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Umbrella Review of 1478 Biomarkers Subject: DOI: 10.1093/schizbullopen/sgae018 Schizophrenia Bulletin Open Volume No: XX Issue No: XX 00,00 00,00 00,00 Author: Paola Fuentes-Claramonte,Andrés Estradé,Aleix Solanes,Valentina Ramella-Cravaro,Maria Angeles Garcia-Leon,Javier de Diego-Adeliño,Conrad Molins,Eric Fung,Marc Valentí,Gerard Anmella,Edith Pomarol-Clotet,Dominic Oliver,Eduard Vieta,Joaquim Radua,Paolo Fusar-Poli Creator: Adobe InDesign 15.1 (Windows) Producer: Adobe PDF Library 15.0 CreationDate: Fri Aug 30 17:38:57 2024 CEST ModDate: Fri Aug 30 17:39:00 2024 CEST Custom Metadata: no Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 16 Encrypted: no Page size: 593.858 x 782.929 pts Page rot: 0 File size: 928875 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- UICBIK+TimesNewRomanMTStd Type 1C Custom yes yes yes 117 0 YPTKMC+TimesNewRomanMTStd-Bold Type 1C Custom yes yes yes 118 0 CGOYQU+TimesNewRomanMTStd-BoldIt Type 1C WinAnsi yes yes yes 119 0 ZUBBVA+TimesNewRomanMTStd-Italic Type 1C Custom yes yes yes 120 0 DLWUZS+TimesNewRomanMTStd-SC700 Type 1C WinAnsi yes yes yes 322 0 UVGNDK+GandhariUnicode-Roman Type 1C Custom yes yes yes 523 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-02-08 02:53:33 CET RepresentationInformation: pmc_11369642.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-02-06 02:52:11 CET Size: 928875 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Tagged PDF PDFMetadata: Objects: 3680 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: true NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: OneColumn PageMode: UseOutlines Language: en-US Outlines: Item: Title: Biomarkers for Psychosis: Are We There Yet? Umbrella Review of 1478 Biomarkers Children: Item: Title: Introduction Item: Title: Methods Children: Item: Title: Search Strategy and Eligibility Criteria Item: Title: Definition of Biomarker Item: Title: Data Extraction and Selection Item: Title: Statistical Analyses Item: Title: Evidence Stratification Item: Title: Results Children: Item: Title: Peripheral Biomarkers Item: Title: Electrophysiologic Biomarkers Item: Title: Neuroimaging Biomarkers Item: Title: Neuropathological Biomarkers Item: Title: Other Biomarkers Item: Title: Discussion Item: Title: Conclusion Item: Title: Supplementary Material Item: Title: References Info: Title: Biomarkers for Psychosis: Are We There Yet? Umbrella Review of 1478 Biomarkers Author: Paola Fuentes-Claramonte,Andrés Estradé,Aleix Solanes,Valentina Ramella-Cravaro,Maria Angeles Garcia-Leon,Javier de Diego-Adeliño,Conrad Molins,Eric Fung,Marc Valentí,Gerard Anmella,Edith Pomarol-Clotet,Dominic Oliver,Eduard Vieta,Joaquim Radua,Paolo Fusar-Poli Subject: DOI: 10.1093/schizbullopen/sgae018 Schizophrenia Bulletin Open Volume No: XX Issue No: XX 00,00 00,00 00,00 Creator: Adobe InDesign 15.1 (Windows) Producer: Adobe PDF Library 15.0 CreationDate: Fri Aug 30 18:08:57 CEST 2024 ModDate: Fri Aug 30 18:09:00 CEST 2024 ID: 0xe5ae095135423a479abe375e5fda4d98, 0x12a83b15bce45542af9501ad4b42a3f2 Filters: FilterPipeline: FlateDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1174 ImageHeight: 546 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1174 ImageHeight: 908 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1167 ImageHeight: 587 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1174 