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Here, we investigated the association between CMR-derived LV-IVPGs and major adverse cardiovascular events (MACE) in a large reperfused STEMI cohort with long-term outcome. Methods and results: In this prospectively enrolled multi-centre cohort study, 307 patients underwent CMR within 14 days after the first STEMI. LV-IVPGs (from apex-to-base) were estimated on the long-axis cine images. During a median follow-up of 9.7 (5.9–12.5) years, MACE (i.e. composite of ca Keywords: ST-elevation myocardial infarction; cardiac magnetic resonance imaging; microvascular injury; feature tracking; intraventricular pressure gradients Author: Lara S.F. Konijnenberg Creator: Servigistics Arbortext Advanced Print Publisher 11.1.4546/W-x64 Producer: PDFlib+PDI 9.0.7p3 (C++/Win64) CreationDate: Mon Mar 25 09:42:08 2024 CET ModDate: Mon Mar 25 14:07:01 2024 CET Custom Metadata: yes Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 9 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 569944 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MOGPFV+GillSansNova-Book CID TrueType Identity-H yes yes yes 1162 0 JQALIL+GillSansNova-Bold CID TrueType Identity-H yes yes yes 1167 0 LJFEFE+GillSansNova-BookItalic CID TrueType Identity-H yes yes yes 1172 0 TZCTGM+GillSansNova-Heavy CID TrueType Identity-H yes yes yes 1177 0 XLCOWA+STIXGeneral-Regular Type 1C Custom yes yes yes 1182 0 RQZXIA+GillSansNova-BoldItalic CID TrueType Identity-H yes yes yes 56 0 KHWSJH+TimesNewRomanPSMT CID TrueType Identity-H yes yes yes 61 0 FUFVFO+STIXGeneral-Bold Type 1C Custom yes yes yes 77 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-02-06 02:50:21 CET RepresentationInformation: pmc_11195698.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-02-05 02:55:15 CET Size: 569944 Format: PDF Version: 1.6 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ErrorMessage: Invalid indirect destination - 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referenced object 'affqyae009-aff8' cannot be found ID: PDF-HUL-122 Offset: 372584 MIMEtype: application/pdf Profile: Tagged PDF PDFMetadata: Objects: 1245 FreeObjects: 4 IncrementalUpdates: 4 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: true NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: OneColumn PageMode: UseOutlines Language: en Outlines: Item: Title: Cardiovascular magnetic resonance imaging-derived intraventricular pressure gradients in ST-segment elevation myocardial infarction: a long-term follow-up study Destination: head1 Children: Item: Title: Introduction Destination: secqyae009-s0 Item: Title: Methods Destination: secqyae009-s1 Children: Item: Title: Study design and population Destination: secqyae009-s1.1 Item: Title: Demographic and clinical characteristics Destination: secqyae009-s1.2 Item: Title: CMR acquisition Destination: secqyae009-s1.3 Children: Item: Title: CMR global LV function analysis Destination: secqyae009-s1.4 Item: Title: CMR feature tracking analysis Destination: secqyae009-s1.5 Item: Title: CMR LV HDF analysis Destination: secqyae009-s1.6 Item: Title: Clinical endpoints Destination: secqyae009-s1.7 Item: Title: Statistical analysis Destination: secqyae009-s1.8 Item: Title: Results Destination: secqyae009-s2 Children: Item: Title: Study population Destination: secqyae009-s2.1 Item: Title: CMR characteristics Destination: secqyae009-s2.2 Item: Title: Association of LV-IVPGs with clinical outcomes Destination: secqyae009-s2.3 Item: Title: Impact of infarct severity on LV-IVPGs Destination: secqyae009-s2.4 Item: Title: Discussion Destination: secqyae009-s3 Children: Item: Title: Clinical relevance Destination: secqyae009-s4 Item: Title: Limitations Destination: secqyae009-s5 Item: Title: Conclusion Destination: secqyae009-s6 Item: Title: Supplementary data Destination: secqyae009-s7 Item: Title: Ethical approval Destination: secqyae009-s8 Item: Title: Consent Destination: secqyae009-s9 Item: Title: Funding Destination: secqyae009-s10 Item: Title: Data availability Destination: secqyae009-s11 Item: Title: Lead author biography Destination: secqyae009-s12 Item: Title: References Destination: reflist Info: Title: Cardiovascular magnetic resonance imaging-derived intraventricular pressure gradients in ST-segment elevation myocardial infarction: a long-term follow-up study Author: Lara S.F. Konijnenberg Subject: DOI: 10.1093/ehjimp/qyae009; European Heart Journal - Imaging Methods and Practice, 2, 1, 2024-02-09.; Abstract: Aims: Recently, novel post-processing tools have become available that measure intraventricular pressure gradients (IVPGs) on routinely obtained long-axis cine cardiac magnetic resonance (CMR) images. IVPGs provide a comprehensive overview of both systolic and diastolic left ventricular (LV) functions. Whether IVPGs are associated with clinical outcome after ST-elevation myocardial infarction (STEMI) is currently unknown. Here, we investigated the association between CMR-derived LV-IVPGs and major adverse cardiovascular events (MACE) in a large reperfused STEMI cohort with long-term outcome. Methods and results: In this prospectively enrolled