38690da45b76104f26a247a356080ca6  pmc_11335212.pdf
5c8da6ffab2a5f82b42825fd2093ccb0b55c5ed0  pmc_11335212.pdf
7f09a9ac6f7301eb880687a42c5ebd52a4638821f23b12616343ef0fedad79a1  pmc_11335212.pdf

Creator:         Adobe InDesign 18.0 (Windows)
Producer:        Adobe PDF Library 17.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
CreationDate:    Sat Jun 22 08:30:49 2024 CEST
ModDate:         Sat Jul  6 05:51:02 2024 CEST
Custom Metadata: yes
Metadata Stream: yes
Tagged:          yes
UserProperties:  no
Suspects:        no
Form:            none
JavaScript:      no
Pages:           22
Encrypted:       no
Page size:       595.276 x 790.866 pts
Page rot:        0
File size:       4305485 bytes
Optimized:       no
PDF version:     1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
MyriadPro-SemiCn                     Type 1C           WinAnsi          yes no  yes     23  0
MyriadPro-Bold                       Type 1C           WinAnsi          yes no  yes     18  0
MyriadPro-Regular                    Type 1C           WinAnsi          yes no  yes     19  0
KKRPLZ+TimesNewRomanPS-ItalicMT      TrueType          WinAnsi          yes yes yes     57  0
ZTKMXV+TimesNewRomanPSMT             CID TrueType      Identity-H       yes yes yes     22  0
Springnew                            TrueType          WinAnsi          yes no  yes   1521  0
JTCKHB+TimesNewRomanPSMT             TrueType          WinAnsi          yes yes yes     21  0
USJOFF+Wingdings-Regular             CID TrueType      Identity-H       yes yes yes   1522  0
MyriadPro-Semibold                   Type 1C           Custom           yes no  yes   1523  0
MyriadPro-SemiboldSemiCn             Type 1C           Custom           yes no  yes     20  0
MyriadPro-Semibold                   Type 1C           WinAnsi          yes no  yes   1572  0
FCVALO+Univers-Bold                  Type 1C           WinAnsi          yes yes no    1576  0
MyriadPro-SemiCn                     Type 1C           WinAnsi          yes no  yes    375  0
Springnew                            TrueType          WinAnsi          yes no  yes    372  0
MyriadPro-BoldSemiCn                 Type 1C           Custom           yes no  yes     44  0
ANTHBT+TimesNewRomanPS-ItalicMT      CID TrueType      Identity-H       yes yes yes     45  0
MyriadPro-SemiCn                     Type 1C           Custom           yes no  yes    405  0
Springnew                            TrueType          WinAnsi          yes no  yes    397  0
BGNDVR+STIX-Regular                  Type 1C           Custom           yes yes yes     56  0
STIX-Italic                          Type 1C           Custom           yes no  yes     84  0
WJYUDB+TimesNewRomanPS-BoldMT        CID TrueType      Identity-H       yes yes yes     85  0
BJHTVR+TimesNewRomanPS-BoldMT        TrueType          WinAnsi          yes yes yes     86  0
LGFBFX+TimesNewRomanPS-BoldItalicMT  TrueType          WinAnsi          yes yes yes    163  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2025-02-06 02:48:57 CET
 RepresentationInformation: pmc_11335212.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2025-02-04 02:26:32 CET
  Size: 4305485
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  Profile: Tagged PDF
  PDFMetadata: 
   Objects: 1640
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: en-US
    Outlines: 
     Item: 
      Title: Endogenous LXR signaling controls pulmonary surfactant homeostasis and prevents lung inflammation
      Children: 
       Item: 
        Title: Abstract
       Item: 
        Title: Introduction
       Item: 
        Title: Materials and methods
        Children: 
         Item: 
          Title: Experimental animals
         Item: 
          Title: MLE-12 cell line
         Item: 
          Title: Mouse peritoneal macrophages
         Item: 
          Title: Pneumocytes cultures
         Item: 
          Title: Bronchoalveolar lavage (BAL)
         Item: 
          Title: Lipidosis induction assay
         Item: 
          Title: Histology
         Item: 
          Title: Immunohistochemistry
         Item: 
          Title: Immunocytochemistry
         Item: 
          Title: Electron-microscopy procedures
         Item: 
          Title: Bone marrow transplant studies
         Item: 
          Title: RNA and protein analysis
         Item: 
          Title: Lipid analysis
         Item: 
          Title: Sensitization to house dust mite aeroallergens
         Item: 
          Title: Assessment of airway reactivity after HDM sensitization
         Item: 
          Title: Lung histological analysis and determination of inflammation score
         Item: 
          Title: Statistical analysis
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: LXR deficiency alters lung morphology
         Item: 
          Title: Alveolar macrophage and type II pneumocytes are involved in lung histopathology in LXR DKO mice
         Item: 
          Title: LXR regulates the expression of genes important for pulmonary surfactant homeostasis
         Item: 
          Title: Role of alveolar macrophages in lung histopathology in LXR DKO mice
         Item: 
          Title: Deficient regulation of surfactant metabolism by type II pneumocytes in LXR-DKO mice
         Item: 
          Title: Inflammation and impaired pulmonary function in LXR DKO lungs
       Item: 
        Title: Discussion
       Item: 
        Title: References
   Info: 
    Creator: Adobe InDesign 18.0 (Windows)
    Producer: Adobe PDF Library 17.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
    CreationDate: Sat Jun 22 08:30:49 CEST 2024
    ModDate: Sat Jul 06 05:51:02 CEST 2024
   ID: 0x2bcd9ef5ea9b28d6239a3e082c03c59d, 0x71c59a9c336db2e3f2f6e1db4d67322b
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1100
      ImageHeight: 90
      ColorSpace: black is zero
