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Title:           Gut microbiota produces biofilm-associated amyloids with potential for neurodegeneration
Subject:         Nature Communications, doi:10.1038/s41467-024-48309-x
Keywords:        
Author:          Ariadna Fernández-Calvet
Creator:         Springer
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      Title: Gut microbiota produces biofilm-associated amyloids with potential for neurodegeneration
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        Title: Results
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        Children: 
         Item: 
          Title: BAP-like genes are part of the accessory genomes of the microbiome
          Destination: B1
         Item: 
          Title: BAP domains form amyloid-like structures that mediate biofilm formation
          Destination: B2
         Item: 
          Title: BAP domains assemble into fibrillar β-sheet-rich structures with amyloid-like properties
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         Item: 
          Title: BAP amyloid-like structures are present in the human fecal microbiota
          Destination: B4
         Item: 
          Title: BAP-derived amyloidogenic domains promote human α-Syn aggregation in Caenorhabditis elegans muscle model’of PD
          Destination: B5
         Item: 
          Title: Prototypical BAP amyloids induced the formation of intracellular α-syn aggregates in human neuronal’cells
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         Item: 
          Title: Intracerebral inoculation of BAP-like amyloids enhances α-Syn pathophysiology
          Destination: B7
         Item: 
          Title: Specific BAP genes are enriched in the microbiomes of PD patients
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       Item: 
        Title: Discussion
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       Item: 
        Title: Methods
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        Children: 
         Item: 
          Title: Oligonucleotides, plasmids, bacterial strains, and culture conditions
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         Item: 
          Title: Library construction of BAP domains using the C-DAG’system
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         Item: 
          Title: Protein production, purification, and in’vitro fibril formation
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         Item: 
          Title: Generation of chimeric proteins and biofilm phenotype
          Destination: B12
         Item: 
          Title: Fecal sample collection and metagenome analysis
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         Item: 
          Title: Filter retention’assay
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         Item: 
          Title: Preparation of protein aggregates
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         Item: 
          Title: Light scattering
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         Item: 
          Title: Amyloid dyes binding
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         Item: 
          Title: Fourier transform infrared spectroscopy’(FTIR)
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         Item: 
          Title: Transmission Electron Microscopy’(TEM)
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         Item: 
          Title: Cross-seeding of α-Syn
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         Item: 
          Title: Maintenance of Caenorhabditis elegans and in’vivo model of α-Syn aggregation
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         Item: 
          Title: Locomotive analysis of C. elegans
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         Item: 
          Title: Quantification of α-Syn aggregation in C. elegans
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         Item: 
          Title: Quantitative PCR from C. elegans
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         Item: 
          Title: SH-SY5Y cell culture and neuronal differentiation
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         Item: 
          Title: Protein extraction and Western-blot analysis of differentiated SH-SY5Y’cells
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         Item: 
          Title: Analysis of α-synuclein half’life
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         Item: 
          Title: Mice and study’design
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         Item: 
          Title: Behavioral assessments
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         Item: 
          Title: Wire hang’test
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         Item: 
          Title: Negative geotaxis
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          Title: Rotarod
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          Title: Immunohistochemistry
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         Item: 
          Title: Western’blots
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         Item: 
          Title: Quantitative’PCR
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         Item: 
          Title: Metagenomic data reanalysis
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         Item: 
          Title: Statistical analysis
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         Item: 
          Title: Reporting summary
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       Item: 
        Title: Data availability
        Destination: M1
       Item: 
        Title: References
        Destination: A4
       Item: 
        Title: Acknowledgements
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       Item: 
        Title: Author contributions
        Destination: A6
       Item: 
        Title: Competing interests
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       Item: 
        Title: Additional information
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