d7ad66e1a6b6f9342f6768cf392084db  pmc_11300303.pdf
1650dede814c85bf2fc90c5e7bf2677caa82a016  pmc_11300303.pdf
a32293805ba5f27dd47a39b92f476b232ca16baa707ec1835e4cf92d2c0758fd  pmc_11300303.pdf

Title:           Randomised, double-blind, placebo-controlled, parallel-group, multicentric, phase IIA clinical trial for evaluating the safety, tolerability, and therapeutic efficacy of daily oral administration of NFX88 to treat neuropathic pain in individuals with spinal cord injury
Subject:         Spinal Cord, doi:10.1038/s41393-024-01006-4
Keywords:        
Author:          Pablo V. Escribá
Creator:         Springer
CreationDate:    Tue Jul 30 11:09:04 2024 CEST
ModDate:         Tue Jul 30 10:56:43 2024 CEST
Custom Metadata: yes
Metadata Stream: yes
Tagged:          no
UserProperties:  no
Suspects:        no
Form:            AcroForm
JavaScript:      no
Pages:           14
Encrypted:       no
Page size:       595.276 x 790.866 pts
Page rot:        0
File size:       3148196 bytes
Optimized:       no
PDF version:     1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
MOHFAD+AdvTT5afe5d37.B               Type 1C           WinAnsi          yes yes no     382  0
MOHGHD+AdvMyriad_R                   Type 1C           WinAnsi          yes yes no     401  0
MOHGHE+AdvOTa20b42a7                 Type 1C           WinAnsi          yes yes no     402  0
Arial-BoldMT                         Type 1C           WinAnsi          yes no  no     383  0
MOHFGD+AdvOT46dcae81                 Type 1C           WinAnsi          yes yes no     387  0
MOHFGE+AdvOT46dcae81+fb              Type 1C           Custom           yes yes yes    388  0
MOHFGF+AdvTT6780a46b                 Type 1C           WinAnsi          yes yes no     389  0
MOHGGA+AdvTT2876772e+27              Type 1C           Custom           yes yes yes    397  0
MOHGGB+AdvOT3b30f6db.B               Type 1C           WinAnsi          yes yes no     398  0
MOHGGC+AdvOT46dcae81+20              Type 1C           WinAnsi          yes yes no     403  0
MOHGHC+AdvMyriad_I                   Type 1C           WinAnsi          yes yes no     404  0
MOHHCB+AdvOT65f8a23b.I               Type 1C           WinAnsi          yes yes no     170  0
MOHHCC+AdvOT46dcae81+22              Type 1C           Custom           yes yes yes    165  0
MOHHCD+AdvTTab7e17fd                 Type 1C           WinAnsi          yes yes no     162  0
MOHHCE+AdvOT7d2ebc01                 Type 1C           WinAnsi          yes yes no     159  0
MOHHGE+AdvOT3b30f6db.B+fb            Type 1C           Custom           yes yes yes    177  0
MOHLEN+AdvOT919a0533.B               Type 1C           WinAnsi          yes yes no     174  0
MOHMCJ+AdvTT6780a46b+fb              Type 1C           Custom           yes yes yes    181  0
MOHMFI+AdvOT3b30f6db.B+20            Type 1C           WinAnsi          yes yes no     185  0
MOIMDI+AdvOT65f8a23b.I+fb            Type 1C           Custom           yes yes yes    192  0
MOIMDJ+AdvTTab7e17fd+22              Type 1C           Custom           yes yes no     188  0
MOJAKP+AdvOT3b30f6db.B+22            Type 1C           Custom           yes yes yes    197  0
MOJALA+AdvTT6780a46b+22              Type 1C           Custom           yes yes yes    193  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2025-02-06 02:49:26 CET
 RepresentationInformation: pmc_11300303.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2025-01-11 02:30:31 CET
  Size: 3148196
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 767
   FreeObjects: 143
   IncrementalUpdates: 0
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseOutlines
    Outlines: 
     Item: 
      Title: Randomised, double-blind, placebo-controlled, parallel-group, multicentric, phase IIA clinical trial for evaluating the safety, tolerability, and therapeutic efficacy of daily oral administration of NFX88 to treat neuropathic pain in individuals with spi温㸾൥湤潢樍㜳㈠〠潢樍㰼⽃嬰⸰‰⸰‰⸰崯䍯畮琠〯䑥獴⣾＀䄀ㄩ⽆‰⽎數琠㜳㐠〠刯偡牥湴‵ㄸ‰⁒⽔楴汥⣾＀䤀渀琀爀漀搀甀挀琀椀漀温㸾൥湤潢樍㜳㌠〠潢樍㰼⽃嬰⸰‰⸰‰⸰崯䍯畮琠〯䑥獴⣾＀䴀ㄩ⽆‰⽐慲敮琠㔱㠠〠刯偲敶‷㌵‰⁒⽔楴汥⣾＀䄀䐀䐀䤀吀䤀伀一䄀䰀 䤀一䘀伀刀䴀䄀吀䤀伀丩㸾൥湤潢樍㜳㔠〠潢樍㰼⽃嬰⸰‰⸰‰⸰崯䍯畮琠〯䑥獴⣾＀䴀ㄩ⽆‰⽎數琠㜳㌠〠刯偡牥湴‵ㄸ‰⁒⽐牥瘠㜳㘠〠刯呩瑬攨ACKNOWLEDGMENTS
      Destination: title_link
      Children: 
       Item: 
        Title: Introduction
        Destination: A1
       Item: 
        Title: Methods
        Destination: A2
        Children: 
         Item: 
          Title: Participants
          Destination: B1
          Children: 
           Item: 
            Title: Eligibility criteria for participants
            Destination: C1
         Item: 
          Title: Trial’design
          Destination: B2
         Item: 
          Title: Outcomes (pre-specified primary and secondary outcome measures)
          Destination: B3
         Item: 
          Title: Blinding
          Destination: B4
          Children: 
           Item: 
            Title: Blinding the analytical process
            Destination: C2
         Item: 
