32023e0acef430db32cdc4c493da98da pmc_11209642.pdf daad05068d37bead55f00adf56ce35e1d5060f24 pmc_11209642.pdf 20d6240b52bd76b37dc1068915f50fd791318065bbf280a573926c019adfa001 pmc_11209642.pdf Title: Critically Appraised Topic on Canine Leishmaniosis: Does Treatment with Antimonials and Allopurinol Have the Same Clinical and Clinicopathological Efficacy as Treatment with Miltefosine and Allopurinol, after One Month of Treatment? Subject: The treatment of canine leishmaniosis commonly involves meglumine antimoniate with allopurinol or miltefosine with allopurinol. This study aims to compare the clinical and clinicopathological efficacy at 28–30 days of conventional dosing regimens for both treatments using the critically appraised topic methodology. A comprehensive search across three databases (PubMed, CAB Abstracts, and Web of Science) from March 2004 to September 2023 yielded 16 relevant articles, encompassing 325 ogs treated with meglumine antimoniate and allopurinol, and 273 dogs treated with miltefosine and allopurinol. The findings indicated a significantly higher rate of complete clinical cure in the group treated with meglumine antimoniate and allopurinol. Most dogs in both groups exhibited improvement in clinicopathological alterations after one month of treatment. No significant difference was observed in the number of dogs that showed a negative Leishmania qPCR between the two groups, one month post-treatment. However, quantitative serology results were not commonly reported in the available data and therefore this aspect could not be compared. Keywords: dogs; leishmaniosis; miltefosine; meglumine antimoniate; allopurinol Author: Marina García, Lluís Ferrer and Laura Ordeix Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Tue Jun 18 11:43:17 2024 CEST ModDate: Tue Jun 18 11:45:47 2024 CEST Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 583115 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- LUWBVJ+VnURWPalladioL-Bold Type 1 Custom yes yes yes 10 0 JHCJRR+URWPalladioL-Bold Type 1 Custom yes yes yes 16 0 GVASHO+URWPalladioL-Roma Type 1 Custom yes yes yes 22 0 FTXIVI+URWPalladioL-Ital Type 1 Custom yes yes yes 27 0 HCRKXL+VnURWPalladioL Type 1 Custom yes yes yes 32 0 CTCXDQ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 48 0 EILUJF+CMSY10 Type 1 Builtin yes yes yes 65 0 KEMBFL+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 92 0 KEMBFM+PalatinoLinotype CID TrueType Identity-H yes yes yes 95 0 KEMBFN+PalatinoLinotype TrueType WinAnsi yes yes no 101 0 KEMBFP+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 104 0 KEMBMN+PalatinoLinotype TrueType MacRoman yes yes no 107 0 KEMEDA+DengXian CID TrueType Identity-H yes yes yes 110 0 CKBPVA+EURM10 Type 1 Builtin yes yes yes 126 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-07-24 02:40:43 CEST RepresentationInformation: pmc_11209642.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-07-18 02:30:06 CEST Size: 583115 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 339 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Item: Title: Results Destination: section.3 Children: Item: Title: Meglumine Antimoniate plus Allopurinol Destination: subsection.3.1 Item: Title: Miltefosine plus Allopurinol Destination: subsection.3.2 Item: Title: Compared Aspects between the Two Groups Destination: subsection.3.3 Item: Title: Discussion Destination: section.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: section.6 Info: Title: Critically Appraised Topic on Canine Leishmaniosis: Does Treatment with Antimonials and Allopurinol Have the Same Clinical and Clinicopathological Efficacy as Treatment with Miltefosine and Allopurinol, after One Month of Treatment? Author: Marina García, Lluís Ferrer and Laura Ordeix Subject: The treatment of canine leishmaniosis commonly involves meglumine antimoniate with allopurinol or miltefosine with allopurinol. This study aims to compare the clinical and clinicopathological efficacy at 28 30 days of conventional dosing regimens for both treatments using the critically appraised topic methodology. A comprehensive search across three databases (PubMed, CAB Abstracts, and Web of Science) from March 2004 to September 2023 yielded 16 relevant articles, encompassing 325 ogs treated with meglumine antimoniate and allopurinol, and 273 dogs treated with miltefosine and allopurinol. The findings indicated a significantly higher rate of complete clinical cure in the group treated with meglumine antimoniate and allopurinol. Most dogs in both groups exhibited improvement in clinicopathological alterations after one month of treatment. No significant difference was observed in the number of dogs that showed a negative Leishmania qPCR between the two groups, one month post-treatment. However, quantitative serology results were not commonly reported in the available data and therefore this aspect could not be compared. 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