8a78a3989d5b2a5b5d0a3e889828ebbc pmc_11011992.pdf d866a405d4df7bba94aa0e8c2096da5eb4daa8ee pmc_11011992.pdf 51cc7404ce46dd35c15830f289ee78065ff9e3bba6bddfea1827a4d864849ab5 pmc_11011992.pdf Title: Quantitative Microvascular Change Analysis Using a Semi-Automated Algorithm in Macula-on Rhegmatogenous Retinal Detachment Assessed by Swept-Source Optical Coherence Tomography Angiography Subject: Purpose: The purpose of this study was to objectively evaluate the longitudinal changes observed in the retinal capillaries in eyes with macula-on rhegmatogenous retinal detachment (RRD), assessed with optical coherence tomography angiography (OCTA), and to assess the role of these microvascular measures as potential biomarkers of postoperative visual outcomes. Methods: This was a prospective, longitudinal study conducted on consecutive patients who underwent 25 G pars plana vitrectomy for primary RRD. The vessel area density (VAD), vessel skeleton density (VSD), and vessel diameter index (VDI) were assessed in the superficial (SCP) and deep (DCP) capillary plexuses. Results: Twenty-three eyes with macula-on RRD were included in the study. The mean preoperative VDI, VAD, and VSD of the RRD eye were 18.6 1.1, 0.43 0.02, and 0.17 0.01 in the SCP; and 18.6 0.6, 0.38 0.03, and 0.15 0.01 in the DCP, respectively. At month 6, eight (34.8%) eyes achieved a best-corrected visual acuity (BCVA) gain 0.1 LogMAR. A preoperative VDI > 17.80, VSD > 0.170, and VDI-change > -0.395 in the SCP; and VDI > 18.11 and VDI change > -0.039 in the DCP were predictors of achieving a BCVA-gain 0.1 LogMAR. Conclusions: The preoperative VDI in SCP and DCP, the preoperative VSD in SCP, and their changes from preoperative values were predictors of visual outcomes. A quantitative OCTA analysis of capillary density and morphology may represent a potential predictive tool for surgical outcomes in RRD. The results reported in this study suggest that OCTA is a useful ancillary test for clinical disease management. Keywords: rhegmatogenous retinal detachment; microvascular changes; optical coherence tomography angiography Author: Pablo Díaz-Aljaro, Xavier Valldeperas, Laura Broc-Iturralde, Nevena Romanic-Bubalo, Ignacio Díaz-Aljaro, Zhongdi Chu, Ruikang K. Wang and Javier Zarranz-Ventura Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Mon Apr 1 10:46:28 2024 CEST ModDate: Mon Apr 1 11:19:16 2024 CEST Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 15 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 3474690 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- WLENKM+VnURWPalladioL-Bold Type 1 Custom yes yes yes 10 0 KDMPWG+URWPalladioL-Bold Type 1 Custom yes yes yes 16 0 RZDHSJ+URWPalladioL-Roma Type 1 Custom yes yes yes 22 0 RNXJNM+URWPalladioL-Ital Type 1 Custom yes yes yes 27 0 CZMDWU+CMSY10 Type 1 Builtin yes yes yes 32 0 PNJMNO+VnURWPalladioL Type 1 Custom yes yes yes 37 0 BXZUUH+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 53 0 JOLHLJ+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 84 0 JOLHMJ+PalatinoLinotype CID TrueType Identity-H yes yes yes 87 0 JOLHMK+PalatinoLinotype TrueType WinAnsi yes yes no 93 0 JOLHMM+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 96 0 JOLINH+PalatinoLinotype TrueType MacRoman yes yes no 99 0 JOLHLJ+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 114 0 JOLHMK+PalatinoLinotype TrueType WinAnsi yes yes no 117 0 JOLHMM+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 120 0 JOLINH+PalatinoLinotype TrueType MacRoman yes yes no 123 0 QLBIEB+URWPalladioL-BoldItal Type 1 Custom yes yes yes 130 0 OVNEXW+EURM10 Type 1 Builtin yes yes yes 138 0 JOLHLJ+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 165 0 JOLHMK+PalatinoLinotype TrueType WinAnsi yes yes no 168 0 JOLHMM+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 171 0 JOLINH+PalatinoLinotype TrueType MacRoman yes yes no 174 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-04-26 02:40:55 CEST RepresentationInformation: pmc_11011992.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-04-24 02:31:03 CEST Size: 3474690 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 329 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Methods Destination: section.2 Children: Item: Title: Study Design Destination: subsection.2.1 Item: Title: Study Participants and Selection Criteria Destination: subsection.2.2 Children: Item: Title: Surgical Technique Destination: subsubsection.2.2.1 Item: Title: Optical Coherence Tomography Angiography Image-Capture Protocol Destination: subsubsection.2.2.2 Item: Title: Main Outcome Measurements Destination: subsection.2.3 Item: Title: Statistical Analysis Destination: subsection.2.4 Item: Title: Results Destination: section.3 Children: Item: Title: Preoperative Demographic and Clinical Characteristics Destination: subsection.3.1 Item: Title: OCTA Parameters Destination: subsection.3.2 Item: Title: Predictive Factors for Functional Outcome Destination: subsection.3.3 Item: Title: ROC Curves Destination: subsection.3.4 Item: Title: Discussion Destination: section.4 Item: Title: References Destination: appendix.A. Info: Title: Quantitative Microvascular Change Analysis Using a Semi-Automated Algorithm in Macula-on Rhegmatogenous Retinal Detachment Assessed by Swept-Source Optical Coherence Tomography Angiography Author: Pablo Díaz-Aljaro, Xavier Valldeperas, Laura Broc-Iturralde, Nevena Romanic-Bubalo, Ignacio Díaz-Aljaro, Zhongdi Chu, Ruikang K. Wang and Javier Zarranz-Ventura Subject: Purpose: The purpose of this study was to objectively evaluate the longitudinal changes observed in the retinal capillaries in eyes with macula-on rhegmatogenous retinal detachment (RRD), assessed with optical coherence tomography angiography (OCTA), and to assess the role of these microvascular measures as potential biomarkers of postoperative visual outcomes. Methods: This was a prospective, longitudinal study conducted on consecutive patients who underwent 25 G pars plana vitrectomy for primary RRD. The vessel area density (VAD), vessel skeleton density (VSD), and vessel diameter index (VDI) were assessed in the superficial (SCP) and deep (DCP) capillary plexuses. Results: Twenty-three eyes with macula-on RRD were included in the study. The mean preoperative VDI, VAD, and VSD of the RRD eye were 18.6 1.1, 0.43 0.02, and 0.17 0.01 in the SCP; and 18.6 0.6, 0.38 0.03, and 0.15 0.01 in the DCP, respectively. At month 6, eight (34.8%) eyes achieved a best-corrected visual acuity (BCVA) gain 0.1 LogMAR. A preoperative VDI > 17.80, VSD > 0.170, and VDI-change > -0.395 in the SCP; and VDI > 18.11 and VDI change > -0.039 in the DCP were predictors of achieving a BCVA-gain 0.1 LogMAR. Conclusions: The preoperative VDI in SCP and DCP, the preoperative VSD in SCP, and their changes from preoperative values were predictors of visual outcomes. A quantitative OCTA analysis of capillary density and morphology may represent a potential predictive tool for surgical outcomes in RRD. The results reported in this study suggest that OCTA is a useful ancillary test for clinical disease management. 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