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Destination: titlink1 Children: Item: Title: Introduction Destination: flink1 Item: Title: Methods Destination: flink2 Children: Item: Title: 23andMe cohort and data collection Destination: slink1 Item: Title: Ethics Destination: slink2 Item: Title: Variant selection Destination: slink3 Item: Title: Phenome-wide association analyses Destination: slink4 Item: Title: Mendelian randomisation Destination: slink5 Item: Title: Role of funders Destination: flink3 Item: Title: Results Destination: flink4 Children: Item: Title: ADH1B rs1229984 Destination: slink6 Item: Title: ADH1B rs2066702 Destination: slink7 Item: Title: ADH1C rs698 Destination: slink8 Item: Title: Mendelian randomisation Destination: slink9 Item: Title: Discussion Destination: flink5 Children: Item: Title: Conclusion Destination: slink10 Item: Title: ContributorsSSR conceived of the idea for the paper, with input from AAP. PF, MVJ, JJMM. and the 23andMe team contributed a ... Destination: blink1 Item: Title: Data sharing statementData collection was not performed as part of this study. Summary statistics from the PheWAS and MR an ... Destination: blink2 Item: Title: Declaration of interests Destination: blink3 Item: Title: Acknowledgements Destination: blink4 Item: Title: Appendix A. Supplementary data Destination: flink6 Item: Title: References Destination: blink5 Info: Title: A phenome-wide association and Mendelian randomisation study of alcohol use variants in a diverse cohort comprising over 3 million individuals Author: Mariela V. Jennings Subject: eBioMedicine, 103 (2024) 105086. doi:10.1016/j.ebiom.2024.105086 Creator: Elsevier Producer: Acrobat Distiller 8.0.0 (Windows) CreationDate: Fri May 10 04:16:53 CEST 2024 ModDate: Fri May 10 04:20:06 CEST 2024 ID: 0x4e6b1620dd1b8c42fa13565034860c4f, 0x6fec7d3e9e428b4e8574729e8b95baba Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1659 ImageHeight: 1684 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1586 ImageHeight: 2391 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: BNGLGL+AdvTT0d8bc80f.B+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: BNGLGL+AdvTT0d8bc80f.B+fb Flags: Symbolic FontBBox: 9, -10, 552, 729 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: BNGLGM+AdvOT4e4587b6.B FontSubset: true FirstChar: 49 LastChar: 83 FontDescriptor: FontName: BNGLGM+AdvOT4e4587b6.B Flags: Nonsymbolic FontBBox: -187, -250, 1052, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BNGLGP+AdvTTac2dc932 FontSubset: true FirstChar: 44 LastChar: 122 FontDescriptor: FontName: BNGLGP+AdvTTac2dc932 Flags: Serif, Nonsymbolic FontBBox: -166, -250, 1010, 833 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BNGLLB+AdvTTae869a4c+20 FontSubset: true FirstChar: 145 LastChar: 151 FontDescriptor: FontName: BNGLLB+AdvTTae869a4c+20 Flags: Nonsymbolic FontBBox: -20, -239, 1197, 729 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BNGLGO+AdvTTae869a4c FontSubset: true FirstChar: 35 LastChar: 243 FontDescriptor: FontName: BNGLGO+AdvTTae869a4c Flags: Serif, Nonsymbolic FontBBox: 0, -250, 927, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BNGLEG+AdvOT20212610.B FontSubset: true FirstChar: 44 LastChar: 121 FontDescriptor: FontName: BNGLEG+AdvOT20212610.B Flags: Nonsymbolic FontBBox: -52, -239, 833, 833 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BNGLFH+AdvOT2867105d.I FontSubset: true FirstChar: 