          Title: Randomisation
          Destination: B5
         Item: 
          Title: Statistical methods
          Destination: B6
          Children: 
           Item: 
            Title: Sample size calculation
            Destination: C3
           Item: 
            Title: Statistical methods used to compare groups for primary and secondary outcomes
            Destination: C4
           Item: 
            Title: Safety assessment (main objective)
            Destination: D1
           Item: 
            Title: Efficacy assessment (secondary objective)
            Destination: D2
           Item: 
            Title: Stratification based on the initial PD-Q classification
            Destination: D3
       Item: 
        Title: Results
        Destination: A3
        Children: 
         Item: 
          Title: Subject demographics and characteristics
          Destination: B7
         Item: 
          Title: Outcomes
          Destination: B8
          Children: 
           Item: 
            Title: Safety and tolerability
            Destination: C5
           Item: 
            Title: Efficacy
            Destination: C6
         Item: 
          Title: Preplanned analysis (VAS, PD-Q and’PGIC)
          Destination: B9
         Item: 
          Title: Time course of the four treatment arms’(VAS)
          Destination: B10
         Item: 
          Title: Responders of the four treatment arms’(VAS)
          Destination: B11
         Item: 
          Title: Dropouts’ analysis
          Destination: B12
         Item: 
          Title: Stratification based on initial PD-Q classification
          Destination: B13
       Item: 
        Title: Discussion
        Destination: A4
       Item: 
        Title: References
        Destination: A5
       Item: 
        Title: Acknowledgements
        Destination: A6
       Item: 
        Title: Author contributions
        Destination: A7
       Item: 
        Title: Funding
        Destination: A8
       Item: 
        Title: Competing interests
        Destination: A9
       Item: 
        Title: Ethical approval
        Destination: A10
       Item: 
        Title: ACKNOWLEDGMENTS
        Destination: M1
       Item: 
        Title: ADDITIONAL INFORMATION
        Destination: M1
   Info: 
    Title: Randomised, double-blind, placebo-controlled, parallel-group, multicentric, phase IIA clinical trial for evaluating the safety, tolerability, and therapeutic efficacy of daily oral administration of NFX88 to treat neuropathic pain in individuals with spinal cord injury
    Author: Pablo V. Escribá
    Subject: Spinal Cord, doi:10.1038/s41393-024-01006-4
    Keywords: 
    Creator: Springer
    CreationDate: Tue Jul 30 11:39:04 CEST 2024
    ModDate: Tue Jul 30 11:26:43 CEST 2024
   ID: 0x53e6b03e0ec6ce8f04012d9a79eeab17, 0x1eb01fcf3672fb4a8f9be6ee19c81b78
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1500
      ImageHeight: 1029
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2000
      ImageHeight: 1350
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 2000
      ImageHeight: 2046
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1500
      ImageHeight: 794
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1389
      ImageHeight: 2500
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1489
      ImageHeight: 2500
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
   Fonts: 
    Type1: 
     Font: 
      BaseFont: MOIMDI+AdvOT65f8a23b.I+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: MOIMDI+AdvOT65f8a23b.I+fb
       Flags: Symbolic
       FontBBox: 0, 0, 781, 718
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MOJALA+AdvTT6780a46b+22
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: MOJALA+AdvTT6780a46b+22
       Flags: Symbolic
       FontBBox: 0, -250, 875, 791
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MOHHCD+AdvTTab7e17fd
      FontSubset: true
      FirstChar: 43
      LastChar: 61
      FontDescriptor: 
       FontName: MOHHCD+AdvTTab7e17fd
       Flags: Nonsymbolic
       FontBBox: -156, -250, 1072, 947
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MOHFGD+AdvOT46dcae81
      FontSubset: true
      FirstChar: 37
      LastChar: 252
      FontDescriptor: 
       FontName: MOHFGD+AdvOT46dcae81
       Flags: Nonsymbolic
       FontBBox: -41, -250, 833, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MOHFGE+AdvOT46dcae81+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: MOHFGE+AdvOT46dcae81+fb
       Flags: Symbolic
       FontBBox: 0, 0, 739, 718
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MOHFGF+AdvTT6780a46b
      FontSubset: true
      FirstChar: 37
      LastChar: 250
      FontDescriptor: 
       FontName: MOHFGF+AdvTT6780a46b
       Flags: Nonsymbolic
       FontBBox: -41, -250, 875, 843
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MOHHCC+AdvOT46dcae81+22
