262bddd45bc3c5b807aa4941ab477f6e pmc_11011138.pdf f616c416779083d360ba95abce2f8b074fee844c pmc_11011138.pdf 01d25ffbffb064c4386dfa21c51f69fdb45ad8bf229f2d0737dafd09c4c3abe5 pmc_11011138.pdf Title: Clinical and Clinico-Pathological Observations of the Erythrocyte Sedimentation Rate in Dogs Affected by Leishmaniosis and Other Inflammatory Diseases Subject: The erythrocyte sedimentation rate (ESR) has been used in canine medicine in several disorders, above all, to evaluate levels of inflammation. This study evaluated the ESR in canine leishmaniosis (CanL) and other inflammatory conditions. Three groups of dogs were examined: CanL affected dogs without clinical signs (INFECTED group, #25) or with clinical signs (SICK group, #43) and dogs affected by acute or acute-on-chronic conditions (OTHER DISEASE group, #65). The ESR was compared with acute phase proteins or reactants either positive or negative (leukogram, fibrinogen, iron, unsaturated iron binding capacity, ferritin, haptoglobin, and albumin) and immunological markers (gamma-globulins, IgG, and IgM). The ESR was higher in the SICK group than in the INFECTED group (median 39 vs. 11 mm/h; p < 0.0001), as well as in the OTHER DISEASE than in the INFECTED groups (median 41 vs. 11 mm/h; p < 0.0001). The ESR appeared outside the reference range for all dogs in the SICK and OTHER DISEASE groups and almost with similar values (mm/h; median 39, 95% CI 31–51 vs. 41, 95% CI 12–87; p > 0.05). The extent of changes in ESR can help to establish the severity of CanL and other inflammatory disorders. As a point-of-care test, the ESR can be used to screen dogs for unhealthy conditions, and its values correlate with the severity of any disease, including CanL. Keywords: dog; erythrocyte sedimentation rate; leishmaniosis; inflammatory markers; immune response markers Author: George Lubas, Saverio Paltrinieri, Roberto Amerigo Papini, Ilaria Lensi, Silvia Lucia Benali, Oscar Cortadellas, Nunzio D’Anna, Alessandra Fondati, Xavier Roura and Eric Zini Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Wed Mar 27 07:10:28 2024 CET ModDate: Wed Mar 27 07:48:13 2024 CET Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 467824 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- TIHYCU+URWPalladioL-Bold Type 1 Custom yes yes yes 10 0 UUEWAV+URWPalladioL-Roma Type 1 Custom yes yes yes 16 0 FORWTN+URWPalladioL-Ital Type 1 Custom yes yes yes 21 0 TRVNCM+VnURWPalladioL Type 1 Custom yes yes yes 26 0 SZMRXJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 43 0 EILUJF+CMSY10 Type 1 Builtin yes yes yes 72 0 OVNEXW+EURM10 Type 1 Builtin yes yes yes 80 0 KNOFGN+PalatinoLinotype-Bold CID TrueType Identity-H yes yes yes 95 0 KNOHPI+Calibri CID TrueType Identity-H yes yes yes 101 0 KNOFHO+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 107 0 KNOFHP+PalatinoLinotype-Italic CID TrueType Identity-H yes yes yes 113 0 KNOFIA+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 119 0 KNOFIB+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 122 0 KNOFJB+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 125 0 KNOFOD+PalatinoLinotype-Roman TrueType MacRoman yes yes no 128 0 WBVKDJ+URWPalladioL-BoldItal Type 1 Custom yes yes yes 134 0 UGLOHL+PazoMath Type 1 Builtin yes yes yes 152 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-12-17 02:57:43 CET RepresentationInformation: pmc_11011138.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-12-12 02:29:43 CET Size: 467824 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 286 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Children: Item: Title: Study Design Destination: subsection.2.1 Item: Title: Enrollment of Dogs Destination: subsection.2.2 Item: Title: Number, Signalment, Clinical Classification, and Study Group of Samples Investigated Destination: subsection.2.3 Item: Title: Laboratory Assays Destination: subsection.2.4 Item: Title: Statistical Analysis Destination: subsection.2.5 Item: Title: Results Destination: section.3 Children: Item: Title: Differences in Signalment Data in the Three Group of Dogs Destination: subsection.3.1 Item: Title: Comparison of Measurements in INFECTED, SICK and OTHER DISEASE Groups Destination: subsection.3.2 Item: Title: Correlation between ESR Values and Other Laboratory Parameters Destination: subsection.3.3 Item: Title: Discussion Destination: section.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: section.6 Info: Title: Clinical and Clinico-Pathological Observations of the Erythrocyte Sedimentation Rate in Dogs Affected by Leishmaniosis and Other Inflammatory Diseases Author: George Lubas, Saverio Paltrinieri, Roberto Amerigo Papini, Ilaria Lensi, Silvia Lucia Benali, Oscar Cortadellas, Nunzio D’Anna, Alessandra Fondati, Xavier Roura and Eric Zini Subject: The erythrocyte sedimentation rate (ESR) has been used in canine medicine in several disorders, above all, to evaluate levels of inflammation. This study evaluated the ESR in canine leishmaniosis (CanL) and other inflammatory conditions. Three groups of dogs were examined: CanL affected dogs without clinical signs (INFECTED group, #25) or with clinical signs (SICK group, #43) and dogs affected by acute or acute-on-chronic conditions (OTHER DISEASE group, #65). The ESR was compared with acute phase proteins or reactants either positive or negative (leukogram, fibrinogen, iron, unsaturated iron binding capacity, ferritin, haptoglobin, and albumin) and immunological markers (gamma-globulins, IgG, and IgM). The ESR was higher in the SICK group than in the INFECTED group (median 39 vs. 11 mm/h; p < 0.0001), as well as in the OTHER DISEASE than in the INFECTED groups (median 41 vs. 11 mm/h; p < 0.0001). The ESR appeared outside the reference range for all dogs in the SICK and OTHER DISEASE groups and almost with similar values (mm/h; median 39, 95% CI 31 51 vs. 41, 95% CI 12 87; p > 0.05). The extent of changes in ESR can help to establish the severity of CanL and other inflammatory disorders. As a point-of-care test, the ESR can be used to screen dogs for unhealthy conditions, and its values correlate with the severity of any disease, including CanL. 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