6b9c06e1cfb8aac0d9daa401998aed07  pmc_11252280.pdf
a36b0a4503c26c1a6245cfc9dd83a5be8e2bac05  pmc_11252280.pdf
9545b7a2d89c301ed3e21baa556a1728fa2c06d1daf511c5fa060fce3e727cee  pmc_11252280.pdf

Title:           Molecular subtypes explain lupus epigenomic heterogeneity unveiling new regulatory genetic risk variants
Subject:         npj Genomic Medicine, doi:10.1038/s41525-024-00420-0
Keywords:        
Author:          Olivia Castellini-Pérez
Creator:         Springer
Producer:        iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
CreationDate:    Tue Jul 16 15:06:34 2024 CEST
ModDate:         Tue Jul 16 20:17:12 2024 CEST
Custom Metadata: yes
Metadata Stream: yes
Tagged:          no
UserProperties:  no
Suspects:        no
Form:            AcroForm
JavaScript:      no
Pages:           13
Encrypted:       no
Page size:       595.276 x 790.866 pts
Page rot:        0
File size:       3355963 bytes
Optimized:       no
PDF version:     1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
JHNKDC+AdvOT1ef757c0+fb              Type 1C           Custom           yes yes yes     59  0
JHNJBG+AdvTT691e30a0                 Type 1C           WinAnsi          yes yes no     288  0
JHNKDD+AdvOT1ef757c0+20              Type 1C           WinAnsi          yes yes no      60  0
JHNKCA+AdvOTf0129623+fb              Type 1C           Custom           yes yes yes    311  0
JHNKDB+AdvOT1ef757c0                 Type 1C           WinAnsi          yes yes no      61  0
JHNHIJ+GraphikNaturel-Regular        Type 1C           WinAnsi          yes yes no     865  0
JHNHJK+AdvOT0c200bf0                 Type 1C           WinAnsi          yes yes no     866  0
JHNHJL+AdvOT34fe1490.B               Type 1C           WinAnsi          yes yes no      62  0
JHNHJM+AdvOTf0129623                 Type 1C           WinAnsi          yes yes no      63  0
JHNHOL+AdvOTf94803d4                 Type 1C           WinAnsi          yes yes no      65  0
JHNHPM+AdvOTfbba3ace.B               Type 1C           WinAnsi          yes yes no     867  0
JHNKKB+AdvOT7d6df7ab.I               Type 1C           WinAnsi          yes yes no      64  0
JHNPKE+AdvOTb65e897d.B               Type 1C           WinAnsi          yes yes no      66  0
JHOIJA+AdvTTab7e17fd                 Type 1C           WinAnsi          yes yes no     135  0
JHOIHO+AdvTTab7e17fd+22              Type 1C           Custom           yes yes no     136  0
JHOIIP+AdvOT34fe1490.B+fb            Type 1C           Custom           yes yes yes    137  0
JHPDLM+AdvOTb65e897d.B+fb            Type 1C           Custom           yes yes yes    148  0
JIAONH+AdvOT1ef757c0+03              Type 1C           Custom           yes yes yes    243  0
JIAPBI+AdvOT7d6df7ab.I+20            Type 1C           WinAnsi          yes yes no     287  0
JIAPBJ+AdvOT45bf69de.BI              Type 1C           WinAnsi          yes yes no     289  0
JIAPBH+AdvOTb65e897d.B+20            Type 1C           WinAnsi          yes yes no     290  0
JIAPBG+AdvOT6601a1b9.BI              Type 1C           WinAnsi          yes yes no     291  0
JIAPEL+AdvOTf0129623+20              Type 1C           WinAnsi          yes yes no     312  0
JIAPEM+AdvOT46dcae81+03              Type 1C           Custom           yes yes yes    313  0
JIAPDK+AdvOTa20b42a7                 Type 1C           WinAnsi          yes yes no     314  0
JIAPEK+AdvOT3a037357.I               Type 1C           WinAnsi          yes yes no     315  0
JIAPGM+AdvOT34fe1490.B+20            Type 1C           Custom           yes yes yes    337  0
JIAPJN+AdvTT153188ed+03              Type 1C           Custom           yes yes yes    528  0
JIAPIN+AdvTT16f3b945.B+03            Type 1C           Custom           yes yes yes    529  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2025-02-06 02:49:57 CET
 RepresentationInformation: pmc_11252280.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2025-01-18 02:37:17 CET
  Size: 3355963
  Format: PDF
  Version: 1.4
  Status: Well-Formed, but not valid
  SignatureMatches:
   PDF-hul
  ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff21' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff26' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff40' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff45' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff36' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff31' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff17' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff22' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff25' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff15' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff32' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff39' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff28' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff35' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff18' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff42' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff19' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff38' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff33' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff14' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff24' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff29' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff43' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff41' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff34' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff13' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff27' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff20' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff16' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff44' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff30' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff37' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff23' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff36' cannot be found
   ID: PDF-HUL-122
   Offset: 2703120
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff31' cannot be found
   ID: PDF-HUL-122
   Offset: 2703120
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff22' cannot be found
   ID: PDF-HUL-122
   Offset: 2703120
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff17' cannot be found
   ID: PDF-HUL-122
   Offset: 2703120
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff41' cannot be found
   ID: PDF-HUL-122
   Offset: 2703120
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff18' cannot be found
   ID: PDF-HUL-122
   Offset: 2703120
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff27' cannot be found
   ID: PDF-HUL-122
   Offset: 2703120
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff13' cannot be found
   ID: PDF-HUL-122
   Offset: 2703120
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff32' cannot be found
   ID: PDF-HUL-122
   Offset: 2703120