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: MOHHCC+AdvOT46dcae81+22
       Flags: Symbolic
       FontBBox: 0, -145, 687, 822
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MOJAKP+AdvOT3b30f6db.B+22
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: MOJAKP+AdvOT3b30f6db.B+22
       Flags: Symbolic
       FontBBox: -10, -156, 718, 833
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MOHHCB+AdvOT65f8a23b.I
      FontSubset: true
      FirstChar: 65
      LastChar: 243
      FontDescriptor: 
       FontName: MOHHCB+AdvOT65f8a23b.I
       Flags: Nonsymbolic
       FontBBox: -104, -250, 885, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MOHGGA+AdvTT2876772e+27
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: MOHGGA+AdvTT2876772e+27
       Flags: Symbolic
       FontBBox: 0, -197, 968, 770
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MOHGGB+AdvOT3b30f6db.B
      FontSubset: true
      FirstChar: 37
      LastChar: 176
      FontDescriptor: 
       FontName: MOHGGB+AdvOT3b30f6db.B
       Flags: Nonsymbolic
       FontBBox: -31, -250, 875, 895
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MOHLEN+AdvOT919a0533.B
      FontSubset: true
      FirstChar: 46
      LastChar: 108
      FontDescriptor: 
       FontName: MOHLEN+AdvOT919a0533.B
       Flags: Nonsymbolic
       FontBBox: -31, -250, 656, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MOHGHD+AdvMyriad_R
      FontSubset: true
      FirstChar: 40
      LastChar: 150
      FontDescriptor: 
       FontName: MOHGHD+AdvMyriad_R
       Flags: Nonsymbolic
       FontBBox: -41, -239, 1125, 750
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MOHHGE+AdvOT3b30f6db.B+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: MOHHGE+AdvOT3b30f6db.B+fb
       Flags: Symbolic
       FontBBox: 0, 0, 833, 718
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MOHGHE+AdvOTa20b42a7
      FontSubset: true
      FirstChar: 48
      LastChar: 121
      FontDescriptor: 
       FontName: MOHGHE+AdvOTa20b42a7
       Flags: Serif, Nonsymbolic
       FontBBox: -72, -239, 979, 906
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MOHGGC+AdvOT46dcae81+20
      FontSubset: true
      FirstChar: 133
      LastChar: 151
      FontDescriptor: 
       FontName: MOHGGC+AdvOT46dcae81+20
       Flags: Nonsymbolic
       FontBBox: 0, -197, 1125, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MOHGHC+AdvMyriad_I
      FontSubset: true
      FirstChar: 67
      LastChar: 114
      FontDescriptor: 
       FontName: MOHGHC+AdvMyriad_I
       Flags: Nonsymbolic
       FontBBox: -104, -239, 1083, 750
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MOHMCJ+AdvTT6780a46b+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: MOHMCJ+AdvTT6780a46b+fb
       Flags: Symbolic
       FontBBox: 9, 0, 875, 750
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MOHMFI+AdvOT3b30f6db.B+20
      FontSubset: true
      FirstChar: 133
      LastChar: 146
      FontDescriptor: 
       FontName: MOHMFI+AdvOT3b30f6db.B+20
       Flags: Nonsymbolic
       FontBBox: -10, -197, 1250, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MOIMDJ+AdvTTab7e17fd+22
      FontSubset: true
      FirstChar: 21
      LastChar: 21
      FontDescriptor: 
       FontName: MOIMDJ+AdvTTab7e17fd+22
       Flags: Nonsymbolic
       FontBBox: -156, -218, 937, 947
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: MOHFAD+AdvTT5afe5d37.B
      FontSubset: true
      FirstChar: 65
      LastChar: 84
      FontDescriptor: 
       FontName: MOHFAD+AdvTT5afe5d37.B
       Flags: Nonsymbolic
       FontBBox: -31, -250, 895, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: Arial-BoldMT
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: Arial-BoldMT
       Flags: Nonsymbolic
       FontBBox: -628, -376, 2000, 1010
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MOHHCE+AdvOT7d2ebc01
      FontSubset: true
      FirstChar: 48
      LastChar: 57
      FontDescriptor: 
       FontName: MOHHCE+AdvOT7d2ebc01
       Flags: Nonsymbolic
       FontBBox: -31, -208, 958, 916
       FontFile3: true
      Encoding: WinAnsiEncoding
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 5.6-c142 87.162696, 2020/06/23-02:37:56        ">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:dc="http://purl.org/dc/elements/1.1/"
            xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/"
            xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/"
            xmlns:crossmark="http://crossref.org/crossmark/1.0/"
            xmlns:xmp="http://ns.adobe.com/xap/1.0/"
            xmlns:xmpRights="http://ns.adobe.com/xap/1.0/rights/"
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/"
            xmlns:jav="http://www.niso.org/schemas/jav/1.0/"
            xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/"
            xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#"
            xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/"
            xmlns:sn="http://springernature.com/ns/xmpExtensions/2.0/"
            xmlns:author="http://springernature.com/ns/xmpExtensions/2.0/authorInfo/"
            xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/"
            xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#"
            xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#"
            xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#"
            xmlns:pdfaField="http://www.aiim.org/pdfa/ns/field#">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>doi:10.1038/s41393-024-01006-4</dc:identifier>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Randomised, double-blind, placebo-controlled, parallel-group, multicentric, phase IIA clinical trial for evaluating the safety, tolerability, and therapeutic efficacy of daily oral administration of NFX88 to treat neuropathic pain in individuals with spinal cord injury</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Pablo V. Escribá</rdf:li>
               <rdf:li>Ángel M. Gil-Agudo</rdf:li>
               <rdf:li>Joan Vidal Samsó</rdf:li>
               <rdf:li>Judith Sánchez-Raya</rdf:li>
               <rdf:li>Sebastián Salvador-de la Barrera</rdf:li>
               <rdf:li>Vanesa Soto-León</rdf:li>
               <rdf:li>Natacha León-Álvarez</rdf:li>
               <rdf:li>Bosco Méndez Ferrer</rdf:li>
               <rdf:li>Miguel David Membrilla-Mesa</rdf:li>
               <rdf:li>Carolina Redondo Galán</rdf:li>
               <rdf:li>Jesús Benito-Penalva</rdf:li>
               <rdf:li>Antonio Montoto-Marqués</rdf:li>
               <rdf:li>Javier Medel Rebollo</rdf:li>
               <rdf:li>Ramiro Palazón García</rdf:li>
               <rdf:li>Francisco Gutiérrez Henares</rdf:li>
               <rdf:li>Marc Miralles</rdf:li>
               <rdf:li>Manuel Torres</rdf:li>
               <rdf:li>Ana B. Nieto-Librero</rdf:li>
               <rdf:li>David García Marco</rdf:li>
               <rdf:li>Carmela Gómez</rdf:li>
               <rdf:li>David Jimeno</rdf:li>
               <rdf:li>Antonio Oliviero</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Springer US</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:subject>
            <rdf:Bag/>
         </dc:subject>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Spinal Cord, doi:10.1038/s41393-024-01006-4</rdf:li>
            </rdf:Alt>
         </dc:description>
         <prism:doi>10.1038/s41393-024-01006-4</prism:doi>
         <prism:url>http://dx.doi.org/10.1038/s41393-024-01006-4</prism:url>
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>Spinal Cord</prism:publicationName>
         <prism:copyright>© 2024, The Author(s)</prism:copyright>
         <prism:issn>1476-5624</prism:issn>
         <pdfx:doi>10.1038/s41393-024-01006-4</pdfx:doi>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>True</crossmark:CrossmarkDomainExclusive>
         <crossmark:DOI>10.1038/s41393-024-01006-4</crossmark:DOI>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
         <xmp:CreatorTool>Springer</xmp:CreatorTool>
         <xmp:ModifyDate>2024-07-30T14:26:43+05:30</xmp:ModifyDate>
         <xmp:CreateDate>2024-07-30T14:39:04+05:30</xmp:CreateDate>
         <xmp:MetadataDate>2024-07-30T14:26:43+05:30</xmp:MetadataDate>
         <xmpRights:Marked>True</xmpRights:Marked>
         <pdf:Keywords/>
         <jav:journal_article_version>VoR</jav:journal_article_version>
         <xmpMM:DocumentID>uuid:4c98a370-10be-4661-bdfd-3daa2aa59cef</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:e255e5f1-757c-4f1a-870b-56c6208763fa</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:4295bf9c-561b-422d-9d60-c53615941407</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2024-07-30T14:26:41+05:30</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
         <sn:authorInfo>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Ángel M. Gil-Agudo</author:name>
                  <author:orcid>http://orcid.org/0000-0001-5082-4225</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Sebastián Salvador-de la Barrera</author:name>
                  <author:orcid>http://orcid.org/0000-0002-9810-7548</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Antonio Montoto-Marqués</author:name>
                  <author:orcid>http://orcid.org/0000-0003-1773-365X</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Manuel Torres</author:name>
                  <author:orcid>http://orcid.org/0000-0002-5076-8486</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Ana B. Nieto-Librero</author:name>
                  <author:orcid>http://orcid.org/0000-0001-6643-247X</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Carmela Gómez</author:name>
                  <author:orcid>http://orcid.org/0000-0002-9041-886X</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Antonio Oliviero</author:name>
