Subtype: Link Rect: 164, 301, 172, 310 Destination: 87 Annotation: Subtype: Link Rect: 282, 301, 316, 310 Destination: 87 Annotation: Subtype: Link Rect: 230, 235, 324, 244 Annotation: Subtype: Link Rect: 333, 224, 418, 233 Annotation: Subtype: Link Rect: 466, 64, 495, 73 Destination: 95 Annotation: Subtype: Link Rect: 500, 64, 552, 73 Annotation: Subtype: Link Rect: 164, 53, 193, 62 Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 520, 200, 550, 209 Destination: 104 Annotation: Subtype: Link Rect: 164, 189, 253, 198 Annotation: Subtype: Link Rect: 203, 132, 233, 141 Destination: 112 Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 207, 75, 216, 84 Destination: 152 Annotation: Subtype: Link Rect: 220, 75, 229, 84 Destination: 152 Annotation: Subtype: Link Rect: 449, 64, 458, 73 Destination: 152 Annotation: Subtype: Link Rect: 463, 64, 472, 73 Destination: 152 Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 481, 130, 489, 139 Destination: 152 Annotation: Subtype: Link Rect: 538, 64, 547, 73 Destination: 152 Annotation: Subtype: Link Rect: 170, 256, 254, 264 Page: Label: 9 Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 471, 691, 480, 700 Destination: 152 Annotation: Subtype: Link Rect: 485, 691, 494, 700 Destination: 152 Annotation: Subtype: Link Rect: 469, 680, 478, 689 Destination: 152 Annotation: Subtype: Link Rect: 521, 614, 530, 623 Destination: 152 Annotation: Subtype: Link Rect: 540, 581, 549, 590 Destination: 152 Annotation: Subtype: Link Rect: 521, 570, 530, 579 Destination: 152 Annotation: Subtype: Link Rect: 538, 570, 547, 579 Destination: 152 Annotation: Subtype: Link Rect: 538, 482, 547, 491 Destination: 152 Annotation: Subtype: Link Rect: 538, 471, 547, 480 Destination: 152 Annotation: Subtype: Link Rect: 318, 273, 327, 282 Destination: 152 Annotation: Subtype: Link Rect: 332, 273, 341, 282 Destination: 155 Annotation: Subtype: Link Rect: 526, 273, 535, 282 Destination: 155 Annotation: Subtype: Link Rect: 429, 196, 438, 205 Destination: 155 Annotation: Subtype: Link Rect: 442, 196, 451, 205 Destination: 155 Annotation: Subtype: Link Rect: 267, 163, 276, 172 Destination: 155 Annotation: Subtype: Link Rect: 217, 152, 226, 161 Destination: 155 Annotation: Subtype: Link Rect: 349, 152, 358, 161 Destination: 155 Annotation: Subtype: Link Rect: 370, 119, 379, 128 Destination: 155 Annotation: Subtype: Link Rect: 454, 97, 463, 106 Destination: 155 Page: Label: 11 Page: Label: 12 Annotations: Annotation: Subtype: Link Rect: 499, 351, 552, 359 Annotation: Subtype: Link Rect: 164, 340, 190, 348 Annotation: Subtype: Link Rect: 386, 208, 450, 216 Page: Label: 13 Page: Label: 14 Checksum: 16a4db2d Type: CRC32 Checksum: 5352ce6b989c829b582a0a86faa393fe Type: MD5 Checksum: 6c8047f187437a15e2870f0af0ab05304554d55a Type: SHA-1 Checksum: a441ab1dc1fb93385770a6c35a2b08542f9a9ad3a61c8f0f340e16e23fa19662 Type: SHA-256