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1524
      ImageHeight: 1245
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1524
      ImageHeight: 1417
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1800
      ImageHeight: 2454
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1524
      ImageHeight: 2200
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1524
      ImageHeight: 1558
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 992
      ImageHeight: 1950
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2055
      ImageHeight: 841
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1524
      ImageHeight: 1636
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1524
      ImageHeight: 2189
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1524
      ImageHeight: 1543
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1524
      ImageHeight: 1221
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
   Fonts: 
    Type0: 
     Font: 
      BaseFont: USJOFF+Wingdings-Regular
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: WJYUDB+TimesNewRomanPS-BoldMT
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: ZTKMXV+TimesNewRomanPSMT
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: ANTHBT+TimesNewRomanPS-ItalicMT
      Encoding: Identity-H
      ToUnicode: true
    Type1: 
     Font: 
      BaseFont: MyriadPro-Bold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Bold
       Flags: Nonsymbolic
       FontBBox: -163, -250, 1256, 989
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Semibold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Semibold
       Flags: Nonsymbolic
       FontBBox: -161, -250, 1198, 972
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Regular
       Flags: Nonsymbolic
       FontBBox: -157, -250, 1126, 952
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-SemiboldSemiCn
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-SemiboldSemiCn
       Flags: Nonsymbolic
       FontBBox: -156, -250, 1115, 963
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: STIX-Italic
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: STIX-Italic
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -970, -305, 1429, 1023
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-SemiCn
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-SemiCn
       Flags: Nonsymbolic
       FontBBox: -152, -250, 1059, 947
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: BGNDVR+STIX-Regular
      FontSubset: true
      FirstChar: 31
      LastChar: 215
      FontDescriptor: 
       FontName: BGNDVR+STIX-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -970, -486, 2208, 1023
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-BoldSemiCn
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-BoldSemiCn
       Flags: Nonsymbolic
       FontBBox: -159, -250, 1161, 980
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
    TrueType: 
     Font: 
      BaseFont: Springnew
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: Springnew
       Flags: Serif, Nonsymbolic
       FontBBox: -1430, -456, 2446, 800
       FontFile2: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: LGFBFX+TimesNewRomanPS-BoldItalicMT
      FontSubset: true
      FirstChar: 35
      LastChar: 35
      FontDescriptor: 
       FontName: LGFBFX+TimesNewRomanPS-BoldItalicMT
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -547, -307, 1401, 1032
       FontFile2: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: JTCKHB+TimesNewRomanPSMT
      FontSubset: true
      FirstChar: 32
      LastChar: 243
      FontDescriptor: 
       FontName: JTCKHB+TimesNewRomanPSMT
       Flags: Serif, Nonsymbolic
       FontBBox: -568, -307, 2046, 1040
       FontFile2: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: BJHTVR+TimesNewRomanPS-BoldMT
      FontSubset: true
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: BJHTVR+TimesNewRomanPS-BoldMT
       Flags: Serif, Nonsymbolic
       FontBBox: -558, -328, 2000, 1056
       FontFile2: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: KKRPLZ+TimesNewRomanPS-ItalicMT
      FontSubset: true
      FirstChar: 32
      LastChar: 120
      FontDescriptor: 
       FontName: KKRPLZ+TimesNewRomanPS-ItalicMT
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -498, -307, 1333, 1023
       FontFile2: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
    CIDFontType2: 
     Font: 
      BaseFont: ANTHBT+TimesNewRomanPS-ItalicMT
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: ANTHBT+TimesNewRomanPS-ItalicMT
       Flags: Serif, Symbolic, Italic
       FontBBox: -498, -307, 1333, 1023
       FontFile2: true
     Font: 
      BaseFont: ZTKMXV+TimesNewRomanPSMT
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: ZTKMXV+TimesNewRomanPSMT
       Flags: Serif, Symbolic
       FontBBox: -568, -307, 2046, 1040
       FontFile2: true
     Font: 
      BaseFont: WJYUDB+TimesNewRomanPS-BoldMT
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: WJYUDB+TimesNewRomanPS-BoldMT
       Flags: Serif, Symbolic
       FontBBox: -558, -328, 2000, 1056
       FontFile2: true
     Font: 
      BaseFont: USJOFF+Wingdings-Regular
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: USJOFF+Wingdings-Regular
       Flags: Symbolic
       FontBBox: 0, -211, 1359, 899
       FontFile2: true