                  <author:orcid>http://orcid.org/0000-0001-7723-0478</author:orcid>
               </rdf:li>
            </rdf:Bag>
         </sn:authorInfo>
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original.</pdfaProperty:description>
                           <pdfaProperty:name>DerivedFrom</pdfaProperty:name>
                           <pdfaProperty:valueType>ResourceRef</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced.</pdfaType:description>
                           <pdfaType:namespaceURI>http://ns.adobe.com/xap/1.0/sType/Part#</pdfaType:namespaceURI>
                           <pdfaType:prefix>stPart</pdfaType:prefix>
                           <pdfaType:type>Part</pdfaType:type>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/t/pg/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpTPg</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Paged-Text</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents).</pdfaProperty:description>
                           <pdfaProperty:name>PlateNames</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A structure containing the characteristics of a font used in a document</pdfaProperty:description>
                           <pdfaProperty:name>Fonts</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag Font</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>A structure containing the characteristics of a font used in a document.</pdfaType:description>
                           <pdfaType:namespaceURI>http://ns.adobe.com/xap/1.0/sType/Font#</pdfaType:namespaceURI>
                           <pdfaType:prefix>stFnt</pdfaType:prefix>
                           <pdfaType:type>Font</pdfaType:type>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>pdfx</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrosMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:DOI</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://crossref.org/crossmark/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>crossmark</pdfaSchema:prefix>
                  <pdfaSchema:schema>crossmark</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Usual same as prism:doi</pdfaProperty:description>
                           <pdfaProperty:name>DOI</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The date when a publication was published.</pdfaProperty:description>
                           <pdfaProperty:name>MajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://prismstandard.org/namespaces/basic/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>prism</pdfaSchema:prefix>
                  <pdfaSchema:schema>Prism</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. &#xA;Comment &#xA;PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. &#xA;Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. &#xA;&#xA;</pdfaProperty:description>
                           <pdfaProperty:name>aggregationType</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Copyright </pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article.&#xA;The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. &#xA;If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). &#xA;</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. &#xA;Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. &#xA;</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. &#xA;Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. &#xA;&#xA;Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” &#xA;</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. &#xA;The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. &#xA;NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. &#xA;</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>sn</pdfaSchema:prefix>
                  <pdfaSchema:schema>Springer Nature ORCID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors.</pdfaProperty:description>
                           <pdfaProperty:name>authorInfo</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag AuthorInformation</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>Specifies the types of author information: name and ORCID of an author.</pdfaType:description>
                           <pdfaType:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/authorInfo/</pdfaType:namespaceURI>
                           <pdfaType:prefix>author</pdfaType:prefix>
                           <pdfaType:type>AuthorInformation</pdfaType:type>
                           <pdfaType:field>
                              <rdf:Seq>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:description>Gives the ORCID of an author.</pdfaField:description>
                                    <pdfaField:name>orcid</pdfaField:name>
                                    <pdfaField:valueType>URI</pdfaField:valueType>