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff16' cannot be found
   ID: PDF-HUL-122
   Offset: 2703120
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff44' cannot be found
   ID: PDF-HUL-122
   Offset: 2703120
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff30' cannot be found
   ID: PDF-HUL-122
   Offset: 2703120
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff37' cannot be found
   ID: PDF-HUL-122
   Offset: 2703120
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff23' cannot be found
   ID: PDF-HUL-122
   Offset: 2703120
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff26' cannot be found
   ID: PDF-HUL-122
   Offset: 2703120
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff19' cannot be found
   ID: PDF-HUL-122
   Offset: 2703120
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff40' cannot be found
   ID: PDF-HUL-122
   Offset: 2703120
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff33' cannot be found
   ID: PDF-HUL-122
   Offset: 2703120
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff24' cannot be found
   ID: PDF-HUL-122
   Offset: 2703120
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff43' cannot be found
   ID: PDF-HUL-122
   Offset: 2703120
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff29' cannot be found
   ID: PDF-HUL-122
   Offset: 2703120
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff34' cannot be found
   ID: PDF-HUL-122
   Offset: 2703120
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff15' cannot be found
   ID: PDF-HUL-122
   Offset: 2703120
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff20' cannot be found
   ID: PDF-HUL-122
   Offset: 2703120
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff25' cannot be found
   ID: PDF-HUL-122
   Offset: 2703120
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff39' cannot be found
   ID: PDF-HUL-122
   Offset: 2703120
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff28' cannot be found
   ID: PDF-HUL-122
   Offset: 2703120
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff35' cannot be found
   ID: PDF-HUL-122
   Offset: 2703120
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff42' cannot be found
   ID: PDF-HUL-122
   Offset: 2703120
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff14' cannot be found
   ID: PDF-HUL-122
   Offset: 2703120
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff38' cannot be found
   ID: PDF-HUL-122
   Offset: 2703120
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff21' cannot be found
   ID: PDF-HUL-122
   Offset: 2703120
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff45' cannot be found
   ID: PDF-HUL-122
   Offset: 2703120
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 993
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseOutlines
    Outlines: 
     Item: 
      Title: Molecular subtypes explain lupus epigenomic heterogeneity unveiling new regulatory genetic risk variants
      Destination: title_link
      Children: 
       Item: 
        Title: Results
        Destination: A1
        Children: 
         Item: 
          Title: Genome-wide DNAm patterns associated with different molecular SLE subtypes
          Destination: B1
         Item: 
          Title: The relationship of autoantibody profile on the SLE epigenome
          Destination: B2
         Item: 
          Title: Genetic drivers of SLE epigenetic signals and mediation role of DNAm on SLE risk
          Destination: B3
         Item: 
          Title: Context-dependent meQTL regulatory function in SLE
          Destination: B4
         Item: 
          Title: SLE-associated epigenetic signals correlate with transcription factor activity and cytokine production
          Destination: B5
         Item: 
          Title: SLE-associated epigenetic signals inform drug discovery
          Destination: B6
       Item: 
        Title: Discussion
        Destination: A2
       Item: 
        Title: Methods
        Destination: A3
        Children: 
         Item: 
          Title: Samples
          Destination: B7
         Item: 
          Title: Ethical declaration
          Destination: B8
         Item: 
          Title: DNAm profiling
          Destination: B9
         Item: 
          Title: Genetic profiling
          Destination: B10
         Item: 
          Title: Epigenome-wide association analyses
          Destination: B11
         Item: 
          Title: Functional enrichment analyses
          Destination: B12
         Item: 
          Title: Methylation quantitative trait loci analysis
          Destination: B13
         Item: 
          Title: Genetic association and mediation analyses
          Destination: B14
         Item: 
          Title: Epigenetic associations with cytokine levels and transcription factor activities (TFact)
          Destination: B15
         Item: 
          Title: Identification of drug targets within epigenetic signals
          Destination: B16
         Item: 
          Title: Reporting summary
          Destination: B17
       Item: 
        Title: Data availability
        Destination: A4
       Item: 
        Title: Code availability
        Destination: A5
       Item: 
        Title: References
        Destination: A6
       Item: 
        Title: Acknowledgements
        Destination: A7
       Item: 
        Title: Author contributions
        Destination: A8
       Item: 
        Title: Funding
        Destination: A9
       Item: 
        Title: Competing interests
        Destination: A10
       Item: 
        Title: Additional information
        Destination: M3
   Info: 
    Title: Molecular subtypes explain lupus epigenomic heterogeneity unveiling new regulatory genetic risk variants
    Author: Olivia Castellini-Pérez
    Subject: npj Genomic Medicine, doi:10.1038/s41525-024-00420-0
    Keywords: 
    Creator: Springer
    Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
    CreationDate: Tue Jul 16 15:36:34 CEST 2024
    ModDate: Tue Jul 16 20:17:12 CEST 2024
   ID: 0x6ce4cbd7c3fdd38de8e989b907e319a5, 0xb032476391bc17c6940257e896b54b0b
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 46
      ImageHeight: 40
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2000
      ImageHeight: 1257
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1450
      ImageHeight: 2137
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2000
      ImageHeight: 2149
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2000
      ImageHeight: 2277
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 2000
      ImageHeight: 1745
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 2000
      ImageHeight: 930
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1100
      ImageHeight: 90
      ColorSpace: black is zero
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     Filter: FlateDecode
   Fonts: 
    Type1: 
     Font: 
      BaseFont: JHNKKB+AdvOT7d6df7ab.I
      FontSubset: true
      FirstChar: 40
      LastChar: 121
