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Keywords:        acute graft rejection, flow cytometry, immunophenotyping, transitional B cells, Breg
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      Title: Molecular screening of transitional B cells as a prognostic marker of improved graft outcome and reduced rejection risk in kidney transplant
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       Item: 
        Title: 1 Introduction
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       Item: 
        Title: 2 Materials and methods
        Destination: s2
        Children: 
         Item: 
          Title: 2.1 Patients
          Destination: s2_1
         Item: 
          Title: 2.2 Demographic data and protocol
          Destination: s2_2
         Item: 
          Title: 2.3 Whole blood processing
          Destination: s2_3
         Item: 
          Title: 2.4 Fresh whole blood cellular immunophenotyping
          Destination: s2_4
         Item: 
          Title: 2.5 Frozen PBMC immunophenotyping and RNA extraction
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         Item: 
          Title: 2.6 Gene expression analysis by qPCR
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         Item: 
          Title: 2.7 Statistical analysis
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       Item: 
        Title: 3 Results
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        Children: 
         Item: 
          Title: 3.1 Higher % of CD19+CD24hiCD38hi transitional B cells at 3 months correlate with improved graft outcome
          Destination: s3_1
         Item: 
          Title: 3.2 Transitional B-cell percentages at 3 months predict improved graft function up to 12 months post-transplantation
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         Item: 
          Title: 3.3 TrB analysis in frozen PBMCs is highly correlated to fresh samples and maintains prognostic values in 1-year allograft functional outcomes
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         Item: 
          Title: 3.4 Novel TrB cell-associated markers are overexpressed in patients with higher TrB cells at 3 months
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         Item: 
          Title: 3.5 TrB cell monitoring and molecular screening of TrB cells at 3 months predict long-term (>1 year) AKF
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        Title: 4 Discussion
        Destination: s4
       Item: 
        Title: Data availability statement
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       Item: 
        Title: Ethics statement
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        Title: Author contributions
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        Title: Funding
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       Item: 
        Title: Acknowledgments
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       Item: 
        Title: Conflict of interest
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       Item: 
        Title: Publisher’s note
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        Title: Supplementary material
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        Title: References
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    <rdf:li>Marta Clos-Sansalvador</rdf:li>
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    <rdf:li>Miriam Font-Morón</rdf:li>
    <rdf:li>Paula Rodríguez-Martínez</rdf:li>
    <rdf:li>Anna Vila-Santandreu</rdf:li>
    <rdf:li>Jordi Bover</rdf:li>
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  Checksum: 6054d9a1
   Type: CRC32
  Checksum: 541bbe1b578cf10a49ff4a95bdbfb3c0
   Type: MD5
  Checksum: 0cb03f39ca6a9ce2ff0862088226df6d67be3aca
   Type: SHA-1
  Checksum: 5b2b16c38b702fe16b4645e5291871c76b6b85308d3fadaf860ba7b16a466235
   Type: SHA-256