                                 </rdf:li>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:description>Gives the name of an author.</pdfaField:description>
                                    <pdfaField:name>name</pdfaField:name>
                                    <pdfaField:valueType>Text</pdfaField:valueType>
                                 </rdf:li>
                              </rdf:Seq>
                           </pdfaType:field>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.niso.org/schemas/jav/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>jav</pdfaSchema:prefix>
                  <pdfaSchema:schema>NISO</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Values for Journal Article Version are one of the following:&#xA;AO = Author’s Original&#xA;SMUR = Submitted Manuscript Under Review&#xA;AM = Accepted Manuscript&#xA;P = Proof&#xA;VoR = Version of Record&#xA;CVoR = Corrected Version of Record&#xA;EVoR = Enhanced Version of Record</pdfaProperty:description>
                           <pdfaProperty:name>journal_article_version</pdfaProperty:name>
                           <pdfaProperty:valueType>Closed Choice of Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 454
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 487, 689, 489, 721
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 487, 695, 543, 727
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 543, 695, 559, 705
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 543, 695, 559, 705
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 191, 557, 192, 565
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 191, 557, 192, 565
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 201, 557, 203, 565
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 194, 557, 201, 565
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 201, 557, 201, 565
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 500, 557, 501, 565
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 500, 557, 501, 565
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 509, 557, 512, 565
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 502, 557, 509, 565
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 509, 557, 510, 565
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 237, 535, 238, 544
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 237, 535, 238, 544
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 247, 535, 250, 544
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 240, 535, 247, 544
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 247, 535, 248, 544
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 159, 524, 160, 533
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 159, 524, 160, 533
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 169, 524, 172, 533
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 162, 524, 169, 533
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 169, 524, 170, 533
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 257, 524, 258, 533
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 257, 524, 258, 533
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 267, 524, 269, 533
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 259, 524, 267, 533
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 267, 524, 267, 533
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 434, 524, 435, 533
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 434, 524, 435, 533
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 443, 524, 446, 533
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 436, 524, 443, 533
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 443, 524, 444, 533
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 109, 513, 110, 522
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 109, 513, 110, 522
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 119, 513, 121, 522
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 112, 513, 119, 522
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 119, 513, 119, 522
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 177, 284, 342, 293
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 130, 199, 135, 208
       Flags: Print
       AppearanceDictionary: true
       Destination: 132
      Annotation: 
       Subtype: Link
       Rect: 141, 199, 145, 208
       Flags: Print
       AppearanceDictionary: true
       Destination: 132
      Annotation: 
       Subtype: Link
       Rect: 47, 169, 52, 178
       Flags: Print
       AppearanceDictionary: true
       Destination: 132
      Annotation: 
       Subtype: Link
       Rect: 47, 149, 52, 158
       Flags: Print
       AppearanceDictionary: true
       Destination: 132
      Annotation: 
       Subtype: Link
       Rect: 449, 229, 454, 238
       Flags: Print
       AppearanceDictionary: true
       Destination: 132
      Annotation: 
       Subtype: Link
       Rect: 458, 229, 463, 238
       Flags: Print