      FontDescriptor: 
       FontName: JHNKKB+AdvOT7d6df7ab.I
       Flags: Nonsymbolic
       FontBBox: -135, -250, 1000, 854
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JHNHOL+AdvOTf94803d4
      FontSubset: true
      FirstChar: 35
      LastChar: 124
      FontDescriptor: 
       FontName: JHNHOL+AdvOTf94803d4
       Flags: Nonsymbolic
       FontBBox: -41, -218, 937, 947
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JHNPKE+AdvOTb65e897d.B
      FontSubset: true
      FirstChar: 40
      LastChar: 124
      FontDescriptor: 
       FontName: JHNPKE+AdvOTb65e897d.B
       Flags: Nonsymbolic
       FontBBox: -20, -250, 968, 854
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JHOIJA+AdvTTab7e17fd
      FontSubset: true
      FirstChar: 43
      LastChar: 43
      FontDescriptor: 
       FontName: JHOIJA+AdvTTab7e17fd
       Flags: Nonsymbolic
       FontBBox: -156, -250, 1072, 947
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JHOIHO+AdvTTab7e17fd+22
      FontSubset: true
      FirstChar: 21
      LastChar: 21
      FontDescriptor: 
       FontName: JHOIHO+AdvTTab7e17fd+22
       Flags: Nonsymbolic
       FontBBox: -156, -218, 937, 947
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: JHOIIP+AdvOT34fe1490.B+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: JHOIIP+AdvOT34fe1490.B+fb
       Flags: Symbolic
       FontBBox: 0, 0, 552, 708
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: JIAPJN+AdvTT153188ed+03
      FontSubset: true
      FirstChar: 0
      LastChar: 0
      FontDescriptor: 
       FontName: JIAPJN+AdvTT153188ed+03
       Flags: Symbolic
       FontBBox: -437, -218, 947, 895
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: JIAPGM+AdvOT34fe1490.B+20
      FontSubset: true
      FirstChar: 2
      LastChar: 146
      FontDescriptor: 
       FontName: JIAPGM+AdvOT34fe1490.B+20
       Flags: Symbolic
       FontBBox: -156, -166, 1072, 718
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: JIAPIN+AdvTT16f3b945.B+03
      FontSubset: true
      FirstChar: 0
      LastChar: 0
      FontDescriptor: 
       FontName: JIAPIN+AdvTT16f3b945.B+03
       Flags: Symbolic
       FontBBox: -437, -375, 1000, 906
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: JHPDLM+AdvOTb65e897d.B+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: JHPDLM+AdvOTb65e897d.B+fb
       Flags: Symbolic
       FontBBox: 0, -10, 843, 697
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: JIAPBI+AdvOT7d6df7ab.I+20
      FontSubset: true
      FirstChar: 146
      LastChar: 146
      FontDescriptor: 
       FontName: JIAPBI+AdvOT7d6df7ab.I+20
       Flags: Nonsymbolic
       FontBBox: -156, -187, 1000, 822
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JHNJBG+AdvTT691e30a0
      FontSubset: true
      FirstChar: 42
      LastChar: 42
      FontDescriptor: 
       FontName: JHNJBG+AdvTT691e30a0
       Flags: Nonsymbolic
       FontBBox: -31, -250, 1020, 895
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JHNHIJ+GraphikNaturel-Regular
      FontSubset: true
      FirstChar: 32
      LastChar: 124
      FontDescriptor: 
       FontName: JHNHIJ+GraphikNaturel-Regular
       Flags: Nonsymbolic
       FontBBox: -230, -252, 1092, 1113
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JIAPBJ+AdvOT45bf69de.BI
      FontSubset: true
      FirstChar: 97
      LastChar: 98
      FontDescriptor: 
       FontName: JIAPBJ+AdvOT45bf69de.BI
       Flags: Nonsymbolic
       FontBBox: -135, -250, 1010, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JHNHJK+AdvOT0c200bf0
      FontSubset: true
      FirstChar: 99
      LastChar: 111
      FontDescriptor: 
       FontName: JHNHJK+AdvOT0c200bf0
       Flags: Nonsymbolic
       FontBBox: -10, -208, 906, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JIAPBH+AdvOTb65e897d.B+20
      FontSubset: true
      FirstChar: 146
      LastChar: 146
      FontDescriptor: 
       FontName: JIAPBH+AdvOTb65e897d.B+20
       Flags: Nonsymbolic
       FontBBox: -125, -177, 1052, 822
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JHNHPM+AdvOTfbba3ace.B
      FontSubset: true
      FirstChar: 77
      LastChar: 121
      FontDescriptor: 
       FontName: JHNHPM+AdvOTfbba3ace.B
       Flags: Nonsymbolic
       FontBBox: -31, -229, 968, 947
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JIAPBG+AdvOT6601a1b9.BI
      FontSubset: true
      FirstChar: 99
      LastChar: 111
      FontDescriptor: 
       FontName: JIAPBG+AdvOT6601a1b9.BI
       Flags: Nonsymbolic
       FontBBox: -125, -208, 1020, 968
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JIAONH+AdvOT1ef757c0+03
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: JIAONH+AdvOT1ef757c0+03
       Flags: Symbolic
       FontBBox: -125, -270, 854, 791
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: JHNKCA+AdvOTf0129623+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: JHNKCA+AdvOTf0129623+fb
       Flags: Symbolic
       FontBBox: 0, 0, 500, 718
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: JIAPEL+AdvOTf0129623+20
      FontSubset: true
      FirstChar: 134
      LastChar: 151
      FontDescriptor: 
       FontName: JIAPEL+AdvOTf0129623+20
       Flags: Nonsymbolic
       FontBBox: -156, -145, 1072, 718
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JIAPEM+AdvOT46dcae81+03
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: JIAPEM+AdvOT46dcae81+03
       Flags: Symbolic
       FontBBox: -31, -208, 739, 802
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: JIAPDK+AdvOTa20b42a7
      FontSubset: true
      FirstChar: 48
      LastChar: 121
      FontDescriptor: 
       FontName: JIAPDK+AdvOTa20b42a7
       Flags: Serif, Nonsymbolic
       FontBBox: -72, -239, 979, 906
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JHNKDC+AdvOT1ef757c0+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: JHNKDC+AdvOT1ef757c0+fb
       Flags: Symbolic
       FontBBox: 0, -10, 781, 708
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: JIAPEK+AdvOT3a037357.I
      FontSubset: true
      FirstChar: 40
      LastChar: 121
      FontDescriptor: 
       FontName: JIAPEK+AdvOT3a037357.I
       Flags: Nonsymbolic
       FontBBox: -125, -208, 979, 947
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JHNKDD+AdvOT1ef757c0+20
      FontSubset: true
      FirstChar: 146
      LastChar: 150
      FontDescriptor: 
       FontName: JHNKDD+AdvOT1ef757c0+20
       Flags: Nonsymbolic
       FontBBox: -135, -187, 1010, 833
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JHNKDB+AdvOT1ef757c0
      FontSubset: true
      FirstChar: 37
      LastChar: 246
      FontDescriptor: 
       FontName: JHNKDB+AdvOT1ef757c0
       Flags: Serif, Nonsymbolic
       FontBBox: -20, -250, 947, 854
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JHNHJL+AdvOT34fe1490.B
      FontSubset: true
      FirstChar: 38
      LastChar: 250
      FontDescriptor: 
       FontName: JHNHJL+AdvOT34fe1490.B
       Flags: Nonsymbolic