   XMP: <x:xmpmeta x:xmptk="Adobe XMP Core 5.6-c142 87.162696, 2019/10/10-02:41:22        " xmlns:x="adobe:ns:meta/">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about="" xmlns:author_1_="http://springernature.com/ns/xmpExtensions/2.0/authorInfo" xmlns:crossmark="http://crossref.org/crossmark/1.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:jav="http://www.niso.org/schemas/jav/1.0/" xmlns:pdf="http://ns.adobe.com/pdf/1.3/" xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/" xmlns:pdfaField="http://www.aiim.org/pdfa/ns/field#" xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#" xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#" xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#" xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/" xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/" xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/" xmlns:sn="http://springernature.com/ns/xmpExtensions/2.0/" xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#" xmlns:stRef="http://ns.adobe.com/xap/1.0/sType/ResourceRef#" xmlns:xmp="http://ns.adobe.com/xap/1.0/" xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmpMM:InstanceID>uuid:7ae6579d-66ec-4b38-a748-c69c468034c5</xmpMM:InstanceID>
         <xmpMM:OriginalDocumentID>adobe:docid:indd:24bb93d9-bd1e-11dd-84db-a83b50d2aaad</xmpMM:OriginalDocumentID>
         <xmpMM:DocumentID>xmp.id:3adceb53-98c1-5b4c-8ffd-fb112463d12b</xmpMM:DocumentID>
         <xmpMM:RenditionClass>proof:pdf</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:DerivedFrom rdf:parseType="Resource">
            <stRef:instanceID>xmp.iid:d04b7974-d2ee-b04e-b9f3-bcb080f594e1</stRef:instanceID>
            <stRef:documentID>xmp.did:86c7673b-73aa-c34d-b923-91bc85a74a54</stRef:documentID>
            <stRef:renditionClass>default</stRef:renditionClass>
         </xmpMM:DerivedFrom>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:parameters>from application/x-indesign to application/pdf</stEvt:parameters>
                  <stEvt:softwareAgent>Adobe InDesign 18.0 (Windows)</stEvt:softwareAgent>
                  <stEvt:when>2024-06-22T08:30:49+02:00</stEvt:when>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:0369754e-c197-4b9f-9786-60e7b051aed8</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2024-06-22T17:04:25+02:00</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
         <xmp:CreateDate>2024-06-22T08:30:49+02:00</xmp:CreateDate>
         <xmp:ModifyDate>2024-07-06T05:51:02+02:00</xmp:ModifyDate>
         <xmp:MetadataDate>2024-07-06T05:51:02+02:00</xmp:MetadataDate>
         <xmp:CreatorTool>Adobe InDesign 18.0 (Windows)</xmp:CreatorTool>
         <prism:aggregationType>journal</prism:aggregationType>
         <crossmark:DOI>10.1007/s00018-024-05310-3</crossmark:DOI>
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:doi>10.1007/s00018-024-05310-3</pdfx:doi>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
         <jav:journal_article_version>VoR</jav:journal_article_version>
         <dc:format>application/pdf</dc:format>
         <pdf:Producer>Adobe PDF Library 17.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)</pdf:Producer>
         <pdf:Trapped>False</pdf:Trapped>
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
         <sn:authorInfo>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <author_1_:name>Antonio Castrillo</author_1_:name>
                  <author_1_:orcid>http://orcid.org/0000-0002-2057-2159</author_1_:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author_1_:name>Carlos Tabraue</author_1_:name>
                  <author_1_:orcid>http://orcid.org/0000-0001-9920-8116</author_1_:orcid>
               </rdf:li>
            </rdf:Bag>
         </sn:authorInfo>
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original.</pdfaProperty:description>
                           <pdfaProperty:name>DerivedFrom</pdfaProperty:name>
                           <pdfaProperty:valueType>ResourceRef</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced.</pdfaType:description>
                           <pdfaType:namespaceURI>http://ns.adobe.com/xap/1.0/sType/Part#</pdfaType:namespaceURI>
                           <pdfaType:prefix>stPart</pdfaType:prefix>
                           <pdfaType:type>Part</pdfaType:type>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/t/pg/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpTPg</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Paged-Text</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A structure containing the characteristics of a font used in a document</pdfaProperty:description>
                           <pdfaProperty:name>Fonts</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag Font</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents).</pdfaProperty:description>
                           <pdfaProperty:name>PlateNames</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>A structure containing the characteristics of a font used in a document.</pdfaType:description>
                           <pdfaType:namespaceURI>http://ns.adobe.com/xap/1.0/sType/Font#</pdfaType:namespaceURI>
                           <pdfaType:prefix>stFnt</pdfaType:prefix>
                           <pdfaType:type>Font</pdfaType:type>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>pdfx</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrosMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:MajorVersionDate</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkMajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:DOI</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://crossref.org/crossmark/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>crossmark</pdfaSchema:prefix>
                  <pdfaSchema:schema>crossmark</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Usual same as prism:doi</pdfaProperty:description>
                           <pdfaProperty:name>DOI</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The date when a publication was published.</pdfaProperty:description>
                           <pdfaProperty:name>MajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://prismstandard.org/namespaces/basic/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>prism</pdfaSchema:prefix>
                  <pdfaSchema:schema>Prism</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. 