       AppearanceDictionary: true
       Destination: 132
      Annotation: 
       Subtype: Link
       Rect: 313, 209, 318, 218
       Flags: Print
       AppearanceDictionary: true
       Destination: 132
      Annotation: 
       Subtype: Link
       Rect: 322, 209, 332, 218
       Flags: Print
       AppearanceDictionary: true
       Destination: 132
      Annotation: 
       Subtype: Link
       Rect: 431, 189, 440, 198
       Flags: Print
       AppearanceDictionary: true
       Destination: 132
      Annotation: 
       Subtype: Link
       Rect: 445, 189, 454, 198
       Flags: Print
       AppearanceDictionary: true
       Destination: 132
      Annotation: 
       Subtype: Link
       Rect: 491, 169, 495, 178
       Flags: Print
       AppearanceDictionary: true
       Destination: 132
      Annotation: 
       Subtype: Link
       Rect: 501, 169, 506, 178
       Flags: Print
       AppearanceDictionary: true
       Destination: 132
      Annotation: 
       Subtype: Link
       Rect: 487, 149, 491, 158
       Flags: Print
       AppearanceDictionary: true
       Destination: 132
      Annotation: 
       Subtype: Link
       Rect: 496, 149, 501, 158
       Flags: Print
       AppearanceDictionary: true
       Destination: 132
      Annotation: 
       Subtype: Link
       Rect: 505, 149, 515, 158
       Flags: Print
       AppearanceDictionary: true
       Destination: 132
      Annotation: 
       Subtype: Link
       Rect: 425, 80, 500, 87
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 45, 749, 114, 757
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 455
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 146, 683, 155, 692
       Flags: Print
       AppearanceDictionary: true
       Destination: 132
      Annotation: 
       Subtype: Link
       Rect: 175, 663, 184, 672
       Flags: Print
       AppearanceDictionary: true
       Destination: 132
      Annotation: 
       Subtype: Link
       Rect: 100, 643, 109, 652
       Flags: Print
       AppearanceDictionary: true
       Destination: 132
      Annotation: 
       Subtype: Link
       Rect: 270, 603, 279, 612
       Flags: Print
       AppearanceDictionary: true
       Destination: 132
      Annotation: 
       Subtype: Link
       Rect: 256, 583, 266, 592
       Flags: Print
       AppearanceDictionary: true
       Destination: 132
      Annotation: 
       Subtype: Link
       Rect: 270, 583, 279, 592
       Flags: Print
       AppearanceDictionary: true
       Destination: 132
      Annotation: 
       Subtype: Link
       Rect: 223, 554, 233, 562
       Flags: Print
       AppearanceDictionary: true
       Destination: 132
      Annotation: 
       Subtype: Link
       Rect: 232, 524, 241, 533
       Flags: Print
       AppearanceDictionary: true
       Destination: 132
      Annotation: 
       Subtype: Link
       Rect: 249, 524, 258, 533
       Flags: Print
       AppearanceDictionary: true
       Destination: 132
      Annotation: 
       Subtype: Link
       Rect: 96, 494, 105, 503
       Flags: Print
       AppearanceDictionary: true
       Destination: 132
      Annotation: 
       Subtype: Link
       Rect: 183, 464, 192, 473
       Flags: Print
       AppearanceDictionary: true
       Destination: 132
      Annotation: 
       Subtype: Link
       Rect: 225, 434, 235, 443
       Flags: Print
       AppearanceDictionary: true
       Destination: 132
      Annotation: 
       Subtype: Link
       Rect: 134, 374, 143, 383
       Flags: Print
       AppearanceDictionary: true
       Destination: 132
      Annotation: 
       Subtype: Link
       Rect: 217, 344, 226, 353
       Flags: Print
       AppearanceDictionary: true
       Destination: 132
      Annotation: 
       Subtype: Link
       Rect: 230, 344, 239, 353
       Flags: Print
       AppearanceDictionary: true
       Destination: 132
      Annotation: 
       Subtype: Link
       Rect: 118, 324, 127, 333
       Flags: Print
       AppearanceDictionary: true
       Destination: 132
      Annotation: 
       Subtype: Link
       Rect: 478, 370, 482, 378
       Flags: Print
       AppearanceDictionary: true
       Destination: 26
      Annotation: 
       Subtype: Link
       Rect: 542, 155, 546, 163
       Flags: Print
       AppearanceDictionary: true
       Destination: 26
     Thumb: true
    Page: 
     Label: 456
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 147, 403, 151, 411
       Flags: Print
       AppearanceDictionary: true
       Destination: 39
      Annotation: 
       Subtype: Link
       Rect: 250, 323, 258, 331
       Flags: Print
       AppearanceDictionary: true
       Destination: 132
      Annotation: 
       Subtype: Link
       Rect: 264, 323, 272, 331
       Flags: Print
       AppearanceDictionary: true
       Destination: 132
      Annotation: 
       Subtype: Link
       Rect: 485, 156, 489, 164
       Flags: Print
