5c73b57ccfc539bcc77e9845d258310f pmc_11174397.pdf 9015a5b2cbdb618c93e7b9c440a49ad9b39ac79a pmc_11174397.pdf c7e033983511f75c056a0c75bc55f6d219a4851e38238711a04947dadcc033b7 pmc_11174397.pdf Title: The Link between Abdominal Obesity Indices and the Progression of Liver Fibrosis: Insights from a Population-Based Study Subject: There is currently no available information on the correlation between abdominal obesity indices and the risk of liver fibrosis progression. We aimed to investigate the relationship between the body mass index (BMI), waist circumference (WC), and the visceral adiposity index (VAI) with the progression of liver fibrosis. The study also evaluated the association between these indices and the prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) and liver fibrosis. A total of 1403 subjects participated in the cross-sectional and longitudinal population-based study. Liver stiffness was assessed via transient elastography, at baseline and follow-up (median: 4.2 years). The subgroup with dysglycemia was also analyzed. In the cross-sectional study, the highest quartile of VAI, BMI 30 kg/m2, and abdominal obesity showed significant associations with the prevalence of MASLD and liver fibrosis, as well as with fibrosis progression. However, VAI showed no association with MASLD incidence. Among the dysglycemic subjects, there was no observed association between VAI and the incidence of MASLD or the progression of fibrosis. In conclusion, the BMI, WC, and the VAI are associated with an increased risk of progression to moderate-to-advanced liver fibrosis in the general population. However, the VAI does not perform better than the BMI and WC measurement. Keywords: metabolic dysfunction-associated steatotic liver disease (MASLD); liver fibrosis; transient elastography (TE); visceral adiposity index (VAI); abdominal obesity; body mass index (BMI); waist circumference (WC) Author: María Teresa Julián, Ingrid Arteaga, Pere Torán-Monserrat, Guillem Pera, Alejandra Pérez-Montes de Oca, Irene Ruiz-Rojano, Elena Casademunt-Gras, Carla Chacón and Nuria Alonso Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Mon Jun 10 12:43:15 2024 CEST ModDate: Mon Jun 10 12:48:14 2024 CEST Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 16 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 2473007 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- JYPLJJ+VnURWPalladioL-Bold Type 1 Custom yes yes yes 10 0 EKASEQ+URWPalladioL-Bold 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TrueType WinAnsi yes yes no 342 0 BCDGEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 346 0 BCDHEE+PalatinoLinotype-Italic CID TrueType Identity-H yes yes yes 350 0 BCDIEE+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 356 0 BCDJEE+PalatinoLinotype-Bold CID TrueType Identity-H yes yes yes 362 0 MPUDFL+PazoMath Type 1 Builtin yes yes yes 371 0 PDXFNG+PazoMath-Bold Type 1 Builtin yes yes yes 376 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-02-06 02:50:37 CET RepresentationInformation: pmc_11174397.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-02-04 02:26:36 CET Size: 2473007 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 601 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Children: Item: Title: Study Design and Participants Destination: subsection.2.1 Item: Title: Definitions Destination: subsection.2.2 Item: Title: Statistical Analysis Destination: subsection.2.3 Item: Title: Results Destination: section.3 Children: Item: Title: Characteristics of the Study Population Destination: subsection.3.1 Item: Title: Abdominal Obesity Indices: Their Relationship with MASLD and Liver Fibrosis Prevalence Destination: subsection.3.2 Item: Title: Abdominal Obesity Indices: Their Relationship with MASLD Incidence and Liver Fibrosis Progression Destination: subsection.3.3 Item: Title: Abdominal Obesity Indices in Dysglycemic Subjects: Their Relationship with MASLD and Liver Fibrosis Prevalence Destination: subsection.3.4 Item: Title: Abdominal Obesity Indices in Dysglycemic Subjects: Their Relationship with MASLD Incidence and Liver Fibrosis Progression Destination: subsection.3.5 Item: Title: Discussion Destination: section.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: appendix.A. Info: Title: The Link between Abdominal Obesity Indices and the Progression of Liver Fibrosis: Insights from a Population-Based Study Author: María Teresa Julián, Ingrid Arteaga, Pere Torán-Monserrat, Guillem Pera, Alejandra Pérez-Montes de Oca, Irene Ruiz-Rojano, Elena Casademunt-Gras, Carla Chacón and Nuria Alonso Subject: There is currently no available information on the correlation between abdominal obesity indices and the risk of liver fibrosis progression. We aimed to investigate the relationship between the body mass index (BMI), waist circumference (WC), and the visceral adiposity index (VAI) with the progression of liver fibrosis. The study also evaluated the association between these indices and the prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) and liver fibrosis. A total of 1403 subjects participated in the cross-sectional and longitudinal population-based study. Liver stiffness was assessed via transient elastography, at baseline and follow-up (median: 4.2 years). The subgroup with dysglycemia was also analyzed. In the cross-sectional study, the highest quartile of VAI, BMI 30 kg/m2, and abdominal obesity showed significant associations with the prevalence of MASLD and liver fibrosis, as well as with fibrosis progression. However, VAI showed no association with MASLD incidence. Among the dysglycemic subjects, there was no observed association between VAI and the incidence of MASLD or the progression of fibrosis. In conclusion, the BMI, WC, and the VAI are associated with an increased risk of progression to moderate-to-advanced liver fibrosis in the general population. However, the VAI does not perform better than the BMI and WC measurement. Keywords: metabolic dysfunction-associated steatotic liver disease (MASLD); liver fibrosis; transient elastography (TE); visceral adiposity index (VAI); abdominal obesity; body mass index (BMI); waist circumference (WC) Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Mon Jun 10 12:43:15 CEST 2024 ModDate: Mon Jun 10 12:48:14 CEST 2024 ID: 0x99951d346fa6dba181f1afbe54eddf01, 0x99951d346fa6dba181f1afbe54eddf01 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: EKASEQ+URWPalladioL-Bold FontSubset: true FirstChar: 3 LastChar: 135 FontDescriptor: FontName: EKASEQ+URWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: SSJMKU+CMSY10 FontSubset: true FirstChar: 0 LastChar: 21 FontDescriptor: FontName: SSJMKU+CMSY10 Flags: Symbolic FontBBox: -29, -960, 1116, 775 FontFile: true ToUnicode: true Font: BaseFont: URYLRZ+URWPalladioL-BoldItal FontSubset: true FirstChar: 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