Comment 
PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. 
Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. 

</pdfaProperty:description>
                           <pdfaProperty:name>aggregationType</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>sn</pdfaSchema:prefix>
                  <pdfaSchema:schema>Springer Nature ORCID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors.</pdfaProperty:description>
                           <pdfaProperty:name>authorInfo</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag AuthorInformation</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>Specifies the types of author information: name and ORCID of an author.</pdfaType:description>
                           <pdfaType:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/authorInfo/</pdfaType:namespaceURI>
                           <pdfaType:prefix>author</pdfaType:prefix>
                           <pdfaType:type>AuthorInformation</pdfaType:type>
                           <pdfaType:field>
                              <rdf:Seq>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:description>Gives the name of an author.</pdfaField:description>
                                    <pdfaField:name>name</pdfaField:name>
                                    <pdfaField:valueType>Text</pdfaField:valueType>
                                 </rdf:li>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:description>Gives the ORCID of an author.</pdfaField:description>
                                    <pdfaField:name>orcid</pdfaField:name>
                                    <pdfaField:valueType>URI</pdfaField:valueType>
                                 </rdf:li>
                              </rdf:Seq>
                           </pdfaType:field>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.niso.org/schemas/jav/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>jav</pdfaSchema:prefix>
                  <pdfaSchema:schema>NISO</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Values for Journal Article Version are one of the following:
AO = Author’s Original
SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
EVoR = Enhanced Version of Record</pdfaProperty:description>
                           <pdfaProperty:name>journal_article_version</pdfaProperty:name>
                           <pdfaProperty:valueType>Closed Choice of Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 526, 609, 539, 597
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 126, 597, 139, 584
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 513, 721, 546, 688
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 110, 130, 115, 117
       Flags: Print
       AppearanceDictionary: true
       Destination: 264
      Annotation: 
       Subtype: Link
       Rect: 120, 130, 125, 117
       Flags: Print
       AppearanceDictionary: true
       Destination: 264
      Annotation: 
       Subtype: Link
       Rect: 478, 268, 483, 254
       Flags: Print
       AppearanceDictionary: true
       Destination: 264
      Annotation: 
       Subtype: Link
       Rect: 422, 193, 427, 179
       Flags: Print
       AppearanceDictionary: true
       Destination: 264
      Annotation: 
       Subtype: Link
       Rect: 346, 130, 351, 117
       Flags: Print
       AppearanceDictionary: true
       Destination: 264
      Annotation: 
       Subtype: Link
       Rect: 356, 130, 361, 117
       Flags: Print
       AppearanceDictionary: true
       Destination: 264
     Thumb: true
    Page: 
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 212, 705, 217, 692
       Flags: Print
       AppearanceDictionary: true
       Destination: 264
      Annotation: 
       Subtype: Link
       Rect: 156, 605, 161, 592
       Flags: Print
       AppearanceDictionary: true
       Destination: 264
      Annotation: 
       Subtype: Link
       Rect: 162, 530, 167, 517
       Flags: Print
       AppearanceDictionary: true
       Destination: 264
      Annotation: 
       Subtype: Link
       Rect: 172, 530, 177, 517
       Flags: Print
       AppearanceDictionary: true
       Destination: 264
      Annotation: 
       Subtype: Link
       Rect: 79, 480, 84, 467
       Flags: Print
       AppearanceDictionary: true
       Destination: 264
      Annotation: 
       Subtype: Link
       Rect: 133, 405, 143, 392
       Flags: Print
       AppearanceDictionary: true
       Destination: 264
      Annotation: 
       Subtype: Link
       Rect: 54, 305, 63, 292
       Flags: Print
       AppearanceDictionary: true
       Destination: 264
      Annotation: 
       Subtype: Link
       Rect: 273, 255, 283, 242
       Flags: Print
       AppearanceDictionary: true
       Destination: 264
      Annotation: 
       Subtype: Link
       Rect: 276, 218, 286, 204
       Flags: Print
       AppearanceDictionary: true
       Destination: 264
      Annotation: 
       Subtype: Link
       Rect: 51, 205, 61, 192
       Flags: Print
       AppearanceDictionary: true
       Destination: 264
      Annotation: 
       Subtype: Link
       Rect: 460, 630, 470, 617
       Flags: Print
       AppearanceDictionary: true
       Destination: 264
      Annotation: 
       Subtype: Link
       Rect: 477, 543, 487, 529
       Flags: Print
       AppearanceDictionary: true
       Destination: 264
     Thumb: true
    Page: 