44 LastChar: 243 FontDescriptor: FontName: BNGLFH+AdvOT2867105d.I Flags: Serif, Nonsymbolic FontBBox: -104, -239, 791, 833 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BNGLLA+AdvTTae869a4c+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: BNGLLA+AdvTTae869a4c+fb Flags: Symbolic FontBBox: 19, -10, 552, 729 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: BNGLFI+AdvstixtSym FontSubset: true FirstChar: 1 LastChar: 4 FontDescriptor: FontName: BNGLFI+AdvstixtSym Flags: Symbolic FontBBox: -20, -1114, 1135, 822 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: BNGLPA+AdvTTb4077e6a FontSubset: true FirstChar: 46 LastChar: 112 FontDescriptor: FontName: BNGLPA+AdvTTb4077e6a Flags: Serif, Nonsymbolic FontBBox: -104, -239, 822, 833 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BNGLFJ+AdvOT3f9da5b7 FontSubset: true FirstChar: 37 LastChar: 242 FontDescriptor: FontName: BNGLFJ+AdvOT3f9da5b7 Flags: Nonsymbolic FontBBox: -52, -239, 791, 833 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BNGLGK+AdvTT0d8bc80f.B FontSubset: true FirstChar: 40 LastChar: 169 FontDescriptor: FontName: BNGLGK+AdvTT0d8bc80f.B Flags: Serif, Nonsymbolic FontBBox: 0, -250, 947, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BNGLFK+AdvOT3f9da5b7+20 FontSubset: true FirstChar: 146 LastChar: 151 FontDescriptor: FontName: BNGLFK+AdvOT3f9da5b7+20 Flags: Nonsymbolic FontBBox: -156, -177, 916, 739 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BNGMKN+AdvOTb0c9bf5d+03 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: BNGMKN+AdvOTb0c9bf5d+03 Flags: Symbolic FontBBox: -479, -364, 854, 927 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: BNGMKO+AdvTTae869a4c+22 FontSubset: true FirstChar: 21 LastChar: 21 FontDescriptor: FontName: BNGMKO+AdvTTae869a4c+22 Flags: Nonsymbolic FontBBox: 19, -10, 520, 729 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: BNGLGN+AdvOTe3b1fbf3.B+22 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: BNGLGN+AdvOTe3b1fbf3.B+22 Flags: Symbolic FontBBox: 0, -406, 1343, 937 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: BNGLKP+AdvOT3f9da5b7+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: BNGLKP+AdvOT3f9da5b7+fb Flags: Symbolic FontBBox: 0, 0, 697, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true XMP: application/pdf doi:10.1016/j.ebiom.2024.105086 A phenome-wide association and Mendelian randomisation study of alcohol use variants in a diverse cohort comprising over 3 million individuals Mariela V. Jennings José Jaime Martínez-Magaña Natasia S. Courchesne-Krak Renata B. Cupertino Laura Vilar-Ribó Sevim B. Bianchi Alexander S. Hatoum Elizabeth G. Atkinson Paola Giusti-Rodriguez Janitza L. Montalvo-Ortiz Joel Gelernter María Soler Artigas 23andMe Inc. Research Team Stella Aslibekyan Adam Auton Elizabeth Babalola Robert K. Bell Jessica Bielenberg Katarzyna Bryc Emily Bullis Daniella Coker Gabriel Cuellar Partida Devika Dhamija Sayantan Das Sarah L. Elson Nicholas Eriksson Teresa Filshtein Alison Fitch Kipper Fletez-Brant Pierre Fontanillas Will Freyman Julie M. Granka Karl Heilbron Alejandro Hernandez Barry Hicks David A. Hinds Ethan M. Jewett Yunxuan Jiang Katelyn Kukar Alan Kwong Keng-Han Lin Bianca A. Llamas Maya Lowe Jey C. McCreight Matthew H. McIntyre Steven J. Micheletti Meghan E. Moreno Priyanka Nandakumar Dominique T. Nguyen Elizabeth S. Noblin Jared O'Connell Aaron A. Petrakovitz G. David Poznik Alexandra