08b5492d9309675d7023c0d0fed4be2f pmc_11050679.pdf 8019850a2db2d233163dc002540e043318897bab pmc_11050679.pdf 579a17ea341924c94d7759a9b274a541013f5d0f75e867b24ec7cfbc57630df7 pmc_11050679.pdf Title: Cognitive Profile and Cardiovascular Risk Factors in Older Adults with Mild Cognitive Impairment Subject: The prevalence of cardiovascular risk factors (CVRFs) in the older adults population and their specific impact on their cognitive profiles still requires further research. For this purpose, a cross-sectional study was carried out to describe the presence of CVRFs and their association with cognitive performance in a sample of older adults (65–85 years old) with Mild Cognitive Impairment (MCI). Participants (n = 185) were divided into three groups concerning their cardiovascular risk level determined by the presence of different CVRFs, including Type 2 Diabetes (T2D), dyslipidemia, hypertension, and obesity. The primary outcome measures were the participant’s scores in the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Sociodemographic, clinical, and psychosocial data were collected. Non-parametrical statistical analyses and effect sizes were calculated. Findings revealed that a greater presence of CVRFs was not associated with a worse overall cognitive performance. High-risk patients were more likely to have significantly worse performance in the attentional domain compared to medium-risk (p = 0.029, r = 0.42) and compared to low-risk (p = 0.041, r = 0.35), specifically in the digits repetition subtest (p = 0.042). T2D alone was the CVRF associated with cognitive differences (p = 0.037, r = 0.32), possibly mediated by the duration of the condition. Consequently, a higher presence of CVRFs did not lead to a worse overall cognitive performance. However, high-risk individuals were more likely to experience cognitive impairment, particularly in the attentional domain. T2D played a significant role in these cognitive profile differences, possibly influenced by its duration. Keywords: cardiovascular risk factors; type 2 diabetes; cognitive impairment; neuropsychological profile; mild cognitive impairment; older adults Author: Julia Vázquez-de Sebastián, Angel M. Ortiz-Zuñiga, Andreea Ciudin, Joan Ars, Marco Inzitari, Rafael Simó, Cristina Hernández, Sergio Ariño-Blasco, María José Barahona, Maite Franco, Xavier Gironès, María Cruz Crespo-Maraver, Joan Carles Rovira, Carmina Castellano-Tejedor and The DIALCAT Consortium Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Mon Apr 22 11:03:30 2024 CEST ModDate: Mon Apr 22 11:06:51 2024 CEST Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 15 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 406062 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- IIWWUS+VnURWPalladioL-Bold Type 1 Custom yes yes yes 10 0 RBMPQT+URWPalladioL-Bold Type 1 Custom yes yes yes 16 0 ZLESXV+URWPalladioL-Roma Type 1 Custom yes yes yes 22 0 LPIXBA+URWPalladioL-Ital Type 1 Custom yes yes yes 27 0 IMFWEW+VnURWPalladioL Type 1 Custom yes yes yes 32 0 LWQXII+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 48 0 IRWHZX+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 51 0 TMLEUV+EURM10 Type 1 Builtin yes yes yes 68 0 JDUPKS+CMSY10 Type 1 Builtin yes yes yes 82 0 FZRLQQ+URWPalladioL-BoldItal Type 1 Custom yes yes yes 90 0 CRUZTT+VnURWPalladioL-Italic Type 1 Custom yes yes yes 120 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-05-15 03:23:46 CEST RepresentationInformation: pmc_11050679.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-05-15 02:37:34 CEST Size: 406062 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 320 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Children: Item: Title: Cardiovascular Risk Factors (CVRFs) and the Aging Population Destination: subsection.1.1 Item: Title: Cardiovascular Risk Factors’ Impact on Cognition Destination: subsection.1.2 Item: Title: Cognitive Impairment-No Dementia Profile Destination: subsection.1.3 Item: Title: Justification for This Research Destination: subsection.1.4 Item: Title: Method Destination: section.2 Children: Item: Title: Study Design Destination: subsection.2.1 Item: Title: Participants Destination: subsection.2.2 Item: Title: Measures and Variables Collected Destination: subsection.2.3 Item: Title: Primary Measures Destination: subsection.2.4 Item: Title: Ethical Aspects Destination: subsection.2.5 Item: Title: Results Destination: section.3 Children: Item: Title: Characteristics of the Sample Destination: subsection.3.1 Item: Title: Comparisons between the Three Groups of CVRL Destination: subsection.3.2 Children: Item: Title: Sociodemographic and Clinical Characteristics Destination: subsubsection.3.2.1 Item: Title: Psychosocial and Functional Measures Destination: subsubsection.3.2.2 Item: Title: Laboratory Parameters Destination: subsubsection.3.2.3 Item: Title: Research Questions Destination: subsection.3.3 Item: Title: Discussion Destination: section.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: section.6 Info: Title: Cognitive Profile and Cardiovascular Risk Factors in Older Adults with Mild Cognitive Impairment Author: Julia Vázquez-de Sebastián, Angel M. Ortiz-Zuñiga, Andreea Ciudin, Joan Ars, Marco Inzitari, Rafael Simó, Cristina Hernández, Sergio Ariño-Blasco, María José Barahona, Maite Franco, Xavier Gironès, María Cruz Crespo-Maraver, Joan Carles Rovira, Carmina Castellano-Tejedor and The DIALCAT Consortium Subject: The prevalence of cardiovascular risk factors (CVRFs) in the older adults population and their specific impact on their cognitive profiles still requires further research. For this purpose, a cross-sectional study was carried out to describe the presence of CVRFs and their association with cognitive performance in a sample of older adults (65 85 years old) with Mild Cognitive Impairment (MCI). Participants (n = 185) were divided into three groups concerning their cardiovascular risk level determined by the presence of different CVRFs, including Type 2 Diabetes (T2D), dyslipidemia, hypertension, and obesity. The primary outcome measures were the participant’s scores in the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Sociodemographic, clinical, and psychosocial data were collected. Non-parametrical statistical analyses and effect sizes were calculated. Findings revealed that a greater presence of CVRFs was not associated with a worse overall cognitive performance. High-risk patients were more likely to have significantly worse performance in the attentional domain compared to medium-risk (p = 0.029, r = 0.42) and compared to low-risk (p = 0.041, r = 0.35), specifically in the digits repetition subtest (p = 0.042). T2D alone was the CVRF associated with cognitive differences (p = 0.037, r = 0.32), possibly mediated by the duration of the condition. Consequently, a higher presence of CVRFs did not lead to a worse overall cognitive performance. However, high-risk individuals were more likely to experience cognitive impairment, particularly in the attentional domain. T2D played a significant role in these cognitive profile differences, possibly influenced by its duration. 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