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 356, 318, 366, 304
       Flags: Print
       AppearanceDictionary: true
       Destination: 264
      Annotation: 
       Subtype: Link
       Rect: 207, 605, 217, 592
       Flags: Print
       AppearanceDictionary: true
       Destination: 264
      Annotation: 
       Subtype: Link
       Rect: 224, 605, 234, 592
       Flags: Print
       AppearanceDictionary: true
       Destination: 264
     Thumb: true
    Page: 
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 309, 605, 319, 592
       Flags: Print
       AppearanceDictionary: true
       Destination: 264
     Thumb: true
    Page: 
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 386, 330, 391, 317
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 134, 693, 144, 679
       Flags: Print
       AppearanceDictionary: true
       Destination: 264
      Annotation: 
       Subtype: Link
       Rect: 191, 218, 196, 204
       Flags: Print
       AppearanceDictionary: true
       Destination: 264
      Annotation: 
       Subtype: Link
       Rect: 201, 218, 206, 204
       Flags: Print
       AppearanceDictionary: true
       Destination: 264
     Thumb: true
    Page: 
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 386, 693, 391, 679
       Flags: Print
       AppearanceDictionary: true
       Destination: 74
      Annotation: 
       Subtype: Link
       Rect: 92, 655, 97, 642
       Flags: Print
       AppearanceDictionary: true
       Destination: 74
      Annotation: 
       Subtype: Link
       Rect: 228, 618, 233, 604
       Flags: Print
       AppearanceDictionary: true
       Destination: 74
      Annotation: 
       Subtype: Link
       Rect: 95, 568, 100, 554
       Flags: Print
       AppearanceDictionary: true
       Destination: 74
      Annotation: 
       Subtype: Link
       Rect: 274, 468, 279, 454
       Flags: Print
       AppearanceDictionary: true
       Destination: 74
     Thumb: true
    Page: 
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 409, 718, 414, 704
       Flags: Print
       AppearanceDictionary: true
       Destination: 112
      Annotation: 
       Subtype: Link
       Rect: 458, 655, 463, 642
       Flags: Print
       AppearanceDictionary: true
       Destination: 112
      Annotation: 
       Subtype: Link
       Rect: 368, 618, 378, 604
       Flags: Print
       AppearanceDictionary: true
       Destination: 264
      Annotation: 
       Subtype: Link
       Rect: 367, 568, 372, 554
       Flags: Print
       AppearanceDictionary: true
       Destination: 129
      Annotation: 
       Subtype: Link
       Rect: 499, 568, 504, 554
       Flags: Print
       AppearanceDictionary: true
       Destination: 129
      Annotation: 
       Subtype: Link
       Rect: 481, 493, 486, 479
       Flags: Print
       AppearanceDictionary: true
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 486, 118, 496, 104
       Flags: Print
       AppearanceDictionary: true
       Destination: 264
      Annotation: 
       Subtype: Link
       Rect: 149, 718, 154, 704
       Flags: Print
       AppearanceDictionary: true
       Destination: 112
      Annotation: 
       Subtype: Link
       Rect: 117, 655, 122, 642
       Flags: Print
       AppearanceDictionary: true
       Destination: 112
      Annotation: 
       Subtype: Link
       Rect: 246, 618, 251, 604
       Flags: Print
       AppearanceDictionary: true
       Destination: 112
      Annotation: 
       Subtype: Link
       Rect: 74, 468, 79, 454
       Flags: Print
       AppearanceDictionary: true
       Destination: 112
      Annotation: 
       Subtype: Link
       Rect: 203, 418, 213, 404
       Flags: Print
       AppearanceDictionary: true
       Destination: 264
      Annotation: 
       Subtype: Link
       Rect: 218, 418, 228, 404
       Flags: Print
       AppearanceDictionary: true
       Destination: 264
      Annotation: 
       Subtype: Link
       Rect: 162, 380, 167, 367
       Flags: Print
       AppearanceDictionary: true
       Destination: 112
      Annotation: 
       Subtype: Link
       Rect: 275, 230, 280, 217
       Flags: Print
       AppearanceDictionary: true
       Destination: 112
     Thumb: true
    Page: 
     Sequence: 9
     Thumb: true
    Page: 
     Sequence: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 433, 680, 438, 667
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 339, 430, 349, 417
       Flags: Print
       AppearanceDictionary: true
       Destination: 264
      Annotation: 
       Subtype: Link
       Rect: 355, 430, 365, 417
       Flags: Print
       AppearanceDictionary: true
       Destination: 264
      Annotation: 
       Subtype: Link
       Rect: 536, 118, 541, 104
       Flags: Print
       AppearanceDictionary: true
       Destination: 159
      Annotation: 
       Subtype: Link
       Rect: 514, 93, 520, 79
       Flags: Print
       AppearanceDictionary: true
       Destination: 159
      Annotation: 
       Subtype: Link
       Rect: 189, 393, 194, 379
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
     Thumb: true
    Page: 
     Sequence: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 276, 193, 281, 179
       Flags: Print
       AppearanceDictionary: true
       Destination: 159
      Annotation: 
       Subtype: Link
       Rect: 131, 143, 136, 129
       Flags: Print
       AppearanceDictionary: true
       Destination: 159