multi-centre cohort study, 307 patients underwent CMR within 14 days after the first STEMI. LV-IVPGs (from apex-to-base) were estimated on the long-axis cine images. During a median follow-up of 9.7 (5.9 12.5) years, MACE (i.e. composite of ca Keywords: ST-elevation myocardial infarction; cardiac magnetic resonance imaging; microvascular injury; feature tracking; intraventricular pressure gradients Creator: Servigistics Arbortext Advanced Print Publisher 11.1.4546/W-x64 Producer: PDFlib+PDI 9.0.7p3 (C++/Win64) CreationDate: Mon Mar 25 10:12:08 CET 2024 ModDate: Mon Mar 25 14:37:01 CET 2024 ID: 0x8d585fe3faae62ae82cccaf427e1cd5a, 0xcf4964f26efc4543936ac53cdb53ad12 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 633 ImageHeight: 767 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 937 ImageHeight: 564 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 248 ImageHeight: 318 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type0: Font: BaseFont: LJFEFE+GillSansNova-BookItalic Encoding: Identity-H ToUnicode: true Font: BaseFont: RQZXIA+GillSansNova-BoldItalic Encoding: Identity-H ToUnicode: true Font: BaseFont: TZCTGM+GillSansNova-Heavy Encoding: Identity-H ToUnicode: true Font: BaseFont: MOGPFV+GillSansNova-Book Encoding: Identity-H ToUnicode: true Font: BaseFont: KHWSJH+TimesNewRomanPSMT Encoding: Identity-H ToUnicode: true Font: BaseFont: JQALIL+GillSansNova-Bold Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: FUFVFO+STIXGeneral-Bold FontSubset: true FirstChar: 1 LastChar: 4 FontDescriptor: FontName: FUFVFO+STIXGeneral-Bold Flags: Nonsymbolic, ForceBold FontBBox: -1030, -455, 2000, 1055 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: XLCOWA+STIXGeneral-Regular FontSubset: true FirstChar: 1 LastChar: 8 FontDescriptor: FontName: XLCOWA+STIXGeneral-Regular Flags: Nonsymbolic FontBBox: -995, -455, 2000, 1055 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true CIDFontType2: Font: BaseFont: JQALIL+GillSansNova-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: JQALIL+GillSansNova-Bold Flags: Nonsymbolic, ForceBold FontBBox: -476, -276, 1276, 961 FontFile2: true Font: BaseFont: LJFEFE+GillSansNova-BookItalic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: LJFEFE+GillSansNova-BookItalic Flags: Nonsymbolic, Italic FontBBox: -316, -235, 1219, 950 FontFile2: true Font: BaseFont: RQZXIA+GillSansNova-BoldItalic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: RQZXIA+GillSansNova-BoldItalic Flags: Nonsymbolic, Italic, ForceBold FontBBox: -404, -250, 1219, 960 FontFile2: true Font: BaseFont: TZCTGM+GillSansNova-Heavy CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: TZCTGM+GillSansNova-Heavy Flags: Nonsymbolic, ForceBold FontBBox: -504, -287, 1375, 966 FontFile2: true Font: BaseFont: MOGPFV+GillSansNova-Book CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: MOGPFV+GillSansNova-Book Flags: Nonsymbolic FontBBox: -420, -251, 1219, 950 FontFile2: true Font: BaseFont: KHWSJH+TimesNewRomanPSMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: KHWSJH+TimesNewRomanPSMT Flags: Nonsymbolic FontBBox: -568, -307, 2046, 1040 FontFile2: true XMP: uuid:1f0ccbe0-3c74-42ef-b532-afe64fc0607d uuid:1D518C0F-A3B4-9004-F837-20E7CD36147B True ST-elevation myocardial infarction; cardiac magnetic resonance imaging; microvascular injury; feature tracking; intraventricular pressure gradients PDFlib+PDI 9.0.7p3 (C++/Win64) application/pdf 10.1093/ehjimp/qyae009 en Oxford University Press Cardiovascular magnetic resonance imaging-derived intraventricular pressure gradients in ST-segment elevation myocardial infarction: a long-term follow-up study Lara S.F. Konijnenberg Casper W.H. Beijnink Maarten van Lieshout Jacqueline L. Vos Laura Rodwell Vicente Bodi José T. Ortiz-Pérez Niels van Royen José Rodriguez Palomares Robin Nijveldt DOI: 10.1093/ehjimp/qyae009; European Heart Journal - Imaging Methods and Practice, 2, 1, 2024-02-09.; Abstract: Aims: Recently, novel post-processing tools have become available that measure intraventricular pressure gradients (IVPGs) on routinely obtained long-axis cine cardiac magnetic resonance (CMR) images. IVPGs provide a comprehensive overview of both systolic and diastolic left ventricular (LV) functions. Whether IVPGs are associated with clinical outcome after ST-elevation myocardial infarction (STEMI) is currently unknown. Here, we investigated the association between CMR-derived LV-IVPGs and major adverse cardiovascular events (MACE) in a large reperfused STEMI cohort with long-term outcome. Methods and results: In this prospectively enrolled multi-centre cohort study, 307 patients underwent CMR within 14 days after the first STEMI. LV-IVPGs (from apex-to-base) were estimated on the long-axis cine images. During a median follow-up of 9.7 (5.9–12.5) years, MACE (i.e. composite of ca © The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology. ST-elevation myocardial infarction cardiac magnetic resonance imaging microvascular injury feature tracking intraventricular pressure gradients Journal European Heart Journal - Imaging Methods and Practice © The Author(s) 2024. 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