       FontBBox: -52, -208, 937, 968
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JHNHJM+AdvOTf0129623
      FontSubset: true
      FirstChar: 37
      LastChar: 252
      FontDescriptor: 
       FontName: JHNHJM+AdvOTf0129623
       Flags: Nonsymbolic
       FontBBox: -52, -208, 906, 947
       FontFile3: true
      Encoding: WinAnsiEncoding
   XMP: <x:xmpmeta x:xmptk="Adobe XMP Core 5.6-c142 87.162696, 2020/06/23-02:37:56        " xmlns:x="adobe:ns:meta/">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about="" xmlns:author="http://springernature.com/ns/xmpExtensions/2.0/authorInfo/" xmlns:crossmark="http://crossref.org/crossmark/1.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:jav="http://www.niso.org/schemas/jav/1.0/" xmlns:pdf="http://ns.adobe.com/pdf/1.3/" xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/" xmlns:pdfaField="http://www.aiim.org/pdfa/ns/field#" xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#" xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#" xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#" xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/" xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/" xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/" xmlns:sn="http://springernature.com/ns/xmpExtensions/2.0/" xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#" xmlns:xmp="http://ns.adobe.com/xap/1.0/" xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/" xmlns:xmpRights="http://ns.adobe.com/xap/1.0/rights/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>doi:10.1038/s41525-024-00420-0</dc:identifier>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Molecular subtypes explain lupus epigenomic heterogeneity unveiling new regulatory genetic risk variants</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Olivia Castellini-Pérez</rdf:li>
               <rdf:li>Elena Povedano</rdf:li>
               <rdf:li>Guillermo Barturen</rdf:li>
               <rdf:li>Manuel Martínez-Bueno</rdf:li>
               <rdf:li>Andrii Iakovliev</rdf:li>
               <rdf:li>Martin Kerick</rdf:li>
               <rdf:li>Raúl López-Domínguez</rdf:li>
               <rdf:li>Concepción Marañón</rdf:li>
               <rdf:li>Javier Martín</rdf:li>
               <rdf:li>Esteban Ballestar</rdf:li>
               <rdf:li>Lorenzo Beretta</rdf:li>
               <rdf:li>Barbara Vigone</rdf:li>
               <rdf:li>Jacques‐Olivier Pers</rdf:li>
               <rdf:li>Alain Saraux</rdf:li>
               <rdf:li>Valérie Devauchelle‐Pensec</rdf:li>
               <rdf:li>Divi Cornec</rdf:li>
               <rdf:li>Sandrine Jousse‐Joulin</rdf:li>
               <rdf:li>Bernard Lauwerys</rdf:li>
               <rdf:li>Julie Ducreux</rdf:li>
               <rdf:li>Anne‐Lise Maudoux</rdf:li>
               <rdf:li>Carlos Vasconcelos</rdf:li>
               <rdf:li>Ana Tavares</rdf:li>
               <rdf:li>Esmeralda Neves</rdf:li>
               <rdf:li>Raquel Faria</rdf:li>
               <rdf:li>Mariana Brandão</rdf:li>
               <rdf:li>Ana Campar</rdf:li>
               <rdf:li>António Marinho</rdf:li>
               <rdf:li>Fátima Farinha</rdf:li>
               <rdf:li>Isabel Almeida</rdf:li>
               <rdf:li>Miguel Angel Gonzalez‐Gay Mantecón</rdf:li>
               <rdf:li>Ricardo Blanco Alonso</rdf:li>
               <rdf:li>Alfonso Corrales Martínez</rdf:li>
               <rdf:li>Ricard Cervera</rdf:li>
               <rdf:li>Ignasi Rodríguez‐Pintó</rdf:li>
               <rdf:li>Gerard Espinosa</rdf:li>
               <rdf:li>Rik Lories</rdf:li>
               <rdf:li>Ellen De Langhe</rdf:li>
               <rdf:li>Nicolas Hunzelmann</rdf:li>
               <rdf:li>Doreen Belz</rdf:li>
               <rdf:li>Torsten Witte</rdf:li>
               <rdf:li>Niklas Baerlecken</rdf:li>
               <rdf:li>Georg Stummvoll</rdf:li>
               <rdf:li>Michael Zauner</rdf:li>
               <rdf:li>Michaela Lehner</rdf:li>
               <rdf:li>Eduardo Collantes</rdf:li>
               <rdf:li>Rafaela Ortega Castro</rdf:li>
               <rdf:li>Ma Angeles Aguirre‐Zamorano</rdf:li>
               <rdf:li>Alejandro Escudero‐Contreras</rdf:li>
               <rdf:li>Ma Carmen Castro‐Villegas</rdf:li>
               <rdf:li>Norberto Ortego</rdf:li>
               <rdf:li>María Concepción Fernández Roldán</rdf:li>
               <rdf:li>Enrique Raya</rdf:li>
               <rdf:li>Inmaculada Jiménez Moleón</rdf:li>
               <rdf:li>Enrique de Ramon</rdf:li>
               <rdf:li>Isabel Díaz Quintero</rdf:li>
               <rdf:li>Pier Luigi Meroni</rdf:li>
               <rdf:li>Maria Gerosa</rdf:li>
               <rdf:li>Tommaso Schioppo</rdf:li>
               <rdf:li>Carolina Artusi</rdf:li>
               <rdf:li>Carlo Chizzolini</rdf:li>
               <rdf:li>Aleksandra Zuber</rdf:li>
               <rdf:li>Donatienne Wynar</rdf:li>
               <rdf:li>Laszló Kovács</rdf:li>
               <rdf:li>Attila Balog</rdf:li>
               <rdf:li>Magdolna Deák</rdf:li>
               <rdf:li>Márta Bocskai</rdf:li>
               <rdf:li>Sonja Dulic</rdf:li>
               <rdf:li>Gabriella Kádár</rdf:li>
               <rdf:li>Falk Hiepe</rdf:li>
               <rdf:li>Velia Gerl</rdf:li>
               <rdf:li>Silvia Thiel</rdf:li>
               <rdf:li>Manuel Rodriguez Maresca</rdf:li>
               <rdf:li>Antonio López‐Berrio</rdf:li>
               <rdf:li>Rocío Aguilar‐Quesada</rdf:li>
               <rdf:li>Héctor Navarro‐Linares</rdf:li>
               <rdf:li>Montserrat Alvarez</rdf:li>
               <rdf:li>Damiana Alvarez‐Errico</rdf:li>
               <rdf:li>Nancy Azevedo</rdf:li>
               <rdf:li>Nuria Barbarroja</rdf:li>
               <rdf:li>Anne Buttgereit</rdf:li>
               <rdf:li>Qingyu Cheng</rdf:li>
               <rdf:li>Carlo Chizzolini</rdf:li>
               <rdf:li>Jonathan Cremer</rdf:li>
               <rdf:li>Aurélie De Groof</rdf:li>
               <rdf:li>Ellen De Langhe</rdf:li>
               <rdf:li>Julie Ducreux</rdf:li>
               <rdf:li>Aleksandra Dufour</rdf:li>
               <rdf:li>Velia Gerl</rdf:li>
               <rdf:li>Maria Hernandez‐Fuentes</rdf:li>
               <rdf:li>Laleh Khodadadi</rdf:li>
               <rdf:li>Katja Kniesch</rdf:li>
               <rdf:li>Tianlu Li</rdf:li>
               <rdf:li>Chary Lopez‐Pedrera</rdf:li>
               <rdf:li>Zuzanna Makowska</rdf:li>
               <rdf:li>Concepción Marañón</rdf:li>
               <rdf:li>Brian Muchmore</rdf:li>
               <rdf:li>Esmeralda Neves</rdf:li>
               <rdf:li>Bénédicte Rouvière</rdf:li>
               <rdf:li>Quentin Simon</rdf:li>
               <rdf:li>Elena Trombetta</rdf:li>
               <rdf:li>Nieves Varela</rdf:li>
               <rdf:li>Torsten Witte</rdf:li>
               <rdf:li>María Orietta Borghi</rdf:li>
               <rdf:li>Weiliang Qiu</rdf:li>
               <rdf:li>Cheng Zhu</rdf:li>
