eac428eae37dadadcd3c25bdcd3c1fae pmc_11367969.pdf 4b477b544ac63315473cd531f52ebbb4b9943912 pmc_11367969.pdf 6ffd2fef020c9914893ff987440505cd7a1daf985967abb36332b111152faa3d pmc_11367969.pdf Title: Left atrial deformation analysis in patients with non-ischaemic dilated cardiomyopathy in atrial fibrillation Subject: DOI: 10.1093/ehjimp/qyae063; European Heart Journal - Imaging Methods and Practice, 2, 1, 2024-6-25.; Abstract: Aims: Atrial fibrillation (AF) is a common comorbidity in non-ischaemic dilated cardiomyopathy (NIDCM) affecting conventional measures of left atrial (LA) function. We aimed to determine whether LA function analysis could identify patients at higher risk of major cardiovascular events (MACEs). Methods and results: A retrospective study of patients with NIDCM in AF referred to a single centre for transthoracic echocardiography (TTE) between 2015 and 2019. Peak atrial longitudinal strain (PALS) was measured along with LA emptying fraction and LA filling index (LAFI = E wave/PALS). Cox regression analysis was conducted. A total of 153 patients were included [median age 74 years, left ventricular ejection fraction (LVEF) 35%], and 57 (37.3%) had MACE after a median follow-up of 3.2 years. LAFI was the only independent TTE parameter associated with MACE after adjustment for age Keywords: left atrial strain; non-ischaemic dilated cardiomyopathy; atrial fibrillation; left atrial filling index; echocardiography Author: Eduard Ródenas-Alesina Creator: Servigistics Arbortext Advanced Print Publisher 11.1.4546/W-x64 Producer: PDFlib+PDI 9.0.7p3 (C++/Win64) CreationDate: Mon Jul 8 15:35:40 2024 CEST ModDate: Mon Jul 8 17:30:28 2024 CEST Custom Metadata: yes Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 9 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 3870326 bytes Optimized: yes PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- FOJQTK+GillSansNova-Book CID TrueType Identity-H yes yes yes 1170 0 VVKZSS+GillSansNova-Bold CID TrueType Identity-H yes yes yes 1173 0 YGTHET+GillSansNova-BookItalic CID TrueType Identity-H yes yes yes 1176 0 RRXOUT+GillSansNova-Heavy CID TrueType Identity-H yes yes yes 1179 0 RWVRFJ+STIXGeneral-Regular Type 1C Custom yes yes yes 1182 0 NBTKMC+TimesNewRomanPSMT CID TrueType Identity-H yes yes yes 92 0 MFZTIU+GillSansNova-BoldItalic CID TrueType Identity-H yes yes yes 100 0 KLDSXZ+STIXGeneral-Bold Type 1C Custom yes yes yes 96 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-02-06 02:48:38 CET RepresentationInformation: pmc_11367969.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-12-19 02:28:57 CET Size: 3870326 Format: PDF Version: 1.6 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ErrorMessage: Invalid indirect destination - referenced object 'affqyae063-aff2' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'affqyae063-aff4' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'affqyae063-aff3' cannot be found ID: PDF-HUL-149 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'affqyae063-aff2' cannot be found ID: PDF-HUL-122 Offset: 3859326 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'affqyae063-aff3' cannot be found ID: PDF-HUL-122 Offset: 3859326 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'affqyae063-aff4' cannot be found ID: PDF-HUL-122 Offset: 3859326 MIMEtype: application/pdf Profile: Linearized PDF, Tagged PDF PDFMetadata: Objects: 0 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: true NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: OneColumn PageMode: UseOutlines Language: en Outlines: Item: Title: Left atrial deformation analysis in patients with non-ischaemic dilated cardiomyopathy in