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Title:           Sequential trypsin and ProAlanase digestions unearth immunological protein biomarkers shrouded by skeletal collagen
Subject:         ISCIENCE, 27 (2024) 109663. doi:10.1016/j.isci.2024.109663
Author:          Shevan Wilkin
Creator:         Elsevier
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       Item: 
        Title: Sequential trypsin and ProAlanase digestions unearth immunological protein biomarkers shrouded by skeletal collagen
        Destination: titlink1
        Children: 
         Item: 
          Title: Introduction
          Destination: flink1
         Item: 
          Title: Results
          Destination: flink2
          Children: 
           Item: 
            Title: Sampling and M. leprae screening of non-leprosarium individuals
            Destination: slink1
           Item: 
            Title: M. leprae genomes recovered from leprosarium individuals, but not from non-leprosarium individuals
            Destination: slink2
           Item: 
            Title: More non-collagenous proteins recovered with trypsin/ProAlanase than trypsin alone
            Destination: slink3
           Item: 
            Title: Bone and dentine samples contain similar immune proteins
            Destination: slink4
           Item: 
            Title: Pellet and supernatant fractions contain similar number of immune-related proteins
            Destination: slink5
           Item: 
            Title: SDS and GuHCl protocols result in similar overall and immune protein recovery
            Destination: slink6
           Item: 
            Title: More immune proteins recovered from leprosarium individuals
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         Item: 
          Title: Discussion
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          Children: 
           Item: 
            Title: Conclusion
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           Item: 
            Title: Limitations of the study
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         Item: 
          Title: Supplemental information
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         Item: 
          Title: Acknowledgments
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         Item: 
          Title: Author contributions
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         Item: 
          Title: Declaration of interests
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         Item: 
          Title: References
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         Item: 
          Title: STAR★Methods
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          Children: 
           Item: 
            Title: Key resources table
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           Item: 
            Title: Resource availability
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             Item: 
              Title: Lead contact
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             Item: 
              Title: Materials availability
              Destination: tlink2
             Item: 
              Title: Data and code availability
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           Item: 
            Title: Method details
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             Item: 
              Title: Methods A: Sample collection
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              Children: 
               Item: 
                Title: Leprosarium and non-Leprosarium individual sample selection
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             Item: 
              Title: Methods B: Protein extractions
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             Item: 
              Title: Methods C: LC-MS/MS analysis
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             Item: 
              Title: Methods D: Protein data analysis
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             Item: 
              Title: Methods E: DNA
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              Children: 
               Item: 
                Title: aDNA extraction, library prep, and shotgun sequencing
                Destination: ftlink10
               Item: 
                Title: Preparation of indexed double-stranded libraries and shotgun sequencing
                Destination: ftlink11
             Item: 
              Title: Methods F: DNA data processing
              Destination: tlink12
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    Title: Sequential trypsin and ProAlanase digestions unearth immunological protein biomarkers shrouded by skeletal collagen
    Author: Shevan Wilkin
    Subject: ISCIENCE, 27 (2024) 109663. doi:10.1016/j.isci.2024.109663
    Creator: Elsevier
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  Checksum: 67da618b
   Type: CRC32
  Checksum: f43ceac7b04f6d9150c371e308073d17
   Type: MD5
  Checksum: 15ba9e0da38ea8bb97b0ee150f76fa22221814db
   Type: SHA-1
  Checksum: 482b9a2d96df9ab1abfd4a520109281e9de0b6a65008938ea7a81d53caa35bdd
   Type: SHA-256