               <rdf:li>Srinivas Shankara</rdf:li>
               <rdf:li>Athina Spiliopoulou</rdf:li>
               <rdf:li>Emanuele Rinaldis</rdf:li>
               <rdf:li>Elena Carnero-Montoro</rdf:li>
               <rdf:li>Marta E. Alarcón-Riquelme</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Springer US</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:subject>
            <rdf:Bag></rdf:Bag>
         </dc:subject>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">npj Genomic Medicine, doi:10.1038/s41525-024-00420-0</rdf:li>
            </rdf:Alt>
         </dc:description>
         <prism:doi>10.1038/s41525-024-00420-0</prism:doi>
         <prism:url>http://dx.doi.org/10.1038/s41525-024-00420-0</prism:url>
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>npj Genomic Medicine</prism:publicationName>
         <prism:copyright>© 2024, The Author(s)</prism:copyright>
         <prism:issn>2056-7944</prism:issn>
         <pdfx:doi>10.1038/s41525-024-00420-0</pdfx:doi>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>True</crossmark:CrossmarkDomainExclusive>
         <crossmark:DOI>10.1038/s41525-024-00420-0</crossmark:DOI>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
         <xmp:CreatorTool>Springer</xmp:CreatorTool>
         <xmp:ModifyDate>2024-07-16T20:17:12+02:00</xmp:ModifyDate>
         <xmp:CreateDate>2024-07-16T18:36:34+05:30</xmp:CreateDate>
         <xmp:MetadataDate>2024-07-16T20:17:12+02:00</xmp:MetadataDate>
         <xmpRights:Marked>True</xmpRights:Marked>
         <pdf:Keywords></pdf:Keywords>
         <jav:journal_article_version>VoR</jav:journal_article_version>
         <xmpMM:DocumentID>uuid:7e87a70d-1e06-4bcd-a24e-f77d3cf773a7</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:a1ba2630-acd6-4a7c-b4df-1db7b17a6fb1</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:c8069391-615b-4a08-b593-11c632265f18</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2024-07-16T18:37:33+05:30</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
         <sn:authorInfo>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Olivia Castellini-Pérez</author:name>
                  <author:orcid>http://orcid.org/0000-0001-9985-1371</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Guillermo Barturen</author:name>
                  <author:orcid>http://orcid.org/0000-0003-2103-1028</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Martin Kerick</author:name>
                  <author:orcid>http://orcid.org/0000-0002-6298-4514</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Raúl López-Domínguez</author:name>
                  <author:orcid>http://orcid.org/0000-0001-8634-117X</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Javier Martín</author:name>
                  <author:orcid>http://orcid.org/0000-0002-2202-0622</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Esteban Ballestar</author:name>
                  <author:orcid>http://orcid.org/0000-0002-1400-2440</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>María Orietta Borghi</author:name>
                  <author:orcid>http://orcid.org/0000-0001-8967-9678</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Athina Spiliopoulou</author:name>
                  <author:orcid>http://orcid.org/0000-0002-5929-6585</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Marta E. Alarcón-Riquelme</author:name>
                  <author:orcid>http://orcid.org/0000-0002-7632-4154</author:orcid>
               </rdf:li>
            </rdf:Bag>
         </sn:authorInfo>
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original.</pdfaProperty:description>
                           <pdfaProperty:name>DerivedFrom</pdfaProperty:name>
                           <pdfaProperty:valueType>ResourceRef</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced.</pdfaType:description>
                           <pdfaType:namespaceURI>http://ns.adobe.com/xap/1.0/sType/Part#</pdfaType:namespaceURI>
                           <pdfaType:prefix>stPart</pdfaType:prefix>
                           <pdfaType:type>Part</pdfaType:type>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/t/pg/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpTPg</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Paged-Text</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents).</pdfaProperty:description>
                           <pdfaProperty:name>PlateNames</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A structure containing the characteristics of a font used in a document</pdfaProperty:description>
                           <pdfaProperty:name>Fonts</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag Font</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>A structure containing the characteristics of a font used in a document.</pdfaType:description>
                           <pdfaType:namespaceURI>http://ns.adobe.com/xap/1.0/sType/Font#</pdfaType:namespaceURI>
                           <pdfaType:prefix>stFnt</pdfaType:prefix>
                           <pdfaType:type>Font</pdfaType:type>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>pdfx</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrosMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:DOI</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://crossref.org/crossmark/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>crossmark</pdfaSchema:prefix>
                  <pdfaSchema:schema>crossmark</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Usual same as prism:doi</pdfaProperty:description>
                           <pdfaProperty:name>DOI</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The date when a publication was published.</pdfaProperty:description>
                           <pdfaProperty:name>MajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://prismstandard.org/namespaces/basic/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>prism</pdfaSchema:prefix>
                  <pdfaSchema:schema>Prism</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. 
Comment 
PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. 
Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. 

</pdfaProperty:description>
                           <pdfaProperty:name>aggregationType</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Copyright </pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article.
The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. 
If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). 
</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. 
Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. 
</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. 
Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. 

Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” 
</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. 
The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. 
NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. 