     Thumb: true
    Page: 
     Sequence: 12
     Thumb: true
    Page: 
     Sequence: 13
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 458, 693, 463, 679
       Flags: Print
       AppearanceDictionary: true
       Destination: 159
      Annotation: 
       Subtype: Link
       Rect: 384, 555, 389, 542
       Flags: Print
       AppearanceDictionary: true
       Destination: 159
      Annotation: 
       Subtype: Link
       Rect: 528, 480, 533, 467
       Flags: Print
       AppearanceDictionary: true
       Destination: 159
      Annotation: 
       Subtype: Link
       Rect: 327, 305, 332, 292
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 414, 280, 419, 267
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 531, 118, 536, 104
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 99, 93, 104, 79
       Flags: Print
       AppearanceDictionary: true
       Destination: 159
     Thumb: true
    Page: 
     Sequence: 14
     Thumb: true
    Page: 
     Sequence: 15
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 130, 180, 135, 167
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
     Thumb: true
    Page: 
     Sequence: 16
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 469, 718, 479, 704
       Flags: Print
       AppearanceDictionary: true
       Destination: 264
      Annotation: 
       Subtype: Link
       Rect: 484, 718, 494, 704
       Flags: Print
       AppearanceDictionary: true
       Destination: 264
      Annotation: 
       Subtype: Link
       Rect: 473, 680, 478, 667
       Flags: Print
       AppearanceDictionary: true
       Destination: 176
      Annotation: 
       Subtype: Link
       Rect: 367, 605, 372, 592
       Flags: Print
       AppearanceDictionary: true
       Destination: 176
      Annotation: 
       Subtype: Link
       Rect: 119, 718, 124, 704
       Flags: Print
       AppearanceDictionary: true
       Destination: 176
      Annotation: 
       Subtype: Link
       Rect: 236, 605, 241, 592
       Flags: Print
       AppearanceDictionary: true
       Destination: 176
     Thumb: true
    Page: 
     Sequence: 17
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 350, 630, 360, 617
       Flags: Print
       AppearanceDictionary: true
       Destination: 264
      Annotation: 
       Subtype: Link
       Rect: 438, 555, 443, 542
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 518, 543, 523, 529
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 244, 643, 248, 629
       Flags: Print
       AppearanceDictionary: true
       Destination: 176
      Annotation: 
       Subtype: Link
       Rect: 71, 580, 76, 567
       Flags: Print
       AppearanceDictionary: true
       Destination: 176
      Annotation: 
       Subtype: Link
       Rect: 212, 543, 216, 529
       Flags: Print
       AppearanceDictionary: true
       Destination: 176
     Thumb: true
    Page: 
     Sequence: 18
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 432, 680, 442, 667
       Flags: Print
       AppearanceDictionary: true
       Destination: 264
      Annotation: 
       Subtype: Link
       Rect: 387, 543, 392, 529
       Flags: Print
       AppearanceDictionary: true
       Destination: 264
      Annotation: 
       Subtype: Link
       Rect: 398, 243, 408, 229
       Flags: Print
       AppearanceDictionary: true
       Destination: 264
      Annotation: 
       Subtype: Link
       Rect: 73, 668, 78, 654
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 234, 505, 244, 492
       Flags: Print
       AppearanceDictionary: true
       Destination: 264
      Annotation: 
       Subtype: Link
       Rect: 251, 505, 261, 492
       Flags: Print
       AppearanceDictionary: true
       Destination: 264
      Annotation: 
       Subtype: Link
       Rect: 110, 455, 115, 442
       Flags: Print
       AppearanceDictionary: true
       Destination: 264
      Annotation: 
       Subtype: Link
       Rect: 152, 268, 162, 254
       Flags: Print
       AppearanceDictionary: true
       Destination: 264
      Annotation: 
       Subtype: Link
       Rect: 218, 268, 228, 254
       Flags: Print
       AppearanceDictionary: true
       Destination: 264
     Thumb: true
    Page: 
     Sequence: 19
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 348, 718, 358, 704
       Flags: Print
       AppearanceDictionary: true
       Destination: 324
      Annotation: 
       Subtype: Link
       Rect: 309, 693, 319, 679
       Flags: Print
       AppearanceDictionary: true
       Destination: 324
      Annotation: 
       Subtype: Link
       Rect: 513, 680, 523, 667
       Flags: Print
       AppearanceDictionary: true
       Destination: 324
      Annotation: 
       Subtype: Link
       Rect: 528, 680, 538, 667
       Flags: Print
       AppearanceDictionary: true
       Destination: 324
      Annotation: 
       Subtype: Link
       Rect: 473, 530, 483, 517
       Flags: Print
       AppearanceDictionary: true
       Destination: 324
      Annotation: 
       Subtype: Link
       Rect: 533, 468, 538, 454
       Flags: Print
       AppearanceDictionary: true
       Destination: 264
      Annotation: 
       Subtype: Link
       Rect: 473, 430, 483, 417
       Flags: Print
       AppearanceDictionary: true
       Destination: 324
      Annotation: 
       Subtype: Link
       Rect: 442, 243, 452, 229
       Flags: Print
       AppearanceDictionary: true