Reynoso Morgan Schumacher Anjali J. Shastri Janie F. Shelton Jingchunzi Shi Suyash Shringarpure Qiaojuan Jane Su Susana A. Tat Christophe Toukam Tchakouté Vinh Tran Joyce Y. Tung Xin Wang Wei Wang Catherine H. Weldon Peter Wilton Corinna D. Wong Sarah L. Elson Howard J. Edenberg Pierre Fontanillas Abraham A. Palmer Sandra Sanchez-Roige Alcohol PheWAS Metabolising enzyme genes ADH1B ADH1C rs1229984 eBioMedicine, 103 (2024) 105086. doi:10.1016/j.ebiom.2024.105086 The Authors journal eBioMedicine © 2024 The Authors. 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359, 661, 555, 668 Annotation: Subtype: Link Rect: 359, 653, 508, 660 Annotation: Subtype: Link Rect: 359, 645, 555, 652 Annotation: Subtype: Link Rect: 359, 637, 412, 644 Annotation: Subtype: Link Rect: 359, 629, 555, 636 Annotation: Subtype: Link Rect: 359, 621, 555, 628 Annotation: Subtype: Link Rect: 359, 613, 555, 620 Annotation: Subtype: Link Rect: 359, 605, 552, 612 Annotation: Subtype: Link Rect: 359, 597, 555, 604 Annotation: Subtype: Link Rect: 359, 589, 555, 596 Annotation: Subtype: Link Rect: 359, 581, 408, 588 Annotation: Subtype: Link Rect: 359, 573, 555, 580 Annotation: Subtype: Link Rect: 359, 565, 555, 572 Annotation: Subtype: Link Rect: 359, 557, 518, 564 Annotation: Subtype: Link Rect: 359, 549, 555, 556 Annotation: Subtype: Link Rect: 359, 541, 555, 548 Annotation: Subtype: Link Rect: 359, 533, 555, 540 Annotation: Subtype: Link Rect: 359, 525, 415, 532 Annotation: Subtype: Link Rect: 359, 517, 555, 524 Annotation: Subtype: Link Rect: 359, 509, 555, 516 Annotation: Subtype: Link Rect: 359, 501, 555, 508 Annotation: Subtype: Link Rect: 359, 493, 480, 500 Annotation: Subtype: Link Rect: 359, 485, 555, 492 Annotation: Subtype: Link Rect: 359, 477, 555, 484 Annotation: Subtype: Link Rect: 359, 469, 503, 476 Annotation: Subtype: Link Rect: 359, 461, 555, 468 Annotation: Subtype: Link Rect: 359, 453, 555, 460 Annotation: Subtype: Link Rect: 359, 445, 555, 452 Annotation: Subtype: Link Rect: 359, 437, 529, 444 Annotation: Subtype: Link Rect: 359, 430, 555, 436 Annotation: Subtype: Link Rect: 359, 422, 555, 428 Annotation: Subtype: Link Rect: 359, 414, 555, 421 Annotation: Subtype: Link Rect: 359, 406, 537, 413 Annotation: Subtype: Link Rect: 359, 398, 555, 405 Annotation: Subtype: Link Rect: 359, 390, 555, 397 Annotation: Subtype: Link Rect: 359, 382, 394, 389 Annotation: Subtype: Link Rect: 359, 374, 555, 381 Annotation: Subtype: Link Rect: 359, 366, 517, 373 Annotation: Subtype: Link Rect: 359, 358, 555, 365 Annotation: Subtype: Link Rect: 359, 350, 555, 357 Annotation: Subtype: Link Rect: 359, 342, 495, 349 Annotation: Subtype: Link Rect: 359, 334, 555, 341 Annotation: Subtype: Link Rect: 359, 326, 555, 333 Annotation: Subtype: Link Rect: 359, 318, 485, 325 Annotation: Subtype: Link Rect: 359, 310, 555, 317 Annotation: Subtype: Link Rect: 359, 302, 555, 309 Annotation: Subtype: Link Rect: 359, 294, 555, 301 Annotation: Subtype: Link Rect: 359, 286, 385, 293 Annotation: Subtype: Link Rect: 359, 278, 555, 285 Annotation: Subtype: Link Rect: 359, 270, 555, 277 Annotation: Subtype: Link Rect: 359, 262, 428, 269 Annotation: Subtype: Link Rect: 441, 12, 498, 19 Checksum: b1a798ae Type: CRC32 Checksum: fd9a93647acfa8ad8efecc1e88adfca0 Type: MD5 Checksum: 14db075533bcdc4a02e2612a66499f3ea4717886 Type: SHA-1 Checksum: 9d3f83ba3be9e426aeac007548b1d2e09c96479db54e22d331f08e139ae207c7 Type: SHA-256