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The net budget impact of AF-screening was estimated in country-specific settings for Denmark, Germany, Ireland, Italy, Netherlands, Serbia, Spain, and Sweden. Country-specific parameters were used to allow for variations in healthcare systems and to reflect the healthcare sector in the country of interest. Similar results can be seen in all countries AF-screening incurs savings of stroke-related costs since AF treatment reduces the number of strokes. However, the increased number of detected AF and higher drug acquisition will increase the drug costs as well as the costs of physician- and control visits. The net budget impact per invited varied from €10 in Ireland to €122 in the Netherlands. The results showed the increased costs of implementing AF-screening were mainly driven by increased drug costs and screening costs. In conclusion, across Europe, though the initial cost of screening and more frequent use of oral anti-coagulants will increase the healthcare payers’ costs, introducing population screening for AF will result in savings of stroke-related costs. Keywords: Atrial fibrillation; Budget impact analysis; Screening; ECG monitoring; Anticoagulation; Stroke prevention Author: Michaela Eklund Creator: Servigistics Arbortext Advanced Print Publisher 11.1.4546/W-x64 Producer: PDFlib+PDI 9.0.7p3 (C++/Win64) CreationDate: Sat Jul 27 14:17:43 2024 CEST ModDate: Wed Jul 31 13:39:51 2024 CEST Custom Metadata: yes Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 14 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 905655 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- HUBVCK+TrebuchetMS-Bold CID TrueType Identity-H yes yes yes 2510 0 NHLHJD+TrebuchetMS-Italic CID TrueType Identity-H yes yes yes 2515 0 TNIEBT+TrebuchetMS CID TrueType Identity-H yes yes yes 2520 0 YCISPI+STIXGeneral-Regular Type 1C Custom yes yes yes 2525 0 KAVEFL+GillSansMT Type 1 Custom yes yes no 27 0 Helvetica-Bold Type 1 Custom no no no 31 0 KMOJZW+GillSansMT Type 1 Custom yes yes no 39 0 Helvetica-Bold Type 1 Custom no no no 43 0 QFPSPA+GillSansMT Type 1 Custom yes yes no 51 0 CQNJLA+GillSansMT Type 1 Custom yes yes no 60 0 BXVGGW+SourceSansPro-Regular Type 1C Custom yes yes yes 76 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-02-17 16:55:14 CET RepresentationInformation: pmc_11292408.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-02-13 02:31:36 CET Size: 905655 Format: PDF Version: 1.6 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ErrorMessage: Invalid indirect destination - 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referenced object 'affsuae076-aff13' cannot be found ID: PDF-HUL-122 Offset: 448776 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'affsuae076-aff4' cannot be found ID: PDF-HUL-122 Offset: 448776 MIMEtype: application/pdf Profile: Tagged PDF PDFMetadata: Objects: 2609 FreeObjects: 8 IncrementalUpdates: 8 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: true NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: OneColumn PageMode: UseOutlines Language: en Outlines: Item: Title: The budget impact of implementing atrial fibrillation-screening in European countries Destination: head1 Children: Item: Title: Introduction Destination: secsuae076-s0 Item: Title: Methods Destination: secsuae076-s1 Children: Item: Title: Budget impact model Destination: secsuae076-s1.1 Item: Title: Country-specific budget holder Destination: secsuae076-s1.2 Item: Title: Inputs Destination: secsuae076-s1.3 Item: Title: Results Destination: secsuae076-s2 Children: Item: Title: Total budget impact of implementing population atrial fibrillation-screening Destination: secsuae076-s2.1 Item: Title: Five-year budget impact of atrial fibrillation-screening per invitee Destination: secsuae076-s2.2 Item: Title: Sensitivity analyses Destination: secsuae076-s2.3 Item: Title: Discussion Destination: secsuae076-s3 Item: Title: Conclusion Destination: secsuae076-s4 Item: Title: Supplementary material Destination: secsuae076-s5 Item: Title: Acknowledgements Destination: acknow Item: Title: Funding Destination: secsuae076-s6 Item: Title: Data availability Destination: secsuae076-s7 Item: Title: References Destination: reflist Info: Title: The budget impact of implementing atrial fibrillation-screening in European countries Author: Michaela Eklund Subject: DOI: 10.1093/eurheartjsupp/suae076; European Heart Journal Supplements, 26, S4, 2024-08-01.; Abstract: A budget impact analysis estimates the short-term difference between the cost of the current treatment strategy and a new treatment strategy, in this case to implement population screening for atrial fibrillation (AF). The aim of this study is to estimate the financial impact of implementing population-based AF-screening of 75-year-olds compared with the current setting of no screening from a healthcare payer perspective in eight European countries. The net budget impact of AF-screening was estimated in country-specific settings for Denmark, Germany, Ireland, Italy, Netherlands, Serbia, Spain, and Sweden. Country-specific parameters were used to allow for variations in healthcare systems and to