       Destination: 324
      Annotation: 
       Subtype: Link
       Rect: 531, 218, 541, 204
       Flags: Print
       AppearanceDictionary: true
       Destination: 324
      Annotation: 
       Subtype: Link
       Rect: 306, 205, 316, 192
       Flags: Print
       AppearanceDictionary: true
       Destination: 324
      Annotation: 
       Subtype: Link
       Rect: 419, 180, 429, 167
       Flags: Print
       AppearanceDictionary: true
       Destination: 264
      Annotation: 
       Subtype: Link
       Rect: 513, 155, 523, 142
       Flags: Print
       AppearanceDictionary: true
       Destination: 264
      Annotation: 
       Subtype: Link
       Rect: 528, 155, 538, 142
       Flags: Print
       AppearanceDictionary: true
       Destination: 264
      Annotation: 
       Subtype: Link
       Rect: 498, 130, 508, 117
       Flags: Print
       AppearanceDictionary: true
       Destination: 324
      Annotation: 
       Subtype: Link
       Rect: 513, 130, 523, 117
       Flags: Print
       AppearanceDictionary: true
       Destination: 324
      Annotation: 
       Subtype: Link
       Rect: 100, 680, 110, 667
       Flags: Print
       AppearanceDictionary: true
       Destination: 264
      Annotation: 
       Subtype: Link
       Rect: 115, 680, 125, 667
       Flags: Print
       AppearanceDictionary: true
       Destination: 264
      Annotation: 
       Subtype: Link
       Rect: 273, 430, 283, 417
       Flags: Print
       AppearanceDictionary: true
       Destination: 264
      Annotation: 
       Subtype: Link
       Rect: 214, 380, 224, 367
       Flags: Print
       AppearanceDictionary: true
       Destination: 264
      Annotation: 
       Subtype: Link
       Rect: 159, 355, 169, 342
       Flags: Print
       AppearanceDictionary: true
       Destination: 264
      Annotation: 
       Subtype: Link
       Rect: 175, 268, 185, 254
       Flags: Print
       AppearanceDictionary: true
       Destination: 324
      Annotation: 
       Subtype: Link
       Rect: 190, 268, 200, 254
       Flags: Print
       AppearanceDictionary: true
       Destination: 324
      Annotation: 
       Subtype: Link
       Rect: 187, 243, 197, 229
       Flags: Print
       AppearanceDictionary: true
       Destination: 324
      Annotation: 
       Subtype: Link
       Rect: 202, 243, 212, 229
       Flags: Print
       AppearanceDictionary: true
       Destination: 324
      Annotation: 
       Subtype: Link
       Rect: 246, 180, 256, 167
       Flags: Print
       AppearanceDictionary: true
       Destination: 324
      Annotation: 
       Subtype: Link
       Rect: 196, 105, 206, 92
       Flags: Print
       AppearanceDictionary: true
       Destination: 264
     Thumb: true
    Page: 
     Sequence: 20
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 436, 647, 544, 635
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 637, 350, 625
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 461, 106, 544, 94
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 96, 372, 84
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 206, 705, 216, 692
       Flags: Print
       AppearanceDictionary: true
       Destination: 324
      Annotation: 
       Subtype: Link
       Rect: 121, 555, 131, 542
       Flags: Print
       AppearanceDictionary: true
       Destination: 324
      Annotation: 
       Subtype: Link
       Rect: 278, 505, 283, 492
       Flags: Print
       AppearanceDictionary: true
       Destination: 264
      Annotation: 
       Subtype: Link
       Rect: 157, 368, 167, 354
       Flags: Print
       AppearanceDictionary: true
       Destination: 324
      Annotation: 
       Subtype: Link
       Rect: 170, 330, 180, 317
       Flags: Print
       AppearanceDictionary: true
       Destination: 324
      Annotation: 
       Subtype: Link
       Rect: 120, 280, 130, 267
       Flags: Print
       AppearanceDictionary: true
       Destination: 324
      Annotation: 
       Subtype: Link
       Rect: 136, 280, 146, 267
       Flags: Print
       AppearanceDictionary: true
       Destination: 324
     Thumb: true
    Page: 
     Sequence: 21
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 507, 735, 544, 724
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 725, 445, 714
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 442, 695, 544, 684
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 685, 382, 674
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 464, 645, 544, 634
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 635, 395, 624
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 464, 605, 544, 594
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 595, 348, 584
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 437, 555, 544, 544
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 545, 371, 534
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 380, 515, 534, 504
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 464, 485, 544, 474
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 475, 377, 464
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 464, 445, 544, 434
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 435, 381, 424
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 464, 405, 544, 394
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 395, 353, 384
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 520, 365, 544, 354