atrial fibrillation Destination: head1 Children: Item: Title: Introduction Destination: secqyae063-s0 Item: Title: Methods Destination: secqyae063-s1 Children: Item: Title: Patient population Destination: secqyae063-s1.1 Item: Title: Echocardiographic study Destination: secqyae063-s1.2 Item: Title: Statistical analysis Destination: secqyae063-s1.3 Item: Title: Results Destination: secqyae063-s2 Item: Title: Discussion Destination: secqyae063-s3 Children: Item: Title: Limitations Destination: secqyae063-s3.1 Item: Title: Conclusion Destination: secqyae063-s4 Item: Title: Acknowledgements Destination: acknow Item: Title: Funding Destination: secqyae063-s5 Item: Title: Data availability Destination: secqyae063-s6 Item: Title: Lead author biography Destination: secqyae063-s8 Item: Title: References Destination: reflist Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 465 ImageHeight: 1051 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1328 ImageHeight: 910 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1162 ImageHeight: 1649 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 275 ImageHeight: 354 BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type0: Font: BaseFont: FOJQTK+GillSansNova-Book Encoding: Identity-H ToUnicode: true Font: BaseFont: MFZTIU+GillSansNova-BoldItalic Encoding: Identity-H ToUnicode: true Font: BaseFont: VVKZSS+GillSansNova-Bold Encoding: Identity-H ToUnicode: true Font: BaseFont: YGTHET+GillSansNova-BookItalic Encoding: Identity-H ToUnicode: true Font: BaseFont: RRXOUT+GillSansNova-Heavy Encoding: Identity-H ToUnicode: true Font: BaseFont: NBTKMC+TimesNewRomanPSMT Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: KLDSXZ+STIXGeneral-Bold FontSubset: true FirstChar: 1 LastChar: 4 FontDescriptor: FontName: KLDSXZ+STIXGeneral-Bold Flags: Nonsymbolic, ForceBold FontBBox: -1030, -455, 2000, 1055 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: RWVRFJ+STIXGeneral-Regular FontSubset: true FirstChar: 1 LastChar: 6 FontDescriptor: FontName: RWVRFJ+STIXGeneral-Regular Flags: Nonsymbolic FontBBox: -995, -455, 2000, 1055 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true CIDFontType2: Font: BaseFont: FOJQTK+GillSansNova-Book CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: FOJQTK+GillSansNova-Book Flags: Nonsymbolic FontBBox: -420, -251, 1219, 950 FontFile2: true Font: BaseFont: MFZTIU+GillSansNova-BoldItalic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: MFZTIU+GillSansNova-BoldItalic Flags: Nonsymbolic, Italic, ForceBold FontBBox: -404, -250, 1219, 960 FontFile2: true Font: BaseFont: VVKZSS+GillSansNova-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: VVKZSS+GillSansNova-Bold Flags: Nonsymbolic, ForceBold FontBBox: -476, -276, 1276, 961 FontFile2: true Font: BaseFont: YGTHET+GillSansNova-BookItalic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: YGTHET+GillSansNova-BookItalic Flags: Nonsymbolic, Italic FontBBox: -316, -235, 1219, 950 FontFile2: true Font: BaseFont: RRXOUT+GillSansNova-Heavy CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: RRXOUT+GillSansNova-Heavy Flags: Nonsymbolic, ForceBold FontBBox: -504, -287, 1375, 966 FontFile2: true Font: BaseFont: NBTKMC+TimesNewRomanPSMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: NBTKMC+TimesNewRomanPSMT Flags: Nonsymbolic FontBBox: -568, -307, 2046, 1040 FontFile2: true XMP: uuid:fc3125f1-4fbb-4896-911d-4b3e56569dfc uuid:4706B37C-562C-F3EB-0F11-4817B30AB341 True left atrial strain; non-ischaemic dilated cardiomyopathy; atrial fibrillation; left atrial filling index; echocardiography PDFlib+PDI 9.0.7p3 (C++/Win64) application/pdf 10.1093/ehjimp/qyae063 en Oxford University