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PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Language: en-US Outlines: Item: Title: Neutralizing IL-­38 activates γδ T cell-­dependent antitumor immunity and sensitizes for chemotherapy Children: Item: Title: Abstract Item: Title: Introduction Item: Title: Methods Children: Item: Title: Animal experiments Item: Title: Flow cytometry Item: Title: Quantitative real-time PCR Item: Title: Selection and production of Fabs binding to mouse IL-38 Item: Title: Production of IgG e04 Item: Title: Bio-layer interferometry Item: Title: T-cell co-culture Item: Title: CD8+ T-cell proliferation assay Item: Title: cDC1 migration Item: Title: XCL1 ELISA Item: Title: Cytometric bead array Item: Title: Immunohistochemistry Item: Title: Whole transcriptome RNA sequencing Item: Title: Differential expression and GSEA analysis Item: Title: Analysis of human publicly available data sets Item: Title: Statistical analysis Item: Title: Data availability Item: Title: Results Children: Item: Title: Elevated antitumor immunity in IL-38-deficient murine mammary carcinoma Item: Title: IL-38 blockade limits mammary tumor growth Item: Title: IL-38 blockade synergizes with chemotherapy Item: Title: IL-38-dependent reduction in tumor growth is reversed by targeting γδ T cells Item: Title: Inhibiting IL-38 increases cDC1 infiltration into PyMT tumors Item: Title: γδ T cells recruit cDC1 via Xcl1 Item: Title: IL-38 is associated with T-cell infiltration and survival in human mammary carcinoma Item: Title: Discussion Item: Title: References Info: Creator: Adobe InDesign 15.1 (Windows) Producer: Adobe PDF Library 15.0 CreationDate: Wed Aug 28 13:20:49 CEST 2024 ModDate: Wed Aug 28 13:20:53 CEST 2024 ID: 0x4f45c92c5f925c42a320c2d1ea5eb09d, 0x351cee41d5757a4785aeafb6fdeff461 Filters: FilterPipeline: FlateDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2205 ImageHeight: 1566 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: 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