4f8642ef826d5e1fd9a80e58e1174f47 pmc_10985324.pdf beebdabbbcf4df45296a90ae0ef5242e8ad57890 pmc_10985324.pdf dcaf61f29fd2c0c29c2e4dc5f8ce2ac9c69ae4266a11b0cb554f21ed53c78205 pmc_10985324.pdf Title: The scene of lung pathology during PRRSV-1 infection Subject: Porcine reproductive and respiratory syndrome (PRRS) is one of the most economically important infectious diseases for the pig industry worldwide. Author: Inés Ruedas-Torres; José María Sánchez-Carvajal; Francisco Javier Salguero; Francisco José Pallarés; Librado Carrasco; Enric Mateu; Jaime Gómez-Laguna; Irene Magdalena Rodríguez-Gómez Creator: Adobe InDesign 14.0 (Windows) Producer: Adobe PDF Library 15.0 CreationDate: Wed Mar 13 13:29:09 2024 CET ModDate: Wed Mar 13 13:29:31 2024 CET Custom Metadata: no Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 14 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 9888836 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- OIQKVV+MuseoSans-500 Type 1C Custom yes yes yes 8 0 MFRYTZ+MuseoSans-300 Type 1C Custom yes yes yes 108 0 KCSMRD+MuseoSans-700 Type 1C Custom yes yes yes 107 0 IZTAPH+MinionPro-Regular Type 1C Custom yes yes yes 9 0 ETQCLP+MinionPro-It Type 1C Custom yes yes yes 10 0 CQRQJT+MuseoSans-300Italic Type 1C WinAnsi yes yes yes 2077 0 ANSEHX+STIXGeneral-Regular Type 1C Custom yes yes yes 11 0 YKTSFB+STIX-Regular Type 1C Custom yes yes yes 12 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-05-15 02:41:40 CEST RepresentationInformation: pmc_10985324.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-05-14 02:32:54 CEST Size: 9888836 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Tagged PDF PDFMetadata: Objects: 2143 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Language: en-GB Outlines: Item: Title: The scene of lung pathology during PRRSV-1 infection Children: Item: Title: 1 Introduction Item: Title: 2 PRRSV-1 lung lesions Children: Item: Title: 2.1 Macroscopic lung lesions after PRRSV-1 infection Item: Title: 2.1.1 Interstitial pneumonia as PRRSV-induced gross lung lesion Item: Title: 2.1.2 Suppurative bronchopneumonia as accompanying lesion to interstitial pneumonia in virulent PRRSV-1-infected animals Item: Title: 2.2 Microscopic lesions induced by PRRSV-1 strains Item: Title: 2.2.1 Histopathological features of PRRSV-induced interstitial pneumonia Item: Title: 2.2.2 Histopathological features of suppurative bronchopneumonia in virulent PRRSV-1 strains Item: Title: 2.2.3 Kinetics of microscopic changes in the lung of PRRSV-1 infected animals Item: Title: 2.2.4 Other microscopic lung lesional patterns associated with PRRSV-1 infection Item: Title: 3 Pathogenic mechanisms of pulmonary lesion in PRRS Children: Item: Title: 3.1 Role of macrophages Item: Title: 3.2 Mechanisms involved in the regulation of lung inflammation Item: Title: 3.2.1 Type I interferon, an interplay among IFN antiviral response and PRRSV replication Item: Title: 3.2.2 Mechanisms of the proinflammatory response at lung level and its mirroring at systemic level Item: Title: 3.2.3 Modulation and balance of the inflammatory response at lung level Item: Title: 4 Conclusion Item: Title: Author contributions Item: Title: Glossary Item: Title: References Info: Title: The scene of lung pathology during PRRSV-1 infection Author: Inés Ruedas-Torres; José María Sánchez-Carvajal; Francisco Javier Salguero; Francisco José Pallarés; Librado Carrasco; Enric Mateu; Jaime Gómez-Laguna; Irene Magdalena Rodríguez-Gómez Subject: Porcine reproductive and respiratory syndrome (PRRS) is one of the most economically important infectious diseases for the pig industry worldwide. 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