ImageHeight: 794 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Fonts: Type1: Font: BaseFont: DLWUZS+TimesNewRomanMTStd-SC700 FontSubset: true FirstChar: 68 LastChar: 68 FontDescriptor: FontName: DLWUZS+TimesNewRomanMTStd-SC700 Flags: Serif, Nonsymbolic FontBBox: -94, -241, 1006, 916 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: UICBIK+TimesNewRomanMTStd FontSubset: true FirstChar: 27 LastChar: 252 FontDescriptor: FontName: UICBIK+TimesNewRomanMTStd Flags: Serif, Nonsymbolic FontBBox: -94, -241, 1006, 916 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: YPTKMC+TimesNewRomanMTStd-Bold FontSubset: true FirstChar: 30 LastChar: 241 FontDescriptor: FontName: YPTKMC+TimesNewRomanMTStd-Bold Flags: Serif, Nonsymbolic FontBBox: -191, -241, 1065, 957 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: CGOYQU+TimesNewRomanMTStd-BoldIt FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: CGOYQU+TimesNewRomanMTStd-BoldIt Flags: Serif, Nonsymbolic, Italic FontBBox: -266, -259, 1076, 942 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: ZUBBVA+TimesNewRomanMTStd-Italic FontSubset: true FirstChar: 31 LastChar: 122 FontDescriptor: FontName: ZUBBVA+TimesNewRomanMTStd-Italic Flags: Serif, Nonsymbolic, Italic FontBBox: -271, -246, 1100, 904 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: UVGNDK+GandhariUnicode-Roman FontSubset: true FirstChar: 27 LastChar: 31 FontDescriptor: FontName: UVGNDK+GandhariUnicode-Roman Flags: Serif, Nonsymbolic FontBBox: -752, -250, 1779, 944 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true XMP: uuid:9dd8e102-a501-4f7e-9e52-13926be0b997 adobe:docid:indd:dd3eee1a-5fba-11e1-9cb2-d75d2d06e590 xmp.id:e0a548f8-b0d0-0845-a1e9-8bec9a605146 proof:pdf xmp.iid:eaba10de-4ef0-0c49-9c7d-853dacd24af6 xmp.did:6f11076e-9fc6-8448-9569-dac06dc984d5 adobe:docid:indd:dd3eee1a-5fba-11e1-9cb2-d75d2d06e590 default converted from application/x-indesign to application/pdf Adobe InDesign 15.1 (Windows) / 2024-08-30T21:08:57+05:30 2024-08-30T21:08:57+05:30 2024-08-30T21:09+05:30 2024-08-30T21:09+05:30 Adobe InDesign 15.1 (Windows) application/pdf Biomarkers for Psychosis: Are We There Yet? Umbrella Review of 1478 Biomarkers DOI: 10.1093/schizbullopen/sgae018 Schizophrenia Bulletin Open Volume No: XX Issue No: XX 00,00 00,00 00,00 © The Author(s) 2024. Published by Oxford University Press on behalf of the University of Maryland's school of medicine, Maryland Psychiatric Research Center. Paola Fuentes-Claramonte,Andrés Estradé,Aleix Solanes,Valentina Ramella-Cravaro,Maria Angeles Garcia-Leon,Javier de Diego-Adeliño,Conrad Molins,Eric Fung,Marc Valentí,Gerard Anmella,Edith Pomarol-Clotet,Dominic Oliver,Eduard Vieta,Joaquim Radua,Paolo Fusar-Poli schizophrenia/ psychotic disorders/ peripheral biomarkers/ electrophysiological biomarkers/ neuroimaging biomarkers/ neuropathological biomarkers True Adobe PDF Library 15.0 False Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 399, 63, 547, 54 Annotation: Subtype: Link Rect: 157, 624, 160, 611 ActionDest: 18 Annotation: Subtype: Link Rect: 162, 624, 165, 611 ActionDest: 18 Annotation: Subtype: Link Rect: 166, 624, 173, 611 ActionDest: 18 Annotation: Subtype: Link Rect: 172, 623, 180, 615 Annotation: Subtype: Link Rect: 172, 623, 180, 615 Annotation: Subtype: Link Rect: 250, 624, 253, 611 ActionDest: 18 Annotation: Subtype: Link Rect: 255, 624, 