Press Left atrial deformation analysis in patients with non-ischaemic dilated cardiomyopathy in atrial fibrillation Eduard Ródenas-Alesina Jordi Lozano-Torres Pablo Eduardo Tobías-Castillo Clara Badia-Molins Rosa Vila-Olives Maria Calvo-Barceló Guillem Casas Toni Soriano-Colomé Aleix Olivella San Emeterio Rubén Fernández-Galera Ana B. Méndez-Fernández José A. Barrabés Ignacio Ferreira-González José Rodríguez-Palomares DOI: 10.1093/ehjimp/qyae063; European Heart Journal - Imaging Methods and Practice, 2, 1, 2024-6-25.; Abstract: Aims: Atrial fibrillation (AF) is a common comorbidity in non-ischaemic dilated cardiomyopathy (NIDCM) affecting conventional measures of left atrial (LA) function. We aimed to determine whether LA function analysis could identify patients at higher risk of major cardiovascular events (MACEs). Methods and results: A retrospective study of patients with NIDCM in AF referred to a single centre for transthoracic echocardiography (TTE) between 2015 and 2019. Peak atrial longitudinal strain (PALS) was measured along with LA emptying fraction and LA filling index (LAFI = E wave/PALS). Cox regression analysis was conducted. A total of 153 patients were included [median age 74 years, left ventricular ejection fraction (LVEF) 35%], and 57 (37.3%) had MACE after a median follow-up of 3.2 years. LAFI was the only independent TTE parameter associated with MACE after adjustment for age © The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology. left atrial strain non-ischaemic dilated cardiomyopathy atrial fibrillation left atrial filling index echocardiography Journal European Heart Journal - Imaging Methods and Practice © The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology. 2755-9637 2 1 1 9 10.1093/ehjimp/qyae063 https://doi.org/10.1093/ehjimp/qyae063 2024-07-08T19:05:40+05:30 2024-07-08T21:00:28+05:30 Servigistics Arbortext Advanced Print Publisher 11.1.4546/W-x64 2024-07-08T21:00:28+05:30 PStill version 1.84.42 1 PDF/UA Universal Accessibility Schema http://www.aiim.org/pdfua/ns/id/ pdfuaid part Integer internal Indicates, which part of ISO 14289 standard is followed Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 197, 581, 207, 591 Flags: Print Annotation: Subtype: Link Rect: 209, 585, 215, 598 Flags: Print Destination: 1107 Annotation: Subtype: Link Rect: 218, 585, 223, 598 Flags: Print Destination: null Annotation: Subtype: Link Rect: 364, 585, 370, 598 Flags: Print Destination: 1107 Annotation: Subtype: Link Rect: 372, 585, 378, 598 Flags: Print Destination: null Annotation: Subtype: Link Rect: 228, 569, 234, 582 Flags: Print Destination: 1107 Annotation: Subtype: Link Rect: 237, 569, 242, 582 Flags: Print Destination: null Annotation: Subtype: Link Rect: 365, 569, 371, 582 Flags: Print Destination: 1107 Annotation: Subtype: Link Rect: 374, 569, 379, 582 Flags: Print Destination: null Annotation: Subtype: Link Rect: 486, 569, 492, 582 Flags: Print Destination: 1107 Annotation: Subtype: Link Rect: 494, 569, 500, 582 Flags: Print Destination: null Annotation: Subtype: Link Rect: 168, 553, 173, 566 Flags: Print Destination: 1107 Annotation: Subtype: Link Rect: 176, 553, 181, 566 Flags: Print Destination: null Annotation: Subtype: Link Rect: 275, 553, 280, 566 Flags: Print Destination: 1107 Annotation: Subtype: Link Rect: 283, 553, 288, 566 Flags: Print Destination: null Annotation: Subtype: Link Rect: 429, 553, 434, 566 Flags: Print Destination: 1107 Annotation: Subtype: Link Rect: 437, 553, 442, 566 Flags: Print Destination: null Annotation: Subtype: Link Rect: 210, 537, 215, 550 Flags: Print Destination: 1107 Annotation: Subtype: Link Rect: 218, 537, 224, 550 Flags: Print Destination: null Annotation: Subtype: Link Rect: 385, 537, 391, 550 Flags: Print Destination: 1107 Annotation: Subtype: Link Rect: 393, 537, 399, 550 Flags: Print Destination: null Annotation: Subtype: Link Rect: 205, 521, 210, 534 Flags: Print Destination: 1107 Annotation: Subtype: Link Rect: 213, 521, 219, 534 Flags: Print Destination: null Annotation: Subtype: Link Rect: 328, 521, 333, 534 Flags: Print Destination: 1107 Annotation: Subtype: Link Rect: 336, 521, 341, 534 Flags: Print Destination: null Annotation: Subtype: Link Rect: 344, 521, 350, 534 Flags: Print Destination: null Annotation: Subtype: Link Rect: 202, 505, 207, 518 Flags: Print Destination: 1107 Annotation: Subtype: Link Rect: 210, 505, 215, 518 Flags: Print Destination: null Annotation: Subtype: Link Rect: 218, 505, 224, 518 Flags: Print Destination: null Annotation: Subtype: Link Rect: 428, 505, 434, 518 Flags: Print Destination: 1107 Annotation: Subtype: Link Rect: 437, 505, 442, 518 Flags: Print Destination: null Annotation: Subtype: Link Rect: 445, 505, 450, 518 Flags: Print Destination: null Annotation: Subtype: Link Rect: 133, 90, 242, 97 Flags: Print Annotation: Subtype: Link Rect: 284, 90, 370, 97 Flags: Print Annotation: Subtype: Link Rect: 336, 63, 458, 70 Flags: Print Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 62, 320, 65, 329 Flags: Print Destination: 30 Annotation: Subtype: Link Rect: 67, 320, 70, 329 Flags: Print Destination: 30 Annotation: Subtype: Link Rect: 180, 310, 183, 319 Flags: Print Destination: 30 Annotation: Subtype: Link Rect: 188, 289, 191, 298 Flags: Print Destination: 30 Annotation: Subtype: Link Rect: 195, 289, 198, 298 Flags: Print Destination: 30 Annotation: Subtype: Link Rect: 214, 236, 217, 245 Flags: Print Destination: 30 Annotation: Subtype: Link Rect: 221, 236, 228, 245 Flags: Print Destination: 30 Annotation: Subtype: Link Rect: 67, 194, 71, 203 Flags: Print Destination: 30 Annotation: Subtype: Link Rect: 74, 194, 77, 203 Flags: Print Destination: 30 Annotation: Subtype: Link Rect: 79, 194, 85, 203 Flags: Print Destination: 30 Annotation: Subtype: Link Rect: 87, 194, 93, 203 Flags: Print Destination: 30 Annotation: Subtype: Link Rect: 119, 89, 123, 98 Flags: Print Destination: 30 Annotation: Subtype: Link Rect: 126, 89, 129, 98 Flags: Print Destination: 30 Annotation: Subtype: Link Rect: 125, 68, 131, 77 Flags: Print Destination: 30 Annotation: Subtype: Link Rect: 133, 68, 139, 77 Flags: Print Destination: 30 Annotation: Subtype: Link Rect: 493, 229, 500, 237 Flags: Print Destination: 30 Annotation: Subtype: Link Rect: 501, 229, 507, 237 Flags: Print Destination: 30 Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 250, 622, 256, 630 Flags: Print Destination: 30 Annotation: Subtype: Link Rect: 90, 574, 97, 583 Flags: Print Destination: 30 Annotation: Subtype: Link Rect: 285, 508, 291, 516 Flags: Print Destination: 30 Annotation: Subtype: Link Rect: 61, 148, 88, 157 Flags: Print Destination: 7 Annotation: Subtype: Link Rect: 118, 96, 144, 105 Flags: Print Destination: 13 Annotation: Subtype: Link Rect: 318, 243, 344, 252 Flags: Print Destination: 16 Annotation: Subtype: Link Rect: 381, 64, 407, 73 Flags: Print Destination: 16 Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 226, 96, 253, 105 Flags: Print Destination: 19 Annotation: Subtype: Link Rect: 448, 127, 475, 136 Flags: Print Destination: 22 Annotation: Subtype: Link Rect: 312, 106, 339, 115 Flags: Print Destination: 26 Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 333, 715, 360, 724 Flags: Print Destination: 26 Annotation: Subtype: Link Rect: 357, 504, 364, 513 Flags: Print Destination: 30 Annotation: Subtype: Link Rect: 543, 441, 550, 450 Flags: Print Destination: 30 Annotation: Subtype: Link Rect: 551, 441, 558, 450 Flags: Print Destination: 30 Annotation: Subtype: Link Rect: 418, 399, 425, 408 Flags: Print Destination: 30 Annotation: Subtype: Link Rect: 379, 389, 386, 398 Flags: Print Destination: 30 Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 58, 131, 65, 140 Flags: Print Destination: 30 Annotation: Subtype: Link Rect: 107, 121, 114, 130 Flags: Print Destination: 30 Annotation: Subtype: Link Rect: 329, 58, 335, 67 Flags: Print Destination: 30 Annotation: Subtype: Link Rect: 337, 58, 343, 67 Flags: Print Destination: 30 Annotation: Subtype: Link Rect: 345, 58, 351, 67 Flags: Print Destination: 30 Annotation: Subtype: Link Rect: 353, 58, 360, 67 Flags: Print Destination: 30 Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 180, 268, 187, 277 Flags: Print Destination: 30 Annotation: Subtype: Link Rect: 124, 236, 131, 245 Flags: Print Destination: 30 Annotation: Subtype: Link Rect: 175, 163, 182, 172 Flags: Print Destination: 30 Annotation: Subtype: Link Rect: 83, 152, 90, 161 Flags: Print Destination: 30 Annotation: Subtype: Link Rect: 551, 289, 558, 298 Flags: Print Destination: 30 Page: Sequence: 8 Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 161, 616, 216, 625 Flags: Print Annotation: Subtype: Link Rect: 46, 326, 49, 333 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 46, 299, 49, 306 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 46, 272, 49, 279 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 46, 245, 49, 252 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 46, 218, 49, 225 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 46, 173, 49, 180 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 46, 146, 49, 153 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 313, 727, 316, 735 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 313, 699, 316, 706 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 309, 670, 316, 677 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 309, 642, 316, 649 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 309, 604, 316, 611 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 309, 575, 316, 582 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 309, 537, 316, 544 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 309, 518, 316, 525 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 309, 489, 316, 497 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 309, 461, 316, 468 Flags: Print Destination: 7 Annotation: Subtype: Link Rect: 309, 432, 316, 439 Flags: Print Destination: 7 Annotation: Subtype: Link Rect: 309, 384, 316, 391 Flags: Print Destination: 16 Annotation: Subtype: Link Rect: 309, 346, 316, 353 Flags: Print Destination: 16 Annotation: Subtype: Link Rect: 309, 318, 316, 325 Flags: Print Destination: 16 Annotation: Subtype: Link Rect: 309, 289, 316, 296 Flags: Print Destination: 16 Annotation: Subtype: Link Rect: 309, 261, 316, 267 Flags: Print Destination: 16 Annotation: Subtype: Link Rect: 309, 242, 316, 249 Flags: Print Destination: 16 Annotation: Subtype: Link Rect: 309, 223, 316, 230 Flags: Print Destination: 19 Annotation: Subtype: Link Rect: 309, 204, 316, 211 Flags: Print Destination: 19 Annotation: Subtype: Link Rect: 309, 176, 316, 183 Flags: Print Destination: 19 Annotation: Subtype: Link Rect: 309, 147, 316, 154 Flags: Print Destination: 22 Checksum: cbf57bdb Type: CRC32 Checksum: eac428eae37dadadcd3c25bdcd3c1fae Type: MD5 Checksum: 4b477b544ac63315473cd531f52ebbb4b9943912 Type: SHA-1 Checksum: 6ffd2fef020c9914893ff987440505cd7a1daf985967abb36332b111152faa3d Type: SHA-256