</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>sn</pdfaSchema:prefix>
                  <pdfaSchema:schema>Springer Nature ORCID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors.</pdfaProperty:description>
                           <pdfaProperty:name>authorInfo</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag AuthorInformation</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>Specifies the types of author information: name and ORCID of an author.</pdfaType:description>
                           <pdfaType:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/authorInfo/</pdfaType:namespaceURI>
                           <pdfaType:prefix>author</pdfaType:prefix>
                           <pdfaType:type>AuthorInformation</pdfaType:type>
                           <pdfaType:field>
                              <rdf:Seq>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:description>Gives the name of an author.</pdfaField:description>
                                    <pdfaField:name>name</pdfaField:name>
                                    <pdfaField:valueType>Text</pdfaField:valueType>
                                 </rdf:li>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:description>Gives the ORCID of an author.</pdfaField:description>
                                    <pdfaField:name>orcid</pdfaField:name>
                                    <pdfaField:valueType>URI</pdfaField:valueType>
                                 </rdf:li>
                              </rdf:Seq>
                           </pdfaType:field>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.niso.org/schemas/jav/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>jav</pdfaSchema:prefix>
                  <pdfaSchema:schema>NISO</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Values for Journal Article Version are one of the following:
AO = Author’s Original
SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
EVoR = Enhanced Version of Record</pdfaProperty:description>
                           <pdfaProperty:name>journal_article_version</pdfaProperty:name>
                           <pdfaProperty:valueType>Closed Choice of Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      <pdf:Producer>iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)</pdf:Producer></rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 471, 563, 479, 595
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 479, 566, 576, 576
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 479, 566, 576, 576
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 132, 552, 134, 561
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 132, 552, 134, 561
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 141, 550, 144, 560
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 134, 550, 141, 560
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 141, 550, 142, 560
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 142, 555, 145, 561
       Flags: Print
       AppearanceDictionary: true
       Destination: 699
      Annotation: 
       Subtype: Link
       Rect: 147, 555, 150, 561
       Flags: Print
       AppearanceDictionary: true
       Destination: 699
      Annotation: 
       Subtype: Link
       Rect: 223, 555, 226, 561
       Flags: Print
       AppearanceDictionary: true
       Destination: 699
      Annotation: 
       Subtype: Link
       Rect: 228, 555, 231, 561
       Flags: Print
       AppearanceDictionary: true
       Destination: 699
      Annotation: 
       Subtype: Link
       Rect: 232, 555, 235, 561
       Flags: Print
       AppearanceDictionary: true
       Destination: 699
      Annotation: 
       Subtype: Link
       Rect: 321, 552, 322, 561
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 321, 552, 322, 561
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 330, 550, 332, 560
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 322, 550, 330, 560
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 330, 550, 331, 560
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 331, 555, 334, 561
       Flags: Print
       AppearanceDictionary: true
       Destination: 699
      Annotation: 
       Subtype: Link
       Rect: 335, 555, 338, 561
       Flags: Print
       AppearanceDictionary: true
       Destination: 699
      Annotation: 
       Subtype: Link
       Rect: 445, 555, 448, 561
       Flags: Print
       AppearanceDictionary: true
       Destination: 699
      Annotation: 
       Subtype: Link
       Rect: 104, 542, 107, 548
       Flags: Print
       AppearanceDictionary: true
       Destination: 699
      Annotation: 
       Subtype: Link
       Rect: 169, 539, 170, 548
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 169, 539, 170, 548
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 178, 538, 180, 547
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 170, 538, 178, 547
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 178, 538, 179, 547
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 179, 542, 182, 548
       Flags: Print
       AppearanceDictionary: true
       Destination: 699
      Annotation: 
       Subtype: Link
       Rect: 286, 539, 288, 548
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 286, 539, 288, 548
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 295, 538, 298, 547
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 288, 538, 295, 547
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 295, 538, 297, 547
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 297, 542, 300, 548
       Flags: Print
       AppearanceDictionary: true
       Destination: 699
      Annotation: 
       Subtype: Link
       Rect: 396, 542, 399, 548
       Flags: Print
       AppearanceDictionary: true
       Destination: 699
      Annotation: 
       Subtype: Link
       Rect: 459, 539, 461, 548
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 459, 539, 461, 548
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 468, 538, 471, 547
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 461, 538, 468, 547
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 468, 538, 470, 547
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 470, 542, 473, 548
       Flags: Print
       AppearanceDictionary: true
       Destination: 699
      Annotation: 
       Subtype: Link
       Rect: 114, 526, 115, 536
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 114, 526, 115, 536
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 123, 525, 125, 534
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 116, 525, 123, 534
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 123, 525, 124, 534
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 124, 530, 127, 535
       Flags: Print
       AppearanceDictionary: true
       Destination: 699
      Annotation: 
       Subtype: Link
       Rect: 126, 514, 127, 523
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 126, 514, 127, 523
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 135, 512, 137, 521
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 127, 512, 135, 521
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 135, 512, 136, 521
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 136, 517, 139, 522
       Flags: Print
       AppearanceDictionary: true
       Destination: 699
      Annotation: 
       Subtype: Link
       Rect: 197, 517, 203, 522
       Flags: Print
       AppearanceDictionary: true
       Destination: 699
      Annotation: 
       Subtype: Link
       Rect: 254, 517, 260, 522
       Flags: Print
       AppearanceDictionary: true
       Destination: 699
      Annotation: 
       Subtype: Link
       Rect: 341, 517, 347, 522
       Flags: Print
       AppearanceDictionary: true
       Destination: 699
      Annotation: 
       Subtype: Link
       Rect: 434, 514, 436, 523
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 434, 514, 436, 523
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 443, 512, 446, 521
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 436, 512, 443, 521
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 443, 512, 444, 521
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 444, 517, 447, 522
       Flags: Print
       AppearanceDictionary: true
       Destination: 699
      Annotation: 
       Subtype: Link
       Rect: 131, 504, 137, 510
       Flags: Print
       AppearanceDictionary: true
       Destination: 699
      Annotation: 
       Subtype: Link
       Rect: 250, 504, 253, 510
       Flags: Print
       AppearanceDictionary: true
       Destination: 699
      Annotation: 
       Subtype: Link
       Rect: 254, 504, 257, 510
       Flags: Print
       AppearanceDictionary: true
       Destination: 699
      Annotation: 
       Subtype: Link
       Rect: 401, 501, 402, 510
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 401, 501, 402, 510
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 410, 499, 412, 509
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 403, 499, 410, 509
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 410, 499, 411, 509
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 411, 504, 414, 510
       Flags: Print
       AppearanceDictionary: true
       Destination: 699
      Annotation: 
       Subtype: Link
       Rect: 416, 504, 422, 510
       Flags: Print
       AppearanceDictionary: true
       Destination: 699
      Annotation: 
       Subtype: Link
       Rect: 242, 170, 245, 175
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 437, 202, 440, 207
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 362, 48, 443, 55
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 447, 48, 529, 55
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 286, 673, 289, 678