258, 611 ActionDest: 18 Annotation: Subtype: Link Rect: 260, 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Annotation: Subtype: Link Rect: 331, 391, 485, 380 ActionDest: 35 Annotation: Subtype: Link Rect: 331, 349, 531, 338 ActionDest: 35 Annotation: Subtype: Link Rect: 331, 307, 387, 296 ActionDest: 35 Annotation: Subtype: Link Rect: 331, 285, 563, 274 ActionDest: 35 Annotation: Subtype: Link Rect: 331, 253, 393, 242 ActionDest: 35 Annotation: Subtype: Link Rect: 331, 221, 418, 210 ActionDest: 36 Annotation: Subtype: Link Rect: 331, 199, 392, 188 ActionDest: 35 Annotation: Subtype: Link Rect: 331, 157, 537, 146 ActionDest: 41 Annotation: Subtype: Link Rect: 331, 125, 500, 114 ActionDest: 35 Annotation: Subtype: Link Rect: 331, 83, 493, 72 ActionDest: 35 Page: Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 51, 721, 219, 710 ActionDest: 43 Annotation: Subtype: Link Rect: 321, 583, 404, 572 ActionDest: 35 Annotation: Subtype: Link Rect: 321, 561, 507, 550 ActionDest: 36 Annotation: Subtype: Link Rect: 321, 529, 469, 518 ActionDest: 36 Annotation: Subtype: Link Rect: 321, 497, 554, 486 ActionDest: 36 Annotation: Subtype: Link Rect: 321, 487, 433, 476 ActionDest: 36 Annotation: Subtype: Link Rect: 321, 445, 494, 434 ActionDest: 36 Annotation: Subtype: Link Rect: 321, 413, 485, 402 ActionDest: 36 Annotation: Subtype: Link Rect: 321, 371, 494, 360 ActionDest: 36 Annotation: Subtype: Link Rect: 321, 329, 489, 318 ActionDest: 43 Annotation: Subtype: Link Rect: 321, 213, 364, 202 ActionDest: 37 Annotation: Subtype: Link Rect: 321, 191, 516, 180 ActionDest: 37 Annotation: Subtype: Link Rect: 321, 159, 379, 148 ActionDest: 37 Annotation: Subtype: Link Rect: 321, 127, 495, 116 ActionDest: 38 Annotation: Subtype: Link Rect: 321, 95, 411, 84 ActionDest: 38 Annotation: Subtype: Link Rect: 321, 73, 445, 62 ActionDest: 41 Page: Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 61, 499, 199, 488 ActionDest: 41 Annotation: Subtype: Link Rect: 61, 457, 212, 446 ActionDest: 41 Annotation: Subtype: Link Rect: 61, 425, 293, 414 ActionDest: 41 Annotation: Subtype: Link Rect: 61, 339, 294, 328 ActionDest: 42 Annotation: Subtype: Link Rect: 61, 329, 68, 318 ActionDest: 42 Annotation: Subtype: Link Rect: 61, 307, 219, 296 ActionDest: 38 Annotation: Subtype: Link Rect: 61, 127, 196, 116 ActionDest: 38 Annotation: Subtype: Link Rect: 61, 95, 226, 84 ActionDest: 42 Annotation: Subtype: Link Rect: 331, 721, 469, 710 ActionDest: 38 Annotation: Subtype: Link Rect: 331, 679, 528, 668 ActionDest: 38 Annotation: Subtype: Link Rect: 331, 637, 563, 626 ActionDest: 40 Annotation: Subtype: Link Rect: 331, 627, 382, 616 ActionDest: 40 Annotation: Subtype: Link Rect: 331, 605, 566, 594 ActionDest: 40 Annotation: Subtype: Link Rect: 331, 595, 401, 584 ActionDest: 40 Annotation: Subtype: Link Rect: 331, 563, 378, 552 ActionDest: 40 Annotation: Subtype: Link Rect: 331, 541, 376, 530 ActionDest: 40 Annotation: Subtype: Link Rect: 331, 509, 478, 498 ActionDest: 40 Annotation: Subtype: Link Rect: 331, 487, 565, 476 ActionDest: 40 Annotation: Subtype: Link Rect: 331, 477, 375, 466 ActionDest: 40 Annotation: Subtype: Link Rect: 331, 445, 521, 434 ActionDest: 40 Annotation: Subtype: Link Rect: 331, 423, 482, 412 ActionDest: 40 Annotation: Subtype: Link Rect: 331, 381, 517, 370 ActionDest: 40 Annotation: Subtype: Link Rect: 331, 253, 473, 242 ActionDest: 42 Annotation: Subtype: Link Rect: 331, 115, 471, 104 ActionDest: 41 Annotation: Subtype: Link Rect: 331, 83, 497, 72 ActionDest: 41 Page: Sequence: 14 Annotations: Annotation: Subtype: Link Rect: 51, 721, 218, 710 ActionDest: 41 Annotation: Subtype: Link Rect: 51, 699, 285, 688 ActionDest: 41 Annotation: Subtype: Link Rect: 51, 689, 60, 678 ActionDest: 41 Annotation: Subtype: Link Rect: 51, 647, 282, 636 ActionDest: 41 Annotation: Subtype: Link Rect: 51, 637, 91, 626 ActionDest: 41 Annotation: Subtype: Link Rect: 51, 605, 214, 594 ActionDest: 41 Annotation: Subtype: Link Rect: 51, 573, 196, 562 ActionDest: 41 Annotation: Subtype: Link Rect: 51, 531, 251, 520 ActionDest: 41 Annotation: Subtype: Link Rect: 51, 489, 198, 478 ActionDest: 41 Annotation: Subtype: Link Rect: 51, 457, 224, 446 ActionDest: 41 Annotation: Subtype: Link Rect: 51, 425, 284, 414 ActionDest: 41 Annotation: Subtype: Link Rect: 51, 415, 56, 404 ActionDest: 41 Annotation: Subtype: Link Rect: 51, 393, 221, 382 ActionDest: 41 Annotation: Subtype: Link Rect: 51, 361, 197, 350 ActionDest: 41 Annotation: Subtype: Link Rect: 51, 319, 285, 308 ActionDest: 41 Annotation: Subtype: Link Rect: 51, 309, 101, 298 ActionDest: 41 Annotation: Subtype: Link Rect: 51, 277, 283, 266 ActionDest: 41 Annotation: Subtype: Link Rect: 51, 267, 64, 256 ActionDest: 41 Annotation: Subtype: Link Rect: 51, 245, 169, 234 ActionDest: 41 Annotation: Subtype: Link Rect: 51, 213, 176, 202 ActionDest: 41 Annotation: Subtype: Link Rect: 51, 171, 282, 160 ActionDest: 41 Annotation: Subtype: Link Rect: 51, 161, 84, 150 ActionDest: 41 Annotation: Subtype: Link Rect: 51, 129, 215, 118 ActionDest: 41 Annotation: Subtype: Link Rect: 51, 77, 117, 66 ActionDest: 41 Annotation: Subtype: Link Rect: 321, 699, 472, 688 ActionDest: 41 Annotation: Subtype: Link Rect: 321, 667, 552, 656 ActionDest: 41 Annotation: Subtype: Link Rect: 321, 657, 414, 646 ActionDest: 41 Annotation: Subtype: Link Rect: 321, 625, 488, 614 ActionDest: 41 Annotation: Subtype: Link Rect: 321, 561, 492, 550 ActionDest: 41 Annotation: Subtype: Link Rect: 321, 508, 552, 498 ActionDest: 41 Annotation: Subtype: Link Rect: 321, 498, 366, 488 ActionDest: 41 Annotation: Subtype: Link Rect: 321, 466, 552, 456 ActionDest: 41 Annotation: Subtype: Link Rect: 321, 424, 553, 413 ActionDest: 41 Annotation: Subtype: Link Rect: 321, 414, 328, 403 ActionDest: 41 Annotation: Subtype: Link Rect: 321, 382, 422, 371 ActionDest: 41 Annotation: Subtype: Link Rect: 321, 349, 487, 339 ActionDest: 41 Annotation: Subtype: Link Rect: 321, 307, 552, 297 ActionDest: 41 Annotation: Subtype: Link Rect: 321, 297, 367, 287 ActionDest: 41 Annotation: Subtype: Link Rect: 321, 265, 556, 254 ActionDest: 41 Annotation: Subtype: Link Rect: 321, 255, 354, 244 ActionDest: 41 Annotation: Subtype: Link Rect: 321, 212, 441, 202 ActionDest: 41 Annotation: Subtype: Link Rect: 321, 180, 552, 170 ActionDest: 41 Annotation: Subtype: Link Rect: 321, 138, 552, 128 ActionDest: 41 Annotation: Subtype: Link Rect: 321, 96, 552, 86 ActionDest: 41 Annotation: Subtype: Link Rect: 321, 86, 383, 76 ActionDest: 41 Page: Sequence: 15 Annotations: Annotation: Subtype: Link Rect: 61, 721, 251, 710 ActionDest: 41 Annotation: Subtype: Link Rect: 61, 583, 293, 572 ActionDest: 41 Annotation: Subtype: Link Rect: 61, 573, 293, 562 ActionDest: 41 Annotation: Subtype: Link Rect: 61, 531, 293, 520 ActionDest: 41 Annotation: Subtype: Link Rect: 61, 361, 209, 350 ActionDest: 42 Annotation: Subtype: Link Rect: 61, 329, 245, 318 ActionDest: 42 Annotation: Subtype: Link Rect: 61, 277, 142, 266 ActionDest: 42 Annotation: Subtype: Link Rect: 61, 245, 194, 234 ActionDest: 42 Annotation: Subtype: Link Rect: 61, 203, 152, 192 ActionDest: 42 Annotation: Subtype: Link Rect: 61, 161, 220, 150 ActionDest: 42 Annotation: Subtype: Link Rect: 61, 119, 225, 108 ActionDest: 42 Annotation: Subtype: Link Rect: 331, 615, 563, 604 ActionDest: 42 Annotation: Subtype: Link Rect: 331, 573, 478, 562 ActionDest: 42 Annotation: Subtype: Link Rect: 331, 393, 501, 382 ActionDest: 42 Annotation: Subtype: Link Rect: 331, 361, 455, 350 ActionDest: 42 Annotation: Subtype: Link Rect: 331, 309, 469, 298 ActionDest: 42 Annotation: Subtype: Link Rect: 331, 277, 477, 266 ActionDest: 42 Annotation: Subtype: Link Rect: 331, 225, 491, 214 ActionDest: 42 Annotation: Subtype: Link Rect: 331, 183, 563, 172 ActionDest: 42 Annotation: Subtype: Link Rect: 331, 151, 563, 140 ActionDest: 42 Annotation: Subtype: Link Rect: 331, 119, 479, 108 ActionDest: 42 Annotation: Subtype: Link Rect: 331, 87, 564, 76 ActionDest: 42 Annotation: Subtype: Link Rect: 331, 77, 406, 66 ActionDest: 42 Page: Sequence: 16 Annotations: Annotation: Subtype: Link Rect: 51, 699, 186, 688 ActionDest: 42 Annotation: Subtype: Link Rect: 51, 667, 130, 656 ActionDest: 42 Annotation: Subtype: Link Rect: 51, 645, 226, 634 ActionDest: 42 Annotation: Subtype: Link Rect: 51, 613, 222, 602 ActionDest: 42 Annotation: Subtype: Link Rect: 51, 581, 282, 570 ActionDest: 42 Annotation: Subtype: Link Rect: 51, 539, 138, 528 ActionDest: 42 Annotation: Subtype: Link Rect: 51, 517, 114, 506 ActionDest: 42 Annotation: Subtype: Link Rect: 51, 485, 231, 474 ActionDest: 42 Annotation: Subtype: Link Rect: 51, 443, 166, 432 ActionDest: 42 Annotation: Subtype: Link Rect: 51, 421, 135, 410 ActionDest: 42 Annotation: Subtype: Link Rect: 51, 389, 282, 378 ActionDest: 42 Annotation: Subtype: Link Rect: 51, 347, 241, 336 ActionDest: 42 Annotation: Subtype: Link Rect: 51, 305, 282, 294 ActionDest: 42 Annotation: Subtype: Link Rect: 51, 273, 182, 262 ActionDest: 42 Annotation: Subtype: Link Rect: 321, 721, 456, 710 ActionDest: 42 Annotation: Subtype: Link Rect: 321, 689, 440, 678 ActionDest: 42 Annotation: Subtype: Link Rect: 321, 667, 556, 656 ActionDest: 42 Annotation: Subtype: Link Rect: 321, 657, 422, 646 ActionDest: 42 Annotation: Subtype: Link Rect: 321, 624, 377, 614 ActionDest: 42 Annotation: Subtype: Link Rect: 321, 602, 503, 591 ActionDest: 43 Annotation: Subtype: Link Rect: 321, 570, 518, 559 ActionDest: 43 Annotation: Subtype: Link Rect: 321, 537, 357, 527 ActionDest: 43 Annotation: Subtype: Link Rect: 321, 515, 519, 504 ActionDest: 43 Annotation: Subtype: Link Rect: 321, 472, 498, 462 ActionDest: 43 Annotation: Subtype: Link Rect: 336, 442, 454, 432 Annotation: Subtype: Link Rect: 321, 430, 483, 419 ActionDest: 43 Annotation: Subtype: Link Rect: 321, 398, 417, 387 ActionDest: 43 Annotation: Subtype: Link Rect: 321, 345, 508, 335 ActionDest: 43 Annotation: Subtype: Link Rect: 321, 293, 478, 282 ActionDest: 43 Checksum: bc513d07 Type: CRC32 Checksum: beb0495e71f3cfbd84a56aeda05ae62f Type: MD5 Checksum: 215d9435928667bb20148d2646606ab19d405f09 Type: SHA-1 Checksum: 49b90e7340cde068edc2c15909ed31ef6b334898d50f704e2520d694fea98cf8 Type: SHA-256