       AppearanceDictionary: true
       Destination: 39
      Annotation: 
       Subtype: Link
       Rect: 410, 129, 414, 137
       Flags: Print
       AppearanceDictionary: true
       Destination: 39
     Thumb: true
    Page: 
     Label: 457
     Sequence: 4
     Thumb: true
    Page: 
     Label: 458
     Sequence: 5
     Thumb: true
    Page: 
     Label: 459
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 355, 76, 359, 85
       Flags: Print
       AppearanceDictionary: true
       Destination: 47
     Thumb: true
    Page: 
     Label: 460
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 130, 466, 134, 475
       Flags: Print
       AppearanceDictionary: true
       Destination: 55
      Annotation: 
       Subtype: Link
       Rect: 125, 327, 129, 336
       Flags: Print
       AppearanceDictionary: true
       Destination: 63
      Annotation: 
       Subtype: Link
       Rect: 71, 217, 75, 226
       Flags: Print
       AppearanceDictionary: true
       Destination: 63
      Annotation: 
       Subtype: Link
       Rect: 246, 148, 250, 157
       Flags: Print
       AppearanceDictionary: true
       Destination: 84
      Annotation: 
       Subtype: Link
       Rect: 287, 118, 291, 127
       Flags: Print
       AppearanceDictionary: true
       Destination: 94
      Annotation: 
       Subtype: Link
       Rect: 283, 98, 288, 107
       Flags: Print
       AppearanceDictionary: true
       Destination: 104
      Annotation: 
       Subtype: Link
       Rect: 552, 397, 556, 406
       Flags: Print
       AppearanceDictionary: true
       Destination: 94
      Annotation: 
       Subtype: Link
       Rect: 387, 367, 392, 376
       Flags: Print
       AppearanceDictionary: true
       Destination: 94
      Annotation: 
       Subtype: Link
       Rect: 548, 337, 552, 346
       Flags: Print
       AppearanceDictionary: true
       Destination: 104
      Annotation: 
       Subtype: Link
       Rect: 489, 88, 494, 97
       Flags: Print
       AppearanceDictionary: true
       Destination: 94
     Thumb: true
    Page: 
     Label: 461
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 104, 137, 109, 146
       Flags: Print
       AppearanceDictionary: true
       Destination: 112
      Annotation: 
       Subtype: Link
       Rect: 131, 137, 135, 146
       Flags: Print
       AppearanceDictionary: true
       Destination: 124
      Annotation: 
       Subtype: Link
       Rect: 272, 77, 277, 86
       Flags: Print
       AppearanceDictionary: true
       Destination: 124
     Thumb: true
    Page: 
     Label: 462
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 368, 265, 377, 274
       Flags: Print
       AppearanceDictionary: true
       Destination: 132
      Annotation: 
       Subtype: Link
       Rect: 385, 255, 394, 264
       Flags: Print
       AppearanceDictionary: true
       Destination: 132
      Annotation: 
       Subtype: Link
       Rect: 545, 255, 555, 264
       Flags: Print
       AppearanceDictionary: true
       Destination: 132
     Thumb: true
    Page: 
     Label: 463
     Sequence: 10
     Thumb: true
    Page: 
     Label: 464
     Sequence: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 129, 225, 134, 234
       Flags: Print
       AppearanceDictionary: true
       Destination: 94
      Annotation: 
       Subtype: Link
       Rect: 124, 205, 129, 214
       Flags: Print
       AppearanceDictionary: true
       Destination: 94
      Annotation: 
       Subtype: Link
       Rect: 353, 185, 362, 194
       Flags: Print
       AppearanceDictionary: true
       Destination: 132
      Annotation: 
       Subtype: Link
       Rect: 496, 145, 506, 154
       Flags: Print
       AppearanceDictionary: true
       Destination: 132
      Annotation: 
       Subtype: Link
       Rect: 510, 145, 520, 154
       Flags: Print
       AppearanceDictionary: true
       Destination: 132
     Thumb: true
    Page: 
     Label: 465
     Sequence: 12
     Thumb: true
    Page: 
     Label: 466
     Sequence: 13
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 323, 553, 529, 560
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 544, 553, 551
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 535, 377, 542
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 467
     Sequence: 14
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 213, 649, 283, 656
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 35, 640, 58, 647
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 531, 643, 549, 650
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 301, 634, 412, 641
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
  Checksum: a326d65b
   Type: CRC32
  Checksum: d7ad66e1a6b6f9342f6768cf392084db
   Type: MD5
  Checksum: 1650dede814c85bf2fc90c5e7bf2677caa82a016
   Type: SHA-1
  Checksum: a32293805ba5f27dd47a39b92f476b232ca16baa707ec1835e4cf92d2c0758fd
   Type: SHA-256