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Silverberg Creator: Springer Producer: Acrobat Distiller 10.1.8 (Windows) CreationDate: Wed Sep 11 16:11:42 2024 CEST ModDate: Wed Sep 11 16:13:03 2024 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 1617259 bytes Optimized: yes PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- ZPYHLK+STIX-Regular Type 1C WinAnsi yes yes yes 251 0 StoneSerifStd-Semibold Type 1C Custom yes no yes 258 0 StoneSerifStd-Medium Type 1C Custom yes no yes 259 0 StoneSansStd-Medium Type 1C WinAnsi yes no yes 268 0 StoneSerifStd-SemiboldIt Type 1C Custom yes no yes 269 0 IOSSEP+Wingdings-Regular Type 1C WinAnsi yes yes yes 276 0 ZPYHLK+STIX-Regular2 Type 1C WinAnsi yes yes yes 308 0 StoneSansStd-Bold Type 1C WinAnsi yes no yes 94 0 CCPMRE+GaramondPremrPro-SmbdIt Type 1C Custom yes yes yes 95 0 MESPBK+GaramondPremrPro-Smbd Type 1C Custom yes yes yes 136 0 XFADZO+GaramondPremrPro Type 1C Custom yes yes yes 142 0 REBOTA+GaramondPremrPro-It Type 1C Custom yes yes yes 141 0 IWHLMS+StoneSerifStd-MediumItalic Type 1C WinAnsi yes yes yes 146 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-04-24 02:40:08 CEST RepresentationInformation: 304811.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-04-23 09:39:30 CEST Size: 1617259 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 371 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Patients with Moderate-to-Severe Atopic Dermatitis Maintain Stable Response with No or Minimal Fluctuations with 1 Year of Lebrikizumab Treatment Children: Item: Title: Abstract Children: Item: Title: Introduction: Item: Title: Methods: Item: Title: Results: Item: Title: Conclusions: Item: Title: Clinical Trial Registration: Item: Title: Plain Language Summary Item: Title: Digital Features Item: Title: Introduction Item: Title: Methods Children: Item: Title: Study Design and Patient Population Item: Title: Outcomes Item: Title: Statistical Analysis Item: Title: Results Children: Item: Title: Baseline Characteristics Item: Title: Skin Improvement Item: Title: Itch Improvement Item: Title: Discussion Item: Title: Conclusion Item: Title: References Info: Title: Patients with Moderate-to-Severe Atopic Dermatitis Maintain Stable Response with No or Minimal Fluctuations with 1 Year of Lebrikizumab Treatment Author: Jonathan I. Silverberg Subject: Dermatology and Therapy, https://doi.org/10.1007/s13555-024-01226-9 Keywords: Atopic dermatitis; Eczema; Fluctuations; Lebrikizumab; Response; Stability Creator: Springer Producer: Acrobat Distiller 10.1.8 (Windows) CreationDate: Wed Sep 11 16:41:42 CEST 2024 ModDate: Wed Sep 11 16:43:03 CEST 2024 ID: 0x440e51d46dae2847a123d0fe5a236b57, 0x45fdc998691d344faec14ceb5e57d720 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1866 ImageHeight: 687 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1866 ImageHeight: 514 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1866 ImageHeight: 1104 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1866 ImageHeight: 508 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Fonts: Type1: Font: BaseFont: StoneSerifStd-Semibold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: StoneSerifStd-Semibold Flags: Serif, Nonsymbolic FontBBox: -190, -251, 1319, 944 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: IWHLMS+StoneSerifStd-MediumItalic FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: IWHLMS+StoneSerifStd-MediumItalic Flags: Serif, Nonsymbolic, Italic FontBBox: -210, -257, 1299, 929 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: StoneSerifStd-Medium FirstChar: 0 LastChar: 255 FontDescriptor: FontName: StoneSerifStd-Medium Flags: Serif, Nonsymbolic FontBBox: -201, -250, 1279, 941 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: IOSSEP+Wingdings-Regular FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: IOSSEP+Wingdings-Regular Flags: Nonsymbolic FontBBox: 0, -103, 1359, 439 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MESPBK+GaramondPremrPro-Smbd FontSubset: true FirstChar: 31 LastChar: 119 FontDescriptor: FontName: MESPBK+GaramondPremrPro-Smbd Flags: Serif, Nonsymbolic FontBBox: -183, -329, 1401, 923 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: ZPYHLK+STIX-Regular FontSubset: true FirstChar: 32 LastChar: 150 FontDescriptor: FontName: ZPYHLK+STIX-Regular Flags: Serif, Nonsymbolic FontBBox: -970, -486, 2208, 1023 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: StoneSansStd-Medium FirstChar: 0 LastChar: 255 FontDescriptor: FontName: StoneSansStd-Medium Flags: Nonsymbolic FontBBox: -179, -250, 1297, 943 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: StoneSerifStd-SemiboldIt FirstChar: 0 LastChar: 255 FontDescriptor: FontName: StoneSerifStd-SemiboldIt Flags: Serif, Nonsymbolic, Italic FontBBox: -209, -256, 1333, 934 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: REBOTA+GaramondPremrPro-It FontSubset: true FirstChar: 31 LastChar: 110 FontDescriptor: FontName: REBOTA+GaramondPremrPro-It Flags: Serif, Nonsymbolic, Italic FontBBox: -229, -424, 1659, 945 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: StoneSansStd-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: StoneSansStd-Bold Flags: Nonsymbolic FontBBox: -158, -250, 1540, 946 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: XFADZO+GaramondPremrPro FontSubset: true FirstChar: 25 LastChar: 146 FontDescriptor: FontName: XFADZO+GaramondPremrPro Flags: Serif, Nonsymbolic FontBBox: -178, -336, 1405, 916 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: CCPMRE+GaramondPremrPro-SmbdIt FontSubset: true FirstChar: 31 LastChar: 121 FontDescriptor: FontName: CCPMRE+GaramondPremrPro-SmbdIt Flags: Serif, Nonsymbolic, Italic FontBBox: -247, -418, 1599, 933 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true XMP: 2024-09-11T19:41:42+05:30 Springer 2024-09-11T19:43:03+05:30 2024-09-11T19:43:03+05:30 Acrobat Distiller 10.1.8 (Windows) Atopic dermatitis; Eczema; Fluctuations; Lebrikizumab; Response; Stability False application/pdf https://doi.org/10.1007/s13555-024-01226-9 Springer Healthcare Dermatology and Therapy, https://doi.org/10.1007/s13555-024-01226-9 Atopic dermatitis Eczema Fluctuations Lebrikizumab Response Stability Patients with Moderate-to-Severe Atopic Dermatitis Maintain Stable Response with No or Minimal Fluctuations with 1 Year of Lebrikizumab Treatment Jonathan I. Silverberg Andreas Wollenberg Linda Stein Gold James Del Rosso Gil Yosipovitch Peter Lio Jose-Manuel Carrascosa Gaia Gallo Yuxin Ding Zhenhui Xu Marta Casillas Evangeline Pierce Helena Agell Sonja Ständer 10.1007/s13555-024-01226-9 2010-04-23 true springer.com springerlink.com https://doi.org/10.1007/s13555-024-01226-9 10.1007/s13555-024-01226-9 2190-9172 journal Dermatology and Therapy The Author(s) 2010-04-23 true 10.1007/s13555-024-01226-9 noindex springer.com springerlink.com CVoR uuid:e706828d-a13f-43d0-9c6c-a0a4e1fe3e0a uuid:a4a144f5-7744-4cd3-9758-a8a0c05c2084 default 1 converted uuid:e706828d-a13f-43d0-9c6c-a0a4e1fe3e0a converted to PDF/A-2b pdfToolbox 2024-09-11T19:42:29+05:30 converted uuid:5c2d6550-7264-4571-a804-41e2999fd942 converted to PDF/A-2b pdfToolbox 2024-09-11T19:43:02+05:30 2 B Jonathan I. 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