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 290, 673, 292, 678
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 208, 652, 210, 657
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 176, 641, 178, 646
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 180, 641, 182, 646
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 283, 609, 285, 614
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 117, 598, 119, 603
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 120, 598, 123, 603
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 191, 577, 194, 582
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 173, 555, 176, 561
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 168, 459, 173, 464
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 176, 459, 181, 464
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 215, 448, 220, 453
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 393, 727, 398, 732
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 530, 716, 535, 721
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 538, 716, 543, 721
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 444, 662, 449, 668
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 554, 662, 559, 668
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 532, 652, 537, 657
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 387, 630, 392, 636
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 373, 598, 375, 603
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 377, 598, 382, 603
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 383, 598, 388, 603
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 540, 422, 545, 431
       Flags: Print
       AppearanceDictionary: true
       Destination: 3
     Thumb: true
    Page: 
     Label: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 271, 144, 276, 153
       Flags: Print
       AppearanceDictionary: true
       Destination: 68
      Annotation: 
       Subtype: Link
       Rect: 240, 52, 245, 57
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 410, 165, 414, 174
       Flags: Print
       AppearanceDictionary: true
       Destination: 68
      Annotation: 
       Subtype: Link
       Rect: 404, 122, 408, 131
       Flags: Print
       AppearanceDictionary: true
       Destination: 68
      Annotation: 
       Subtype: Link
       Rect: 527, 69, 531, 78
       Flags: Print
       AppearanceDictionary: true
       Destination: 68
     Thumb: true
    Page: 
     Label: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 163, 679, 167, 688
       Flags: Print
       AppearanceDictionary: true
       Destination: 68
      Annotation: 
       Subtype: Link
       Rect: 247, 668, 251, 677
       Flags: Print
       AppearanceDictionary: true
       Destination: 68
      Annotation: 
       Subtype: Link
       Rect: 180, 662, 185, 668
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 101, 497, 105, 506
       Flags: Print
       AppearanceDictionary: true
       Destination: 68
      Annotation: 
       Subtype: Link
       Rect: 151, 433, 156, 442
       Flags: Print
       AppearanceDictionary: true
       Destination: 68
      Annotation: 
       Subtype: Link
       Rect: 241, 422, 246, 431
       Flags: Print
       AppearanceDictionary: true
       Destination: 68
      Annotation: 
       Subtype: Link
       Rect: 284, 304, 288, 313
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 84, 240, 88, 249
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 39, 219, 43, 228
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 57, 154, 62, 163
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 443, 701, 447, 709
       Flags: Print
       AppearanceDictionary: true
       Destination: 152
      Annotation: 
       Subtype: Link
       Rect: 432, 679, 436, 688
       Flags: Print
       AppearanceDictionary: true
       Destination: 152
      Annotation: 
       Subtype: Link
       Rect: 547, 658, 552, 667
       Flags: Print
       AppearanceDictionary: true
       Destination: 152
      Annotation: 
       Subtype: Link
       Rect: 306, 615, 310, 624
       Flags: Print
       AppearanceDictionary: true
       Destination: 152
      Annotation: 
       Subtype: Link
       Rect: 547, 540, 551, 549
       Flags: Print
       AppearanceDictionary: true
       Destination: 152
      Annotation: 
       Subtype: Link
       Rect: 540, 465, 544, 474
       Flags: Print
       AppearanceDictionary: true
       Destination: 152
      Annotation: 
       Subtype: Link
       Rect: 464, 411, 469, 420
       Flags: Print
       AppearanceDictionary: true
       Destination: 152
      Annotation: 
       Subtype: Link
       Rect: 476, 401, 480, 410
       Flags: Print
       AppearanceDictionary: true
       Destination: 152
      Annotation: 
       Subtype: Link
       Rect: 550, 369, 554, 377
       Flags: Print
       AppearanceDictionary: true
       Destination: 152
      Annotation: 
       Subtype: Link
       Rect: 377, 283, 381, 292
       Flags: Print
       AppearanceDictionary: true
       Destination: 152
      Annotation: 
       Subtype: Link
       Rect: 377, 234, 382, 239
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 514, 186, 519, 195
       Flags: Print
       AppearanceDictionary: true
       Destination: 157
      Annotation: 
       Subtype: Link
       Rect: 369, 79, 374, 88
       Flags: Print
       AppearanceDictionary: true
       Destination: 157
      Annotation: 
       Subtype: Link
       Rect: 323, 58, 327, 67
       Flags: Print
       AppearanceDictionary: true
       Destination: 157
     Thumb: true
    Page: 
     Label: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 179, 47, 183, 56
       Flags: Print
       AppearanceDictionary: true
       Destination: 157
      Annotation: 
       Subtype: Link
       Rect: 463, 90, 467, 99
       Flags: Print
       AppearanceDictionary: true
       Destination: 157
      Annotation: 
       Subtype: Link
       Rect: 437, 69, 442, 78
       Flags: Print
       AppearanceDictionary: true
       Destination: 157
     Thumb: true
    Page: 
     Label: 6
     Thumb: true
    Page: 
     Label: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 227, 165, 231, 174
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 59, 122, 63, 131
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 506, 84, 509, 89
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
     Thumb: true
    Page: 
     Label: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 174, 437, 179, 443
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 193, 405, 198, 411
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 216, 341, 221, 346
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 216, 298, 221, 304
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 58, 234, 61, 239
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 74, 138, 79, 143
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 101, 95, 106, 100
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 102, 73, 108, 79
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 109, 73, 114, 79
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 430, 384, 433, 389
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 380, 255, 382, 261
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 524, 234, 529, 239
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
     Thumb: true
    Page: 
     Label: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 197, 705, 202, 711
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 203, 705, 208, 711
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 105, 694, 110, 700
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 261, 684, 266, 689
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 98, 619, 103, 625
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 263, 609, 268, 614
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 175, 523, 180, 529
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 181, 523, 186, 529
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 182, 459, 187, 464
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 188, 459, 193, 464
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 211, 341, 216, 346
       Flags: Print
       AppearanceDictionary: true
       Destination: 321
      Annotation: 
       Subtype: Link
       Rect: 219, 341, 224, 346
       Flags: Print
       AppearanceDictionary: true
       Destination: 321
      Annotation: 
       Subtype: Link
       Rect: 143, 320, 148, 325
       Flags: Print
       AppearanceDictionary: true
       Destination: 321
      Annotation: 
       Subtype: Link
       Rect: 242, 298, 247, 304
       Flags: Print
       AppearanceDictionary: true
       Destination: 321
      Annotation: 
       Subtype: Link
       Rect: 248, 298, 253, 304
       Flags: Print
       AppearanceDictionary: true
       Destination: 321
      Annotation: 
       Subtype: Link
       Rect: 115, 212, 120, 218
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 121, 212, 126, 218
       Flags: Print
       AppearanceDictionary: true
       Destination: 321
      Annotation: 
       Subtype: Link
       Rect: 385, 512, 388, 518
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 513, 491, 518, 496
       Flags: Print
       AppearanceDictionary: true
       Destination: 321
      Annotation: 
       Subtype: Link
       Rect: 438, 405, 441, 411
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 424, 138, 429, 143
       Flags: Print
       AppearanceDictionary: true
       Destination: 321
     Thumb: true
    Page: 
     Label: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 233, 652, 238, 657
       Flags: Print
       AppearanceDictionary: true
       Destination: 321
      Annotation: 
       Subtype: Link
       Rect: 178, 641, 183, 646
