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(2023-03-16) LastModified: 2025-04-11 05:19:14 CEST Size: 707817 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 617 FreeObjects: 3 IncrementalUpdates: 2 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: C-reactive protein-complement factor H axis as a biomarker of activity in early and intermediate age-related macular degeneration Destination: bmark_-919135813 Children: Item: Title: 1 Introduction Destination: s1 Item: Title: 2 Methods Destination: s2 Children: Item: Title: 2.1 Study design, patient population, and data collection Destination: s2_1 Item: Title: 2.2 Genotyping Destination: s2_2 Item: Title: 2.3 Determination of systemic levels of FH, pCRP and mCRP Destination: s2_3 Item: Title: 2.4 Statistical analysis Destination: s2_4 Item: Title: 3 Results Destination: s3 Children: Item: Title: 3.1 Systemic levels of CRP conformations in AMD Destination: s3_1 Item: Title: 3.2 Low levels of systemic FH are associated with intermediate AMD Destination: s3_2 Item: Title: 3.3 Impact of Y402H SNP on systemic levels of CRP conformations and FH Destination: s3_3 Item: Title: 4 Discussion Destination: s4 Item: Title: Data availability statement Destination: s5 Item: Title: Ethics statement Destination: s6 Item: Title: Author contributions Destination: s7 Item: Title: Funding Destination: bmark_1865464027 Item: Title: Acknowledgments Destination: bmark_-366698314 Item: Title: Conflict of interest Destination: bmark_1089982005 Item: Title: Publisher’s note Destination: bmark_-1256977648 Item: Title: References Destination: bmark_2090415954 Info: Keywords: age-related macular degeneration, inflammation, complement factor H, C-reactive protein, retina, biomarker ID: 0xe6d0308f88989469854cefdd236fdee7, 0x9b03a13f5ea71141985ac241c2affc28 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg 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Front. Immunol. 15:1330913 Copyright © 2024 Giralt, Figueras-Roca, Eguileor, Romero, Zarranz-Ventura, Alforja, Santiago, Bolaños, Lozano, Dotti-Boada, Sala-Puigdollers, Dura, Izquierdo-Serra, Valero, Adan, Fonollosa and Molins. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. age-related macular degeneration inflammation complement factor H C-reactive protein retina biomarker C-reactive protein-complement factor H axis as a biomarker of activity in early and intermediate age-related macular degeneration age-related macular degeneration, inflammation, complement factor H, C-reactive protein, retina, biomarker True https://www.frontiersin.org/legal/copyright-statement Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 221, 685, 532, 706 Annotation: Subtype: Link Rect: 221, 660, 498, 681 Annotation: Subtype: Link Rect: 221, 635, 434, 656 Annotation: Subtype: Link Rect: 221, 610, 462, 631 Annotation: Subtype: Link Rect: 221, 585, 434, 606 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Annotation: Subtype: Link Rect: 49, 690, 125, 705 Annotation: Subtype: Link Rect: 60, 537, 144, 544 Annotation: Subtype: Link 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