reflect the healthcare sector in the country of interest. Similar results can be seen in all countries AF-screening incurs savings of stroke-related costs since AF treatment reduces the number of strokes. However, the increased number of detected AF and higher drug acquisition will increase the drug costs as well as the costs of physician- and control visits. The net budget impact per invited varied from €10 in Ireland to €122 in the Netherlands. The results showed the increased costs of implementing AF-screening were mainly driven by increased drug costs and screening costs. In conclusion, across Europe, though the initial cost of screening and more frequent use of oral anti-coagulants will increase the healthcare payers’ costs, introducing population screening for AF will result in savings of stroke-related costs. Keywords: Atrial fibrillation; Budget impact analysis; Screening; ECG monitoring; Anticoagulation; Stroke prevention Creator: Servigistics Arbortext Advanced Print Publisher 11.1.4546/W-x64 Producer: PDFlib+PDI 9.0.7p3 (C++/Win64) CreationDate: Sat Jul 27 14:47:43 CEST 2024 ModDate: Wed Jul 31 14:09:51 CEST 2024 ID: 0xabed96fc9e9618d33bbece7670a60ced, 0x08b7463d092d094f9f7132c7641455de Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1283 ImageHeight: 520 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type0: Font: BaseFont: NHLHJD+TrebuchetMS-Italic Encoding: Identity-H ToUnicode: true Font: BaseFont: TNIEBT+TrebuchetMS Encoding: Identity-H ToUnicode: true Font: BaseFont: HUBVCK+TrebuchetMS-Bold Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: BXVGGW+SourceSansPro-Regular FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: BXVGGW+SourceSansPro-Regular Flags: Nonsymbolic FontBBox: -192, -323, 1160, 952 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: YCISPI+STIXGeneral-Regular FontSubset: true FirstChar: 1 LastChar: 6 FontDescriptor: FontName: YCISPI+STIXGeneral-Regular Flags: Nonsymbolic FontBBox: -995, -455, 2000, 1055 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true CIDFontType2: Font: BaseFont: HUBVCK+TrebuchetMS-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: HUBVCK+TrebuchetMS-Bold Flags: Nonsymbolic, ForceBold FontBBox: -101, -270, 1130, 980 FontFile2: true Font: BaseFont: NHLHJD+TrebuchetMS-Italic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: NHLHJD+TrebuchetMS-Italic Flags: Nonsymbolic, Italic FontBBox: -110, -258, 1108, 946 FontFile2: true Font: BaseFont: TNIEBT+TrebuchetMS CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: TNIEBT+TrebuchetMS Flags: Nonsymbolic FontBBox: -86, -262, 1082, 943 FontFile2: true XMP: uuid:d6b8b7e2-2418-44ea-8873-f1132e2fcccc uuid:CE562160-3C81-78A8-C31A-4844AC94115C True Atrial fibrillation; Budget impact analysis; Screening; ECG monitoring; Anticoagulation; Stroke prevention PDFlib+PDI 9.0.7p3 (C++/Win64) application/pdf 10.1093/eurheartjsupp/suae076 en Oxford University Press The budget impact of implementing atrial fibrillation-screening in European countries Michaela Eklund Lars Bernfort Kajsa Appelberg Daniel Engler Renate B. Schnabel Carlos Martinez Christopher Wallenhorst Giuseppe Boriani Claire M. Buckley Søren Zöga Diederichsen Jesper Hastrup Svendsen Joan Montaner Tatjana Potpara Lars-Åke Levin Johan Lyth DOI: 10.1093/eurheartjsupp/suae076; European Heart Journal Supplements, 26, S4, 2024-08-01.; Abstract: A budget impact analysis estimates the short-term difference between the cost of the current treatment strategy and a new treatment strategy, in this case to implement population screening for atrial fibrillation (AF). The aim of this study is to estimate the financial impact of implementing population-based AF-screening of 75-year-olds compared with the current setting of no screening from a healthcare payer perspective in eight European countries. The net budget impact of AF-screening was estimated in country-specific settings for Denmark, Germany, Ireland, Italy, Netherlands, Serbia, Spain, and Sweden. Country-specific parameters were used to allow for variations in healthcare systems and to reflect the healthcare sector in the country of interest. Similar results can be seen in all countries AF-screening incurs savings of stroke-related costs since AF treatment reduces the number of strokes. However, the increased number of detected AF and higher drug acquisition will increase the drug costs as well as the costs of physician- and control visits. The net budget impact per invited varied from €10 in Ireland to €122 in the Netherlands. The results showed the increased costs of implementing AF-screening were mainly driven by increased drug costs and screening costs. In conclusion, across Europe, though the initial cost of screening and more frequent use of oral anti-coagulants will increase the healthcare payers’ costs, introducing population screening for AF will result in savings of stroke-related costs. © The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology. Atrial fibrillation Budget impact analysis Screening ECG monitoring Anticoagulation Stroke prevention Journal European Heart Journal Supplements © The Author(s) 2024. 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