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 355, 455, 344
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 386, 325, 502, 314
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 388, 295, 542, 284
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 245, 434, 234
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 507, 225, 544, 214
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 215, 426, 204
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 507, 185, 544, 174
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 175, 432, 164
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 507, 145, 544, 134
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 135, 418, 124
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 520, 115, 544, 104
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 105, 450, 94
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 209, 700, 289, 688
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 690, 179, 678
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 125, 650, 254, 638
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 209, 630, 289, 618
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 620, 82, 608
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 252, 590, 289, 578
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 580, 190, 568
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 108, 540, 257, 528
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 252, 520, 289, 508
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 510, 165, 498
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 252, 470, 289, 458
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 460, 221, 448
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 125, 430, 272, 418
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 209, 400, 289, 388
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 390, 185, 378
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 252, 370, 289, 358
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 360, 222, 348
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 209, 320, 289, 308
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 310, 134, 298
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 117, 270, 266, 258
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 133, 240, 274, 228
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 204, 210, 289, 198
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 200, 133, 188
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 209, 170, 289, 158
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 160, 150, 148
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 22
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 340, 705, 510, 694
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 389, 625, 511, 614
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 459, 595, 544, 584
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 585, 380, 574
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 507, 565, 544, 554
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 555, 475, 544
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 507, 535, 544, 524
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 525, 450, 514
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 507, 505, 544, 494
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 495, 403, 484
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 464, 465, 544, 454
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 455, 407, 444
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 459, 415, 544, 404
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 405, 382, 394
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 365, 466, 354
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 209, 735, 289, 724
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 725, 135, 714
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 209, 695, 289, 684
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 685, 152, 674
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 196, 645, 289, 634
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 635, 113, 624
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 125, 605, 263, 594
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 112, 565, 264, 554
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 198, 535, 289, 524
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 525, 155, 514
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 93, 475, 233, 464
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 252, 445, 289, 434
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 435, 144, 424
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 252, 405, 289, 394
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 395, 177, 384
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 204, 375, 289, 364
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 365, 128, 354
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 136, 325, 283, 314
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 295, 206, 284
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
  Checksum: c2e4184a
   Type: CRC32
  Checksum: 38690da45b76104f26a247a356080ca6
   Type: MD5
  Checksum: 5c8da6ffab2a5f82b42825fd2093ccb0b55c5ed0
   Type: SHA-1
  Checksum: 7f09a9ac6f7301eb880687a42c5ebd52a4638821f23b12616343ef0fedad79a1
   Type: SHA-256