1c615b68ddebd8749f9a3b27f8166400 pmc_11240532.pdf 61bd83ee4f7dc87fad83115f60d0eea9245bd750 pmc_11240532.pdf 306f45c2bceeea4c05cee737c7c76207737d1518c1081187ace8a4a52bd8c6d5 pmc_11240532.pdf Title: Comparing Two Targeted Biopsy Schemes for Detecting Clinically Significant Prostate Cancer in Magnetic Resonance Index Lesions: Two- to Four-Core versus Saturated Transperineal Targeted Biopsy Subject: Since the optimal scheme for targeted biopsies of magnetic resonance imaging (MRI) suspicious lesions remains unclear, we compare the efficacy of two schemes for these index lesions. A prospective trial was conducted in 1161 men with Prostate Imaging Reporting and Data System v 2.1 3–5 undergoing targeted and 12-core systematic biopsy in four centers between 2021 and 2023. Two- to four-core MRI-transrectal ultrasound fusion-targeted biopsies via the transperineal route were conducted in 900 men in three centers, while a mapping per 0.5 mm core method (saturated scheme) was employed in 261 men biopsied in another center. A propensity-matched 261 paired cases were selected for avoiding confounders other than the targeted biopsy scheme. CsPCa (grade group 2) was identified in 125 index lesions (41.1%) when the two- to four-core scheme was employed, while in 187 (71.9%) when the saturated biopsy (p < 0.001) was used. Insignificant PCa (iPCa) was detected in 18 and 11.1%, respectively (p = 0.019). Rates of csPCa and iPCa remained similar in systematic biopsies. CsPCa detected only in systematic biopsies were 5 and 1.5%, respectively (p = 0.035) in each group. The saturated scheme for targeted biopsies detected more csPCa and less iPCa than did the two- to four-core scheme in the index lesions. The rate of csPCa detected only in the systematic biopsies decreased when the saturated scheme was employed. Keywords: prostate cancer; targeted biopsy; index lesion; number of cores Author: Juan Morote, Nahuel Paesano, Natàlia Picola, Berta Miró, José M. Abascal, Pol Servian, Enrique Trilla and Olga Méndez Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Mon Jul 8 07:31:19 2024 CEST ModDate: Mon Jul 8 07:37:06 2024 CEST Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1076220 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- PURWBA+VnURWPalladioL-Bold Type 1 Custom yes yes yes 10 0 NTNUYB+URWPalladioL-Bold Type 1 Custom yes yes yes 16 0 WJFRVQ+URWPalladioL-Roma Type 1 Custom yes yes yes 22 0 KGXBXY+URWPalladioL-Ital Type 1 Custom yes yes yes 27 0 HCPSKZ+CMSY10 Type 1 Builtin yes yes yes 32 0 RVDESI+VnURWPalladioL Type 1 Custom yes yes yes 37 0 LCJEVJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 54 0 WBVKDJ+URWPalladioL-BoldItal Type 1 Custom yes yes yes 77 0 BCDEEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 90 0 BCDFEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 94 0 BCDGEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 98 0 BCDIEE+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 102 0 TimesNewRomanPSMT TrueType WinAnsi no no no 109 0 BCDEEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 121 0 BCDFEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 125 0 BCDGEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 129 0 BCDIEE+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 133 0 TimesNewRomanPSMT TrueType WinAnsi no no no 140 0 BCDEEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 148 0 BCDFEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 152 0 BCDGEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 156 0 BCDIEE+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 160 0 TimesNewRomanPSMT TrueType WinAnsi no no no 167 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-02-06 02:50:05 CET RepresentationInformation: pmc_11240532.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-09-18 02:31:18 CEST Size: 1076220 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 300 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Children: Item: Title: Design, Setting, and Participants Destination: subsection.2.1 Item: Title: Diagnostic Approach for csPCa Detection Destination: subsection.2.2 Item: Title: Variables in the Study and Outcome Variables Destination: subsection.2.3 Item: Title: Statistical Analysis Destination: subsection.2.4 Item: Title: Results Destination: section.3 Children: Item: Title: Baseline Characteristics of the Study Population Destination: subsection.3.1 Item: Title: CsPCa Detection in the Index Lesions according to the PI-RADS Score and the Biopsy Scheme Destination: subsection.3.2 Item: Title: Detection of csPCa and iPCa in the Index Lesions, According to the Employed Biopsy Scheme and Those Detected in Systematic Biopsies Destination: subsection.3.3 Item: Title: Discussion Destination: section.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: section.6 Info: Title: Comparing Two Targeted Biopsy Schemes for Detecting Clinically Significant Prostate Cancer in Magnetic Resonance Index Lesions: Two- to Four-Core versus Saturated Transperineal Targeted Biopsy Author: Juan Morote, Nahuel Paesano, Natàlia Picola, Berta Miró, José M. Abascal, Pol Servian, Enrique Trilla and Olga Méndez Subject: Since the optimal scheme for targeted biopsies of magnetic resonance imaging (MRI) suspicious lesions remains unclear, we compare the efficacy of two schemes for these index lesions. A prospective trial was conducted in 1161 men with Prostate Imaging Reporting and Data System v 2.1 3 5 undergoing targeted and 12-core systematic biopsy in four centers between 2021 and 2023. Two- to four-core MRI-transrectal ultrasound fusion-targeted biopsies via the transperineal route were conducted in 900 men in three centers, while a mapping per 0.5 mm core method (saturated scheme) was employed in 261 men biopsied in another center. A propensity-matched 261 paired cases were selected for avoiding confounders other than the targeted biopsy scheme. CsPCa (grade group 2) was identified in 125 index lesions (41.1%) when the two- to four-core scheme was employed, while in 187 (71.9%) when the saturated biopsy (p < 0.001) was used. Insignificant PCa (iPCa) was detected in 18 and 11.1%, respectively (p = 0.019). Rates of csPCa and iPCa remained similar in systematic biopsies. CsPCa detected only in systematic biopsies were 5 and 1.5%, respectively (p = 0.035) in each group. The saturated scheme for targeted biopsies detected more csPCa and less iPCa than did the two- to four-core scheme in the index lesions. The rate of csPCa detected only in the systematic biopsies decreased when the saturated scheme was employed. 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