5841098adaef84db64f6d63fce1594d1 pmc_11012802.pdf f03ccd08eb4d7f06d5111ab263f4159ec6778b35 pmc_11012802.pdf f923973fc6dca8b8621f3e9ba55b37bcb92ec5016593400f9a9d8ca0cc58e0bc pmc_11012802.pdf Title: New Insights into First-Line Therapy in Diffuse Large B-Cell Lymphoma: Are We Improving Outcomes? Subject: Diffuse large B-cell lymphoma (DLBCL) is the most prevalent subtype of lymphoma, comprising heterogeneous patient subgroups with distinctive biological and clinical characteristics. The R-CHOP combination (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) has been the standard initial treatment, yielding prolonged remissions in over 60% of patients with advanced-stage disease. Several attempts to enhance the outcomes of this regimen over the last two decades have shown limited success. Various novel therapeutic approaches have recently emerged in lymphoma, demonstrating promising results. These include small molecules, novel monoclonal antibodies, antibody–drug conjugates (ADC), bispecific antibodies (BsAbs), and chimeric antigen receptor (CAR) T-cell therapy. This review explores recent advancements in therapeutic strategies for DLBCL and their potential impact on the initial management of DLBCL patients. Keywords: diffuse large B-cell lymphoma; first-line therapy; novel therapies Author: Pau Abrisqueta Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Wed Mar 27 06:16:35 2024 CET ModDate: Wed Mar 27 06:37:12 2024 CET Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 276375 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- NSRJAB+VnURWPalladioL Type 1 Custom yes yes yes 10 0 FTEJCM+URWPalladioL-Bold Type 1 Custom yes yes yes 16 0 GMOIYR+URWPalladioL-Roma Type 1 Custom yes yes yes 22 0 TOBBQE+URWPalladioL-Ital Type 1 Custom yes yes yes 27 0 XPUSBJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 43 0 BSDWLC+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 46 0 WBVKDJ+URWPalladioL-BoldItal Type 1 Custom yes yes yes 61 0 IKKWKP+CMSY10 Type 1 Builtin yes yes yes 66 0 WCBGZO+EURM10 Type 1 Builtin yes yes yes 71 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-06-06 02:43:24 CEST RepresentationInformation: pmc_11012802.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-05-31 06:26:33 CEST Size: 276375 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 354 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Intensifying Chemotherapy Did Not Yield Improvement over R-CHOP Destination: section.2 Children: Item: Title: Intensified Regimens Destination: subsection.2.1 Item: Title: Escalation of Treatment Based on Interim PET in DLBCL and Maintenance Strategies Destination: subsection.2.2 Item: Title: Molecular Targeted Agents Plus R-CHOP Destination: section.3 Children: Item: Title: Randomized Trials with Targeted Agents in Front-Line DLBCL Destination: subsection.3.1 Item: Title: Future Directions with Molecular Targeted Agents in DLBCL Destination: subsection.3.2 Item: Title: Novel Strategies in the Initial Management of Advance-Stage DLBCL Destination: section.4 Item: Title: Future Directions in the Initial Management of Patients with DLBCL Destination: section.5 Children: Item: Title: Novel Monoclonal Antibodies Destination: subsection.5.1 Item: Title: CAR-T-Cell Therapy Destination: subsection.5.2 Item: Title: Bispecific Antibodies (BsAbs) Destination: subsection.5.3 Item: Title: Immune Checkpoint Blockade Destination: subsection.5.4 Item: Title: High-Grade B-Cell Lymphoma (HGBCL) with MYC and BCL2 and/or BCL6 Rearrangements Destination: section.6 Item: Title: Elderly and Frail Patients with DLBCL Destination: section.7 Item: Title: Concluding Remarks Destination: section.8 Item: Title: References Destination: section.9 Info: Title: New Insights into First-Line Therapy in Diffuse Large B-Cell Lymphoma: Are We Improving Outcomes? Author: Pau Abrisqueta Subject: Diffuse large B-cell lymphoma (DLBCL) is the most prevalent subtype of lymphoma, comprising heterogeneous patient subgroups with distinctive biological and clinical characteristics. The R-CHOP combination (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) has been the standard initial treatment, yielding prolonged remissions in over 60% of patients with advanced-stage disease. Several attempts to enhance the outcomes of this regimen over the last two decades have shown limited success. Various novel therapeutic approaches have recently emerged in lymphoma, demonstrating promising results. These include small molecules, novel monoclonal antibodies, antibody drug conjugates (ADC), bispecific antibodies (BsAbs), and chimeric antigen receptor (CAR) T-cell therapy. This review explores recent advancements in therapeutic strategies for DLBCL and their potential impact on the initial management of DLBCL patients. 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