       Flags: Print
       AppearanceDictionary: true
       Destination: 321
      Annotation: 
       Subtype: Link
       Rect: 188, 630, 193, 636
       Flags: Print
       AppearanceDictionary: true
       Destination: 321
      Annotation: 
       Subtype: Link
       Rect: 103, 491, 106, 496
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 235, 454, 240, 463
       Flags: Print
       AppearanceDictionary: true
       Destination: 3
      Annotation: 
       Subtype: Link
       Rect: 81, 437, 83, 443
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 134, 245, 139, 250
       Flags: Print
       AppearanceDictionary: true
       Destination: 321
      Annotation: 
       Subtype: Link
       Rect: 111, 234, 116, 239
       Flags: Print
       AppearanceDictionary: true
       Destination: 321
      Annotation: 
       Subtype: Link
       Rect: 153, 170, 158, 175
       Flags: Print
       AppearanceDictionary: true
       Destination: 321
      Annotation: 
       Subtype: Link
       Rect: 536, 641, 541, 646
       Flags: Print
       AppearanceDictionary: true
       Destination: 321
      Annotation: 
       Subtype: Link
       Rect: 344, 587, 349, 593
       Flags: Print
       AppearanceDictionary: true
       Destination: 321
      Annotation: 
       Subtype: Link
       Rect: 547, 459, 552, 464
       Flags: Print
       AppearanceDictionary: true
       Destination: 321
      Annotation: 
       Subtype: Link
       Rect: 384, 448, 389, 453
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 351, 304, 355, 313
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 384, 122, 483, 131
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 368, 69, 487, 78
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 478, 58, 561, 67
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 47, 361, 56
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 250, 347, 289, 355
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 56, 337, 135, 345
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 56, 337, 135, 345
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 158, 369, 283, 377
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 56, 358, 91, 366
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 56, 358, 91, 366
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 326, 460, 334
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 262, 414, 270
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 350, 90, 507, 98
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 13
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 107, 717, 113, 723
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 182, 717, 188, 723
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 280, 717, 286, 723
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 343, 717, 349, 723
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 471, 717, 477, 723
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 530, 717, 536, 723
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 138, 705, 144, 710
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 225, 705, 231, 710
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 293, 705, 299, 710
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 388, 705, 394, 710
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 482, 705, 488, 710
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 544, 705, 550, 710
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 113, 692, 118, 697
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 176, 692, 182, 697
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 259, 692, 265, 697
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 322, 692, 328, 697
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 402, 692, 408, 697
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 475, 692, 481, 697
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 547, 692, 553, 697
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 200, 679, 205, 685
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 306, 679, 312, 685
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 426, 679, 432, 685
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 500, 679, 506, 685
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 135, 666, 141, 672
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 216, 666, 222, 672
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 268, 666, 274, 672
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 347, 666, 353, 672
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 444, 666, 450, 672
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 506, 666, 512, 672
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 96, 654, 101, 659
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 182, 654, 188, 659
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 266, 654, 271, 659
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 341, 654, 347, 659
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 422, 654, 428, 659
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 510, 654, 516, 659
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 133, 641, 139, 647
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 273, 641, 279, 647
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 412, 641, 418, 647
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 539, 641, 545, 647
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 108, 628, 114, 634
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 272, 628, 278, 634
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 337, 628, 343, 634
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 466, 628, 472, 634
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 552, 628, 558, 634
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 124, 616, 130, 621
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 205, 616, 211, 621
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 273, 616, 278, 621
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 368, 616, 374, 621
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 440, 616, 446, 621
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 516, 616, 522, 621
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 114, 603, 120, 608
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 202, 603, 208, 608
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 273, 603, 279, 608
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 332, 603, 338, 608
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 409, 603, 415, 608
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 480, 603, 486, 608
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 538, 603, 544, 608
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 104, 590, 110, 596
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 159, 590, 165, 596
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 209, 590, 215, 596
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 264, 590, 270, 596
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 390, 590, 396, 596
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 490, 590, 496, 596
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 77, 578, 83, 583
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 193, 578, 199, 583
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 119, 407, 125, 412
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 229, 407, 235, 412
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 305, 407, 311, 412
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 385, 407, 391, 412
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 393, 407, 399, 412
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 469, 407, 475, 412
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 539, 407, 545, 412
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 104, 394, 110, 400
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 188, 394, 194, 400
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 267, 394, 273, 400
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 346, 394, 352, 400
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 413, 394, 419, 400
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 502, 394, 508, 400
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 552, 394, 558, 400
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 148, 381, 154, 387
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 230, 381, 236, 387
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 299, 381, 305, 387
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 344, 381, 350, 387
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 445, 381, 451, 387
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 540, 381, 546, 387
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 130, 369, 133, 374
       Flags: Print
       AppearanceDictionary: true
       Destination: 699
      Annotation: 
       Subtype: Link
       Rect: 208, 369, 211, 374
       Flags: Print
       AppearanceDictionary: true
       Destination: 699
      Annotation: 
       Subtype: Link
       Rect: 289, 369, 295, 374
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 382, 369, 388, 374
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 454, 369, 460, 374
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 534, 369, 540, 374
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 96, 356, 102, 362
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 169, 356, 175, 362
       Flags: Print
       AppearanceDictionary: true
       Destination: null
     Thumb: true
  Checksum: bd685289
   Type: CRC32
  Checksum: 6b9c06e1cfb8aac0d9daa401998aed07
   Type: MD5
  Checksum: a36b0a4503c26c1a6245cfc9dd83a5be8e2bac05
   Type: SHA-1
  Checksum: 9545b7a2d89c301ed3e21baa556a1728fa2c06d1daf511c5fa060fce3e727cee
   Type: SHA-256